PL3580330T3 - Sposób wytwarzania progenitorów komórek t - Google Patents

Sposób wytwarzania progenitorów komórek t

Info

Publication number: PL3580330T3
Authority: PL; Poland
Prior art keywords: generating; cells progenitors; progenitors; cells
Prior art date: 2017-02-13

Application number

PL18704551.3T

Other languages

English (en)

Inventor

Isabelle Andre

Marina Cavazzana

Kuiying MA

John TCHEN

Tayebeh-Shabi Soheili

Ranjita Devi Moirangthem

Original Assignee

Assistance Publique - Hôpitaux De Paris

Fondation Imagine - Institut Des Maladies Génétiques

Université Paris Cité

Institut National De La Santé Et De La Recherche Médicale (Inserm)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-02-13

Filing date

2018-02-12

Publication date

2023-01-16

2018-02-12 Application filed by Assistance Publique - Hôpitaux De Paris, Fondation Imagine - Institut Des Maladies Génétiques, Université Paris Cité, Institut National De La Santé Et De La Recherche Médicale (Inserm) filed Critical Assistance Publique - Hôpitaux De Paris

2023-01-16 Publication of PL3580330T3 publication Critical patent/PL3580330T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biotechnology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Cell Biology (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Developmental Biology & Embryology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

PL18704551.3T 2017-02-13 2018-02-12 Sposób wytwarzania progenitorów komórek t PL3580330T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17305161		2017-02-13
PCT/EP2018/053406 WO2018146297A1 (en)	2017-02-13	2018-02-12	Method for generating t cells progenitors

Publications (1)

Publication Number	Publication Date
PL3580330T3 true PL3580330T3 (pl)	2023-01-16

Family

ID=58185453

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL18704551.3T PL3580330T3 (pl)	2017-02-13	2018-02-12	Sposób wytwarzania progenitorów komórek t

Country Status (17)

