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PT1021171E - Sistema de administracao de farmacos no tracto gastrointestinal de libertacao total prolongada - Google Patents

Sistema de administracao de farmacos no tracto gastrointestinal de libertacao total prolongada

Info

Publication number
PT1021171E
PT1021171E PT98949742T PT98949742T PT1021171E PT 1021171 E PT1021171 E PT 1021171E PT 98949742 T PT98949742 T PT 98949742T PT 98949742 T PT98949742 T PT 98949742T PT 1021171 E PT1021171 E PT 1021171E
Authority
PT
Portugal
Prior art keywords
core
drug
coating
gastrointestinal tract
insoluble
Prior art date
Application number
PT98949742T
Other languages
English (en)
Inventor
E Itzhak Lerner
Moshe Flashner
Adel Penhasi
Original Assignee
Dexcel Pharma Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dexcel Pharma Technologies Ltd filed Critical Dexcel Pharma Technologies Ltd
Publication of PT1021171E publication Critical patent/PT1021171E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
PT98949742T 1997-10-09 1998-10-01 Sistema de administracao de farmacos no tracto gastrointestinal de libertacao total prolongada PT1021171E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94823597A 1997-10-09 1997-10-09
US16320298A 1998-09-30 1998-09-30

Publications (1)

Publication Number Publication Date
PT1021171E true PT1021171E (pt) 2003-10-31

Family

ID=26859435

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98949742T PT1021171E (pt) 1997-10-09 1998-10-01 Sistema de administracao de farmacos no tracto gastrointestinal de libertacao total prolongada

Country Status (20)

