PT1871368E - COMPOSTOS DE DIHIDROPIRIDINA PARA DOENÇAS NEURODEGENERATIVAS E DEMjNCIA - Google Patents
COMPOSTOS DE DIHIDROPIRIDINA PARA DOENÇAS NEURODEGENERATIVAS E DEMjNCIA Download PDFInfo
- Publication number
- PT1871368E PT1871368E PT06740387T PT06740387T PT1871368E PT 1871368 E PT1871368 E PT 1871368E PT 06740387 T PT06740387 T PT 06740387T PT 06740387 T PT06740387 T PT 06740387T PT 1871368 E PT1871368 E PT 1871368E
- Authority
- PT
- Portugal
- Prior art keywords
- therapeutically effective
- effective amounts
- disease
- dementia
- dihydropyridine compounds
- Prior art date
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 3
- 206010012289 Dementia Diseases 0.000 title abstract 2
- 230000004770 neurodegeneration Effects 0.000 title abstract 2
- 125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 title 1
- MMWRGWQTAMNAFC-UHFFFAOYSA-N 1,2-Dihydropyridine Natural products C1NC=CC=C1 MMWRGWQTAMNAFC-UHFFFAOYSA-N 0.000 abstract 3
- -1 1,2-dihydropyridine compounds Chemical class 0.000 abstract 3
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 3
- 229940098747 AMPA receptor antagonist Drugs 0.000 abstract 2
- 239000000775 AMPA receptor antagonist Substances 0.000 abstract 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 abstract 2
- 239000002664 nootropic agent Substances 0.000 abstract 2
- 230000001777 nootropic effect Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 229940122041 Cholinesterase inhibitor Drugs 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 229960003530 donepezil Drugs 0.000 abstract 1
- PRMWGUBFXWROHD-UHFFFAOYSA-N perampanel Chemical compound O=C1C(C=2C(=CC=CC=2)C#N)=CC(C=2N=CC=CC=2)=CN1C1=CC=CC=C1 PRMWGUBFXWROHD-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66766505P | 2005-04-04 | 2005-04-04 | |
| US68951905P | 2005-06-13 | 2005-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1871368E true PT1871368E (pt) | 2011-08-30 |
Family
ID=37074003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06740387T PT1871368E (pt) | 2005-04-04 | 2006-04-04 | COMPOSTOS DE DIHIDROPIRIDINA PARA DOENÇAS NEURODEGENERATIVAS E DEMjNCIA |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20060270709A1 (pt) |
| EP (2) | EP1871368B1 (pt) |
| JP (2) | JP2008537552A (pt) |
| KR (1) | KR20080007233A (pt) |
| AT (1) | ATE511843T1 (pt) |
| AU (1) | AU2006232517A1 (pt) |
| CA (1) | CA2603258A1 (pt) |
| CY (1) | CY1112427T1 (pt) |
| DK (1) | DK1871368T3 (pt) |
| HR (1) | HRP20110524T1 (pt) |
| IL (1) | IL186412A0 (pt) |
| ME (1) | ME01224B (pt) |
| PL (1) | PL1871368T3 (pt) |
| PT (1) | PT1871368E (pt) |
| RS (1) | RS51822B (pt) |
| WO (2) | WO2006107860A2 (pt) |
Families Citing this family (45)
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| JP4614884B2 (ja) * | 2003-11-14 | 2011-01-19 | シャンハイ ゲノミックス インク | ピリドンの誘導体とその使用 |
| ME01224B (me) * | 2005-04-04 | 2013-06-20 | Eisai R&D Man Co Ltd | Jedinjenja dihidropiridina za liječenje neurodegenerativnih bolesti i demencije |
| RU2007141401A (ru) * | 2005-04-08 | 2009-05-20 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Терапевтический агент для лечения дискинезии |
| PT1928454E (pt) | 2005-05-10 | 2014-12-04 | Intermune Inc | Derivativos da piridona para modulação do sistema de proteína quinase ativada pelo stress |
| WO2007126060A1 (ja) * | 2006-04-28 | 2007-11-08 | Eisai R & D Management Co., Ltd | １，２－ジヒドロピリジン化合物の塩 |
| CA2667553A1 (en) * | 2006-10-27 | 2008-05-02 | Medivation Neurology, Inc. | Methods and combination therapies for treating alzheimer's disease |
| EP2121613A2 (en) | 2007-01-31 | 2009-11-25 | Vertex Pharmaceuticals, Inc. | 2-aminopyridine derivatives useful as kinase inhibitors |
| JP2010520154A (ja) * | 2007-03-05 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患のためのａｍｐａレセプターアンタゴニストおよびｎｍｄａレセプターアンタゴニスト |
| JP2010533126A (ja) * | 2007-07-13 | 2010-10-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経因性疼痛の治療ためのａｍｐａ受容体アンタゴニストとアセチルコリンエステラーゼ阻害剤との併用 |
