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PL3080284T3 - Sposób wytwarzania chiralnej 2-(4-aminofenylo)morfoliny - Google Patents

Sposób wytwarzania chiralnej 2-(4-aminofenylo)morfoliny

Info

Publication number
PL3080284T3
PL3080284T3 PL14808637T PL14808637T PL3080284T3 PL 3080284 T3 PL3080284 T3 PL 3080284T3 PL 14808637 T PL14808637 T PL 14808637T PL 14808637 T PL14808637 T PL 14808637T PL 3080284 T3 PL3080284 T3 PL 3080284T3
Authority
PL
Poland
Prior art keywords
aminophenyl
chiral
morpholine
preparation
Prior art date
Application number
PL14808637T
Other languages
English (en)
Inventor
Rene Trussardi
Hans Iding
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of PL3080284T3 publication Critical patent/PL3080284T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/008Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL14808637T 2013-12-11 2014-12-08 Sposób wytwarzania chiralnej 2-(4-aminofenylo)morfoliny PL3080284T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13196638 2013-12-11
EP14808637.4A EP3080284B1 (en) 2013-12-11 2014-12-08 Process for the preparation of a chiral 2-(4-aminophenyl)morpholine
PCT/EP2014/076831 WO2015086495A1 (en) 2013-12-11 2014-12-08 Process for the preparation of chiral 2-aryl morpholines

Publications (1)

Publication Number Publication Date
PL3080284T3 true PL3080284T3 (pl) 2018-05-30

Family

ID=49759111

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14808637T PL3080284T3 (pl) 2013-12-11 2014-12-08 Sposób wytwarzania chiralnej 2-(4-aminofenylo)morfoliny

Country Status (11)

Country Link
US (1) US10337039B2 (pl)
EP (1) EP3080284B1 (pl)
JP (1) JP6511448B2 (pl)
KR (1) KR20160097291A (pl)
CN (1) CN105793430B (pl)
CA (1) CA2932003A1 (pl)
ES (1) ES2653559T3 (pl)
MX (1) MX2016007140A (pl)
PL (1) PL3080284T3 (pl)
RU (1) RU2677328C1 (pl)
WO (1) WO2015086495A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108570014B (zh) * 2018-04-24 2019-05-21 上海馨远医药科技有限公司 一种手性吗啉化合物的制备方法
CA3146830A1 (en) 2019-07-11 2021-01-14 F. Hoffmann-La Roche Ag Process for the preparation of substituted pyrazole derivatives
WO2023079128A1 (en) 2021-11-08 2023-05-11 F. Hoffmann-La Roche Ag Catalytic hydrogenation of aromatic nitro compounds
CN114317619B (zh) * 2021-12-31 2024-08-27 山西大学 一种酮还原酶连续化反应制备手性醇的方法
AR129909A1 (es) 2022-07-15 2024-10-09 Hoffmann La Roche Cetorreductasa mutante con mayor actividad de cetorreductasa así como métodos y usos de esta
TW202444712A (zh) * 2023-04-28 2024-11-16 大陸商江蘇豪森藥業集團有限公司 一種嗎啉雜環類化合物的鹽及其製備方法和應用
WO2025096445A1 (en) 2023-10-30 2025-05-08 Alkermes, Inc. Synthesis of intermediates for the preparation of macrocyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0605033B1 (en) * 1992-12-21 1999-07-21 Duphar International Research B.V Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer
DE10119274A1 (de) 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
OA13014A (en) * 2002-12-10 2006-11-10 Pfizer Morpholine derivatives for use as dopamine agonists in the treatment of i.a sexual dysfunction.
AT501928B1 (de) 2004-10-27 2010-09-15 Iep Gmbh Verfahren zur herstellung von chiralen alkoholen
ATE518946T1 (de) 2007-02-08 2011-08-15 Codexis Inc Ketoreduktasen und anwendungen davon
HUE055413T2 (hu) 2009-06-22 2021-11-29 Codexis Inc Ketoreduktáz-közvetített sztereoszelektív útvonal alfa-klóralkoholokhoz
US9132136B2 (en) 2010-08-02 2015-09-15 Hoffmann-La Roche Inc. Pharmaceutical combination
US8802673B2 (en) * 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives

Also Published As

Publication number Publication date
MX2016007140A (es) 2016-07-21
EP3080284B1 (en) 2017-10-18
EP3080284A1 (en) 2016-10-19
RU2677328C1 (ru) 2019-01-16
ES2653559T3 (es) 2018-02-07
CA2932003A1 (en) 2015-06-18
CN105793430B (zh) 2020-03-03
WO2015086495A1 (en) 2015-06-18
KR20160097291A (ko) 2016-08-17
JP6511448B2 (ja) 2019-05-15
US10337039B2 (en) 2019-07-02
US20160289718A1 (en) 2016-10-06
HK1223654A1 (zh) 2017-08-04
CN105793430A (zh) 2016-07-20
RU2016125459A (ru) 2018-01-23
JP2017500308A (ja) 2017-01-05

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