PL2364973T3 - Heterocykliczne inhibitory MEK i sposoby ich stosowania - Google Patents

Heterocykliczne inhibitory MEK i sposoby ich stosowania

Info

Publication number: PL2364973T3
Authority: PL; Poland
Prior art keywords: mek; methods; heterocyclic inhibitors; heterocyclic; inhibitors
Prior art date: 2005-05-18

Application number

PL11003826T

Other languages

English (en)

Inventor

Richard Anthony Storey

Rebecca Jane Booth

John David Pittam

Allison L Marlow

Eli Wallace

Jeongbeob Seo

Joseph P Lyssikatos

Hong Woon Yang

Jim Blake

John Leonard

Mark Richard Fielding

Original Assignee

Array Biopharma Inc

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-18

Filing date

2006-05-17

Publication date

2014-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37943261&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2364973(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-05-17 Application filed by Array Biopharma Inc, Astrazeneca Ab filed Critical Array Biopharma Inc

2014-12-31 Publication of PL2364973T3 publication Critical patent/PL2364973T3/pl

Classifications

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- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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PL11003826T 2005-05-18 2006-05-17 Heterocykliczne inhibitory MEK i sposoby ich stosowania PL2364973T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68233505P	2005-05-18	2005-05-18
EP06836069A EP1922307B1 (en)	2005-05-18	2006-05-17	Heterocyclic inhibitors of mek and methods of use thereof
EP11003826.2A EP2364973B1 (en)	2005-05-18	2006-05-17	Heterocyclic inhibitors of mek and methods of use thereof

Publications (1)

Publication Number	Publication Date
PL2364973T3 true PL2364973T3 (pl)	2014-12-31

Family

ID=37943261

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL06836069T PL1922307T3 (pl)	2005-05-18	2006-05-17	Heterocykliczne inhibitory MEK i sposoby ich stosowania
PL11003827T PL2361905T3 (pl)	2005-05-18	2006-05-17	Heterocykliczne inhibitory MEK i sposoby ich stosowania
PL11003826T PL2364973T3 (pl)	2005-05-18	2006-05-17	Heterocykliczne inhibitory MEK i sposoby ich stosowania

Family Applications Before (2)