Country Link
EP (1) EP1021171B1 (pt)
JP (1) JP2001519379A (pt)
KR (1) KR20010031034A (pt)
CN (1) CN100548279C (pt)
AT (1) ATE238774T1 (pt)
AU (1) AU740757B2 (pt)
BR (1) BR9815240A (pt)
CA (1) CA2305762C (pt)
CZ (1) CZ301028B6 (pt)
DE (1) DE69814122T2 (pt)
DK (1) DK1021171T3 (pt)
ES (1) ES2198756T3 (pt)
HU (1) HUP0004945A3 (pt)
IL (1) IL135502A (pt)
NO (1) NO20001829L (pt)
NZ (1) NZ503820A (pt)
PL (1) PL203733B1 (pt)
PT (1) PT1021171E (pt)
TR (1) TR200000944T2 (pt)
WO (1) WO1999018938A1 (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534263A (en) 1995-02-24 1996-07-09 Alza Corporation Active agent dosage form comprising a matrix and at least two insoluble bands
US6231888B1 (en) * 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
US6632451B2 (en) * 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
JP4659316B2 (ja) 1999-08-09 2011-03-30 大日本住友製薬株式会社 キトサン粉末含有固形製剤およびその製造方法
CN1285333C (zh) * 2000-06-07 2006-11-22 张昊 结肠定位释放的口服制剂及其制备方法
US6932861B2 (en) 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
CA2725833A1 (en) 2001-01-12 2002-07-18 Sun Pharmaceutical Industries Limited Spaced drug delivery system
DK1377276T3 (da) * 2001-04-10 2012-01-02 Sun Pharma Advanced Res Co Ltd Beregning af puls-frigivelsessammensætning
TW200303919A (en) * 2001-12-05 2003-09-16 Hiroyuki Ohno Cytotoxic protein and the use
NO20021592D0 (no) 2002-04-04 2002-04-04 Fmc Biopolymer As Polysakkaridkapsler og fremgangsmåte ved fremstilling derav
KR100592511B1 (ko) * 2002-12-30 2006-07-03 안경섭 벤즈이미다졸 유도체 또는 약리학적으로 허용되는 이의염을 활성물질로 하는 안정성이 강화된 방출제어형 제제및 그 제조방법
JP4790597B2 (ja) 2003-04-24 2011-10-12 ヤゴテック アーゲー 規定されたコア幾何学的配置を有する遅延放出錠
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
KR100645019B1 (ko) * 2004-06-03 2006-11-14 주식회사 리젠 바이오텍 비수용성 무기화합물이 포집되어 있는 고분자 비드, 이의제조방법 및 용도
JP2008531755A (ja) * 2005-01-05 2008-08-14 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム 二重画像化および放射線化学療法のためのコンジュゲート：組成物、製造および適応
EP1909765A1 (en) * 2005-07-22 2008-04-16 Dow Gloval Technologies Inc. Oral drug compliance monitoring using sound detection
ES2560240T5 (es) 2005-07-29 2022-11-08 Stichting Groningen Centre For Drug Res Sistema de suministro pulsátil controlado por pH, métodos para la preparación y uso del mismo
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
EP1991196B1 (en) 2006-03-03 2016-10-12 Fmc Corporation Method and apparatus for the preparation of capsules.
JP2007284483A (ja) * 2006-04-13 2007-11-01 Daito Kasei Kogyo Kk 吸湿性顔料およびそれを含有する化粧料
WO2007136737A1 (en) * 2006-05-19 2007-11-29 Adamas Pharmaceuticals, Inc. Methods and compositions for the treatment of viral infections
DK2049123T4 (en) 2006-08-03 2016-11-28 Horizon Pharma Ag LATE discharge-glucocorticoid treatment of rheumatoid ILLNESS
WO2008044236A2 (en) * 2006-10-10 2008-04-17 Dexcel Pharma Technologies Ltd. Improved release of statins in the intestine
US20090131386A1 (en) 2007-11-13 2009-05-21 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
CA2704949A1 (en) 2007-11-13 2009-05-22 Meritage Pharma, Inc. Gastrointestinal delivery systems
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
ES2425762T3 (es) * 2008-10-27 2013-10-17 Roquette Freres Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon
WO2015161139A1 (en) 2014-04-16 2015-10-22 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
CA2835845C (en) * 2011-05-13 2020-07-28 Emotional Brain B.V. Drug delivery system
DK3089737T3 (da) 2013-12-31 2021-12-13 Rapamycin Holdings Llc Orale rapamycin-nanopartikelpræparater og anvendelse.
KR20220027271A (ko) 2014-02-21 2022-03-07 프린시피아 바이오파마, 인코퍼레이티드 Btk 억제제의 염 및 고체 형태
CA2970723C (en) 2014-12-18 2023-09-05 Principia Biopharma Inc. Treatment of pemphigus
IL252913B (en) * 2014-12-24 2022-06-01 Principia Biopharma Inc Dose of site-specific btk inhibitor
MA42242A (fr) 2015-06-24 2018-05-02 Principia Biopharma Inc Inhibiteurs de la tyrosine kinase
GB201511284D0 (en) * 2015-06-26 2015-08-12 Univ Witwatersrand Jhb An oral pharmaceutical dosage form for the delivery of a peptide and/or protein
CN105434403A (zh) * 2015-12-30 2016-03-30 成都医学院 一种溴吡斯的明包衣缓释微丸及其制备方法
WO2018005849A1 (en) 2016-06-29 2018-01-04 Principia Biopharma Inc. Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
JP6780412B2 (ja) * 2016-09-28 2020-11-04 ライオン株式会社 コーティング組成物ならびにコーティング製剤及びその製造方法
TWI877239B (zh) 2019-10-14 2025-03-21 美商普林斯匹亞生物製藥公司 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法
BR112022014149A2 (pt) 2020-01-22 2022-09-27 Principia Biopharma Inc Formas cristalinas de 2-[3-[4-amino-3-(2-fluoro-4-fenóxi-fenil)-1h-pirazolo[3,4-d]pirimidina-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrila
EP4164598A1 (en) * 2020-06-11 2023-04-19 Janssen Biotech, Inc. Controlled release of self-embedding particles for localized drug delivery
CN112544964B (zh) * 2020-12-28 2024-03-19 苏州大学 一种可服用胶囊及其制备方法与应用
CN115176879B (zh) * 2022-09-09 2022-11-18 山东新和成氨基酸有限公司 一种过瘤胃蛋氨酸的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518301D0 (en) * 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
US4891223A (en) * 1987-09-03 1990-01-02 Air Products And Chemicals, Inc. Controlled release delivery coating formulation for bioactive substances
EP0408496A3 (en) * 1989-07-12 1992-07-01 Ciba-Geigy Ag Solid dosage form for pharmaceutical substances
US5229131A (en) * 1990-02-05 1993-07-20 University Of Michigan Pulsatile drug delivery system
NZ242065A (en) * 1991-03-26 1996-06-25 Csl Ltd Delayed release implant having a degradable or rupturable polymeric coating
US5260069A (en) * 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
ES2082723B1 (es) * 1994-07-20 1996-10-01 Lilly Sa Formulacion farmaceutica de fluoxetina en forma dispersable.
US5534263A (en) * 1995-02-24 1996-07-09 Alza Corporation Active agent dosage form comprising a matrix and at least two insoluble bands
US5945124A (en) * 1995-07-05 1999-08-31 Byk Gulden Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
DE19603019C2 (de) * 1996-01-17 1998-10-15 Lancaster Group Gmbh Kosmetisches Hautreinigungsmittel auf Basis natürlicher Wirkstoffe
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
JP2000053316A (ja) * 1998-08-06 2000-02-22 Sony Corp フィルム剥離装置

Also Published As

Publication number Publication date
KR20010031034A (ko) 2001-04-16
CN1274280A (zh) 2000-11-22
CZ20001256A3 (cs) 2000-10-11
IL135502A (en) 2006-07-05
EP1021171A1 (en) 2000-07-26
NO20001829L (no) 2000-06-07
PL203733B1 (pl) 2009-11-30
NO20001829D0 (no) 2000-04-07
HUP0004945A3 (en) 2005-03-29
BR9815240A (pt) 2001-10-30
DK1021171T3 (da) 2003-08-25
ATE238774T1 (de) 2003-05-15
WO1999018938A1 (en) 1999-04-22
DE69814122D1 (de) 2003-06-05
AU740757B2 (en) 2001-11-15
ES2198756T3 (es) 2004-02-01
CA2305762A1 (en) 1999-04-22
JP2001519379A (ja) 2001-10-23
CZ301028B6 (cs) 2009-10-14
IL135502A0 (en) 2001-05-20
NZ503820A (en) 2004-02-27
PL339861A1 (en) 2001-01-15
DE69814122T2 (de) 2004-03-18
AU9600198A (en) 1999-05-03
CN100548279C (zh) 2009-10-14
TR200000944T2 (tr) 2000-11-21
CA2305762C (en) 2006-09-26
EP1021171B1 (en) 2003-05-02
HUP0004945A2 (hu) 2001-08-28

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