| WO2009054543A1 (en) * | 2007-10-26 | 2009-04-30 | Eisai R & D Management Co., Ltd. | Ampa receptor antagonists and zonisamide for parkinson's disease and movement disorders |
| EP2254577A1 (en) * | 2007-12-26 | 2010-12-01 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists for epilepsy, mental disorders or deficits in sensory organ |
| US20090221554A1 (en) * | 2008-02-28 | 2009-09-03 | Zenyaku Kogyo Kabushiki Kaisha | Method of treating cognitive impairment |
| US8598150B1 (en) | 2008-04-02 | 2013-12-03 | Jonathan R. Brestoff | Composition and method for affecting obesity and related conditions |
| US8987245B2 (en) | 2008-04-02 | 2015-03-24 | Jonathan R. Brestoff Parker | Composition and method for affecting obesity and related conditions |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| WO2010011768A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| WO2010011756A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| CA2732765A1 (en) | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
| AU2009331659B2 (en) | 2008-12-23 | 2015-09-03 | F. Hoffmann-La Roche Ag | Dihydropyridone amides as P2X7 modulators |
| CN102264701A (zh) | 2008-12-23 | 2011-11-30 | 霍夫曼-拉罗奇有限公司 | 作为p2x7调节剂的二氢吡啶酮脲 |
| SG172785A1 (en) | 2008-12-23 | 2011-08-29 | Hoffmann La Roche | Dihydropyridone amides as p2x7 modulators |
| US8153808B2 (en) | 2008-12-23 | 2012-04-10 | Roche Palo Alto Llc | Dihydropyridone amides as P2X7 modulators |
| CA2745952A1 (en) | 2008-12-23 | 2010-07-01 | F.Hoffmann-La Roche Ag | Dihydropyridone amides as p2x7 modulators |
| EP2427464A1 (en) | 2009-05-06 | 2012-03-14 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
| EP2582702A1 (en) | 2010-01-27 | 2013-04-24 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
| MX2012008641A (es) | 2010-01-27 | 2012-11-23 | Vertex Pharma | Inhibidores de cinasas de pirazolopirazinas. |
| WO2011094273A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| JP6093770B2 (ja) | 2011-09-27 | 2017-03-08 | アムジエン・インコーポレーテツド | 癌の治療のためのｍｄｍ２阻害剤としての複素環化合物 |
| ES2643507T3 (es) | 2012-03-12 | 2017-11-23 | William J. Binder | Tratamiento de las cefaleas por migraña con la neurotoxina presináptica |
| US8722060B2 (en) * | 2012-05-23 | 2014-05-13 | William J. Binder | Method of treating vertigo |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| TW201441193A (zh) | 2012-12-06 | 2014-11-01 | Kyowa Hakko Kirin Co Ltd | 吡啶酮化合物 |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| AU2014223547B2 (en) | 2013-02-28 | 2017-11-16 | Amgen Inc. | A benzoic acid derivative MDM2 inhibitor for the treatment of cancer |
| JP6377123B2 (ja) | 2013-03-14 | 2018-08-22 | アムジエン・インコーポレーテツド | 癌の治療のためのｍｄｍ２阻害剤としてのヘテロアリール酸モルホリノン化合物 |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
| WO2016106331A1 (en) | 2014-12-22 | 2016-06-30 | The United States Of America | Mutant idh1 inhibitors useful for treating cancer |
| SMT202300197T1 (it) * | 2016-04-26 | 2023-09-06 | H Lundbeck As | Uso di un inibitore di acetilcolinesterasi e idalopirdina per ridurre cadute in pazienti con morbo di parkinson. |
| US11364225B2 (en) * | 2019-08-21 | 2022-06-21 | Bn Intellectual Properties, Inc. | Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same |
| EP4403184A4 (en) * | 2021-09-15 | 2025-09-24 | Univ Of The Ryukyus | PHARMACEUTICAL COMPOSITION INTENDED FOR USE IN THE TREATMENT OF EITHER THE DECLINE OF COGNITIVE FUNCTIONS OR OVERWEIGHT OR OBESITY |
| WO2023042888A1 (ja) * | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
| US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
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| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| US5262165A (en) | 1992-02-04 | 1993-11-16 | Schering Corporation | Transdermal nitroglycerin patch with penetration enhancers |
| JP3075566B2 (ja) | 1990-05-15 | 2000-08-14 | エーザイ株式会社 | 光学活性インダノン誘導体 |
| JP2965675B2 (ja) | 1990-11-21 | 1999-10-18 | エーザイ株式会社 | （―）―１―ベンジル―４―〔（５，６―ジメトキシ―１―インダノン）―２―イル〕メチルピペリジンの製造方法 |
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| US5843945A (en) | 1993-05-13 | 1998-12-01 | Neurosearch A/S | AMPA antagonists and a method of treatment |
