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PL2445915T3 - Związki 3-podstawionego-8-podstawionego-3H imidazo[5,1-d][1,2,3,5 tetrazyn]-4-onu i ich zastosowanie - Google Patents

Związki 3-podstawionego-8-podstawionego-3H imidazo[5,1-d][1,2,3,5 tetrazyn]-4-onu i ich zastosowanie

Info

Publication number
PL2445915T3
PL2445915T3 PL10727119.9T PL10727119T PL2445915T3 PL 2445915 T3 PL2445915 T3 PL 2445915T3 PL 10727119 T PL10727119 T PL 10727119T PL 2445915 T3 PL2445915 T3 PL 2445915T3
Authority
PL
Poland
Prior art keywords
substituted
tetrazin
imidazo
compounds
Prior art date
Application number
PL10727119.9T
Other languages
English (en)
Inventor
Marc Geoffery Hummersone
Malcolm Francis Graham Stevens
David Cousin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2445915T3 publication Critical patent/PL2445915T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL10727119.9T 2009-06-23 2010-06-23 Związki 3-podstawionego-8-podstawionego-3H imidazo[5,1-d][1,2,3,5 tetrazyn]-4-onu i ich zastosowanie PL2445915T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21957509P 2009-06-23 2009-06-23

Publications (1)

Publication Number Publication Date
PL2445915T3 true PL2445915T3 (pl) 2016-10-31

Family

ID=42563083

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10727119.9T PL2445915T3 (pl) 2009-06-23 2010-06-23 Związki 3-podstawionego-8-podstawionego-3H imidazo[5,1-d][1,2,3,5 tetrazyn]-4-onu i ich zastosowanie

Country Status (12)

Country Link
US (1) US9024018B2 (pl)
EP (1) EP2445915B1 (pl)
JP (1) JP2012530775A (pl)
CN (1) CN102803264A (pl)
AU (1) AU2010264339A1 (pl)
BR (1) BRPI1011822A2 (pl)
CA (1) CA2763766A1 (pl)
ES (1) ES2583006T3 (pl)
IL (1) IL216794A0 (pl)
PL (1) PL2445915T3 (pl)
WO (1) WO2010149968A1 (pl)
ZA (1) ZA201108849B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
BRPI1011822A2 (pt) 2009-06-23 2016-03-29 Pharminox Ltd "compostos de 3-substituída-8-substituída-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona e sua aplicação"
JP2013540363A (ja) 2010-10-22 2013-10-31 コモンウェルス サイエンティフィック アンドインダストリアル リサーチ オーガナイゼーション 有機エレクトロルミネッセント素子
WO2012085501A1 (en) * 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
US10562901B2 (en) 2016-09-22 2020-02-18 The University Of Massachusetts Temozolomide compounds, polymers prepared therefrom, and method of treating a disease
MX2021001567A (es) 2018-08-09 2021-04-29 Univ Illinois Compuestos de imidazotetrazina.
GB201907813D0 (en) 2019-05-31 2019-07-17 Univ Nottingham Therapeutic compounds
US20240400572A1 (en) * 2021-09-23 2024-12-05 Yale University Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
OA07174A (fr) 1981-08-24 1984-04-30 May & Baker Ltd Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent.
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4504475A (en) 1983-05-24 1985-03-12 Warner Lambert Company 3-(Haloethyl)-4-oxopyrazolo[5,1-D]-1,2,3,5-tetrazine-8-carboxamide compounds
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
GB9504361D0 (en) 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
CA2434308C (en) 2001-01-18 2010-09-21 Schering Corporation Synthesis of temozolomide and analogs
CN1742723A (zh) 2004-09-02 2006-03-08 天津倍方科技发展有限公司 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途
PE20091101A1 (es) * 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
GB0807103D0 (en) 2008-04-18 2008-05-21 Univ Bradford The Compounds
BRPI1011822A2 (pt) 2009-06-23 2016-03-29 Pharminox Ltd "compostos de 3-substituída-8-substituída-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona e sua aplicação"
WO2011107726A1 (en) 2010-03-01 2011-09-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines

Also Published As

Publication number Publication date
BRPI1011822A2 (pt) 2016-03-29
IL216794A0 (en) 2012-02-29
US20120083513A1 (en) 2012-04-05
HK1172321A1 (zh) 2013-04-19
CN102803264A (zh) 2012-11-28
AU2010264339A1 (en) 2011-12-22
EP2445915A1 (en) 2012-05-02
ZA201108849B (en) 2013-02-27
JP2012530775A (ja) 2012-12-06
US9024018B2 (en) 2015-05-05
ES2583006T3 (es) 2016-09-16
WO2010149968A1 (en) 2010-12-29
EP2445915B1 (en) 2016-04-20
CA2763766A1 (en) 2010-12-29

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