PT1756063E - Compostos amido e seu uso como produtos farmacêuticos - Google Patents

Compostos amido e seu uso como produtos farmacêuticos Download PDF

Info

Publication number: PT1756063E
Authority: PT; Portugal
Prior art keywords: pharmaceuticals; amido compounds; amido; compounds
Prior art date: 2004-05-07

Application number

PT57456568T

Other languages

English (en)

Portuguese (pt)

Inventor

Brian Metcalf

Wenqing Yao

Jincong Zhuo

Meizhong Xu

Chunhong He

Ding-Quan Qian

Colin Zhang

Original Assignee

Incyte Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-07

Filing date

2005-05-04

Publication date

2015-09-15

2005-05-04 Application filed by Incyte Corp filed Critical Incyte Corp

2015-09-15 Publication of PT1756063E publication Critical patent/PT1756063E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT57456568T 2004-05-07 2005-05-04 Compostos amido e seu uso como produtos farmacêuticos PT1756063E (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US56927304P	2004-05-07	2004-05-07
US60205104P	2004-08-17	2004-08-17
US60279104P	2004-08-19	2004-08-19
US63880304P	2004-12-22	2004-12-22

Publications (1)

Publication Number	Publication Date
PT1756063E true PT1756063E (pt)	2015-09-15

Family

ID=35394113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT57456568T PT1756063E (pt)	2004-05-07	2005-05-04	Compostos amido e seu uso como produtos farmacêuticos

Country Status (29)

