PT1988910T - Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparação - Google Patents
Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparaçãoInfo
- Publication number
- PT1988910T PT1988910T PT77520963T PT07752096T PT1988910T PT 1988910 T PT1988910 T PT 1988910T PT 77520963 T PT77520963 T PT 77520963T PT 07752096 T PT07752096 T PT 07752096T PT 1988910 T PT1988910 T PT 1988910T
- Authority
- PT
- Portugal
- Prior art keywords
- acryloyloxyethylphosphorylcholine
- preparation
- containing polymer
- polymer conjugates
- conjugates
- Prior art date
Links
- LWLHCZLCSDUDEL-UHFFFAOYSA-O C[N+](C)(C)CC(O)=P(=O)CCOC(=O)C=C Chemical compound C[N+](C)(C)CC(O)=P(=O)CCOC(=O)C=C LWLHCZLCSDUDEL-UHFFFAOYSA-O 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77691606P | 2006-02-28 | 2006-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1988910T true PT1988910T (pt) | 2018-02-07 |
Family
ID=38459678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT77520963T PT1988910T (pt) | 2006-02-28 | 2007-02-28 | Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparação |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20100166700A1 (pt) |
| EP (2) | EP1988910B1 (pt) |
| JP (2) | JP5528710B2 (pt) |
| DK (1) | DK1988910T3 (pt) |
| ES (1) | ES2657628T3 (pt) |
| LT (1) | LT1988910T (pt) |
| PT (1) | PT1988910T (pt) |
| SI (1) | SI1988910T1 (pt) |
| WO (2) | WO2007100902A2 (pt) |
Families Citing this family (39)
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|---|---|---|---|---|
| JP2928685B2 (ja) | 1992-07-29 | 1999-08-03 | エナジーサポート株式会社 | ガス開閉器における開閉表示用指針軸の構造 |
| GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| JP5528710B2 (ja) | 2006-02-28 | 2014-06-25 | オリガシス コーポレイション | アクリロイルオキシエチルホスホリルコリン含有ポリマー抱合体及びその製法 |
| WO2010033216A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of nesiritide peptides |
| EP2260873B1 (en) * | 2009-06-08 | 2019-07-24 | Biocompatibles UK Limited | Pcylation of proteins |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| KR102416359B1 (ko) * | 2010-04-15 | 2022-07-01 | 코디악 사이언시스 인코포레이티드 | 고분자량 쌍성이온-함유 중합체 |
| CN101870735B (zh) * | 2010-06-02 | 2013-06-12 | 北京精益泰翔技术发展有限公司 | 一种新型高糖基化促红细胞生成素免疫融合蛋白 |
| WO2012061165A2 (en) * | 2010-10-25 | 2012-05-10 | Lu Xiandan Sharon | Methods and compositions for improving admet properties |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| EP3434691A1 (en) | 2010-12-01 | 2019-01-30 | AlderBio Holdings LLC | Anti-ngf compositions and use thereof |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9872864B2 (en) * | 2011-08-12 | 2018-01-23 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
| JP6195848B2 (ja) * | 2012-01-27 | 2017-09-13 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 糖ポリマーを用いた生体分子の安定化 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| JP6542128B2 (ja) | 2013-01-11 | 2019-07-10 | コルセア ファーマ インコーポレイテッド | トレプロスチニルのプロドラッグ |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| PL3041513T3 (pl) * | 2013-09-08 | 2021-01-25 | Kodiak Sciences Inc. | Obojnaczojonowe polimerowe koniugaty czynnika viii |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| WO2016061562A2 (en) | 2014-10-17 | 2016-04-21 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
| JP6802157B2 (ja) * | 2014-11-26 | 2020-12-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | タンパク質送達のためのステルス性ナノカプセル |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| CN116327923A (zh) | 2015-08-24 | 2023-06-27 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 生物医药组合物 |