Country	Link
US (5)	US20200046767A1 (pl)
EP (2)	EP3580330B1 (pl)
JP (2)	JP7164798B2 (pl)
KR (1)	KR102666158B1 (pl)
CN (1)	CN110506110B (pl)
AU (1)	AU2018217404B2 (pl)
BR (1)	BR112019016672A8 (pl)
CA (1)	CA3053294A1 (pl)
DK (1)	DK3580330T3 (pl)
ES (1)	ES2931530T3 (pl)
HU (1)	HUE060548T2 (pl)
IL (1)	IL268641B2 (pl)
MA (1)	MA47541A (pl)
PL (1)	PL3580330T3 (pl)
PT (1)	PT3580330T (pl)
WO (1)	WO2018146297A1 (pl)
ZA (1)	ZA201905470B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL268641B2 (en) *	2017-02-13	2024-10-01	Assist Publique Hopitaux Paris Aphp	Method for generating t cells progenitors
US20200308540A1 (en) *	2017-09-29	2020-10-01	Regents Of The University Of Minnesota	Methods of making, expanding, and using a human progenitor t cell
CN112041431A (zh)	2018-02-14	2020-12-04	桑尼布鲁克研究所	产生t细胞谱系细胞的方法
CA3109546A1 (en) *	2018-09-07	2020-03-12	Wisconsin Alumni Research Foundation	Generation of hematopoietic progenitor cells from human pluripotent stem cells
US20220315895A1 (en) *	2019-05-01	2022-10-06	Transfusion Health, Llc	Methods of making oligopotent and unipotent precursors
CA3144640A1 (en) *	2019-06-24	2020-12-30	Children's Hospital Los Angeles	Bcl11b overexpression to enhance human thymopoiesis and t cell function
CA3159629A1 (en) *	2019-11-14	2021-05-20	Peter William ZANDSTRA	Media formulations and methods for producing progenitor t cells
US20230159891A1 (en) *	2020-03-31	2023-05-25	Kyoto University	T cell progenitor production method
JP2023553313A (ja)	2020-11-30	2023-12-21	チョファーマインコーポレイテッド	細胞を富化するための抗体
CA3213581A1 (en) *	2021-05-25	2022-12-01	Kai Ling LIANG	Generating t cell precursors via agonizing tumor necrosis factor receptor 2
EP4426319A1 (en)	2021-11-04	2024-09-11	APHP (Assistance Publique - Hôpitaux de Paris)	Method for generating nk cells
FR3130843A1 (fr) *	2021-12-21	2023-06-23	Universite Claude Bernard Lyon 1	Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt
AU2024211048A1 (en)	2023-01-27	2025-08-07	Notch Therapeutics (Canada), Inc.	Method for generating t cell lineage populations from stem/progenitor cells
WO2024175738A1 (en) *	2023-02-22	2024-08-29	Smart Immune	Method for thymus regeneration
US20250332260A1 (en)	2024-04-10	2025-10-30	Garuda Therapeutics, Inc.	Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
WO2025219552A1 (en)	2024-04-17	2025-10-23	Assitance Publique Hopitaux De Paris	Method for producing t cell progenitors from human pluripotent stem cells
CN119709836B (zh) *	2024-12-21	2025-08-08	湖南农业大学	OsProT2基因在调控水稻镉含量、镉耐受性及产量中的应用和方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6093531A (en)	1997-09-29	2000-07-25	Neurospheres Holdings Ltd.	Generation of hematopoietic cells from multipotent neural stem cells
JP2001525176A (ja)	1997-12-04	2001-12-11	デューク・ユニバーシティー	Ｃｄ７＋ｃｄ３４−ｌｉｎ−造血細胞を単離し、使用する方法
US10059923B2 (en)	2008-01-30	2018-08-28	Memorial Sloan Kettering Cancer Center	Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors
RU2535966C2 (ru)	2008-09-12	2014-12-20	Криопрашис Криобиоложия Лтда.	Клеточная терапия ишемической ткани
US8772028B2 (en) *	2008-11-07	2014-07-08	Sunnybrook Health Sciences Centre	CD34+CD7+CD5+CD1a-human progenitor T-cells produced in vitro and methods of using
WO2011068962A1 (en)	2009-12-03	2011-06-09	The University Of Utah Research Foundation	Methods for generating t lymphocytes from hematopoietic stem cells
US20130095079A1 (en)	2010-04-09	2013-04-18	Fred Hutchinson Cancer Research Center	Compositions and methods for providing hematopoietic function without hla matching
WO2013074916A1 (en)	2011-11-18	2013-05-23	Board Of Regents, The University Of Texas System	Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
US9834755B2 (en) *	2011-12-08	2017-12-05	Fred Hutchinson Cancer Research Center	Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2014110353A1 (en)	2013-01-11	2014-07-17	The Trustees Of The University Of Pennsylvania	Notch ligand bound bicompatible substrates and their use in bone formation
EP3027755B1 (en) *	2013-08-02	2019-10-09	The Regents of The University of California	Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors
US20170128556A1 (en)	2013-12-26	2017-05-11	Thyas Co. Ltd.	Immunotherapy using t precursor cells derived from pluripotent stem cells having rearranged t cell receptor genes
KR20160145802A (ko)	2014-04-23	2016-12-20	보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템	요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
US10131876B2 (en) *	2014-04-24	2018-11-20	Miltenyi Biotec Gmbh	Method for automated generation of genetically modified T cells
WO2016039933A1 (en)	2014-09-11	2016-03-17	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Lentiviral vector for treating hemoglobin disorders
FR3026744B1 (fr) *	2014-10-06	2024-04-19	Hopitaux Paris Assist Publique	Methode de generation de progeniteurs de cellules t
WO2016205680A1 (en) *	2015-06-17	2016-12-22	The Uab Research Foundation	Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
EP3440198A4 (en)	2016-04-08	2019-11-06	The Governing Council of the Universtiy of Toronto	PROCESS FOR THE PRODUCTION OF PRE-TREATMENT T CELLS FROM TRUNK AND / OR PRECURSOR CELLS AND USE THEREOF
IL268641B2 (en) *	2017-02-13	2024-10-01	Assist Publique Hopitaux Paris Aphp	Method for generating t cells progenitors

