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PT1296981E - Derivados substituidos da pirrolopiridinona uteis como inibidores da fosfodiesterase - Google Patents

Derivados substituidos da pirrolopiridinona uteis como inibidores da fosfodiesterase

Info

Publication number
PT1296981E
PT1296981E PT01935050T PT01935050T PT1296981E PT 1296981 E PT1296981 E PT 1296981E PT 01935050 T PT01935050 T PT 01935050T PT 01935050 T PT01935050 T PT 01935050T PT 1296981 E PT1296981 E PT 1296981E
Authority
PT
Portugal
Prior art keywords
uteis
pyrrolopyridinone
substituted derivatives
phosphodiesterase inhibitors
phosphodiesterase
Prior art date
Application number
PT01935050T
Other languages
English (en)
Inventor
Zhihua Sui
Mark J Macielag
Jihua Guan
Jiang Weiqin
James C Lanter
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of PT1296981E publication Critical patent/PT1296981E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT01935050T 2000-05-17 2001-05-03 Derivados substituidos da pirrolopiridinona uteis como inibidores da fosfodiesterase PT1296981E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20464600P 2000-05-17 2000-05-17

Publications (1)

Publication Number Publication Date
PT1296981E true PT1296981E (pt) 2004-12-31

Family

ID=22758822

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01935050T PT1296981E (pt) 2000-05-17 2001-05-03 Derivados substituidos da pirrolopiridinona uteis como inibidores da fosfodiesterase

Country Status (29)

Country Link
US (3) US6635638B2 (pt)
EP (1) EP1296981B1 (pt)
JP (1) JP5366349B2 (pt)
KR (2) KR100854050B1 (pt)
CN (1) CN1280291C (pt)
AR (1) AR028575A1 (pt)
AT (1) ATE278690T1 (pt)
AU (1) AU6117801A (pt)
BG (1) BG65925B1 (pt)
CA (1) CA2409743C (pt)
CZ (1) CZ20023945A3 (pt)
DE (1) DE60106252T2 (pt)
ES (1) ES2230316T3 (pt)
GE (1) GEP20053510B (pt)
HK (1) HK1054034B (pt)
HR (1) HRP20020911B1 (pt)
HU (1) HUP0302226A3 (pt)
IL (2) IL152872A0 (pt)
MX (1) MXPA02011425A (pt)
MY (1) MY126917A (pt)
NO (1) NO324843B1 (pt)
NZ (1) NZ522732A (pt)
PL (1) PL363150A1 (pt)
PT (1) PT1296981E (pt)
RU (1) RU2267490C2 (pt)
SK (1) SK286992B6 (pt)
UA (1) UA72611C2 (pt)
WO (1) WO2001087882A2 (pt)
ZA (1) ZA200210114B (pt)

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ES2272695T3 (es) 2001-02-12 2007-05-01 Lilly Icos Llc Derivados de carbolina.
ES2289159T3 (es) 2001-11-14 2008-02-01 Ortho-Mcneil Pharmaceutical Corporation Derivados tetraciclicos sustituidos de pirroloquinolona utilizados como inhibidores de fosfodiesterasa.
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US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
SG184755A1 (en) 2004-03-15 2012-10-30 Ptc Therapeutics Inc Carboline derivatives useful in the inhibition of angiogenesis
WO2006093719A1 (en) * 2005-02-25 2006-09-08 Janssen Pharmaceutica, N.V. An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one
EP1851227A4 (en) * 2005-02-25 2010-03-10 Janssen Pharmaceutica Nv EFFICIENT AND STEREOSELECTIVE PROCEDURE FOR THE MASS SYNTHESIS OF 3- (R) -3- (2,3-DIHYDROBENZOFURAN-5-YL) -1,2,3,4-TETRAHYDROPYRROLO {3,4-B} CHINOLIN-9-ON
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
RU2451686C1 (ru) * 2010-12-27 2012-05-27 Александр Васильевич Иващенко ЗАМЕЩЕННЫЕ ГИДРИРОВАННЫЕ ТИЕНО-ПИРРОЛО [3,2-c] ПИРИДИНЫ, ЛИГАНДЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИХ ПРИМЕНЕНИЯ
KR101236188B1 (ko) * 2011-03-10 2013-02-22 한국화학연구원 신규한 피롤로피리디논 유도체 및 그의 ｍｃｈ 수용체-1 관련 질환에 대한 치료학적 용도
ES2632443T3 (es) 2011-09-22 2017-09-13 Viiv Healthcare Uk Limited Compuestos de pirrolopiridinona y procedimientos de tratamiento del VIH
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
MX388871B (es) 2014-06-27 2025-03-20 Nogra Pharma Ltd Moduladores del receptor arilo y metodos para elaborar y usar los mismos.
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107216327A (zh) * 2017-06-27 2017-09-29 山东大学 5型磷酸二酯酶抑制剂及其制备方法和用途
CN108752340B (zh) * 2018-07-18 2020-09-01 山东中医药大学附属医院 吡咯并喹啉衍生物及其在治疗心律失常中的用途
CN109134463B (zh) * 2018-09-17 2020-05-08 山东大学 β-咔啉类5型磷酸二酯酶抑制剂及其制备方法和用途

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Also Published As

Publication number Publication date
SK286992B6 (sk) 2009-09-07
US6818646B2 (en) 2004-11-16
NO20025525L (no) 2003-01-03
ATE278690T1 (de) 2004-10-15
KR100854050B1 (ko) 2008-08-26
DE60106252D1 (de) 2004-11-11
DE60106252T2 (de) 2006-03-02
CZ20023945A3 (cs) 2003-10-15
HUP0302226A3 (en) 2012-12-28
HK1054034A1 (en) 2003-11-14
WO2001087882A3 (en) 2002-05-23
IL152872A (en) 2010-11-30
CA2409743A1 (en) 2001-11-22
US6635638B2 (en) 2003-10-21
RU2267490C2 (ru) 2006-01-10
KR20020094063A (ko) 2002-12-16
JP2003533524A (ja) 2003-11-11
ES2230316T3 (es) 2005-05-01
JP5366349B2 (ja) 2013-12-11
ZA200210114B (en) 2004-03-12
CN1280291C (zh) 2006-10-18
NO20025525D0 (no) 2002-11-18
CA2409743C (en) 2010-10-19
EP1296981B1 (en) 2004-10-06
AR028575A1 (es) 2003-05-14
IL152872A0 (en) 2003-06-24
HK1054034B (en) 2005-04-29
BG65925B1 (bg) 2010-05-31
PL363150A1 (en) 2004-11-15
SK17132002A3 (sk) 2003-12-02
MY126917A (en) 2006-10-31
GEP20053510B (en) 2005-05-10
WO2001087882A2 (en) 2001-11-22
EP1296981A2 (en) 2003-04-02
CN1441801A (zh) 2003-09-10
US20050113402A1 (en) 2005-05-26
BG107284A (bg) 2003-07-31
AU6117801A (en) 2001-11-26
HRP20020911B1 (en) 2009-01-31
MXPA02011425A (es) 2004-09-06
HRP20020911A2 (en) 2004-12-31
UA72611C2 (uk) 2005-03-15
HUP0302226A2 (hu) 2003-11-28
NZ522732A (en) 2004-10-29
US20040044021A1 (en) 2004-03-04
NO324843B1 (no) 2007-12-17
US20020010183A1 (en) 2002-01-24
KR20030031483A (ko) 2003-04-21

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