PL3039153T3 - Mikroorganizm do wytwarzania metioniny o ulepszonej aktywności syntazy metioniny i wypływie metioniny - Google Patents
Mikroorganizm do wytwarzania metioniny o ulepszonej aktywności syntazy metioniny i wypływie metioninyInfo
- Publication number
- PL3039153T3 PL3039153T3 PL14757955T PL14757955T PL3039153T3 PL 3039153 T3 PL3039153 T3 PL 3039153T3 PL 14757955 T PL14757955 T PL 14757955T PL 14757955 T PL14757955 T PL 14757955T PL 3039153 T3 PL3039153 T3 PL 3039153T3
- Authority
- PL
- Poland
- Prior art keywords
- methionine
- microorganism
- efflux
- improved
- production
- Prior art date
Links
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title 2
- 229930182817 methionine Natural products 0.000 title 2
- 102000011848 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Human genes 0.000 title 1
- 108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01013—Methionine synthase (2.1.1.13)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13306185 | 2013-08-30 | ||
| EP14757955.1A EP3039153B1 (en) | 2013-08-30 | 2014-09-01 | Microorganism for methionine production with improved methionine synthase activity and methionine efflux |
| PCT/EP2014/068539 WO2015028674A1 (en) | 2013-08-30 | 2014-09-01 | Microorganism for methionine production with improved methionine synthase activity and methionine efflux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3039153T3 true PL3039153T3 (pl) | 2019-02-28 |
Family
ID=49162096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14757955T PL3039153T3 (pl) | 2013-08-30 | 2014-09-01 | Mikroorganizm do wytwarzania metioniny o ulepszonej aktywności syntazy metioniny i wypływie metioniny |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10196658B2 (pl) |
| EP (1) | EP3039153B1 (pl) |
| JP (1) | JP2016529899A (pl) |
| KR (1) | KR102270626B1 (pl) |
| CN (1) | CN105658803B (pl) |
| BR (1) | BR112016004367B1 (pl) |
| CA (1) | CA2922597A1 (pl) |
| ES (1) | ES2693789T3 (pl) |
| MX (1) | MX374056B (pl) |
| PL (1) | PL3039153T3 (pl) |
| RU (1) | RU2016110763A (pl) |
| WO (1) | WO2015028674A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017525379A (ja) * | 2014-09-01 | 2017-09-07 | メタボリック エクスプローラー | メチオニン排出を改善した発酵によるメチオニン産生の方法及び微生物 |
| CN108026516A (zh) | 2015-08-07 | 2018-05-11 | 赢创德固赛有限公司 | 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产 |
| PL3380627T3 (pl) | 2015-11-27 | 2020-01-31 | Evonik Degussa Gmbh | Sposób wytwarzania L-metioniny |
| KR20180093981A (ko) | 2016-01-08 | 2018-08-22 | 에보니크 데구사 게엠베하 | 발효적 생산에 의해 l-메티오닌을 생산하는 방법 |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| CN109055289B (zh) * | 2018-07-27 | 2020-10-27 | 浙江工业大学 | 一种高产l-甲硫氨酸的重组大肠杆菌及其应用 |
| CN112961807B (zh) * | 2021-03-30 | 2023-01-20 | 中国科学院成都生物研究所 | 一种微生物组合物及在促进青稞种子发芽和生长上的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4110641B2 (ja) | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるｌ−メチオニンの製造法 |
| JP2000157267A (ja) | 1998-11-24 | 2000-06-13 | Ajinomoto Co Inc | 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法 |
| DE19943587A1 (de) | 1999-09-11 | 2001-03-15 | Degussa | Neue für das dapF-Gen codierende Nukleotidsequenzen |
| WO2002010209A1 (en) | 2000-08-02 | 2002-02-07 | Degussa Ag | Nucleotide sequences which code for the meth gene |
| BR122013017189B1 (pt) | 2001-02-13 | 2017-02-07 | Ajinomoto Kk | bactéria produtora de l-aminoácido pertencente ao gênero escherichia, e, método para produzir l-aminoácido |
| DE10126164A1 (de) | 2001-05-30 | 2002-12-05 | Degussa | Für das metD-gen kodierende Nukleotidsequenzen |
| JP2006521083A (ja) | 2002-11-29 | 2006-09-21 | ビーエーエスエフ アクチェンゲゼルシャフト | メチオニンの生産方法 |
| BRPI0407600A (pt) | 2003-02-18 | 2006-02-14 | Metabolic Explorer Sa | processos de preparação de microorganismos evoluìdos e de uma proteìna evoluìda e de biotransformação, gene evoluìdo, proteìna evoluìda, e utilização de um microorganismo evoluìdo ou de uma proteìna evoluìda |
| EP1656454A4 (en) | 2003-07-08 | 2011-06-22 | Novus Int Inc | PROCESS FOR METHIONINAL RECOVERY |
| DE10359668A1 (de) | 2003-12-18 | 2005-07-14 | Basf Ag | Verfahren zur Herstellung von Methionin |
