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MX374126B - Conjugados de anticuerpo-fármaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada. - Google Patents

Conjugados de anticuerpo-fármaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada.

Info

Publication number
MX374126B
MX374126B MX2019011494A MX2019011494A MX374126B MX 374126 B MX374126 B MX 374126B MX 2019011494 A MX2019011494 A MX 2019011494A MX 2019011494 A MX2019011494 A MX 2019011494A MX 374126 B MX374126 B MX 374126B
Authority
MX
Mexico
Prior art keywords
cancer
duocarmycin
drug conjugates
antibody
treatment
Prior art date
Application number
MX2019011494A
Other languages
English (en)
Other versions
MX2019011494A (es
Inventor
Gijsbertus Franciscus Maria Verheijden
Patrick Henry Beusker
Peter Johannes Goedings
Willem Dokter
Original Assignee
Byondis Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byondis Bv filed Critical Byondis Bv
Publication of MX2019011494A publication Critical patent/MX2019011494A/es
Publication of MX374126B publication Critical patent/MX374126B/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a conjugados de anticuerpo-farmaco (ADC) que contienen duocarmicina para su uso en el tratamiento de tumores solidos humanos y malignidades hematologicas que expresan a HER2, en particular cancer de mama, cancer gastrico, cancer de vejiga, cancer de ovario, cancer de pulmon, cancer de prostata, cancer pancreatico, cáncer colorrectal, cancer escamocelular de cabeza y cuello u osteosarcoma y leucemia linfoblastica aguda; en particular, la presente invencion se refiere a ADC que contienen duocarmicina para su uso en el tratamiento de tumores solidos humanos con estado de tejido HER2 IHC 2+ o 1+ y negativo para FISH de HER2; en forma ventajosa, la presente invencion se refiere a ADC que contienen duocarmicina para su uso en el tratamiento de cancer de mama triplemente negativo (TNBC).
MX2019011494A 2014-01-10 2015-01-09 Conjugados de anticuerpo-fármaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada. MX374126B (es)

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ZA201604535B (en) 2018-11-28
MX2016009070A (es) 2016-09-09
JP2017503858A (ja) 2017-02-02
DK2948184T3 (en) 2016-06-27
EP2948184B1 (en) 2016-03-23
PL2948184T3 (pl) 2016-11-30
US20170014525A1 (en) 2017-01-19
NO3069735T3 (es) 2018-08-11
CN105899236A (zh) 2016-08-24
EP3069735B1 (en) 2018-03-14
US20180140711A1 (en) 2018-05-24
HUE029255T2 (en) 2017-02-28
RU2689779C2 (ru) 2019-05-29
ES2575508T3 (es) 2016-06-29
BR112016015848A2 (pt) 2017-08-08
MY207293A (en) 2025-02-14
AU2015205509B2 (en) 2019-08-15
KR102344354B1 (ko) 2021-12-28
MX368396B (es) 2019-10-01
US20190314513A1 (en) 2019-10-17
KR20160106693A (ko) 2016-09-12
CY1117687T1 (el) 2017-05-17
KR102323302B1 (ko) 2021-11-09
CN105899236B (zh) 2019-07-26
US10603387B2 (en) 2020-03-31
SG11201605602XA (en) 2016-08-30
RU2016132759A (ru) 2018-02-16
EP2948184A2 (en) 2015-12-02
KR20210130826A (ko) 2021-11-01
PT2948184T (pt) 2016-07-08
ES2668984T3 (es) 2018-05-23
RU2019114963A (ru) 2019-07-17
LT3069735T (lt) 2018-06-11
US11382982B2 (en) 2022-07-12
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RU2019114963A3 (es) 2021-09-28
CA2935433A1 (en) 2015-07-16
PL3069735T3 (pl) 2018-08-31
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AU2019264575A1 (en) 2019-12-05
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US20160008486A1 (en) 2016-01-14
EP3069735A1 (en) 2016-09-21
RU2769700C2 (ru) 2022-04-05
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JP6430603B2 (ja) 2018-11-28
JP6342517B2 (ja) 2018-06-13
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