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PL2451438T3 - Kompozycja farmaceutyczna inhibitora proteazy wirusowego zapalenia wątroby typu C - Google Patents

Kompozycja farmaceutyczna inhibitora proteazy wirusowego zapalenia wątroby typu C

Info

Publication number
PL2451438T3
PL2451438T3 PL10731685T PL10731685T PL2451438T3 PL 2451438 T3 PL2451438 T3 PL 2451438T3 PL 10731685 T PL10731685 T PL 10731685T PL 10731685 T PL10731685 T PL 10731685T PL 2451438 T3 PL2451438 T3 PL 2451438T3
Authority
PL
Poland
Prior art keywords
hepatitis
pharmaceutical composition
protease inhibitor
viral protease
viral
Prior art date
Application number
PL10731685T
Other languages
English (en)
Inventor
Feng-Jing Chen
Robert J Schwabe
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PL2451438T3 publication Critical patent/PL2451438T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL10731685T 2009-07-07 2010-07-01 Kompozycja farmaceutyczna inhibitora proteazy wirusowego zapalenia wątroby typu C PL2451438T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22350709P 2009-07-07 2009-07-07
PCT/US2010/040734 WO2011005646A2 (en) 2009-07-07 2010-07-01 Pharmaceutical composition for a hepatitis c viral protease inhibitor
EP10731685.3A EP2451438B8 (en) 2009-07-07 2010-07-01 Pharmaceutical composition for a hepatitis c viral protease inhibitor

Publications (1)

Publication Number Publication Date
PL2451438T3 true PL2451438T3 (pl) 2014-07-31

Family

ID=43245003

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10731685T PL2451438T3 (pl) 2009-07-07 2010-07-01 Kompozycja farmaceutyczna inhibitora proteazy wirusowego zapalenia wątroby typu C

Country Status (35)

Country Link
US (1) US9034831B2 (pl)
EP (1) EP2451438B8 (pl)
JP (1) JP5607736B2 (pl)
KR (1) KR101685941B1 (pl)
CN (1) CN102470103B (pl)
AP (1) AP2011005979A0 (pl)
AR (1) AR077393A1 (pl)
AU (1) AU2010270783B2 (pl)
BR (1) BR112012000287B8 (pl)
CA (1) CA2767692C (pl)
CL (1) CL2012000054A1 (pl)
CO (1) CO6480980A2 (pl)
DK (1) DK2451438T3 (pl)
EA (1) EA023433B1 (pl)
EC (1) ECSP12011624A (pl)
ES (1) ES2464367T3 (pl)
GE (1) GEP20146016B (pl)
HR (1) HRP20140445T1 (pl)
IL (1) IL216098A (pl)
MA (1) MA33491B1 (pl)
ME (1) ME01718B (pl)
MX (1) MX2011013824A (pl)
MY (1) MY154683A (pl)
NZ (1) NZ596928A (pl)
PE (1) PE20120322A1 (pl)
PL (1) PL2451438T3 (pl)
PT (1) PT2451438E (pl)
RS (1) RS53209B (pl)
SG (1) SG177569A1 (pl)
SI (1) SI2451438T1 (pl)
TN (1) TN2012000009A1 (pl)
TW (1) TWI490216B (pl)
UA (1) UA104195C2 (pl)
UY (1) UY32760A (pl)
WO (1) WO2011005646A2 (pl)

