[go: up one dir, main page]

PT1105360E - Identificação de interacções entre compostos-proteínas, utilizando bibliotecas de moléculas de fusão entre proteínas-ácidos nucleicos - Google Patents

Identificação de interacções entre compostos-proteínas, utilizando bibliotecas de moléculas de fusão entre proteínas-ácidos nucleicos Download PDF

Info

Publication number
PT1105360E
PT1105360E PT99948042T PT99948042T PT1105360E PT 1105360 E PT1105360 E PT 1105360E PT 99948042 T PT99948042 T PT 99948042T PT 99948042 T PT99948042 T PT 99948042T PT 1105360 E PT1105360 E PT 1105360E
Authority
PT
Portugal
Prior art keywords
compound
protein
fusion
nucleic acid
library
Prior art date
Application number
PT99948042T
Other languages
English (en)
Inventor
Peter Lohse
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT1105360E publication Critical patent/PT1105360E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PT99948042T 1998-08-17 1999-08-16 Identificação de interacções entre compostos-proteínas, utilizando bibliotecas de moléculas de fusão entre proteínas-ácidos nucleicos PT1105360E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9682098P 1998-08-17 1998-08-17

Publications (1)

Publication Number Publication Date
PT1105360E true PT1105360E (pt) 2009-09-30

Family

ID=22259237

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99948042T PT1105360E (pt) 1998-08-17 1999-08-16 Identificação de interacções entre compostos-proteínas, utilizando bibliotecas de moléculas de fusão entre proteínas-ácidos nucleicos

Country Status (12)

Country Link
US (1) US6602685B1 (pt)
EP (1) EP1105360B1 (pt)
JP (1) JP4278872B2 (pt)
AT (1) ATE437844T1 (pt)
AU (1) AU757955B2 (pt)
CA (1) CA2337490C (pt)
CY (1) CY1110515T1 (pt)
DE (1) DE69941193D1 (pt)
DK (1) DK1105360T3 (pt)
ES (1) ES2329205T3 (pt)
PT (1) PT1105360E (pt)
WO (1) WO2000009464A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6517781B1 (en) * 1997-06-02 2003-02-11 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
EP1212452B1 (en) * 1999-08-27 2013-07-17 Bristol-Myers Squibb Company Methods for encoding and sorting in vitro translated proteins
US7022479B2 (en) 2000-01-24 2006-04-04 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
WO2001053539A1 (en) 2000-01-24 2001-07-26 Phylos, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
GB2360282A (en) * 2000-03-17 2001-09-19 Bioinvent Int Ab Making and using micro-arrays of biological materials
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
US20040229271A1 (en) 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
US6980674B2 (en) 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
US6539102B1 (en) 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
EP1432817A4 (en) * 2001-10-16 2006-12-27 Yingjian Wang PROCESSES AND ARRAYS FOR DETECTION OF BIOLOGICAL MOLECULES
US7125669B2 (en) * 2001-11-27 2006-10-24 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
US20060014145A1 (en) * 2002-04-26 2006-01-19 Miller Brian S Methods and articles for high throughput analysis of biomolecular interactions
EP1514942A4 (en) * 2002-05-17 2007-05-16 Kyowa Hakko Kogyo Kk METHOD FOR SEARCHING FOR A SUBSTANCE ANTIDIABETIC EFFECT
WO2004010106A2 (en) 2002-07-24 2004-01-29 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
US20040142379A1 (en) * 2003-01-16 2004-07-22 Carlsberg Research Laboratory Affinity fishing for ligands and proteins receptors
CN1906307B (zh) * 2003-11-20 2011-08-24 圣诺菲·帕斯图尔公司 纯化百日咳毒素的方法及其中有用的肽
WO2007037706A2 (en) * 2005-09-27 2007-04-05 Bernd Helmut Adam Rehm Polymer particles and uses thereof
CN101454461A (zh) 2005-11-16 2009-06-10 Ambrx公司 包括非天然氨基酸的方法和组合物
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
WO2009009186A2 (en) 2007-04-13 2009-01-15 The Regents Of The University Of California Receptors useful for gas phase chemical sensing
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
TWI543768B (zh) 2007-11-30 2016-08-01 艾伯維生物技術有限責任公司 蛋白質調配物及製造其之方法
CN102177438A (zh) 2008-07-25 2011-09-07 理查德·W·瓦格纳 蛋白筛选方法
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100158822A1 (en) 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
KR20120073161A (ko) 2009-03-30 2012-07-04 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 화장품 제제 운반용 펩티드계 시스템
AU2011214465A1 (en) 2010-02-10 2012-08-30 Novartis Ag Methods and compounds for muscle growth
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
ES2926988T3 (es) 2011-03-15 2022-10-31 X Body Inc Métodos de cribado de anticuerpos
KR20140027174A (ko) * 2011-03-24 2014-03-06 옵코 파마슈티칼스, 엘엘씨 비드 또는 입자 기초 라이브러리들, 진단적 키트들을 및 치료제들을 사용한 복합 생물학적 유체에서 바이오마커 발견
ES2925799T3 (es) 2011-04-28 2022-10-19 Univ Leland Stanford Junior Identificación de polinucleótidos asociados a una muestra
WO2013085972A1 (en) 2011-12-05 2013-06-13 X-Body, Inc. Pdgf receptor beta binding polypeptides
WO2014145458A1 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents On Behalf Of Arizona State University Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling
SG10201806428YA (en) 2013-06-28 2018-08-30 X Body Inc Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
ES2827281T3 (es) 2013-09-23 2021-05-20 X Body Inc Métodos y composiciones para la generación de agentes de unión contra antígenos de superficie celular
JP6814634B2 (ja) 2014-02-05 2021-01-20 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4587044A (en) 1983-09-01 1986-05-06 The Johns Hopkins University Linkage of proteins to nucleic acids
DE3546806C2 (pt) 1985-03-30 1991-03-28 Marc Genf/Geneve Ch Ballivet
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
CA2067194C (en) 1989-10-05 2003-03-18 Glenn Kawasaki Cell-free synthesis and isolation of novel genes and polypeptides
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
WO1992002536A1 (en) 1990-08-02 1992-02-20 The Regents Of The University Of Colorado Systematic polypeptide evolution by reverse translation
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5795747A (en) 1991-04-16 1998-08-18 Evotec Biosystems Gmbh Process for manufacturing new biopolymers
DE4112440C1 (pt) 1991-04-16 1992-10-22 Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De
AU2313392A (en) 1991-08-01 1993-03-02 University Research Corporation Systematic polypeptide evolution by reverse translation
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5635602A (en) 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5561043A (en) 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
DK0744958T3 (da) 1994-01-31 2003-10-20 Univ Boston Polyklonale antistofbiblioteker
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
WO1995032425A1 (en) 1994-05-23 1995-11-30 Smithkline Beecham Corporation Encoded combinatorial libraries
US5627024A (en) 1994-08-05 1997-05-06 The Scripps Research Institute Lambdoid bacteriophage vectors for expression and display of foreign proteins
US5559000A (en) 1995-01-18 1996-09-24 The Scripps Research Institute Encoded reaction cassette
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5872015A (en) * 1996-05-10 1999-02-16 Board Of Trustees Of The University Of Illinois Molecular diversity screening method
US5962645A (en) * 1996-10-04 1999-10-05 University Of Maryland Antiproliferative factor from patients with interstitial cystitis
JP3683282B2 (ja) 1996-10-17 2005-08-17 三菱化学株式会社 遺伝子型と表現型の対応付け分子及びその利用
DE69835143T2 (de) * 1997-01-21 2007-06-06 The General Hospital Corp., Boston Selektion von proteinen mittels rns-protein fusionen
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
GB9712512D0 (en) 1997-06-16 1997-08-20 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US5985575A (en) 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function

