PL2981520T3 - Nowy sposób syntezy 1-(2-((2,4-dimetylofenylo)tio)fenylo)piperazyny - Google Patents
Nowy sposób syntezy 1-(2-((2,4-dimetylofenylo)tio)fenylo)piperazynyInfo
- Publication number
- PL2981520T3 PL2981520T3 PL14715016T PL14715016T PL2981520T3 PL 2981520 T3 PL2981520 T3 PL 2981520T3 PL 14715016 T PL14715016 T PL 14715016T PL 14715016 T PL14715016 T PL 14715016T PL 2981520 T3 PL2981520 T3 PL 2981520T3
- Authority
- PL
- Poland
- Prior art keywords
- dimethylphenyl
- thio
- piperazine
- phenyl
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
- C07C323/37—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13162296 | 2013-04-04 | ||
| EP14715016.3A EP2981520B1 (en) | 2013-04-04 | 2014-04-04 | New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine |
| PCT/EP2014/056769 WO2014161976A1 (en) | 2013-04-04 | 2014-04-04 | New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2981520T3 true PL2981520T3 (pl) | 2019-09-30 |
Family
ID=48040094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14715016T PL2981520T3 (pl) | 2013-04-04 | 2014-04-04 | Nowy sposób syntezy 1-(2-((2,4-dimetylofenylo)tio)fenylo)piperazyny |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9493409B2 (pl) |
| EP (2) | EP2981520B1 (pl) |
| CN (1) | CN105283442B (pl) |
| ES (1) | ES2724246T3 (pl) |
| PL (1) | PL2981520T3 (pl) |
| SI (1) | SI2981520T1 (pl) |
| TR (1) | TR201906691T4 (pl) |
| WO (1) | WO2014161976A1 (pl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2981520T1 (sl) | 2013-04-04 | 2019-07-31 | Lek Pharmaceuticals D.D. | Novi proces za sintezo 1-(2-((2,4-dimetilfenil)tio)fenil)piperazina |
| CZ2014471A3 (cs) * | 2014-07-08 | 2016-01-20 | Zentiva, K.S. | Způsob přípravy vortioxetinu |
| WO2016079751A2 (en) * | 2014-11-17 | 2016-05-26 | Megafine Pharma (P) Ltd. | A process for preparation of vortioxetine and polymorphs thereof |
| ES2634496T3 (es) | 2014-11-21 | 2017-09-28 | Dipharma Francis S.R.L. | Proceso para la preparación de un antidepresivo y los intermedios del mismo |
| CN104356092B (zh) * | 2014-11-27 | 2017-03-22 | 合肥创新医药技术有限公司 | 沃替西汀的制备方法 |
| WO2016125191A2 (en) * | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| AU2016224930A1 (en) | 2015-02-25 | 2017-09-07 | Lupin Limited | Process for the preparation of Vortioxetine |
| EP3274330A1 (en) | 2015-03-26 | 2018-01-31 | Cipla Limited | Method for making serotonin reuptake inhibitors |
| CN104829557B (zh) * | 2015-04-23 | 2017-06-27 | 山东百诺医药股份有限公司 | 一种新化合物1‑[2‑（2,4‑二甲基苯基硫基）苯基]‑2‑氧哌嗪及其制备方法和在沃替西汀合成中的应用 |
| CN105153066B (zh) * | 2015-09-07 | 2018-01-09 | 浙江大学 | 盐酸沃替西汀的结晶型物及其制备方法 |
| CN105541759A (zh) * | 2016-01-07 | 2016-05-04 | 美吉斯制药（厦门）有限公司 | 一种制备沃替西汀的新方法 |
| WO2018065348A1 (en) | 2016-10-05 | 2018-04-12 | Hexal Ag | Novel enteric-coated tablet comprising vortioxetine |
| US10428033B2 (en) | 2017-02-15 | 2019-10-01 | Piramal Enterprises Limited | Process for the preparation of vortioxetine and salts thereof |
| GB2564887A (en) * | 2017-07-26 | 2019-01-30 | Azad Pharmaceutical Ingredients Ag | New route of synthesis to vortioxetine salts |
| CN107266390A (zh) * | 2017-08-07 | 2017-10-20 | 山东鲁宁药业有限公司 | 一种氢溴酸沃替西汀的合成新工艺 |
| PL3810582T3 (pl) | 2018-06-20 | 2024-05-13 | Vio Ag Pharmaceuticals S.A. | Jednonaczyniowy sposób organopseudokatalitycznej aktywacji c-h do wytwarzania wortioksetyny i związku pośredniego wortioksetyny |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN111320592A (zh) * | 2018-12-17 | 2020-06-23 | 天津理工大学 | 一种1-[2-(2,4-二甲基苯硫基)-苯基]哌嗪的制备方法 |
| CN113214210B (zh) * | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的制备方法 |
| CN113185485B (zh) | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的半合成方法 |
| US20240101524A1 (en) * | 2021-05-31 | 2024-03-28 | R L Fine Chem Private Limited | A method for preparation of 1-(2-((2,4-dimethylphenyl)thio)phenyl) piperazine and its salts |
| CN115181077B (zh) * | 2022-07-27 | 2024-03-29 | 安徽峆一药业股份有限公司 | 一种低杂质含量的沃替西汀合成方法 |
| CN115894314A (zh) * | 2022-12-20 | 2023-04-04 | 苏州敬业医药化工有限公司 | 一种2'-氨基-(2,4-二甲基)二苯硫醚的制备工艺 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200201683T2 (tr) * | 1999-12-30 | 2002-12-23 | H. Lundbeck A/S | İkameli fenil-piperazin türevleri, bunların hazırlanması ve kullanımları |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| EP2439201B1 (en) | 2006-06-16 | 2013-08-07 | H. Lundbeck A/S | Compounds with combined sert, 5-ht3 and 5-ht1a activity |
| SI2981520T1 (sl) | 2013-04-04 | 2019-07-31 | Lek Pharmaceuticals D.D. | Novi proces za sintezo 1-(2-((2,4-dimetilfenil)tio)fenil)piperazina |
-
2014
- 2014-04-04 SI SI201431188T patent/SI2981520T1/sl unknown
- 2014-04-04 PL PL14715016T patent/PL2981520T3/pl unknown
- 2014-04-04 CN CN201480029642.2A patent/CN105283442B/zh not_active Expired - Fee Related
- 2014-04-04 US US14/781,716 patent/US9493409B2/en not_active Expired - Fee Related
- 2014-04-04 ES ES14715016T patent/ES2724246T3/es active Active
- 2014-04-04 EP EP14715016.3A patent/EP2981520B1/en not_active Revoked
- 2014-04-04 EP EP19153299.3A patent/EP3495347A1/en not_active Withdrawn
- 2014-04-04 TR TR2019/06691T patent/TR201906691T4/tr unknown
- 2014-04-04 WO PCT/EP2014/056769 patent/WO2014161976A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN105283442B (zh) | 2018-04-13 |
| EP3495347A1 (en) | 2019-06-12 |
| ES2724246T3 (es) | 2019-09-09 |
| CN105283442A (zh) | 2016-01-27 |
| EP2981520B1 (en) | 2019-03-06 |
| EP2981520A1 (en) | 2016-02-10 |
| SI2981520T1 (sl) | 2019-07-31 |
| TR201906691T4 (tr) | 2019-05-21 |
| WO2014161976A1 (en) | 2014-10-09 |
| US20160060215A1 (en) | 2016-03-03 |
| US9493409B2 (en) | 2016-11-15 |
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