Country	Link
US (7)	US7304081B2 (fr)
EP (2)	EP1756063B1 (fr)
JP (2)	JP5265913B2 (fr)
KR (1)	KR101252227B1 (fr)
AU (1)	AU2005243222C1 (fr)
BR (1)	BRPI0510736B1 (fr)
CA (1)	CA2565238C (fr)
CR (1)	CR8702A (fr)
CY (1)	CY1116779T1 (fr)
DK (1)	DK1756063T3 (fr)
EA (1)	EA025359B1 (fr)
EC (1)	ECSP066978A (fr)
ES (1)	ES2550006T3 (fr)
GE (1)	GEP201706611B (fr)
HK (1)	HK1218545A1 (fr)
HR (1)	HRP20151064T1 (fr)
HU (1)	HUE025521T2 (fr)
IL (1)	IL179042A (fr)
ME (1)	ME02231B (fr)
MX (1)	MX340538B (fr)
NO (1)	NO340031B1 (fr)
NZ (1)	NZ550775A (fr)
PL (1)	PL1756063T3 (fr)
PT (1)	PT1756063E (fr)
RS (1)	RS54236B1 (fr)
SG (1)	SG151329A1 (fr)
SI (1)	SI1756063T1 (fr)
TW (1)	TWI350168B (fr)
WO (1)	WO2005110992A1 (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7064211B2 (en) *	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
TWI350168B (en)	2004-05-07	2011-10-11	Incyte Corp	Amido compounds and their use as pharmaceuticals
US20050288338A1 (en) *	2004-06-24	2005-12-29	Wenqing Yao	Amido compounds and their use as pharmaceuticals
US20050288317A1 (en) *	2004-06-24	2005-12-29	Wenqing Yao	Amido compounds and their use as pharmaceuticals
CA2589565A1 (fr) *	2004-06-24	2006-01-05	Incyte Corporation	Composes amido et leur utilisation en tant que produits pharmaceutiques
US8071624B2 (en) *	2004-06-24	2011-12-06	Incyte Corporation	N-substituted piperidines and their use as pharmaceuticals
JP2008504278A (ja) *	2004-06-24	2008-02-14	インサイト・コーポレイション	アミド化合物およびその医薬としての使用
JP2008504280A (ja) *	2004-06-24	2008-02-14	インサイト・コーポレイション	２−メチルプロパンアミドおよびその医薬としての使用
KR101257233B1 (ko) *	2004-07-29	2013-04-29	아더시스 인코포레이티드	세로토닌 수용체 조절제로서의 트리사이클릭 인데노-피롤유도체
WO2006020598A2 (fr) *	2004-08-10	2006-02-23	Incyte Corporation	Composes amido et leur utilisation comme produits pharmaceutiques
US8110581B2 (en)	2004-11-10	2012-02-07	Incyte Corporation	Lactam compounds and their use as pharmaceuticals
CA2585797C (fr) *	2004-11-10	2015-01-06	Incyte Corporation	Composes de lactame et leur utilisation en temps que substances pharmaceutiques
CN101103016A (zh) *	2004-11-18	2008-01-09	因塞特公司	11-β羟基类固醇脱氢酶1型抑制剂及其使用方法
SG176463A1 (en)	2005-02-22	2011-12-29	Univ Michigan	Small molecule inhibitors of mdm2 and uses thereof
JP5140577B2 (ja)	2005-03-31	2013-02-06	タケダカリフォルニアインコーポレイテッド	ヒドロキシステロイドデヒドロゲナーゼ阻害剤
AR053710A1 (es)	2005-04-11	2007-05-16	Xenon Pharmaceuticals Inc	Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en)	2005-04-11	2011-11-30	Xenon Pharmaceuticals Inc	Spiro-oxindole compounds and their uses as therapeutic agents
DE102005044813A1 (de)	2005-05-19	2007-10-04	Grünenthal GmbH	Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
US20090291988A1 (en) *	2005-06-14	2009-11-26	Renata Oballa	Reversible Inhibitors of Monoamine Oxidase A and B
CA2621255A1 (fr) *	2005-09-21	2007-04-05	Incyte Corporation	Utilisation pharmaceutique de composes amido
KR20080048502A (ko)	2005-09-29	2008-06-02	머크 앤드 캄파니 인코포레이티드	멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
WO2007067504A2 (fr) *	2005-12-05	2007-06-14	Incyte Corporation	Composes lactames et procedes d'utilisation de ceux-ci
WO2007084314A2 (fr) *	2006-01-12	2007-07-26	Incyte Corporation	MODULATEURS de la 11-ß HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCEDES D'UTILISATION
AU2007207055B2 (en)	2006-01-18	2011-06-02	F. Hoffmann-La Roche Ag	Thiazoles as 11 beta-HSD1 inhibitors
TW200804341A (en) *	2006-01-31	2008-01-16	Incyte Corp	Amido compounds and their use as pharmaceuticals
EP1981848A2 (fr)	2006-02-07	2008-10-22	Wyeth	Inhibiteurs 11-beta hsd1
US20070213311A1 (en) *	2006-03-02	2007-09-13	Yun-Long Li	Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
WO2007103719A2 (fr) *	2006-03-03	2007-09-13	Incyte Corporation	MODULATEURS DE LA 11-β-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCÉDÉS D'UTILISATION
US7834050B2 (en) *	2006-03-29	2010-11-16	Duke University	Small molecule insulin mimetics absent quinones
EP2013163A1 (fr) *	2006-05-01	2009-01-14	Incyte Corporation	Urées tétrasubstituées modulateurs de la 11-beta hydroxyl stéroïd déshydrogénase de type 1
PE20110235A1 (es)	2006-05-04	2011-04-14	Boehringer Ingelheim Int	Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP2018378A2 (fr)	2006-05-17	2009-01-28	Incyte Corporation	Inhibiteurs hétérocycliques de la déshydrogénase du stéroïde hydroxyle 11-b de type 1 et leurs procédés d'utilisation