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PL06836069T PL1922307T3 (pl)	2005-05-18	2006-05-17	Heterocykliczne inhibitory MEK i sposoby ich stosowania
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Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7517994B2 (en) *	2003-11-19	2009-04-14	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
WO2005051300A2 (en) *	2003-11-19	2005-06-09	Array Biopharma Inc.	Bicyclic inhibitors of mek and methods of use thereof
US7732616B2 (en) *	2003-11-19	2010-06-08	Array Biopharma Inc.	Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
EP1967516B1 (en)	2005-05-18	2009-11-04	Array Biopharma, Inc.	4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases
AU2007353385A1 (en)	2006-10-23	2008-11-20	Takeda Pharmaceutical Company Limited	MAPK/ERK kinase inhibitors
GB0625691D0 (en) *	2006-12-22	2007-01-31	Astrazeneca Ab	Combination product
WO2008120004A1 (en) *	2007-04-02	2008-10-09	Astrazeneca Ab	Combination of a mek- inhibitor and a b-raf inhibitor for the treatment of cancer
EP2134340A1 (en) *	2007-04-13	2009-12-23	AstraZeneca AB	Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii
WO2009050506A2 (en) *	2007-10-15	2009-04-23	Astrazeneca Ab	Combination 059
ES2456966T3 (es) *	2007-11-12	2014-04-24	Takeda Pharmaceutical Company Limited	Inhibidores de MAPK/ERK cinasa
EP2231281A2 (en) *	2007-12-12	2010-09-29	AstraZeneca AB	Combination comprising a mek inhibitor and an aurora kinase inhibitor
WO2010006225A1 (en)	2008-07-11	2010-01-14	Novartis Ag	Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway
JP5651125B2 (ja)	2008-12-10	2015-01-07	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	Ｍｅｋ阻害剤に対する耐性を付与するｍｅｋ突然変異
CN102448938A (zh) *	2009-03-27	2012-05-09	阿迪生物科学公司	作为mek抑制剂的二氢吡啶磺酰胺和二氢吡啶硫酰胺
CN102020851B (zh)	2009-09-16	2013-10-16	大连路明发光科技股份有限公司	一种光转换柔性高分子材料及其用途
EP2538943B1 (en)	2010-02-25	2016-03-30	Dana-Farber Cancer Institute, Inc.	Braf mutations conferring resistance to braf inhibitors
BR112012022801B8 (pt)	2010-03-09	2019-10-29	Dana Farber Cancer Inst Inc	método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer
TWI507381B (zh)	2010-09-08	2015-11-11	Sumitomo Chemical Co	製造嗒酮化合物的方法及其中間物
CN102020651B (zh)	2010-11-02	2012-07-18	北京赛林泰医药技术有限公司	6-芳基氨基吡啶酮甲酰胺mek抑制剂
KR102703637B1 (ko)	2010-12-22	2024-09-05	페이트 세러퓨틱스, 인코포레이티드	단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
FI20115234A0 (fi)	2011-03-08	2011-03-08	Biotie Therapies Corp	Uusia pyridatsinoni- ja pyridoniyhdisteitä
WO2012145503A1 (en)	2011-04-21	2012-10-26	Novartis Ag	Pharmaceutical combinations
CN102358730A (zh) *	2011-08-24	2012-02-22	济南赛文医药技术有限公司	一种小分子mek蛋白激酶抑制剂
AU2012333092B2 (en) *	2011-08-31	2016-04-21	Novartis Ag	Synergistic combinations of PI3K- and MEK-inhibitors
WO2013109142A1 (en)	2012-01-16	2013-07-25	Stichting Het Nederlands Kanker Instituut	Combined pdk and mapk/erk pathway inhibition in neoplasia
CN103204825B (zh)	2012-01-17	2015-03-04	上海科州药物研发有限公司	作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途
GB201201332D0 (en)	2012-01-26	2012-03-14	Imp Innovations Ltd	Method
WO2013169858A1 (en)	2012-05-08	2013-11-14	The Broad Institute, Inc.	Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
PL2925366T3 (pl)	2012-11-29	2018-08-31	Novartis Ag	Kombinacje farmaceutyczne
TW201441193A (zh)	2012-12-06	2014-11-01	Kyowa Hakko Kirin Co Ltd	吡啶酮化合物
PL2975030T3 (pl) *	2013-03-13	2021-01-11	Chugai Seiyaku Kabushiki Kaisha	Pochodna dihydropirydazyno-3,5-dionu
WO2014204263A1 (en)	2013-06-20	2014-12-24	The Asan Foundation	Substituted pyridinone compounds as mek inhibitors
US9629851B2 (en)	2013-09-20	2017-04-25	Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis	ROCK in combination with MAPK pathway
WO2015041534A1 (en)	2013-09-20	2015-03-26	Stichting Het Nederlands Kanker Instituut	P90rsk in combination with raf/erk/mek
