DK1105360T3 - Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler - Google Patents
Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekylerInfo
- Publication number
- DK1105360T3 DK1105360T3 DK99948042T DK99948042T DK1105360T3 DK 1105360 T3 DK1105360 T3 DK 1105360T3 DK 99948042 T DK99948042 T DK 99948042T DK 99948042 T DK99948042 T DK 99948042T DK 1105360 T3 DK1105360 T3 DK 1105360T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- protein
- fusion
- nucleic acid
- libraries
- Prior art date
Links
- 230000004927 fusion Effects 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000003993 interaction Effects 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000007787 solid Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9682098P | 1998-08-17 | 1998-08-17 | |
| PCT/US1999/018600 WO2000009464A1 (en) | 1998-08-17 | 1999-08-16 | Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1105360T3 true DK1105360T3 (da) | 2009-11-02 |
Family
ID=22259237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99948042T DK1105360T3 (da) | 1998-08-17 | 1999-08-16 | Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6602685B1 (da) |
| EP (1) | EP1105360B1 (da) |
| JP (1) | JP4278872B2 (da) |
| AT (1) | ATE437844T1 (da) |
| AU (1) | AU757955B2 (da) |
| CA (1) | CA2337490C (da) |
| CY (1) | CY1110515T1 (da) |
| DE (1) | DE69941193D1 (da) |
| DK (1) | DK1105360T3 (da) |
| ES (1) | ES2329205T3 (da) |
| PT (1) | PT1105360E (da) |
| WO (1) | WO2000009464A1 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6517781B1 (en) * | 1997-06-02 | 2003-02-11 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
| JP4803933B2 (ja) * | 1999-08-27 | 2011-10-26 | ブリストル−マイヤーズ スクウィブ カンパニー | インビトロ翻訳タンパク質の符号化方法および選別方法 |
| US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
| JP2003520050A (ja) | 2000-01-24 | 2003-07-02 | フィロス インク. | タンパク質分析のための高感度多重化診断アッセイ法 |
| GB2360282A (en) * | 2000-03-17 | 2001-09-19 | Bioinvent Int Ab | Making and using micro-arrays of biological materials |
| US20040229271A1 (en) | 2000-05-19 | 2004-11-18 | Williams Richard B. | Compositions and methods for the identification and selection of nucleic acids and polypeptides |
| US6962781B1 (en) | 2000-05-19 | 2005-11-08 | Proteonova, Inc. | In vitro evolution of nucleic acids and encoded polypeptide |
| US7410761B2 (en) * | 2000-05-19 | 2008-08-12 | Proteonova, Inc. | System for rapid identification and selection of nucleic acids and polypeptides, and method thereof |
| US6980674B2 (en) | 2000-09-01 | 2005-12-27 | Large Scale Proteomics Corp. | Reference database |
| US6539102B1 (en) | 2000-09-01 | 2003-03-25 | Large Scale Proteomics | Reference database |
| WO2003029490A1 (en) * | 2001-10-01 | 2003-04-10 | Yingjian Wang | Methods and arrays for detecting biological molecules |
| AU2002365404A1 (en) * | 2001-11-27 | 2003-06-10 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
| US20060014145A1 (en) * | 2002-04-26 | 2006-01-19 | Miller Brian S | Methods and articles for high throughput analysis of biomolecular interactions |
| WO2003097862A1 (en) * | 2002-05-17 | 2003-11-27 | Kyowa Hakko Kogyo Co., Ltd. | Method of searching substane having antidiabetic activity |
| AU2003252136A1 (en) | 2002-07-24 | 2004-02-09 | Ptc Therapeutics, Inc. | METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY |
| US20040142379A1 (en) * | 2003-01-16 | 2004-07-22 | Carlsberg Research Laboratory | Affinity fishing for ligands and proteins receptors |
| JP4885729B2 (ja) * | 2003-11-20 | 2012-02-29 | サノフィ パストゥール インコーポレイテッド | 百日咳毒素を精製する方法およびそれに有用なペプチド |