US7737174B2 (en)	2006-08-30	2010-06-15	The Regents Of The University Of Michigan	Indole inhibitors of MDM2 and the uses thereof
US8222288B2 (en)	2006-08-30	2012-07-17	The Regents Of The University Of Michigan	Small molecule inhibitors of MDM2 and the uses thereof
EP2061791A1 (fr) *	2006-09-15	2009-05-27	Schering Corporation	Dérivés d'azétidine spiro-condensés convenant pour le traitement de la douleur, du diabète et des troubles du métabolisme des lipides
AU2007294771A1 (en)	2006-09-15	2008-03-20	Schering Corporation	Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism
JP2010503676A (ja) *	2006-09-15	2010-02-04	シェーリングコーポレイション	疼痛、糖尿病および脂質代謝の障害の治療
CN103271906A (zh)	2006-10-12	2013-09-04	泽农医药公司	螺-吲哚酮化合物作为治疗剂的用途
US20080306102A1 (en) *	2007-05-18	2008-12-11	Kowa Co., Ltd.	Novel spirooxyindole compounds and drugs containing same
ATE508110T1 (de) *	2007-06-05	2011-05-15	Nsab Af Neurosearch Sweden Ab	Neue disubstituierte phenylpyrrolidine als modulatoren der kortikalen katecholaminergen neurotransmission
CL2008001839A1 (es)	2007-06-21	2009-01-16	Incyte Holdings Corp	Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
PE20091057A1 (es)	2007-12-19	2009-07-20	Lilly Co Eli	Antagonistas del receptor mineralcorticoide y metodos de uso
US20100022572A1 (en)	2008-07-18	2010-01-28	Kowa Company, Ltd.	Novel spiro compound and medicine comprising the same
WO2010023931A1 (fr)	2008-08-29	2010-03-04	興和株式会社	Dérivé 1-adamantylazétidine-2-one et préparation pharmaceutique comprenant ce dérivé
US8101647B2 (en)	2008-10-17	2012-01-24	Xenon Pharmaceuticals Inc.	Spiro-oxindole compounds and their use as therapeutic agents
CN103664973B (zh)	2008-10-17	2017-04-19	泽农医药公司	螺羟吲哚化合物及其作为治疗剂的用途
TW201022210A (en)	2008-10-29	2010-06-16	Kowa Co	1,2-diazetidin-3-one derivatives and drugs containing same
CA2744987C (fr)	2008-12-02	2018-01-16	Chiralgen, Ltd.	Procede pour la synthese d'acides nucleiques modifies par des atomes de phosphore
JP5609150B2 (ja) *	2009-02-27	2014-10-22	アステラス製薬株式会社	ピペリジン誘導体
ES2350077B1 (es)	2009-06-04	2011-11-04	Laboratorios Salvat, S.A.	Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
CA2767253A1 (fr)	2009-07-06	2011-01-13	Ontorii, Inc.	Nouveaux precurseurs d'acide nucleique et leurs methodes d'utilisation
US8445696B2 (en)	2009-10-14	2013-05-21	Xenon Pharmaceuticals Inc.	Synthetic methods for spiro-oxindole compounds
JP2013510860A (ja)	2009-11-12	2013-03-28	ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン	スピロ−オキシインドールｍｄｍ２アンタゴニスト
BR112012021086A2 (pt)	2010-02-26	2016-05-17	Xenon Pharmaceuticals Inc	composições farmacêuticas de composto espiro-oxindole para administração tópica e seu uso como agentes terapêuticos
WO2011140425A1 (fr)	2010-05-06	2011-11-10	Vertex Pharmaceuticals Incorporated	Amides de chromène hétérocyclique-pipéridine spirocyclique utiles comme modulateurs des canaux ioniques
WO2012039448A1 (fr) *	2010-09-24	2012-03-29	株式会社キラルジェン	Groupe auxiliaire asymétrique
TWI535723B (zh)	2010-11-12	2016-06-01	密西根大學董事會	螺－吲哚酮ｍｄｍ２拮抗劑
TW201604196A (zh)	2011-02-02	2016-02-01	維泰克斯製藥公司	作為離子通道調節劑之吡咯并吡－螺環哌啶醯胺
MX2013009393A (es)	2011-02-18	2013-08-29	Vertex Pharma	Piperidinamidas cromano-espirociclicas como moduladores de canales de iones.
EP2686325B1 (fr)	2011-03-14	2016-12-14	Vertex Pharmaceuticals Incorporated	Amides de pipéridine spirocycliques morpholines utilisés en tant que modulateurs de canaux ioniques
SG194873A1 (en)	2011-05-11	2013-12-30	Sanofi Sa	Spiro-oxindole mdm2 antagonists
WO2013012758A1 (fr)	2011-07-19	2013-01-24	Ontorii, Inc.	Procédés pour la synthèse d'acides nucléiques fonctionnalisés
US9073881B2 (en)	2011-09-23	2015-07-07	Hoffmann-La Roche Inc.	Benzoic acid derivatives
JP6050238B2 (ja) *	2011-10-19	2016-12-21	興和株式会社	新規なスピロインドリン化合物、及びそれを含有する医薬
JP6268157B2 (ja)	2012-07-13	2018-01-24	株式会社ＷａｖｅＬｉｆｅＳｃｉｅｎｃｅｓＪａｐａｎ	不斉補助基
CN104684923B (zh)	2012-07-13	2018-09-28	株式会社新日本科学	手性核酸佐剂
KR102712879B1 (ko)	2012-07-13	2024-10-04	웨이브 라이프 사이언시스 리미티드	키랄 제어
JPWO2015108048A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10144933B2 (en)	2014-01-15	2018-12-04	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108046A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
