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PL2421829T3 - 2,5-dipodstawione arylosulfonamidy jako antagoniści CCR3 - Google Patents

2,5-dipodstawione arylosulfonamidy jako antagoniści CCR3

Info

Publication number
PL2421829T3
PL2421829T3 PL10714821T PL10714821T PL2421829T3 PL 2421829 T3 PL2421829 T3 PL 2421829T3 PL 10714821 T PL10714821 T PL 10714821T PL 10714821 T PL10714821 T PL 10714821T PL 2421829 T3 PL2421829 T3 PL 2421829T3
Authority
PL
Poland
Prior art keywords
ccr3 antagonists
disubstituted arylsulfonamide
arylsulfonamide ccr3
disubstituted
antagonists
Prior art date
Application number
PL10714821T
Other languages
English (en)
Inventor
Tai Wei Ly
Marie Chantal Siu-Ying Tran
Erik Dean Raaum
Original Assignee
Axikin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42344061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2421829(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Axikin Pharmaceuticals Inc filed Critical Axikin Pharmaceuticals Inc
Publication of PL2421829T3 publication Critical patent/PL2421829T3/pl

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
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    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
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    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
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  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
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PL10714821T 2009-04-22 2010-04-21 2,5-dipodstawione arylosulfonamidy jako antagoniści CCR3 PL2421829T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17177509P 2009-04-22 2009-04-22
PCT/US2010/031828 WO2010123956A2 (en) 2009-04-22 2010-04-21 2,5-disubstituted arylsulfonamide ccr3 antagonists
EP10714821.5A EP2421829B1 (en) 2009-04-22 2010-04-21 2,5-disubstituted arylsulfonamide ccr3 antagonists

Publications (1)

Publication Number Publication Date
PL2421829T3 true PL2421829T3 (pl) 2016-03-31

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ID=42344061

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10714821T PL2421829T3 (pl) 2009-04-22 2010-04-21 2,5-dipodstawione arylosulfonamidy jako antagoniści CCR3

Country Status (27)

Country Link
US (2) US8399456B2 (pl)
EP (2) EP2421829B1 (pl)
JP (1) JP2012524789A (pl)
KR (1) KR20120070629A (pl)
CN (2) CN104177313A (pl)
AR (1) AR078120A1 (pl)
AU (1) AU2010239337B2 (pl)
CA (1) CA2758985A1 (pl)
CL (1) CL2011002618A1 (pl)
CO (1) CO6470794A2 (pl)
CR (1) CR20110534A (pl)
DK (1) DK2421829T3 (pl)
EC (1) ECSP11011472A (pl)
ES (1) ES2556235T3 (pl)
HU (1) HUE028223T2 (pl)
IL (1) IL215727A0 (pl)
MX (1) MX2011011139A (pl)
NI (1) NI201100183A (pl)
NZ (2) NZ620048A (pl)
PE (2) PE20120809A1 (pl)
PL (1) PL2421829T3 (pl)
PT (1) PT2421829E (pl)
RU (1) RU2532515C2 (pl)
SG (1) SG175748A1 (pl)
TW (1) TW201041583A (pl)
UA (1) UA108073C2 (pl)
WO (1) WO2010123956A2 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120810A1 (es) * 2009-04-22 2012-07-08 Axikin Pharmaceuticals Inc Compuestos derivados de 5-ciano-2-(feniltio)bencensulfonamida como antagonistas de ccr3
EP2542542B1 (en) * 2010-03-02 2015-04-22 Axikin Pharmaceuticals, Inc. Isotopically enriched arylsulfonamide ccr3 antagonists
CN102892754A (zh) * 2010-03-17 2013-01-23 埃克希金医药品有限公司 芳基磺酰胺ccr3拮抗剂
CN103298786B (zh) * 2010-10-11 2016-01-20 埃克希金医药品有限公司 芳基磺酰胺盐ccr3拮抗剂
US10213421B2 (en) * 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
CN104781240A (zh) * 2012-09-07 2015-07-15 埃克希金医药品有限公司 同位素富集的芳基磺酰胺ccr3拮抗剂
FR3022142B1 (fr) * 2014-06-16 2019-07-12 Universite Paul Sabatier - Toulouse Iii Inhibition de la chimiokine ccl7 ou de son recepteur ccr3 pour le traitement et le diagnostic du cancer de la prostate

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