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LT3027598T - Oksochinazolinil-butanamido dariniai - Google Patents

Oksochinazolinil-butanamido dariniai

Info

Publication number
LT3027598T
LT3027598T LTEP14739045.4T LT14739045T LT3027598T LT 3027598 T LT3027598 T LT 3027598T LT 14739045 T LT14739045 T LT 14739045T LT 3027598 T LT3027598 T LT 3027598T
Authority
LT
Lithuania
Prior art keywords
oxoquinazolinyl
butanamide derivatives
butanamide
derivatives
Prior art date
Application number
LTEP14739045.4T
Other languages
English (en)
Inventor
Dieter Dorsch
Hans-Peter Buchstaller
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of LT3027598T publication Critical patent/LT3027598T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LTEP14739045.4T 2013-07-31 2014-07-10 Oksochinazolinil-butanamido dariniai LT3027598T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003815 2013-07-31
PCT/EP2014/001895 WO2015014442A1 (en) 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamide derivatives

Publications (1)

Publication Number Publication Date
LT3027598T true LT3027598T (lt) 2017-06-12

Family

ID=48915813

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14739045.4T LT3027598T (lt) 2013-07-31 2014-07-10 Oksochinazolinil-butanamido dariniai

Country Status (25)

Country Link
US (1) US9901577B2 (lt)
EP (1) EP3027598B1 (lt)
JP (1) JP6423875B2 (lt)
KR (1) KR102331389B1 (lt)
CN (1) CN105392784B (lt)
AR (1) AR097087A1 (lt)
AU (1) AU2014298955B2 (lt)
BR (1) BR112016001645B1 (lt)
CA (1) CA2919905C (lt)
DK (1) DK3027598T3 (lt)
ES (1) ES2632988T3 (lt)
HR (1) HRP20171053T1 (lt)
HU (1) HUE032846T2 (lt)
IL (1) IL243734B (lt)
LT (1) LT3027598T (lt)
MX (1) MX359656B (lt)
NZ (1) NZ716593A (lt)
PL (1) PL3027598T3 (lt)
PT (1) PT3027598T (lt)
RS (1) RS56211B1 (lt)
RU (1) RU2669393C2 (lt)
SG (1) SG11201600743WA (lt)
SI (1) SI3027598T1 (lt)
WO (1) WO2015014442A1 (lt)
ZA (1) ZA201601333B (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6673853B2 (ja) * 2014-05-07 2020-03-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung ヘテロシクリル−ブタンアミド誘導体
BR112018007358A2 (pt) * 2015-11-02 2018-10-23 Merck Patent Gmbh derivados de 1,4-dicarbonil-piperidila
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
US11034670B2 (en) * 2016-12-30 2021-06-15 Mitobridge, Inc. Poly-ADP ribose polymerase (PARP) inhibitors
EP3728207B1 (en) * 2017-12-21 2023-02-01 Ribon Therapeutics Inc. Quinazolinones as parp14 inhibitors
CN109180702B (zh) * 2018-10-29 2021-11-30 四川大学 一种噻吩并嘧啶酮化合物及其用途
WO2020114892A1 (en) 2018-12-03 2020-06-11 Merck Patent Gmbh 4-heteroarylcarbonyl-n-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases
US20240382468A2 (en) * 2020-03-19 2024-11-21 Merck Patent Gmbh Tetrazole derivatives
WO2023161881A1 (en) * 2022-02-25 2023-08-31 Glaxosmithkline Intellectual Property Development Limited Cytotoxicity targeting chimeras for ccr2-expressing cells
WO2025111705A1 (en) * 2023-11-30 2025-06-05 Waverley Pharma Inc. Quinazolinone derivatives as poly (adp ribose) polymerase 1 (parp-1) inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
DE60105424T2 (de) * 2000-05-26 2005-09-22 Idenix (Cayman) Ltd. Methoden zur behandlung von delta hepatitis virus infektionen mit beta-l-2' deoxy-nucleosiden
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
EP1396488A1 (en) * 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
EP1633724B1 (en) * 2003-03-12 2011-05-04 Kudos Pharmaceuticals Limited Phthalazinone derivatives
CN1976906B (zh) * 2004-06-30 2010-09-01 詹森药业有限公司 用作parp抑制剂的取代2-烷基喹唑啉酮衍生物
AR070221A1 (es) * 2008-01-23 2010-03-25 Astrazeneca Ab Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
CN101492425A (zh) * 2009-02-27 2009-07-29 无锡市凯奥善生物医药科技有限公司 一类parp抑制剂的化合物
WO2013012723A1 (en) 2011-07-13 2013-01-24 Novartis Ag Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
US9505749B2 (en) * 2012-08-29 2016-11-29 Amgen Inc. Quinazolinone compounds and derivatives thereof

Also Published As

Publication number Publication date
IL243734B (en) 2019-09-26
RU2016106952A (ru) 2017-09-04
CA2919905A1 (en) 2015-02-05
RS56211B1 (sr) 2017-11-30
BR112016001645A2 (pt) 2017-08-01
CN105392784B (zh) 2018-10-09
HRP20171053T1 (hr) 2017-10-06
US20160184310A1 (en) 2016-06-30
BR112016001645A8 (pt) 2020-01-21
NZ716593A (en) 2021-07-30
KR20160037985A (ko) 2016-04-06
DK3027598T3 (da) 2017-05-22
AU2014298955A1 (en) 2016-03-10
CN105392784A (zh) 2016-03-09
BR112016001645B1 (pt) 2023-04-11
AU2014298955B2 (en) 2018-03-01
HK1222391A1 (zh) 2017-06-30
MX359656B (es) 2018-10-05
CA2919905C (en) 2021-08-10
EP3027598B1 (en) 2017-04-12
WO2015014442A1 (en) 2015-02-05
ZA201601333B (en) 2019-12-18
RU2016106952A3 (lt) 2018-05-14
ES2632988T3 (es) 2017-09-18
US9901577B2 (en) 2018-02-27
RU2669393C2 (ru) 2018-10-11
SG11201600743WA (en) 2016-02-26
SI3027598T1 (sl) 2017-08-31
MX2016001136A (es) 2016-04-29
HUE032846T2 (en) 2017-11-28
JP6423875B2 (ja) 2018-11-14
IL243734A0 (en) 2016-04-21
KR102331389B1 (ko) 2021-11-26
AR097087A1 (es) 2016-02-17
PL3027598T3 (pl) 2017-09-29
EP3027598A1 (en) 2016-06-08
JP2016525556A (ja) 2016-08-25
PT3027598T (pt) 2017-07-17

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