EP4137572A1 (fr)	2014-01-16	2023-02-22	Wave Life Sciences Ltd.	Conception chirale
EP3134408B1 (fr)	2014-04-22	2020-08-12	Merck Sharp & Dohme Corp.	Inhibiteurs du facteur xia
WO2016127068A1 (fr)	2015-02-05	2016-08-11	Teva Pharmaceuticals International Gmbh	Procédés de traitement d'une névralgie post-herpétique à l'aide d'une formule topique d'un composé de spiro-oxindole
WO2017074833A1 (fr) *	2015-10-29	2017-05-04	Merck Sharp & Dohme Corp.	Dérivé spirocarbamate macrocyclique comme inhibiteurs du facteur xia, compositions pharmaceutiquement acceptables et leur utilisation
EP3235813A1 (fr)	2016-04-19	2017-10-25	Cidqo 2012, S.L.	Dérivés aza-tétra-cycliques
WO2020048830A1 (fr)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	Composés 5-aryl-3,9-diazaspiro[5.5]undécan-2-one
WO2020048826A1 (fr)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	Composés de la 1-oxa-3,9-diazaspiro[5.5]undécan-2-one substituée en position 5
TW202024083A (zh)	2018-09-03	2020-07-01	德商拜耳廠股份有限公司	3,9-二氮雜螺[5.5]十一烷化合物
CN110305141B (zh) *	2019-07-18	2022-01-11	深圳市三启药物开发有限公司	一种螺(3,3’-异丙基吡咯烷氧化吲哚)类肝x受体调节剂及其制备方法和应用
EP4308125A4 (fr) *	2021-03-18	2025-03-12	Merck Sharp & Dohme LLC	Inhibiteurs de kallicréine plasmatique
US20240208994A1 (en) *	2021-04-22	2024-06-27	Merck Sharp & Dohme Llc	Plasma kallikrein inhibitors
JP2025503737A (ja)	2022-01-18	2025-02-04	メイズセラピューティクス，インコーポレイテッド	Ａｐｏｌ１阻害剤及び使用方法
WO2025015104A2 (fr) *	2023-07-11	2025-01-16	Maze Therapeutics, Inc.	Inhibiteurs d'apol1 et procédés d'utilisation
TW202517642A (zh) *	2023-07-11	2025-05-01	美商梅斯治療股份有限公司	Ａｐｏｌ１抑制劑及其使用方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL262366A (fr) *	1960-03-14
US3201466A (en) *	1963-03-08	1965-08-17	Gulf Oil Corp	Substituted cyclopropanecarboxanilide herbicides
DE2114420A1 (de) *	1971-03-25	1972-10-05	Merck Patent Gmbh, 6100 Darmstadt	Substituierte Phenylalkanol-Derivate und Verfahren zu ihrer Herstellung
GB1460389A (en) *	1974-07-25	1977-01-06	Pfizer Ltd	4-substituted quinazoline cardiac stimulants
US3933829A (en) *	1974-08-22	1976-01-20	John Wyeth & Brother Limited	4-Aminoquinoline derivatives
TR18917A (tr) *	1974-10-31	1977-12-09	Ciba Geigy Ag	1-(bis-triflormetilfenil)-2-oksopirolidin-4-karbonik asitleri ve bunlarin tuerevleri
FR2312247A1 (fr)	1975-05-30	1976-12-24	Parcor	Derives de la thieno-pyridine, leur procede de preparation et leurs applications
US4145435A (en) *	1976-11-12	1979-03-20	The Upjohn Company	2-aminocycloaliphatic amide compounds
GB2068961B (en) *	1980-02-13	1983-11-30	Sankyo Co	Quinazoline derivatives
JPS57156450A (en) *	1981-03-24	1982-09-27	Ihara Chem Ind Co Ltd	1-(4-chlorophenyl)-1-cyclopentanecarboxylic acid derivative, its preparation, and aquatic life repellent containing said compound as active component
US4439606A (en)	1982-05-06	1984-03-27	American Cyanamid Company	Antiatherosclerotic 1-piperazinecarbonyl compounds
EP0273659A1 (fr)	1986-12-27	1988-07-06	Takeda Chemical Industries, Ltd.	Composés azaspiro, leur préparation et leur utilisation
US5206240A (en)	1989-12-08	1993-04-27	Merck & Co., Inc.	Nitrogen-containing spirocycles
US5852029A (en)	1990-04-10	1998-12-22	Israel Institute For Biological Research	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
JPH04334357A (ja)	1991-05-02	1992-11-20	Fujirebio Inc	酵素阻害作用を有するアシル誘導体
DE4234295A1 (de)	1992-10-12	1994-04-14	Thomae Gmbh Dr K	Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW239211B (en) *	1993-04-02	1995-01-21	Hyundai Electronics America	Electromagnetic lens actuator for optical disk drive
FR2705343B1 (fr)	1993-05-17	1995-07-21	Fournier Ind & Sante	Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2724656B1 (fr)	1994-09-15	1996-12-13	Adir	Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2736053B1 (fr)	1995-06-28	1997-09-19	Sanofi Sa	Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
GB9517622D0 (en) *	1995-08-29	1995-11-01	Univ Edinburgh	Regulation of intracellular glucocorticoid concentrations
EP1090012A4 (fr)	1998-07-02	2005-04-06	Merck & Co Inc	Inhibiteurs de prenyl-proteine transferase
TWI248435B (en)	1998-07-04	2006-02-01	Boehringer Ingelheim Pharma	Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