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
| DE102004009454A1 (de) | 2004-02-27 | 2005-09-15 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von rekombinanten Mikroorganismen |
| WO2005111202A1 (en) | 2004-05-12 | 2005-11-24 | Metabolic Explorer | Recombinant enzyme with altered feedback sensitivity |
| KR100651220B1 (ko) | 2004-06-29 | 2006-11-29 | 씨제이 주식회사 | Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법 |
| DE102004035065A1 (de) | 2004-07-20 | 2006-02-16 | Basf Ag | P-ET-TS-Expressionseinheiten |
| WO2006138689A2 (en) | 2005-06-17 | 2006-12-28 | Microbia, Inc. | Improved amino acid and metabolite biosynthesis |
| JP4061557B2 (ja) | 2005-07-11 | 2008-03-19 | 三菱マテリアル株式会社 | 相変化膜形成用スパッタリングターゲットおよびその製造方法。 |
| AU2006269864A1 (en) | 2005-07-18 | 2007-01-25 | Evonik Degussa Gmbh | Methionine producing recombinant microorganisms |
| CA2615315C (en) | 2005-07-18 | 2015-10-06 | Basf Aktiengesellschaft | Use of dimethyl disulfide for methionine production in microorganisms |
| WO2007077041A1 (en) | 2006-01-04 | 2007-07-12 | Metabolic Explorer | Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism with enhanced sulfate permease expression |
| WO2007135188A2 (en) | 2006-05-24 | 2007-11-29 | Evonik Degussa Gmbh | Process for the preparation of l-methionine |
| KR20080061801A (ko) * | 2006-12-28 | 2008-07-03 | 씨제이제일제당 (주) | L-메티오닌 생산능을 향상시키는 폴리펩타이드, 상기 폴리펩타이드를 과발현하는 미생물 및 상기 미생물을 이용한 l- 메티오닌 생산방법 |
| JP2010514431A (ja) | 2006-12-29 | 2010-05-06 | エボニック デグサ ゲーエムベーハー | 生成物阻害が低減されたメチオニンシンターゼ |
| PL2132306T3 (pl) * | 2007-04-11 | 2013-05-31 | Cj Cheiljedang Corp | Kompozycje i sposoby wytwarzania metioniny |
| WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| US8163532B2 (en) | 2008-05-28 | 2012-04-24 | Evonik Degussa Gmbh | Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase |
| WO2010020290A1 (en) | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Producing methionine without n-acetyl methionine |
| WO2011073738A1 (en) | 2009-12-14 | 2011-06-23 | Metabolic Explorer | Use of inducible promoters in the production of methionine |
| AR083468A1 (es) | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
| WO2012090021A1 (en) * | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| EP2479279A1 (de) * | 2011-01-20 | 2012-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren |
| AR086790A1 (es) | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| EP2861726B1 (en) | 2012-06-18 | 2017-05-31 | Evonik Degussa GmbH | Recombinant microorganism for the fermentative production of methionine |
-
2014
- 2014-09-01 PL PL14757955T patent/PL3039153T3/pl unknown
- 2014-09-01 US US14/915,137 patent/US10196658B2/en active Active
- 2014-09-01 RU RU2016110763A patent/RU2016110763A/ru not_active Application Discontinuation
- 2014-09-01 ES ES14757955.1T patent/ES2693789T3/es active Active
- 2014-09-01 MX MX2016002616A patent/MX374056B/es active IP Right Grant
- 2014-09-01 BR BR112016004367-7A patent/BR112016004367B1/pt active IP Right Grant
- 2014-09-01 CN CN201480058241.XA patent/CN105658803B/zh active Active
- 2014-09-01 EP EP14757955.1A patent/EP3039153B1/en active Active
- 2014-09-01 CA CA2922597A patent/CA2922597A1/en not_active Abandoned
- 2014-09-01 KR KR1020167007918A patent/KR102270626B1/ko active Active
- 2014-09-01 JP JP2016537330A patent/JP2016529899A/ja active Pending
- 2014-09-01 WO PCT/EP2014/068539 patent/WO2015028674A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US10196658B2 (en) | 2019-02-05 |
| MX2016002616A (es) | 2016-06-06 |
| RU2016110763A (ru) | 2017-10-05 |
| US20160177352A1 (en) | 2016-06-23 |
| BR112016004367B1 (pt) | 2022-06-14 |
| ES2693789T3 (es) | 2018-12-13 |
| EP3039153B1 (en) | 2018-08-22 |
| CN105658803A (zh) | 2016-06-08 |
| KR20160044037A (ko) | 2016-04-22 |
| KR102270626B1 (ko) | 2021-06-30 |
| WO2015028674A1 (en) | 2015-03-05 |
| BR112016004367A2 (pt) | 2017-10-17 |
| JP2016529899A (ja) | 2016-09-29 |
| CA2922597A1 (en) | 2015-03-05 |
| CN105658803B (zh) | 2020-06-23 |
| EP3039153A1 (en) | 2016-07-06 |
| MX374056B (es) | 2020-07-27 |
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