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| PT784054E (pt) * | 1994-09-27 | 2002-05-31 | Yamanouchi Pharma Co Ltd | Derivados de tetraidroquinoxalinadiona 1,2,3,4 e sua utilizacao como antagonistas do receptor glutamato |
| UA48973C2 (uk) | 1995-06-07 | 2002-09-16 | Орто-Макнейл Фармасьютікалз Інк. | Трансдермальний пластир на основі 17-деацетилноргестимату для попередження овуляції |
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| US6060479A (en) * | 1997-06-09 | 2000-05-09 | Pfizer Inc | Quinazoline-4-one AMPA antagonists |
| US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| US6245911B1 (en) * | 1997-12-05 | 2001-06-12 | Eisai Co., Ltd. | Donepezil polycrystals and process for producing the same |
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| JP2002047272A (ja) * | 2000-07-26 | 2002-02-12 | Dai Ichi Seiyaku Co Ltd | ポリアミンアミド誘導体 |
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| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
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| JP4208512B2 (ja) * | 2002-07-23 | 2009-01-14 | 株式会社クラレ | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
| JP2004189706A (ja) * | 2002-12-13 | 2004-07-08 | Eisai Co Ltd | 高度アルツハイマー型痴呆治療剤 |
| MY148809A (en) * | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| ME01224B (me) * | 2005-04-04 | 2013-06-20 | Eisai R&D Man Co Ltd | Jedinjenja dihidropiridina za liječenje neurodegenerativnih bolesti i demencije |
-
2006
- 2006-04-04 ME MEP-2011-133A patent/ME01224B/me unknown
- 2006-04-04 KR KR1020077025426A patent/KR20080007233A/ko not_active Ceased
- 2006-04-04 HR HR20110524T patent/HRP20110524T1/hr unknown
- 2006-04-04 AU AU2006232517A patent/AU2006232517A1/en not_active Abandoned
- 2006-04-04 RS RS20110318A patent/RS51822B/sr unknown
- 2006-04-04 DK DK06740387.3T patent/DK1871368T3/da active
- 2006-04-04 CA CA002603258A patent/CA2603258A1/en not_active Abandoned
- 2006-04-04 US US11/396,555 patent/US20060270709A1/en not_active Abandoned
- 2006-04-04 WO PCT/US2006/012285 patent/WO2006107860A2/en not_active Ceased
- 2006-04-04 US US11/396,621 patent/US20060276510A1/en not_active Abandoned
- 2006-04-04 US US11/887,729 patent/US20090131480A1/en not_active Abandoned
- 2006-04-04 AT AT06740387T patent/ATE511843T1/de active
- 2006-04-04 EP EP06740387A patent/EP1871368B1/en active Active
- 2006-04-04 JP JP2008505418A patent/JP2008537552A/ja not_active Withdrawn
- 2006-04-04 EP EP06749149A patent/EP1871369A4/en not_active Withdrawn
- 2006-04-04 PL PL06740387T patent/PL1871368T3/pl unknown
- 2006-04-04 JP JP2008505417A patent/JP5180816B2/ja not_active Expired - Fee Related
- 2006-04-04 PT PT06740387T patent/PT1871368E/pt unknown
- 2006-04-04 WO PCT/US2006/012284 patent/WO2006107859A2/en not_active Ceased
-
2007
- 2007-10-07 IL IL186412A patent/IL186412A0/en unknown
-
2011
- 2011-07-29 CY CY20111101013T patent/CY1112427T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1871368B1 (en) | 2011-06-08 |
| AU2006232517A1 (en) | 2006-10-12 |
| ME01224B (me) | 2013-06-20 |
| EP1871369A4 (en) | 2009-11-11 |
| US20060270709A1 (en) | 2006-11-30 |
| JP5180816B2 (ja) | 2013-04-10 |
| WO2006107859A3 (en) | 2009-04-09 |
| WO2006107860A3 (en) | 2009-04-09 |
| JP2008538216A (ja) | 2008-10-16 |
| CA2603258A1 (en) | 2006-10-12 |
| WO2006107859A8 (en) | 2007-11-08 |
| HRP20110524T1 (hr) | 2011-08-31 |
| WO2006107859A2 (en) | 2006-10-12 |
| ATE511843T1 (de) | 2011-06-15 |
| CY1112427T1 (el) | 2015-12-09 |
| WO2006107860A2 (en) | 2006-10-12 |
| EP1871368A2 (en) | 2008-01-02 |
| US20060276510A1 (en) | 2006-12-07 |
| EP1871368A4 (en) | 2009-11-11 |
| KR20080007233A (ko) | 2008-01-17 |
| DK1871368T3 (da) | 2011-09-19 |
| PL1871368T3 (pl) | 2011-12-30 |
| US20090131480A1 (en) | 2009-05-21 |
| RS51822B (sr) | 2012-02-29 |
| IL186412A0 (en) | 2008-08-07 |
| JP2008537552A (ja) | 2008-09-18 |
| EP1871369A2 (en) | 2008-01-02 |
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