EP1165500A1 (fr) *	1999-04-02	2002-01-02	Du Pont Pharmaceuticals Company	Nouveaux derives d'amides faisant office d'inhibiteurs de metalloproteases matricielles, de tnf-alpha, et de l'aggrecanase
IT1313552B1 (it)	1999-06-29	2002-09-09	European Molecular Biology Lab Embl	Isoforme del recettore alfa degli estrogeni umano
US6659293B1 (en)	1999-07-07	2003-12-09	Odwalla, Inc.	Pull-out shelf stocking system
BR0012590A (pt)	1999-07-21	2002-04-09	Astrazeneca Ab	Composto, processo para a preparação do mesmo, formulação farmacêutica, uso de um composto, e, métodos para tratamento ou profilaxia de dor ou desconforto, e para tratamento ou profilaxia de dor neuropática ou central
WO2001010823A1 (fr)	1999-08-07	2001-02-15	Boehringer Ingelheim Pharma Kg	Amides d'acide carboxylique, leur production et leur utilisation comme medicaments
WO2001030780A2 (fr)	1999-10-27	2001-05-03	Cor Therapeutics, Inc.	Composes spirocycliques pyridiles inhibiteurs de l'agregation plaquettaire dependant des fibrinogenes
US6496627B1 (en)	2000-07-14	2002-12-17	Tyco Telecommunications (Us) Inc.	Device and method for improved long term signal attenuation performance of fiber optic cable and apparatus interfaces
CA2422055A1 (fr) *	2000-09-11	2002-03-21	Sepracor, Inc.	Ligands pour les recepteurs de monoamine et transporteurs, et procedes d'utilisation de ces derniers
US7294637B2 (en) *	2000-09-11	2007-11-13	Sepracor, Inc.	Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
US7102009B2 (en) *	2001-01-12	2006-09-05	Amgen Inc.	Substituted amine derivatives and methods of use
WO2002069973A1 (fr) *	2001-03-02	2002-09-12	Sepracor, Inc.	Ligand piperidine-piperazine pour recepteurs neurotransmetteurs
WO2003000657A1 (fr) *	2001-06-20	2003-01-03	Daiichi Pharmaceutical Co., Ltd.	Derives de diamine
US6547958B1 (en) *	2001-07-13	2003-04-15	Chevron U.S.A. Inc.	Hydrocarbon conversion using zeolite SSZ-59
WO2003006364A2 (fr) *	2001-07-13	2003-01-23	Chevron U.S.A. Inc.	Zeolite ssz-59
GB0118238D0 (en)	2001-07-26	2001-09-19	Smithkline Beecham Plc	Medicaments
WO2003037271A2 (fr)	2001-10-30	2003-05-08	Millennium Pharmaceuticals,Inc.	Composes, compositions pharmaceutiques et methodes d'utilisation
GB0126292D0 (en)	2001-11-01	2002-01-02	Smithkline Beecham Plc	Compounds
US6649606B1 (en) *	2001-11-09	2003-11-18	Bristol-Myers Squibb Co.	Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
US7074788B2 (en) *	2001-11-22	2006-07-11	Biovitrum Ab	Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7030141B2 (en)	2001-11-29	2006-04-18	Christopher Franklin Bigge	Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
WO2003049736A1 (fr)	2001-12-11	2003-06-19	Sepracor, Inc.	Piperidines 4-substitues, et methodes d'utilisation
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
JP2003231633A (ja)	2002-02-06	2003-08-19	Tanabe Seiyaku Co Ltd	医薬組成物
US6818772B2 (en)	2002-02-22	2004-11-16	Abbott Laboratories	Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
TWI329111B (en)	2002-05-24	2010-08-21	X Ceptor Therapeutics Inc	Azepinoindole and pyridoindole derivatives as pharmaceutical agents
AR040241A1 (es)	2002-06-10	2005-03-23	Merck & Co Inc	Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
SE0202133D0 (sv)	2002-07-08	2002-07-08	Astrazeneca Ab	Novel compounds
WO2004018479A1 (fr)	2002-08-21	2004-03-04	Astrazeneca Ab	Composes de thieno-pyrrole utilises comme antagonistes de l'hormone de liberation de gonadotrophine
TW200413351A (en)	2002-08-21	2004-08-01	Astrazeneca Ab	Chemical compounds
AU2003263323A1 (en)	2002-09-07	2004-03-29	Celltech R And D Limited	Quinazolinone derivatives
WO2004024065A2 (fr)	2002-09-12	2004-03-25	Merck & Co., Inc.	Derives de thiophene bicycliques substitues, compostions contenant lesdits composes et methodes d'utilisation
MXPA05003632A (es) *	2002-10-11	2005-06-03	Astrazeneca Ab	Derivados de piperidina 1, 4-disustituidos y su uso como inhibidores de 11-beta-hidroesteroide deshidrogenasa humana de tipo 1 (11betahsd1).
WO2004058727A1 (fr)	2002-12-20	2004-07-15	Bayer Pharmaceuticals Corporation	3,5-dihydro-4-h-imidazol-4-ones substitues utilises dans le traitement de l'obesite