| DK1929010T3 (da) * | 2005-09-27 | 2014-03-10 | Polybatics Ltd | Anvendelse af polymer partikler |
| JP2009520949A (ja) | 2005-11-16 | 2009-05-28 | アンブルックス,インコーポレイテッド | 非天然アミノ酸を含んでいる組成物および方法 |
| US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
| WO2009009186A2 (en) * | 2007-04-13 | 2009-01-15 | The Regents Of The University Of California | Receptors useful for gas phase chemical sensing |
| US7951559B2 (en) * | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
| US7678883B2 (en) * | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
| US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
| US7794963B2 (en) | 2007-11-02 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| TWI661833B (zh) | 2007-11-30 | 2019-06-11 | 百慕達商艾伯維生物技術有限責任公司 | 蛋白質調配物及製造其之方法 |
| KR20110036638A (ko) | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
| US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
| US20100158846A1 (en) * | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
| US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
| US20100158822A1 (en) | 2008-12-18 | 2010-06-24 | E .I. Du Pont De Nemours And Company | Peptides that bind to silica-coated particles |
| US8481678B2 (en) | 2009-03-30 | 2013-07-09 | E I Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
| CN102596155A (zh) | 2009-03-30 | 2012-07-18 | 庄臣消费者有限公司 | 用于递送美容试剂的基于肽的系统 |
| JP2013519869A (ja) | 2010-02-10 | 2013-05-30 | ノバルティス アーゲー | 筋肉成長のための方法および化合物 |
| DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
| ES2926988T3 (es) | 2011-03-15 | 2022-10-31 | X Body Inc | Métodos de cribado de anticuerpos |
| JP6153921B2 (ja) * | 2011-03-24 | 2017-06-28 | オプコ ファーマシューティカルズ、エルエルシー | ビーズまたは粒子ベースのライブラリーを用いた液体生体試料中でのバイオマーカー発見、並びに診断キットおよび治療法 |
| EP3421591B1 (en) | 2011-04-28 | 2023-09-27 | The Board of Trustees of the Leland Stanford Junior University | Identification of polynucleotides associated with a sample |
| CA2857721C (en) | 2011-12-05 | 2022-05-31 | X-Body, Inc. | Pdgf receptor beta binding polypeptides |
| US9938523B2 (en) | 2013-03-15 | 2018-04-10 | Arizona Board Of Regents On Behalf Of Arizona State University | Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling |
| MX374317B (es) | 2013-06-28 | 2025-03-06 | X Body Inc | Selecciones fenotípicas, descubrimiento del antígeno objetivo y uso de los mismos para la identificación de epítopes objetivo específicos de células objetivo. |
| EP3779440A1 (en) | 2013-09-23 | 2021-02-17 | X-Body, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
| US10421958B2 (en) | 2014-02-05 | 2019-09-24 | Molecular Templates, Inc. | Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537861A (en) * | 1983-02-03 | 1985-08-27 | Elings Virgil B | Apparatus and method for homogeneous immunoassay |
| US4587044A (en) | 1983-09-01 | 1986-05-06 | The Johns Hopkins University | Linkage of proteins to nucleic acids |
| WO1986005803A1 (fr) | 1985-03-30 | 1986-10-09 | Marc Ballivet | Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| CA2067194C (en) | 1989-10-05 | 2003-03-18 | Glenn Kawasaki | Cell-free synthesis and isolation of novel genes and polypeptides |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
| AU8498091A (en) | 1990-08-02 | 1992-03-02 | Regents Of The University Of Colorado, The | Systematic polypeptide evolution by reverse translation |
| US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
| DE4112440C1 (da) | 1991-04-16 | 1992-10-22 | Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De | |
