DK3580330T3 - Fremgangsmåde til generering af t-celleprogenitorer - Google Patents

Fremgangsmåde til generering af t-celleprogenitorer Download PDF

Info

Publication number: DK3580330T3
Authority: DK; Denmark
Prior art keywords: generation; cell progenitors; progenitors; cell
Prior art date: 2017-02-13

Application number

DK18704551.3T

Other languages

English (en)

Inventor

Marina Cavazzana

Kuiying Ma

John Tchen

Isabelle Andre

Tayebeh-Shabi Soheili

Moirangthem Ranjita Devi

Original Assignee

Hopitaux Paris Assist Publique

Fondation Imagine Inst Des Maladies Genetiques

Inst Nat Sante Rech Med

Univ Paris Cite

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-02-13

Filing date

2018-02-12

Publication date

2022-12-05

2018-02-12 Application filed by Hopitaux Paris Assist Publique, Fondation Imagine Inst Des Maladies Genetiques, Inst Nat Sante Rech Med, Univ Paris Cite filed Critical Hopitaux Paris Assist Publique

2022-12-05 Application granted granted Critical

2022-12-05 Publication of DK3580330T3 publication Critical patent/DK3580330T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biotechnology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Cell Biology (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Developmental Biology & Embryology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

DK18704551.3T 2017-02-13 2018-02-12 Fremgangsmåde til generering af t-celleprogenitorer DK3580330T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17305161		2017-02-13
PCT/EP2018/053406 WO2018146297A1 (en)	2017-02-13	2018-02-12	Method for generating t cells progenitors

Publications (1)

Publication Number	Publication Date
DK3580330T3 true DK3580330T3 (da)	2022-12-05

Family

ID=58185453

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK18704551.3T DK3580330T3 (da)	2017-02-13	2018-02-12	Fremgangsmåde til generering af t-celleprogenitorer

Country Status (17)