WO2004056744A1 (fr)	2002-12-23	2004-07-08	Janssen Pharmaceutica N.V.	Adamantyl acetamides utilises comme inhibiteurs de la hydroxysteroide deshydrogenase
TW200503994A (en)	2003-01-24	2005-02-01	Novartis Ag	Organic compounds
US7205318B2 (en)	2003-03-18	2007-04-17	Bristol-Myers Squibb Company	Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors
US20040188324A1 (en) *	2003-03-26	2004-09-30	Saleh Elomari	Hydrocarbon conversion using molecular sieve SSZ-65
WO2004094347A2 (fr)	2003-03-26	2004-11-04	Chevron U.S.A. Inc.	Tamis moleculaire ssz-65
DE602004027171D1 (de)	2003-04-11	2010-06-24	High Point Pharmaceuticals Llc	Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
AU2004232939A1 (en)	2003-04-17	2004-11-04	Merck Sharp & Dohme Corp.	Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
GEP20084393B (en)	2003-04-24	2008-06-10	Incyte Corp	Aza spiro alkane derivatives as inhibitors of metalloproteases
SE0302755D0 (sv)	2003-10-17	2003-10-17	Astrazeneca Ab	Novel compounds
EP1683797A1 (fr)	2003-11-13	2006-07-26	Ono Pharmaceutical Co., Ltd.	Compose spiranique heterocyclique
JP2007514731A (ja)	2003-12-19	2007-06-07	ファイザーインコーポレイテッド	糖尿病及び肥満症の治療のための１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１型（１１−β−ｈｓｄ−１）の阻害剤としてのベンゼンスルホニルアミノ−ピリジン−２−イル誘導体及び関連化合物
SE0303541D0 (sv)	2003-12-22	2003-12-22	Astrazeneca Ab	New compounds
JP2007536369A (ja)	2004-05-06	2007-12-13	ファイザー・インク	プロリン及びモルホリン誘導体の新規化合物
TWI350168B (en) *	2004-05-07	2011-10-11	Incyte Corp	Amido compounds and their use as pharmaceuticals
JP2008504280A (ja)	2004-06-24	2008-02-14	インサイト・コーポレイション	２−メチルプロパンアミドおよびその医薬としての使用
CA2589565A1 (fr) *	2004-06-24	2006-01-05	Incyte Corporation	Composes amido et leur utilisation en tant que produits pharmaceutiques
US8071624B2 (en)	2004-06-24	2011-12-06	Incyte Corporation	N-substituted piperidines and their use as pharmaceuticals
JP2008504278A (ja) *	2004-06-24	2008-02-14	インサイト・コーポレイション	アミド化合物およびその医薬としての使用
US20050288317A1 (en) *	2004-06-24	2005-12-29	Wenqing Yao	Amido compounds and their use as pharmaceuticals
US20050288338A1 (en) *	2004-06-24	2005-12-29	Wenqing Yao	Amido compounds and their use as pharmaceuticals
WO2006020598A2 (fr)	2004-08-10	2006-02-23	Incyte Corporation	Composes amido et leur utilisation comme produits pharmaceutiques
MX2007004799A (es)	2004-10-22	2007-06-25	Cargill Inc	Proceso para la produccion de maltodextrinas y maltodextrinas.
CA2585797C (fr)	2004-11-10	2015-01-06	Incyte Corporation	Composes de lactame et leur utilisation en temps que substances pharmaceutiques
US8110581B2 (en) *	2004-11-10	2012-02-07	Incyte Corporation	Lactam compounds and their use as pharmaceuticals
CN101103016A (zh)	2004-11-18	2008-01-09	因塞特公司	11-β羟基类固醇脱氢酶1型抑制剂及其使用方法
AU2006203918B2 (en)	2005-01-05	2011-05-19	Abbvie Inc.	Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
BRPI0609062A2 (pt)	2005-03-03	2010-02-17	F. Hofmann-La Roche Ag	composição farmacêutica, compostos, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de deidrogenase de hidroxiesteróide-11ß e utilização dos compostos
CA2621255A1 (fr)	2005-09-21	2007-04-05	Incyte Corporation	Utilisation pharmaceutique de composes amido
WO2007067504A2 (fr) *	2005-12-05	2007-06-14	Incyte Corporation	Composes lactames et procedes d'utilisation de ceux-ci
WO2007084314A2 (fr)	2006-01-12	2007-07-26	Incyte Corporation	MODULATEURS de la 11-ß HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCEDES D'UTILISATION
TW200804341A (en) *	2006-01-31	2008-01-16	Incyte Corp	Amido compounds and their use as pharmaceuticals
US20070213311A1 (en) *	2006-03-02	2007-09-13	Yun-Long Li	Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
WO2007103719A2 (fr)	2006-03-03	2007-09-13	Incyte Corporation	MODULATEURS DE LA 11-β-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCÉDÉS D'UTILISATION
EP2013163A1 (fr) *	2006-05-01	2009-01-14	Incyte Corporation	Urées tétrasubstituées modulateurs de la 11-beta hydroxyl stéroïd déshydrogénase de type 1
EP2018378A2 (fr) *	2006-05-17	2009-01-28	Incyte Corporation	Inhibiteurs hétérocycliques de la déshydrogénase du stéroïde hydroxyle 11-b de type 1 et leurs procédés d'utilisation
CL2008001839A1 (es) *	2007-06-21	2009-01-16	Incyte Holdings Corp	Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