| AU2016381964B2 (en) * | 2015-12-30 | 2024-02-15 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| US9695138B1 (en) | 2016-10-17 | 2017-07-04 | Acenda Pharma, Inc. | Phenothiazine derivatives and methods of use thereof |
| US11584790B2 (en) | 2017-04-14 | 2023-02-21 | Kodiak Sciences Inc. | Complement factor D antagonist antibodies and conjugates thereof |
| CN112203679A (zh) * | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| WO2020176547A1 (en) | 2019-02-25 | 2020-09-03 | Ginkgo Bioworks, Inc. | Biosynthesis of cannabinoids and cannabinoid precursors |
| CN110627937B (zh) * | 2019-09-27 | 2021-03-30 | 西北大学 | 仿细胞膜聚合物的制备方法、及其修饰壳聚糖-金自组装载药纳米粒子的制备方法和应用 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN111978390B (zh) * | 2020-08-31 | 2022-10-14 | 上海景泽生物技术有限公司 | 聚乙二醇修饰的rhBNP及其用途 |
| WO2022255479A1 (ja) * | 2021-06-04 | 2022-12-08 | タグシクス・バイオ株式会社 | 中分子化合物の血中動態改善のための中分子化合物コンジュゲート体およびその製造方法 |
| CN116970120A (zh) * | 2022-04-21 | 2023-10-31 | 大连理工大学 | 一种无重金属参与的引发聚合技术制备多肽或蛋白质-高分子偶联物的方法 |
| CN115845076A (zh) * | 2022-11-22 | 2023-03-28 | 中山大学 | 一种两性离子聚合物-胰岛素偶联物及其制备方法和应用 |
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|---|---|---|---|---|
| US5162218A (en) | 1988-11-18 | 1992-11-10 | The Regents Of The University Of California | Conjugated polypeptides and methods for their preparation |
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| US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
| US5807937A (en) | 1995-11-15 | 1998-09-15 | Carnegie Mellon University | Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties |
| US5789487A (en) | 1996-07-10 | 1998-08-04 | Carnegie-Mellon University | Preparation of novel homo- and copolymers using atom transfer radical polymerization |
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| WO1999019472A1 (en) | 1997-10-16 | 1999-04-22 | University Of Georgia Research Foundation, Inc. | Vectors comprising a magnum-specific promoter for avian transgenesis |
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| US6121371A (en) | 1998-07-31 | 2000-09-19 | Carnegie Mellon University | Application of atom transfer radical polymerization to water-borne polymerization systems |
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| US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
| US6384146B1 (en) * | 1999-04-05 | 2002-05-07 | The Research Foundation Of State University Of New York | Graft, graft-block, block-graft, and star-shaped copolymers and methods of making them |
| CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| US7049373B2 (en) | 1999-08-06 | 2006-05-23 | Carnegie Mellon University | Process for preparation of graft polymers |
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| IL144815A (en) | 2000-08-11 | 2005-07-25 | Sumitomo Chemical Co | Process for producing carbonyl or hydroxy compound |
| EP1337563B1 (en) | 2000-10-06 | 2006-12-20 | Carnegie-Mellon University | Polymerization process for ionic monomers |
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| AU2001296670A1 (en) | 2000-10-06 | 2002-04-15 | Carnegie-Mellon University | A catalyst system for controlled polymerization |
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| US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US20040253596A1 (en) | 2001-08-27 | 2004-12-16 | Michael Pawlak | Bioanalytical recognition surface with optimized recognition element density |
| US6759491B2 (en) | 2001-10-12 | 2004-07-06 | Carnegie Mellon University | Simultaneous reverse and normal initiation of ATRP |
| US7064166B2 (en) | 2001-10-12 | 2006-06-20 | Carnegie Mellon University | Process for monomer sequence control in polymerizations |
