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PE20150926A1 - Antagonistas ccr3 arilsulfonamida 2,5-disustituidos - Google Patents

Antagonistas ccr3 arilsulfonamida 2,5-disustituidos

Info

Publication number
PE20150926A1
PE20150926A1 PE2015000561A PE2015000561A PE20150926A1 PE 20150926 A1 PE20150926 A1 PE 20150926A1 PE 2015000561 A PE2015000561 A PE 2015000561A PE 2015000561 A PE2015000561 A PE 2015000561A PE 20150926 A1 PE20150926 A1 PE 20150926A1
Authority
PE
Peru
Prior art keywords
ccr3
disustituted
arylsulfonamide
antagonists
ylsulfonyl
Prior art date
Application number
PE2015000561A
Other languages
English (en)
Inventor
Tai Wei Ly
Marie Chantal Siu-Ying Tran
Erick Dean Baaum
Original Assignee
Axikin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42344061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20150926(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Axikin Pharmaceuticals Inc filed Critical Axikin Pharmaceuticals Inc
Publication of PE20150926A1 publication Critical patent/PE20150926A1/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

La invencion proporciona las arilsulfonamidas 2,5-disustituidas de formula (I); en donde X es O o S; Y es -N(R1a)-, -C(R1a)(R1d)- o -C(R1a)(NR1bR1c)-; los cuales son utiles para modular la actividad CCR3 y composiciones farmaceuticas de las mismas. Tambien proporcionados en la presente estan los metodos de su uso para tratar, prevenir o mejorar uno o mas sintomas de un trastorno enfermedad o padecimiento mediados por CCR3. Los compuestos preferidos son: 4-(2,5-dimetilfenoxi)-3-(piperazin-1-ilsulfonil)benzonitrilo; 4-(2,5-diclorofenoxi)-3-(4-metilpiperidin-1-ilsulfonil) benzonitrilo; entre otros
PE2015000561A 2009-04-22 2010-04-21 Antagonistas ccr3 arilsulfonamida 2,5-disustituidos PE20150926A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17177509P 2009-04-22 2009-04-22

Publications (1)

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PE20150926A1 true PE20150926A1 (es) 2015-06-13

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PE2015000561A PE20150926A1 (es) 2009-04-22 2010-04-21 Antagonistas ccr3 arilsulfonamida 2,5-disustituidos
PE2011001842A PE20120809A1 (es) 2009-04-22 2010-04-21 Antagonistas ccr3 arilsulfonamida 2,5-disustituidos

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US (2) US8399456B2 (es)
EP (2) EP2727908A3 (es)
JP (1) JP2012524789A (es)
KR (1) KR20120070629A (es)
CN (2) CN104177313A (es)
AR (1) AR078120A1 (es)
AU (1) AU2010239337B2 (es)
CA (1) CA2758985A1 (es)
CL (1) CL2011002618A1 (es)
CO (1) CO6470794A2 (es)
CR (1) CR20110534A (es)
DK (1) DK2421829T3 (es)
EC (1) ECSP11011472A (es)
ES (1) ES2556235T3 (es)
HU (1) HUE028223T2 (es)
IL (1) IL215727A0 (es)
MX (1) MX2011011139A (es)
NI (1) NI201100183A (es)
NZ (2) NZ620048A (es)
PE (2) PE20150926A1 (es)
PL (1) PL2421829T3 (es)
PT (1) PT2421829E (es)
RU (1) RU2532515C2 (es)
SG (1) SG175748A1 (es)
TW (1) TW201041583A (es)
UA (1) UA108073C2 (es)
WO (1) WO2010123956A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20150925A1 (es) * 2009-04-22 2015-06-14 Axikin Pharmaceuticals Inc Antagonistas de ccr3 de arilsulfonamida 2,5-disustituida
EP2542542B1 (en) * 2010-03-02 2015-04-22 Axikin Pharmaceuticals, Inc. Isotopically enriched arylsulfonamide ccr3 antagonists
MX336559B (es) * 2010-03-17 2016-01-25 Axikin Pharmaceuticals Inc Antagonistas de ccr3 de arilsulfonamida.
US20120088769A1 (en) * 2010-10-11 2012-04-12 Axikin Pharmaceuticals, Inc. Salts of arylsulfonamide ccr3 antagonists
US10213421B2 (en) * 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
HK1212351A1 (en) 2012-09-07 2016-06-10 埃克希金医药品有限公司 Isotopically enriched arylsulfonamide ccr3 antagonists
FR3022142B1 (fr) 2014-06-16 2019-07-12 Universite Paul Sabatier - Toulouse Iii Inhibition de la chimiokine ccl7 ou de son recepteur ccr3 pour le traitement et le diagnostic du cancer de la prostate

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