2005
- 2005-04-29 TW TW094113962A patent/TWI350168B/zh not_active IP Right Cessation
- 2005-05-04 MX MXPA06012894A patent/MX340538B/es active IP Right Grant
- 2005-05-04 EP EP05745656.8A patent/EP1756063B1/fr not_active Expired - Lifetime
- 2005-05-04 JP JP2007511571A patent/JP5265913B2/ja not_active Expired - Lifetime
- 2005-05-04 DK DK05745656.8T patent/DK1756063T3/en active
- 2005-05-04 BR BRPI0510736-9A patent/BRPI0510736B1/pt active IP Right Grant
- 2005-05-04 HU HUE05745656A patent/HUE025521T2/en unknown
- 2005-05-04 NZ NZ550775A patent/NZ550775A/en not_active IP Right Cessation
- 2005-05-04 PT PT57456568T patent/PT1756063E/pt unknown
- 2005-05-04 ME MEP-2015-166A patent/ME02231B/me unknown
- 2005-05-04 CA CA2565238A patent/CA2565238C/fr not_active Expired - Lifetime
- 2005-05-04 ES ES05745656.8T patent/ES2550006T3/es not_active Expired - Lifetime
- 2005-05-04 PL PL05745656T patent/PL1756063T3/pl unknown
- 2005-05-04 AU AU2005243222A patent/AU2005243222C1/en not_active Expired
- 2005-05-04 SI SI200532008T patent/SI1756063T1/sl unknown
- 2005-05-04 GE GEAP20059736A patent/GEP201706611B/en unknown
- 2005-05-04 WO PCT/US2005/015559 patent/WO2005110992A1/fr not_active Ceased
- 2005-05-04 EA EA200602062A patent/EA025359B1/ru unknown
- 2005-05-04 EP EP15168750.6A patent/EP2963021A1/fr not_active Withdrawn
- 2005-05-04 US US11/122,309 patent/US7304081B2/en not_active Expired - Lifetime
- 2005-05-04 RS RS20150594A patent/RS54236B1/sr unknown
- 2005-05-04 HR HRP20151064TT patent/HRP20151064T1/hr unknown
- 2005-05-04 SG SG200902188-2A patent/SG151329A1/en unknown
- 2005-05-04 KR KR1020067023362A patent/KR101252227B1/ko not_active Expired - Lifetime
2006
- 2006-10-24 CR CR8702A patent/CR8702A/es unknown
- 2006-11-02 IL IL179042A patent/IL179042A/en active IP Right Grant
- 2006-11-08 EC ECSP066978 patent/ECSP066978A/es unknown
- 2006-11-27 NO NO20065442A patent/NO340031B1/no unknown
2007
- 2007-04-06 US US11/784,450 patent/US20070179142A1/en not_active Abandoned
2008
- 2008-06-10 US US12/136,529 patent/US7776874B2/en not_active Expired - Lifetime
2010
- 2010-06-17 US US12/817,887 patent/US8058288B2/en not_active Expired - Lifetime
2011
- 2011-09-23 US US13/243,565 patent/US9126927B2/en not_active Expired - Lifetime
2013
- 2013-03-06 JP JP2013044576A patent/JP2013151519A/ja active Pending
2015
- 2015-07-24 US US14/808,337 patent/US9670154B2/en not_active Expired - Fee Related
- 2015-10-07 CY CY20151100899T patent/CY1116779T1/el unknown
2016
- 2016-06-07 HK HK16106552.9A patent/HK1218545A1/en unknown
2017
- 2017-05-23 US US15/602,693 patent/US9957229B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20050282858A1 (en)	2005-12-22
CR8702A (es)	2009-01-09
US20080255154A1 (en)	2008-10-16
JP5265913B2 (ja)	2013-08-14
AU2005243222B2 (en)	2012-05-03
NO20065442L (no)	2006-11-27
SG151329A1 (en)	2009-04-30
HK1101397A1 (en)	2007-10-18
RS54236B1 (sr)	2015-12-31
PL1756063T3 (pl)	2015-12-31
WO2005110992A1 (fr)	2005-11-24
KR101252227B1 (ko)	2013-04-05
MXPA06012894A (es)	2007-02-15
US7304081B2 (en)	2007-12-04
US20150329561A1 (en)	2015-11-19
US8058288B2 (en)	2011-11-15
US9126927B2 (en)	2015-09-08
EP1756063A4 (fr)	2009-03-25
GEP201706611B (en)	2017-02-10
ES2550006T3 (es)	2015-11-03
ECSP066978A (es)	2006-12-29
JP2013151519A (ja)	2013-08-08
CA2565238C (fr)	2014-08-05
US7776874B2 (en)	2010-08-17
IL179042A (en)	2013-10-31
US20170334847A1 (en)	2017-11-23
CA2565238A1 (fr)	2005-11-24
EA200602062A1 (ru)	2007-04-27
JP2007536252A (ja)	2007-12-13
US9957229B2 (en)	2018-05-01
US20100256114A1 (en)	2010-10-07
HUE025521T2 (en)	2016-02-29
BRPI0510736B1 (pt)	2021-06-01
CY1116779T1 (el)	2018-01-10
KR20070007184A (ko)	2007-01-12
NZ550775A (en)	2009-11-27
HK1218545A1 (en)	2017-03-31
NO340031B1 (no)	2017-02-27
US20070179142A1 (en)	2007-08-02
EP1756063A1 (fr)	2007-02-28
AU2005243222C1 (en)	2012-12-13
EP1756063B1 (fr)	2015-07-08
TW200539858A (en)	2005-12-16
US9670154B2 (en)	2017-06-06
AU2005243222A1 (en)	2005-11-24
HRP20151064T1 (hr)	2015-11-06
MX340538B (es)	2016-07-13
EP2963021A1 (fr)	2016-01-06
BRPI0510736A (pt)	2007-11-06
ME02231B (me)	2016-02-20
DK1756063T3 (en)	2015-07-20
TWI350168B (en)	2011-10-11
IL179042A0 (en)	2007-03-08
US20120015928A1 (en)	2012-01-19
SI1756063T1 (sl)	2015-12-31
EA025359B1 (ru)	2016-12-30