Country	Link
US (5)	US20200046767A1 (da)
EP (2)	EP3580330B1 (da)
JP (2)	JP7164798B2 (da)
KR (1)	KR102666158B1 (da)
CN (1)	CN110506110B (da)
AU (1)	AU2018217404B2 (da)
BR (1)	BR112019016672A8 (da)
CA (1)	CA3053294A1 (da)
DK (1)	DK3580330T3 (da)
ES (1)	ES2931530T3 (da)
HU (1)	HUE060548T2 (da)
IL (1)	IL268641B2 (da)
MA (1)	MA47541A (da)
PL (1)	PL3580330T3 (da)
PT (1)	PT3580330T (da)
WO (1)	WO2018146297A1 (da)
ZA (1)	ZA201905470B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE060548T2 (hu) *	2017-02-13	2023-03-28	Hopitaux Paris Assist Publique	Módszer a T-sejtek progenitorainak elõéllítására
US20200308540A1 (en) *	2017-09-29	2020-10-01	Regents Of The University Of Minnesota	Methods of making, expanding, and using a human progenitor t cell
US12467034B2 (en)	2018-02-14	2025-11-11	Sunnybrook Research Institute	Method for generating cells of the T cell lineage
EP3847243A1 (en) *	2018-09-07	2021-07-14	Wisconsin Alumni Research Foundation	Generation of hematopoietic progenitor cells from human pluripotent stem cells
CA3138298A1 (en) *	2019-05-01	2020-11-05	Transfusion Health, Llc	Methods of making oligopotent and unipotent precursors
WO2020264019A1 (en) *	2019-06-24	2020-12-30	Children's Hospital Los Angeles	Bcl11b overexpression to enhance human thymopoiesis and t cell function
JP2023502965A (ja) *	2019-11-14	2023-01-26	ウィリアムザンドストラ，ピーター	前駆ｔ細胞を製造するための培地処方および方法
WO2021200901A1 (ja) *	2020-03-31	2021-10-07	国立大学法人京都大学	Ｔ前駆細胞の製造方法
EP4251651A4 (en)	2020-11-30	2025-07-09	Cho Pharma Inc	ANTIBODIES FOR CELL ENRICHMENT
US20240240144A1 (en) *	2021-05-25	2024-07-18	Universiteit Gent	Generating t cell precursors via agonizing tumor necrosis factor receptor 2
JP2024542151A (ja) *	2021-11-04	2024-11-13	エーピーエイチピー（アシスタンスパブリック－オピトークスドパリ）	Ｎｋ細胞の生成法
FR3130843A1 (fr) *	2021-12-21	2023-06-23	Universite Claude Bernard Lyon 1	Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt
US12338460B2 (en)	2023-01-27	2025-06-24	Notch Therapeutics (Canada), Inc.	Method for generating T cell lineage populations from stem/progenitor cells
KR20250152088A (ko) *	2023-02-22	2025-10-22	메이라지티엑스 셀 테라피스	흉선 재생 방법
WO2025217462A1 (en)	2024-04-10	2025-10-16	Garuda Therapeutics, Inc.	Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease- specific populations
WO2025219552A1 (en)	2024-04-17	2025-10-23	Assitance Publique Hopitaux De Paris	Method for producing t cell progenitors from human pluripotent stem cells
CN119709836B (zh) *	2024-12-21	2025-08-08	湖南农业大学	OsProT2基因在调控水稻镉含量、镉耐受性及产量中的应用和方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6093531A (en)	1997-09-29	2000-07-25	Neurospheres Holdings Ltd.	Generation of hematopoietic cells from multipotent neural stem cells
EP1034288A4 (en)	1997-12-04	2002-11-27	Univ Duke	METHODS OF ISOLATING AND USING CD7 + CD34-LIN- HEMATOPOIETIC CELLS
US10059923B2 (en)	2008-01-30	2018-08-28	Memorial Sloan Kettering Cancer Center	Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors
BRPI0919020A2 (pt)	2008-09-12	2017-08-22	Univ South Florida	Uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris
EP2352816B1 (en) *	2008-11-07	2015-06-24	Sunnybrook Health Sciences Centre	Human progenitor t-cells
WO2011068962A1 (en)	2009-12-03	2011-06-09	The University Of Utah Research Foundation	Methods for generating t lymphocytes from hematopoietic stem cells
US20130095079A1 (en)	2010-04-09	2013-04-18	Fred Hutchinson Cancer Research Center	Compositions and methods for providing hematopoietic function without hla matching
WO2013074916A1 (en)	2011-11-18	2013-05-23	Board Of Regents, The University Of Texas System	Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
AU2012347534B2 (en) *	2011-12-08	2018-01-25	Fred Hutchinson Cancer Research Center	Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US20150352180A1 (en)	2013-01-11	2015-12-10	The Trustee Of The University Of Pennsylvania	Notch Ligand Bound Biocompatible Substrates And Their Use In Bone Formation
WO2015017755A1 (en)	2013-08-02	2015-02-05	The Regents Of The University Of California	Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors
US20170128556A1 (en)	2013-12-26	2017-05-11	Thyas Co. Ltd.	Immunotherapy using t precursor cells derived from pluripotent stem cells having rearranged t cell receptor genes
KR20160145802A (ko)	2014-04-23	2016-12-20	보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템	요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
ES2708584T3 (es) *	2014-04-24	2019-04-10	Miltenyi Biotec Gmbh	Método para la generación automatizada de células T modificadas genéticamente
EP3191596B1 (en)	2014-09-11	2019-10-09	The U.S.A. as represented by the Secretary, Department of Health and Human Services	Lentiviral vector for treating hemoglobin disorders
FR3026744B1 (fr) *	2014-10-06	2024-04-19	Hopitaux Paris Assist Publique	Methode de generation de progeniteurs de cellules t
EP3310931B1 (en) *	2015-06-17	2021-11-17	The UAB Research Foundation	Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
JP7049261B2 (ja)	2016-04-08	2022-04-06	ザガバニングカウンシルオブザユニバーシティオブトロント	幹細胞および／または前駆細胞からｔ前駆細胞を作製する方法ならびに該ｔ前駆細胞の使用
HUE060548T2 (hu) *	2017-02-13	2023-03-28	Hopitaux Paris Assist Publique	Módszer a T-sejtek progenitorainak elõéllítására

2018
- 2018-02-12 HU HUE18704551A patent/HUE060548T2/hu unknown
- 2018-02-12 CA CA3053294A patent/CA3053294A1/en active Pending
- 2018-02-12 US US16/485,488 patent/US20200046767A1/en not_active Abandoned
- 2018-02-12 PT PT187045513T patent/PT3580330T/pt unknown
- 2018-02-12 ES ES18704551T patent/ES2931530T3/es active Active
- 2018-02-12 KR KR1020197024529A patent/KR102666158B1/ko active Active
- 2018-02-12 PL PL18704551.3T patent/PL3580330T3/pl unknown
- 2018-02-12 MA MA047541A patent/MA47541A/fr unknown
- 2018-02-12 EP EP18704551.3A patent/EP3580330B1/en active Active
- 2018-02-12 DK DK18704551.3T patent/DK3580330T3/da active
- 2018-02-12 BR BR112019016672A patent/BR112019016672A8/pt unknown
- 2018-02-12 JP JP2019565052A patent/JP7164798B2/ja active Active
- 2018-02-12 WO PCT/EP2018/053406 patent/WO2018146297A1/en not_active Ceased
- 2018-02-12 AU AU2018217404A patent/AU2018217404B2/en active Active
- 2018-02-12 CN CN201880024963.1A patent/CN110506110B/zh active Active
- 2018-02-12 EP EP22158116.8A patent/EP4067482A1/en active Pending
- 2018-02-12 IL IL268641A patent/IL268641B2/en unknown
2019
- 2019-08-19 ZA ZA2019/05470A patent/ZA201905470B/en unknown
2020
- 2020-09-02 US US17/010,208 patent/US11426430B2/en active Active
2021
- 2021-02-11 US US17/173,632 patent/US11638723B2/en active Active
- 2021-02-11 US US17/173,668 patent/US11642376B2/en active Active
2022
- 2022-09-28 JP JP2022154550A patent/JP2022185024A/ja active Pending
2023
- 2023-04-06 US US18/296,623 patent/US20230293586A1/en active Pending