| US6964859B2 (en) | 2001-10-16 | 2005-11-15 | Massachusetts Institute Of Technology | Suppressor tRNA system |
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| ES2291613T3 (es) | 2002-01-16 | 2008-03-01 | Biocompatibles Uk Limited | Conjugados de polimeros. |
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| WO2004014963A2 (en) | 2002-08-09 | 2004-02-19 | Carnegie Mellon University | Polymers, supersoft elastomers and methods for preparing the same |
| JP4431498B2 (ja) | 2002-09-25 | 2010-03-17 | バイオコンパティブルズ ユーケー リミテッド | 動物投与用ポリマー組成物 |
| EP1558658B1 (fr) | 2002-11-07 | 2012-12-19 | Rhodia Chimie | Copolymere a structure controlee presentant une partie amphotere ou zwitterionique. |
| GB0301014D0 (en) | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| CN1777440A (zh) * | 2003-04-11 | 2006-05-24 | Pr药品有限公司 | 位点特异性蛋白质偶联物的制备方法 |
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| JP5557373B2 (ja) | 2006-11-21 | 2014-07-23 | アボット ラボラトリーズ | 薬剤溶出性コーティングにおけるテトラフルオロエチレン、ヘキサフルオロプロピレン、及びフッ化ビニリデンのターポリマーの使用 |
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| WO2010075423A2 (en) | 2008-12-23 | 2010-07-01 | The Regents Of The University Of Michigan | Dendrimer based modular platforms |
| EP2260873B1 (en) * | 2009-06-08 | 2019-07-24 | Biocompatibles UK Limited | Pcylation of proteins |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| KR102416359B1 (ko) | 2010-04-15 | 2022-07-01 | 코디악 사이언시스 인코포레이티드 | 고분자량 쌍성이온-함유 중합체 |
| WO2013059137A1 (en) | 2011-10-17 | 2013-04-25 | Oligasis | High molecular weight zwitterion-containing polymers |
-
2007
- 2007-02-28 JP JP2008557399A patent/JP5528710B2/ja active Active
- 2007-02-28 DK DK07752096.3T patent/DK1988910T3/en active
- 2007-02-28 WO PCT/US2007/005372 patent/WO2007100902A2/en not_active Ceased
- 2007-02-28 LT LTEP07752096.3T patent/LT1988910T/lt unknown
- 2007-02-28 ES ES07752096.3T patent/ES2657628T3/es active Active
- 2007-02-28 EP EP07752096.3A patent/EP1988910B1/en active Active
- 2007-02-28 SI SI200731999T patent/SI1988910T1/en unknown
- 2007-02-28 EP EP17165316.5A patent/EP3222142A1/en not_active Withdrawn
- 2007-02-28 WO PCT/US2007/005381 patent/WO2007100905A2/en not_active Ceased
- 2007-02-28 US US12/281,071 patent/US20100166700A1/en not_active Abandoned
- 2007-02-28 PT PT77520963T patent/PT1988910T/pt unknown
-
2013
- 2013-08-05 US US13/959,563 patent/US8846021B2/en active Active
- 2013-11-13 JP JP2013235314A patent/JP5745009B2/ja active Active
-
2014
- 2014-08-11 US US14/456,875 patent/US20150050714A1/en not_active Abandoned
-
2019
- 2019-05-28 US US16/424,265 patent/US20200000930A1/en not_active Abandoned
-
2021
- 2021-12-16 US US17/553,605 patent/US20220096643A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007100902A3 (en) | 2008-11-20 |
| EP1988910A4 (en) | 2013-03-06 |
| US20100166700A1 (en) | 2010-07-01 |
| LT1988910T (lt) | 2018-01-10 |
| US20200000930A1 (en) | 2020-01-02 |
| JP5528710B2 (ja) | 2014-06-25 |
| US20220096643A1 (en) | 2022-03-31 |
| JP2014043456A (ja) | 2014-03-13 |
| WO2007100905A2 (en) | 2007-09-07 |
| EP3222142A1 (en) | 2017-09-27 |
| ES2657628T3 (es) | 2018-03-06 |
| JP2009532330A (ja) | 2009-09-10 |
| EP1988910A2 (en) | 2008-11-12 |
| EP1988910B1 (en) | 2017-12-06 |
| US8846021B2 (en) | 2014-09-30 |
| US20150050714A1 (en) | 2015-02-19 |
| WO2007100905A3 (en) | 2008-10-16 |
| WO2007100902A2 (en) | 2007-09-07 |
| JP5745009B2 (ja) | 2015-07-08 |
| DK1988910T3 (en) | 2018-01-22 |
| SI1988910T1 (en) | 2018-02-28 |
| US20130337534A1 (en) | 2013-12-19 |
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