| US5795747A (en) | 1991-04-16 | 1998-08-18 | Evotec Biosystems Gmbh | Process for manufacturing new biopolymers |
| WO1993003172A1 (en) | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US6087186A (en) * | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
| US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
| AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| DK1231268T3 (da) | 1994-01-31 | 2005-11-21 | Univ Boston | Polyklonale antistofbiblioteker |
| US5561043A (en) | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| JPH10500951A (ja) | 1994-05-23 | 1998-01-27 | スミスクライン・ビーチャム・コーポレイション | コードされた組合せライブラリー |
| US5627024A (en) | 1994-08-05 | 1997-05-06 | The Scripps Research Institute | Lambdoid bacteriophage vectors for expression and display of foreign proteins |
| US5559000A (en) | 1995-01-18 | 1996-09-24 | The Scripps Research Institute | Encoded reaction cassette |
| US6100026A (en) * | 1995-04-25 | 2000-08-08 | Irori | Matrices with memories and uses thereof |
| US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
| US5763263A (en) * | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US5872015A (en) * | 1996-05-10 | 1999-02-16 | Board Of Trustees Of The University Of Illinois | Molecular diversity screening method |
| US5962645A (en) * | 1996-10-04 | 1999-10-05 | University Of Maryland | Antiproliferative factor from patients with interstitial cystitis |
| DE69739163D1 (de) | 1996-10-17 | 2009-01-22 | Mitsubishi Chem Corp | Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen |
| PT971946E (pt) * | 1997-01-21 | 2006-11-30 | Gen Hospital Corp | Selecção de proteínas utilizando fusões arn-proteína |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| GB9712512D0 (en) | 1997-06-16 | 1997-08-20 | Bioinvent Int Ab | A method for in vitro molecular evolution of protein function |
| US5985575A (en) | 1998-05-20 | 1999-11-16 | Wisconsin Alumni Research Foundation | Tethered function assay for protein function |
-
1999
- 1999-08-16 DK DK99948042T patent/DK1105360T3/da active
- 1999-08-16 ES ES99948042T patent/ES2329205T3/es not_active Expired - Lifetime
- 1999-08-16 US US09/374,964 patent/US6602685B1/en not_active Expired - Lifetime
- 1999-08-16 AU AU61296/99A patent/AU757955B2/en not_active Expired
- 1999-08-16 PT PT99948042T patent/PT1105360E/pt unknown
- 1999-08-16 CA CA2337490A patent/CA2337490C/en not_active Expired - Lifetime
- 1999-08-16 AT AT99948042T patent/ATE437844T1/de active
- 1999-08-16 EP EP99948042A patent/EP1105360B1/en not_active Expired - Lifetime
- 1999-08-16 WO PCT/US1999/018600 patent/WO2000009464A1/en not_active Ceased
- 1999-08-16 DE DE69941193T patent/DE69941193D1/de not_active Expired - Lifetime
- 1999-08-16 JP JP2000564919A patent/JP4278872B2/ja not_active Expired - Lifetime
-
2009
- 2009-10-13 CY CY20091101052T patent/CY1110515T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1110515T1 (el) | 2015-04-29 |
| AU6129699A (en) | 2000-03-06 |
| JP2002522057A (ja) | 2002-07-23 |
| CA2337490A1 (en) | 2000-02-24 |
| ATE437844T1 (de) | 2009-08-15 |
| DE69941193D1 (de) | 2009-09-10 |
| EP1105360A4 (en) | 2005-06-22 |
| WO2000009464A1 (en) | 2000-02-24 |
| WO2000009464A9 (en) | 2000-09-28 |
| CA2337490C (en) | 2012-01-03 |
| EP1105360A1 (en) | 2001-06-13 |
| PT1105360E (pt) | 2009-09-30 |
| AU757955B2 (en) | 2003-03-13 |
| US6602685B1 (en) | 2003-08-05 |
| EP1105360B1 (en) | 2009-07-29 |
| JP4278872B2 (ja) | 2009-06-17 |
| ES2329205T3 (es) | 2009-11-23 |
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