Also Published As

Publication number Publication date
ES2329205T3 (es) 2009-11-23
US6602685B1 (en) 2003-08-05
WO2000009464A1 (en) 2000-02-24
CY1110515T1 (el) 2015-04-29
DE69941193D1 (de) 2009-09-10
JP2002522057A (ja) 2002-07-23
AU6129699A (en) 2000-03-06
EP1105360A4 (en) 2005-06-22
CA2337490C (en) 2012-01-03
DK1105360T3 (da) 2009-11-02
WO2000009464A9 (en) 2000-09-28
AU757955B2 (en) 2003-03-13
EP1105360B1 (en) 2009-07-29
EP1105360A1 (en) 2001-06-13
ATE437844T1 (de) 2009-08-15
CA2337490A1 (en) 2000-02-24
JP4278872B2 (ja) 2009-06-17

Similar Documents

Publication Publication Date Title
PT1105360E (pt) Identificação de interacções entre compostos-proteínas, utilizando bibliotecas de moléculas de fusão entre proteínas-ácidos nucleicos
EP0156641B1 (en) Enzymic method of detecting analytes and novel substrates therefor
Johannsson et al. A fast highly sensitive colorimetric enzyme immunoassay system demonstrating benefits of enzyme amplification in clinical chemistry
US6673542B2 (en) Assays for measuring nucleic acid damaging activities
Choi‐Rhee et al. Promiscuous protein biotinylation by Escherichia coli biotin protein ligase
US7439017B2 (en) Assays for measuring nucleic acid binding proteins and enzyme activities
Tomohiro et al. Cross‐linking chemistry and biology: development of multifunctional photoaffinity probes
ATE322558T1 (de) Sensible und multiplexe diagnostische tests zur proteinanalyse
HK1040547A1 (zh) 自動化分析儀
PL328272A1 (en) Methods of and compositions for detecting ligand pair bonds using non-fluoroscent labelling
EP1418430A3 (en) A homogeneous assay for determining analyte
CA2451909A1 (en) High throughput assays for the proteolytic activities of clostridial neurotoxins
MXPA03001879A (es) Metodo y sistema para detectar acidos nucleicos.
Meyer et al. Orthogonal protein decoration of DNA nanostructures
Visser et al. Surface‐Plasmon‐Resonance‐Based Chemical Proteomics: Efficient Specific Extraction and Semiquantitative Identification of Cyclic Nucleotide‐Binding Proteins from Cellular Lysates by Using a Combination of Surface Plasmon Resonance, Sequential Elution and Liquid Chromatography–Tandem Mass Spectrometry
Lovrinovic et al. Microtiter plate‐based screening for the optimization of DNA–protein conjugate synthesis by means of expressed protein ligation
EP1360329B8 (en) Biochemical method and apparatus for detecting genetic characteristics
EP1117841A4 (en) METHOD FOR DETECTING COMPOUNDS THAT INFLUENCE THE INTERACTION OF RNA AND RNA-BINDING PROTEINS
WO1994024283A3 (en) A mammalian guanine nucleotide binding protein with an adp-rybosylation factor domain
AU2986395A (en) Method for screening compound libraries
CA1304292C (en) Catalyst transformation by protein phosphorylation as a means for enzymeimmunoassay
US6569636B2 (en) Assay for modulators of metallo-enzyme activity
DK1180138T3 (da) Polynukleotidmotor, motorsystem, fremstilling og anvendelse deraf
AU6718894A (en) Hippuricase gene
DE60029363D1 (de) Fluoreszenzverfahren zum Messen von Enzymaktivität unter Verwendung von Polyionen