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MA33491B1 (fr) 2009-07-07 2012-08-01 Boehringer Ingelheim Int Composition pharmaceutique pour un inhibiteur de protease virale de l'hépatite c
NZ598465A (en) 2009-10-30 2013-10-25 Boehringer Ingelheim Int Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
BR112013007423A2 (pt) 2010-09-30 2016-07-12 Boehringer Ingelheim Int terapia combinada no que diz respeito ao tratamento da infecção por hcv
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PT107894A (pt) 2011-10-21 2014-10-31 Abbvie Inc Métodos para o tratamento de hcv compreendendo pelo menos dois agentes antivirais de actuação directa, ribavirina, mas não interferão.
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
AU2013208024A1 (en) 2012-01-12 2014-07-10 Boehringer Ingelheim International Gmbh Stabilized pharmaceutical formulations of a potent HCV inhibitor
WO2013137869A1 (en) 2012-03-14 2013-09-19 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection in an hcv-hiv coinfected patient population
WO2013147750A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
WO2013147749A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient subgenotype populations
JP2015512900A (ja) 2012-03-28 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 特別な患者の遺伝子亜型分集団のhcv感染症を治療するための併用療法
MX360452B (es) 2012-10-19 2018-11-01 Bristol Myers Squibb Co Inhibidores del virus de la hepatitis c.
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914613B1 (en) 2012-11-02 2017-11-22 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914598B1 (en) 2012-11-02 2017-10-18 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP6342922B2 (ja) 2013-03-07 2018-06-13 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company C型肝炎ウイルス阻害剤
WO2014138374A1 (en) 2013-03-08 2014-09-12 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
CA2903831A1 (en) * 2013-03-15 2014-09-25 Boehringer Ingelheim International Gmbh Solid oral dosage formulation of hcv inhibitor in the amorphous state
EP2899207A1 (en) 2014-01-28 2015-07-29 Amikana.Biologics New method for testing HCV protease inhibition
US11192914B2 (en) 2016-04-28 2021-12-07 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP3959240A1 (en) 2019-04-24 2022-03-02 Sanofi Biotechnology Methods of diagnosis and treatment of rheumatoid arthritis
AU2020288561A1 (en) 2019-06-04 2021-12-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating pain in subjects with rheumatoid arthritis
CN114641485A (zh) 2020-04-05 2022-06-17 辉瑞大药厂 用于治疗covid-19的化合物和方法

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Also Published As

Publication number Publication date
UY32760A (es) 2011-02-28
GEP20146016B (en) 2014-01-27
CN102470103B (zh) 2016-09-07
KR20120059481A (ko) 2012-06-08
MX2011013824A (es) 2012-01-30
WO2011005646A2 (en) 2011-01-13
JP2012532192A (ja) 2012-12-13
NZ596928A (en) 2013-05-31
AU2010270783B2 (en) 2013-06-27
MY154683A (en) 2015-07-15
EP2451438A2 (en) 2012-05-16
KR101685941B1 (ko) 2016-12-13
AP2011005979A0 (en) 2011-12-31
IL216098A0 (en) 2012-01-31
CN102470103A (zh) 2012-05-23
EA023433B1 (ru) 2016-06-30
TW201114766A (en) 2011-05-01
PT2451438E (pt) 2014-03-26
IL216098A (en) 2016-02-29
UA104195C2 (ru) 2014-01-10
AR077393A1 (es) 2011-08-24
ECSP12011624A (es) 2012-02-29
ES2464367T3 (es) 2014-06-02
EA201200096A1 (ru) 2012-08-30
BR112012000287B1 (pt) 2020-12-08
CL2012000054A1 (es) 2012-10-12
PE20120322A1 (es) 2012-04-14
TWI490216B (zh) 2015-07-01
US20110160149A1 (en) 2011-06-30
EP2451438B8 (en) 2014-04-09
AU2010270783A1 (en) 2011-12-15
BR112012000287A2 (pt) 2016-02-23
BR112012000287B8 (pt) 2021-05-25
EP2451438B1 (en) 2014-02-26
HRP20140445T1 (hr) 2014-06-20
CA2767692C (en) 2017-03-07
SI2451438T1 (sl) 2014-04-30
TN2012000009A1 (en) 2013-09-19
US9034831B2 (en) 2015-05-19
WO2011005646A3 (en) 2011-12-22
CO6480980A2 (es) 2012-07-16
CA2767692A1 (en) 2011-01-13
SG177569A1 (en) 2012-03-29
RS53209B (sr) 2014-06-30
MA33491B1 (fr) 2012-08-01
JP5607736B2 (ja) 2014-10-15
DK2451438T3 (da) 2014-03-10
ME01718B (me) 2014-09-20

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