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PL2948184T3 - ADC duokarmycyny wykazujące poprawioną aktywność przeciwnowotworową in vivo - Google Patents

ADC duokarmycyny wykazujące poprawioną aktywność przeciwnowotworową in vivo

Info

Publication number
PL2948184T3
PL2948184T3 PL15701106.5T PL15701106T PL2948184T3 PL 2948184 T3 PL2948184 T3 PL 2948184T3 PL 15701106 T PL15701106 T PL 15701106T PL 2948184 T3 PL2948184 T3 PL 2948184T3
Authority
PL
Poland
Prior art keywords
antitumor activity
vivo antitumor
showing improved
duocarmycin
duocarmycin adcs
Prior art date
Application number
PL15701106.5T
Other languages
English (en)
Inventor
Willem Dokter
Peter Johannes Goedings
Gijsbertus Franciscus Maria Verheijden
Patrick Henry Beusker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2948184T3 publication Critical patent/PL2948184T3/pl

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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