Also Published As

Publication number	Publication date
WO2018146297A1 (en)	2018-08-16
IL268641A (en)	2019-10-31
AU2018217404B2 (en)	2024-03-28
CN110506110A (zh)	2019-11-26
US11642376B2 (en)	2023-05-09
KR102666158B1 (ko)	2024-05-16
ZA201905470B (en)	2024-12-18
US20230293586A1 (en)	2023-09-21
KR20190117550A (ko)	2019-10-16
BR112019016672A8 (pt)	2022-11-22
IL268641B1 (en)	2024-06-01
MA47541A (fr)	2019-12-18
PL3580330T3 (pl)	2023-01-16
JP2020513844A (ja)	2020-05-21
IL268641B2 (en)	2024-10-01
EP3580330A1 (en)	2019-12-18
US20200390817A1 (en)	2020-12-17
AU2018217404A2 (en)	2019-09-19
ES2931530T3 (es)	2022-12-30
JP7164798B2 (ja)	2022-11-02
CA3053294A1 (en)	2018-08-16
CN110506110B (zh)	2024-09-06
EP3580330B1 (en)	2022-08-31
JP2022185024A (ja)	2022-12-13
RU2019125600A (ru)	2021-03-15
US11426430B2 (en)	2022-08-30
AU2018217404A1 (en)	2019-09-05
US11638723B2 (en)	2023-05-02
US20210169935A1 (en)	2021-06-10
US20210169934A1 (en)	2021-06-10
HUE060548T2 (hu)	2023-03-28
BR112019016672A2 (pt)	2020-04-14
US20200046767A1 (en)	2020-02-13
RU2019125600A3 (da)	2021-11-03
PT3580330T (pt)	2022-12-06
EP4067482A1 (en)	2022-10-05

Publication	Publication Date	Title
DK3580330T3 (da)	2022-12-05	Fremgangsmåde til generering af t-celleprogenitorer
DK3500664T3 (da)	2021-12-06	Fremgangsmåde til differentiering af pluripotente celler
DK3444334T3 (da)	2021-11-08	Fremgangsmåde til inducering af CD8+ T-celler
DK3636753T3 (da)	2024-05-06	Fremgangsmåde til fremstilling af DNA-redigeret eukaryotisk celle
DK3453065T3 (da)	2021-05-17	Reaktor med avanceret arkitektur til elektrokemisk reduktion af cox
DK3116902T3 (da)	2020-04-06	Fremgangsmåde til generering af T-celler kompatible for allogen transplantation
DK3315610T3 (da)	2021-03-08	Fremgangsmåde til fremstilling af fucosylerede oligosaccharider
DK3285784T3 (da)	2020-08-24	Fremgangsmåde til fremstilling af en prøve af fækal mikrobiota
DK3292134T3 (da)	2020-11-23	Metode til dyrkning af akkermansia
DK3402773T3 (da)	2020-05-04	Fremgangsmåde til fremstilling af methanol
DK3294700T3 (da)	2020-04-14	Fremgangsmåde til fremstilling af limonen-4-ol
DK3460102T3 (da)	2020-07-13	Fremgangsmåde til fremstilling af en elektrokatalysator
DK3665173T3 (da)	2025-08-04	Ny fremgangsmåde til yntetisering af amanitiner
DK3487443T3 (da)	2021-06-07	Fremgangsmåde til opmåling af en implantat-implantat-situation
DK3178137T3 (da)	2019-07-22	Fremgangsmåde og generator til generering af ultrakorte lysimpulser
DK3210276T3 (da)	2025-03-03	Fremgangsmåde til drift af et uafhængigt netværk
DK3423714T3 (da)	2020-09-28	Fremgangsmåde til generering af elektricitet
DK3622081T3 (da)	2021-09-13	Fremgangsmåde til fremstilling af en azaphilon i talaromyces atroroseus
DK3529233T3 (da)	2020-10-12	Fremgangsmåde til fremstilling af 3-alkylsulfanyl-2-chlor-n-(1-alkyl-1h-tetrazol-5-yl)-4-trifluoromethyl-benzamider
DK3661562T3 (da)	2024-12-16	Fremgangsmåde til konjugation af cys-mabs
DK3625236T3 (da)	2022-03-21	Fremgangsmåde til fremstilling af et optisk aktivt cineolderivat
DK4235628T3 (da)	2024-03-11	System til frembringelse af en omgivelse
DK3347481T3 (da)	2020-07-27	Fremgangsmåde til oprensning af biomassehydrolysat
DK3331986T3 (da)	2020-08-31	Fremgangsmåde til fremstilling af celledyrkningsmedium
DK3548427T3 (da)	2021-05-31	Fremgangsmåde til fremstilling af hydrogen