2018
- 2018-02-12 IL IL268641A patent/IL268641B2/en unknown
- 2018-02-12 US US16/485,488 patent/US20200046767A1/en not_active Abandoned
- 2018-02-12 PT PT187045513T patent/PT3580330T/pt unknown
- 2018-02-12 AU AU2018217404A patent/AU2018217404B2/en active Active
- 2018-02-12 ES ES18704551T patent/ES2931530T3/es active Active
- 2018-02-12 BR BR112019016672A patent/BR112019016672A8/pt unknown
- 2018-02-12 MA MA047541A patent/MA47541A/fr unknown
- 2018-02-12 DK DK18704551.3T patent/DK3580330T3/da active
- 2018-02-12 EP EP18704551.3A patent/EP3580330B1/en active Active
- 2018-02-12 HU HUE18704551A patent/HUE060548T2/hu unknown
- 2018-02-12 JP JP2019565052A patent/JP7164798B2/ja active Active
- 2018-02-12 EP EP22158116.8A patent/EP4067482A1/en active Pending
- 2018-02-12 PL PL18704551.3T patent/PL3580330T3/pl unknown
- 2018-02-12 CA CA3053294A patent/CA3053294A1/en active Pending
- 2018-02-12 CN CN201880024963.1A patent/CN110506110B/zh active Active
- 2018-02-12 WO PCT/EP2018/053406 patent/WO2018146297A1/en not_active Ceased
- 2018-02-12 KR KR1020197024529A patent/KR102666158B1/ko active Active
2019
- 2019-08-19 ZA ZA2019/05470A patent/ZA201905470B/en unknown
2020
- 2020-09-02 US US17/010,208 patent/US11426430B2/en active Active
2021
- 2021-02-11 US US17/173,632 patent/US11638723B2/en active Active
- 2021-02-11 US US17/173,668 patent/US11642376B2/en active Active
2022
- 2022-09-28 JP JP2022154550A patent/JP2022185024A/ja active Pending
2023
- 2023-04-06 US US18/296,623 patent/US20230293586A1/en active Pending

Also Published As

Publication number	Publication date
US11426430B2 (en)	2022-08-30
JP7164798B2 (ja)	2022-11-02
US20210169934A1 (en)	2021-06-10
HUE060548T2 (hu)	2023-03-28
US11638723B2 (en)	2023-05-02
ES2931530T3 (es)	2022-12-30
KR20190117550A (ko)	2019-10-16
JP2022185024A (ja)	2022-12-13
AU2018217404A1 (en)	2019-09-05
AU2018217404A2 (en)	2019-09-19
US20210169935A1 (en)	2021-06-10
MA47541A (fr)	2019-12-18
US20230293586A1 (en)	2023-09-21
CN110506110B (zh)	2024-09-06
IL268641B2 (en)	2024-10-01
KR102666158B1 (ko)	2024-05-16
IL268641A (en)	2019-10-31
RU2019125600A3 (pl)	2021-11-03
CA3053294A1 (en)	2018-08-16
CN110506110A (zh)	2019-11-26
AU2018217404B2 (en)	2024-03-28
PT3580330T (pt)	2022-12-06
IL268641B1 (en)	2024-06-01
RU2019125600A (ru)	2021-03-15
US11642376B2 (en)	2023-05-09
JP2020513844A (ja)	2020-05-21
BR112019016672A2 (pt)	2020-04-14
EP3580330A1 (en)	2019-12-18
DK3580330T3 (da)	2022-12-05
ZA201905470B (en)	2024-12-18
BR112019016672A8 (pt)	2022-11-22
US20200046767A1 (en)	2020-02-13
EP4067482A1 (en)	2022-10-05
WO2018146297A1 (en)	2018-08-16
EP3580330B1 (en)	2022-08-31
US20200390817A1 (en)	2020-12-17

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