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CL2015002309A1 - Proceso de fabricacion de vortioxetina. - Google Patents

Proceso de fabricacion de vortioxetina.

Info

Publication number
CL2015002309A1
CL2015002309A1 CL2015002309A CL2015002309A CL2015002309A1 CL 2015002309 A1 CL2015002309 A1 CL 2015002309A1 CL 2015002309 A CL2015002309 A CL 2015002309A CL 2015002309 A CL2015002309 A CL 2015002309A CL 2015002309 A1 CL2015002309 A1 CL 2015002309A1
Authority
CL
Chile
Prior art keywords
vortioxetine
manufacturing process
salts
vortioxetina
piperazine
Prior art date
Application number
CL2015002309A
Other languages
English (en)
Inventor
Kim Lasse Christensen
Thomas Ruhland
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of CL2015002309A1 publication Critical patent/CL2015002309A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCESO PARA LA PRODUCCION DE 1-[2-(2,4-DIMETILFENILSULFANIL)FENIL]PIPERAZINA (VORTIOXETINA) Y SALES DE ESTA; Y VORTIOXETINA Y SALES DE ESTA.
CL2015002309A 2013-02-22 2015-08-18 Proceso de fabricacion de vortioxetina. CL2015002309A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201300104 2013-02-22

Publications (1)

Publication Number Publication Date
CL2015002309A1 true CL2015002309A1 (es) 2016-03-04

Family

ID=59215387

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002309A CL2015002309A1 (es) 2013-02-22 2015-08-18 Proceso de fabricacion de vortioxetina.

Country Status (37)

Country Link
US (1) US9353073B2 (es)
EP (1) EP2958903B1 (es)
JP (1) JP6464098B2 (es)
KR (1) KR102230628B1 (es)
CN (1) CN104995181B (es)
AP (1) AP2015008640A0 (es)
AU (1) AU2014220735B2 (es)
BR (1) BR112015019268B1 (es)
CA (1) CA2901821A1 (es)
CL (1) CL2015002309A1 (es)
CR (1) CR20150423A (es)
CY (1) CY1118883T1 (es)
DK (1) DK2958903T3 (es)
DO (1) DOP2015000187A (es)
EA (1) EA027756B1 (es)
ES (1) ES2625380T3 (es)
GE (1) GEP201706749B (es)
HR (1) HRP20170607T1 (es)
IL (1) IL240501B (es)
LT (1) LT2958903T (es)
MA (1) MA38338B1 (es)
ME (1) ME02671B (es)
MX (1) MX362355B (es)
MY (1) MY172337A (es)
PE (1) PE20151589A1 (es)
PH (1) PH12015501807B1 (es)
PL (1) PL2958903T3 (es)
PT (1) PT2958903T (es)
RS (1) RS55932B1 (es)
RU (1) RU2652265C2 (es)
SG (1) SG11201506651SA (es)
SI (1) SI2958903T1 (es)
SM (1) SMT201700238T1 (es)
TN (1) TN2015000335A1 (es)
UA (1) UA116236C2 (es)
WO (1) WO2014128207A1 (es)
ZA (1) ZA201506050B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354133B (es) 2010-08-18 2018-02-14 Samumed Llc Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.
MY176004A (en) 2013-02-22 2020-07-21 Samumed Llc Gamma-diketones as wnt/beta-catenin signaling pathway activators
EP3206686B1 (en) 2014-08-20 2019-10-09 Samumed, LLC Gamma-diketones for treatment and prevention of aging skin and wrinkles
WO2016125191A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
EP3274330A1 (en) 2015-03-26 2018-01-31 Cipla Limited Method for making serotonin reuptake inhibitors
CN106279065A (zh) * 2015-05-12 2017-01-04 北京深蓝海生物医药科技有限公司 一种氢溴酸沃替西汀的精制转晶方法
JO3456B1 (ar) 2015-05-13 2020-07-05 H Lundbeck As فيروتيوكسيتين بيروجلوتامات
ES2819831T3 (es) * 2016-02-08 2021-04-19 H Lundbeck As Síntesis de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]piperazina
US9820984B1 (en) 2016-07-01 2017-11-21 H. Lundbeck A/S Dosing regimens for fast onset of antidepressant effect
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
CN109912538B (zh) * 2019-01-22 2021-03-12 安徽赛乐普制药有限公司 一种抗抑郁药沃替西汀的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
IL161966A0 (en) * 2001-12-20 2005-11-20 Lundbeck & Co As H Aryloxyphenyl and arylsulfanylphenyl
US8722684B2 (en) * 2006-06-16 2014-05-13 H. Lundbeck A/S 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Also Published As

Publication number Publication date
US9353073B2 (en) 2016-05-31
RU2652265C2 (ru) 2018-04-27
PL2958903T3 (pl) 2017-08-31
SI2958903T1 (sl) 2017-09-29
UA116236C2 (uk) 2018-02-26
MA38338A1 (fr) 2016-09-30
TN2015000335A1 (en) 2017-01-03
CA2901821A1 (en) 2014-08-28
CY1118883T1 (el) 2018-01-10
PE20151589A1 (es) 2015-12-03
HK1216098A1 (en) 2016-10-14
PH12015501807B1 (en) 2019-05-31
SG11201506651SA (en) 2015-09-29
JP6464098B2 (ja) 2019-02-06
MX362355B (es) 2019-01-14
EA027756B1 (ru) 2017-08-31
AU2014220735A1 (en) 2015-08-20
CN104995181A (zh) 2015-10-21
WO2014128207A1 (en) 2014-08-28
RS55932B1 (sr) 2017-09-29
PT2958903T (pt) 2017-05-26
MX2015010656A (es) 2015-12-17
HRP20170607T1 (hr) 2017-06-30
IL240501B (en) 2018-08-30
AP2015008640A0 (en) 2015-08-31
MY172337A (en) 2019-11-21
LT2958903T (lt) 2017-08-25
EA201591349A1 (ru) 2015-12-30
ES2625380T3 (es) 2017-07-19
EP2958903B1 (en) 2017-04-12
RU2015134407A (ru) 2017-03-28
AU2014220735B2 (en) 2017-06-22
GEP201706749B (en) 2017-10-10
ZA201506050B (en) 2017-08-30
BR112015019268B1 (pt) 2023-01-10
BR112015019268A2 (pt) 2020-01-28
CN104995181B (zh) 2017-03-08
DK2958903T3 (en) 2017-05-15
PH12015501807A1 (en) 2015-11-09
IL240501A0 (en) 2015-09-24
DOP2015000187A (es) 2015-11-30
US20160009670A1 (en) 2016-01-14
CR20150423A (es) 2015-10-20
KR20150118146A (ko) 2015-10-21
ME02671B (me) 2017-06-20
JP2016509042A (ja) 2016-03-24
MA38338B1 (fr) 2018-10-31
EP2958903A1 (en) 2015-12-30
KR102230628B1 (ko) 2021-03-22
SMT201700238T1 (it) 2017-07-18

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