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PL3027598T3 - Pochodne oksochinazolinylo-butanoamidowe - Google Patents

Pochodne oksochinazolinylo-butanoamidowe

Info

Publication number
PL3027598T3
PL3027598T3 PL14739045T PL14739045T PL3027598T3 PL 3027598 T3 PL3027598 T3 PL 3027598T3 PL 14739045 T PL14739045 T PL 14739045T PL 14739045 T PL14739045 T PL 14739045T PL 3027598 T3 PL3027598 T3 PL 3027598T3
Authority
PL
Poland
Prior art keywords
oxoquinazolinyl
butanamide derivatives
butanamide
derivatives
Prior art date
Application number
PL14739045T
Other languages
English (en)
Inventor
Dieter Dorsch
Hans-Peter Buchstaller
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL3027598T3 publication Critical patent/PL3027598T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL14739045T 2013-07-31 2014-07-10 Pochodne oksochinazolinylo-butanoamidowe PL3027598T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13003815 2013-07-31

Publications (1)

Publication Number Publication Date
PL3027598T3 true PL3027598T3 (pl) 2017-09-29

Family

ID=48915813

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14739045T PL3027598T3 (pl) 2013-07-31 2014-07-10 Pochodne oksochinazolinylo-butanoamidowe

Country Status (25)

Country Link
US (1) US9901577B2 (pl)
EP (1) EP3027598B1 (pl)
JP (1) JP6423875B2 (pl)
KR (1) KR102331389B1 (pl)
CN (1) CN105392784B (pl)
AR (1) AR097087A1 (pl)
AU (1) AU2014298955B2 (pl)
BR (1) BR112016001645B1 (pl)
CA (1) CA2919905C (pl)
DK (1) DK3027598T3 (pl)
ES (1) ES2632988T3 (pl)
HR (1) HRP20171053T1 (pl)
HU (1) HUE032846T2 (pl)
IL (1) IL243734B (pl)
LT (1) LT3027598T (pl)
MX (1) MX359656B (pl)
NZ (1) NZ716593A (pl)
PL (1) PL3027598T3 (pl)
PT (1) PT3027598T (pl)
RS (1) RS56211B1 (pl)
RU (1) RU2669393C2 (pl)
SG (1) SG11201600743WA (pl)
SI (1) SI3027598T1 (pl)
WO (1) WO2015014442A1 (pl)
ZA (1) ZA201601333B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6673853B2 (ja) * 2014-05-07 2020-03-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung ヘテロシクリル−ブタンアミド誘導体
RU2018119935A (ru) * 2015-11-02 2019-12-04 Мерк Патент Гмбх 1,4-дикарбонилпиперидильные производные
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
EP3562822B1 (en) * 2016-12-30 2021-03-10 Mitobridge, Inc. Poly-adp ribose polymerase (parp) inhibitors
HRP20230183T1 (hr) * 2017-12-21 2023-05-12 Ribon Therapeutics Inc. Kinazolinoni kao inhibitori parp14
CN109180702B (zh) * 2018-10-29 2021-11-30 四川大学 一种噻吩并嘧啶酮化合物及其用途
CA3121697A1 (en) 2018-12-03 2020-06-11 Merck Patent Gmbh 4-heteroarylcarbonyl-n-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases
WO2021185793A1 (en) * 2020-03-19 2021-09-23 Merck Patent Gmbh Tetrazole derivatives
WO2023161881A1 (en) * 2022-02-25 2023-08-31 Glaxosmithkline Intellectual Property Development Limited Cytotoxicity targeting chimeras for ccr2-expressing cells
WO2025111705A1 (en) * 2023-11-30 2025-06-05 Waverley Pharma Inc. Quinazolinone derivatives as poly (adp ribose) polymerase 1 (parp-1) inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
CN100490818C (zh) * 2000-05-26 2009-05-27 诺瓦蒂斯有限公司 β-L-2′-脱氧核苷在制备用于治疗丁型肝炎病毒感染的药物中的用途
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
WO2002094790A1 (en) * 2001-05-23 2002-11-28 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
MXPA05009661A (es) * 2003-03-12 2006-03-08 Kudos Pharm Ltd Derivados de ftalazinona.
CA2569826C (en) * 2004-06-30 2013-07-16 Janssen Pharmaceutica N.V. Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
UY31603A1 (es) * 2008-01-23 2009-08-31 Derivados de ftalazinona
CN101492425A (zh) 2009-02-27 2009-07-29 无锡市凯奥善生物医药科技有限公司 一类parp抑制剂的化合物
US9181266B2 (en) 2011-07-13 2015-11-10 Novartis Ag 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
US9505749B2 (en) * 2012-08-29 2016-11-29 Amgen Inc. Quinazolinone compounds and derivatives thereof

Also Published As

Publication number Publication date
CN105392784A (zh) 2016-03-09
IL243734B (en) 2019-09-26
MX359656B (es) 2018-10-05
HUE032846T2 (en) 2017-11-28
RS56211B1 (sr) 2017-11-30
BR112016001645A8 (pt) 2020-01-21
SI3027598T1 (sl) 2017-08-31
AR097087A1 (es) 2016-02-17
KR20160037985A (ko) 2016-04-06
HK1222391A1 (zh) 2017-06-30
EP3027598B1 (en) 2017-04-12
IL243734A0 (en) 2016-04-21
PT3027598T (pt) 2017-07-17
MX2016001136A (es) 2016-04-29
DK3027598T3 (da) 2017-05-22
ZA201601333B (en) 2019-12-18
CA2919905C (en) 2021-08-10
RU2016106952A (ru) 2017-09-04
AU2014298955A1 (en) 2016-03-10
CN105392784B (zh) 2018-10-09
ES2632988T3 (es) 2017-09-18
BR112016001645A2 (pt) 2017-08-01
KR102331389B1 (ko) 2021-11-26
JP2016525556A (ja) 2016-08-25
JP6423875B2 (ja) 2018-11-14
RU2016106952A3 (pl) 2018-05-14
HRP20171053T1 (hr) 2017-10-06
SG11201600743WA (en) 2016-02-26
US20160184310A1 (en) 2016-06-30
WO2015014442A1 (en) 2015-02-05
BR112016001645B1 (pt) 2023-04-11
CA2919905A1 (en) 2015-02-05
RU2669393C2 (ru) 2018-10-11
US9901577B2 (en) 2018-02-27
EP3027598A1 (en) 2016-06-08
AU2014298955B2 (en) 2018-03-01
LT3027598T (lt) 2017-06-12
NZ716593A (en) 2021-07-30

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