Publication	Publication Date	Title
TWI350168B (en)	2011-10-11	Amido compounds and their use as pharmaceuticals
EP1773780A4 (fr)	2008-01-09	Composes amido et utilisations de ces derniers en tant que produits pharmaceutiques
IL181174A0 (en)	2007-07-04	Amido compounds and their use as pharmaceuticals
EP1758882A4 (fr)	2008-01-23	Composes amido et utilisation de ceux-ci comme agents pharmaceutiques
IL179519A0 (en)	2007-05-15	Amido compounds and their use as pharmaceuticals
EP1773773A4 (fr)	2009-07-29	Composes amido et leur utilisation en tant que produits pharmaceutiques
IL192965A0 (en)	2009-02-11	Amido compounds and their use as pharmaceuticals
IL182876A0 (en)	2007-08-19	Lactam compounds and their use as pharmaceuticals
IL181670A0 (en)	2007-07-04	Substituted phenylaminothiazoles and use thereof
ZA200610602B (en)	2008-08-27	Amido compounds and their use as pharmaceuticals
ZA200806638B (en)	2010-10-27	Amido compounds and their use as pharmaceuticals
HK1104462A (en)	2008-01-18	Amido compounds and their use as pharmaceuticals
HK1104541A (en)	2008-01-18	Amido compounds and their use as pharmaceuticals
HK1098152A (en)	2007-07-13	Amido compounds and their use as pharmaceuticals
HK1099684A (en)	2007-08-24	Amido compounds and their use as pharmaceuticals
HK1098151A (en)	2007-07-13	Amido compounds and their use as pharmaceuticals
GB0427723D0 (en)	2005-01-19	Compounds and their use
IL176969A0 (en)	2006-12-10	Novel long-working beta-2-agonists and use thereof as medicaments
HK1123800A (en)	2009-06-26	Amido compounds and their use as pharmaceuticals
HK1100035A (en)	2007-08-31	2-methylpropanamides and their use as pharmaceuticals
EP1732545A4 (fr)	2009-07-29	Composes de tetrahydro-beta-carboline et leur utilisation
GB0423234D0 (en)	2004-11-24	Compounds and their use
GB0416630D0 (en)	2004-08-25	Compounds and their use
GB0409377D0 (en)	2004-06-02	Compounds and their use
GB0401243D0 (en)	2004-02-25	Compounds and their use