MX377816B (es) *	2013-10-25	2025-03-11	Shanghai hengrui pharmaceutical co ltd	Derivados de piridil cetona, metodo de preparacion de los mismos, y la aplicacion farmaceutica de los mismos.
EP3094736A4 (en)	2014-01-14	2017-10-25	Dana-Farber Cancer Institute, Inc.	Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
AU2015222865B2 (en) *	2014-02-28	2019-06-20	Takeda Pharmaceutical Company Limited	TYK2 inhibitors and uses thereof
CN120536341A (zh)	2014-03-04	2025-08-26	菲特治疗公司	改良的重编程方法和细胞培养平台
US20170027940A1 (en)	2014-04-10	2017-02-02	Stichting Het Nederlands Kanker Instituut	Method for treating cancer
WO2015178770A1 (en)	2014-05-19	2015-11-26	Stichting Het Nederlands Kanker Instituut	Compositions for cancer treatment
US10023879B2 (en)	2014-06-04	2018-07-17	Fate Therapeutics, Inc.	Minimal volume reprogramming of mononuclear cells
WO2016057367A1 (en)	2014-10-06	2016-04-14	Dana-Farber Cancer Institute, Inc.	Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
JP6800859B2 (ja)	2015-01-26	2020-12-16	フェイトセラピューティクス，インコーポレイテッド	造血細胞分化を誘導するための方法および組成物
MA41866A (fr)	2015-03-31	2018-02-06	Massachusetts Gen Hospital	Molécules à auto-assemblage pour l'administration ciblée de médicaments
AU2016314082B2 (en)	2015-08-28	2019-07-25	Novartis Ag	Mdm2 inhibitors and combinations thereof
CA3001917A1 (en)	2015-10-16	2017-04-20	Fate Therapeutics, Inc.	Platform for the induction & maintenance of ground state pluripotency
CN108473961B (zh)	2015-11-04	2022-11-29	菲特治疗公司	用于诱导造血细胞分化的方法和组合物
PT3371314T (pt)	2015-11-04	2023-08-31	Fate Therapeutics Inc	Modificação genómica de células pluripotentes
CA3005261A1 (en) *	2015-11-18	2017-05-26	Fmc Corporation	Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives
WO2017127729A1 (en)	2016-01-20	2017-07-27	Fate Therapeutics, Inc.	Compositions and methods for immune cell modulation in adoptive immunotherapies
WO2017127755A1 (en)	2016-01-20	2017-07-27	Fate Therapeutics, Inc.	Compositions and methods for immune cell modulation in adoptive immunotherapies
CA3016311C (en) *	2016-03-10	2021-01-05	Lutris Pharma Ltd.	Use of braf inhibitors for treating cutaneous reactions
WO2018092064A1 (en)	2016-11-18	2018-05-24	Novartis Ag	Combinations of mdm2 inhibitors and bcl-xl inhibitors
WO2018106595A1 (en)	2016-12-05	2018-06-14	Fate Therapeutics, Inc.	Compositions and methods for immune cell modulation in adoptive immunotherapies
KR102435424B1 (ko) *	2017-09-13	2022-08-23	엘지디스플레이 주식회사	듀티 구동 기능을 갖는 표시장치 및 이의 구동방법
BR112021018168B1 (pt)	2019-03-21	2023-11-28	Onxeo	Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
TWI817018B (zh)	2019-06-28	2023-10-01	美商艾瑞生藥股份有限公司	用於治療ｂｒａｆ相關的疾病和失調症之化合物
CN114761006A (zh)	2019-11-08	2022-07-15	Inserm(法国国家健康医学研究院)	对激酶抑制剂产生耐药性的癌症的治疗方法
AR121078A1 (es)	2020-01-22	2022-04-13	Chugai Pharmaceutical Co Ltd	Derivados de arilamida con actividad antitumoral
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
JP7312335B2 (ja)	2020-06-09	2023-07-20	アレイバイオファーマインコーポレイテッド	Ｂｒａｆ関連疾患および障害を処置するための４－オキソ－３，４－ジヒドロキナゾリノン化合物
TWI825637B (zh)	2021-03-31	2023-12-11	美商輝瑞股份有限公司	啶－１，６（２ｈ，７ｈ）－二酮
US12280055B2 (en)	2021-05-27	2025-04-22	Mirati Therapeutics, Inc.	Combination therapies
EP4532470A1 (en)	2022-05-25	2025-04-09	Ikena Oncology, Inc.	Mek inhibitors and uses thereof
WO2025073765A1 (en)	2023-10-03	2025-04-10	Institut National de la Santé et de la Recherche Médicale	Methods of prognosis and treatment of patients suffering from melanoma

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3682932A (en)	1970-11-23	1972-08-08	Hoffmann La Roche	2-chloro-6-hydroxynicotinic acid
DE2150772A1 (de)	1971-10-12	1973-04-19	Cassella Farbwerke Mainkur Ag	Verfahren zur herstellung von 6-hydroxy-2-pyridon-3-carbonsaeureamidverbindungen
DE2307169A1 (de)	1973-02-14	1974-09-26	Bayer Ag	Azofarbstoffe
US4851535A (en)	1985-01-23	1989-07-25	Toyama Chemical Co., Ltd.	Nicotinic acid derivatives
AT392789B (de)	1985-01-23	1991-06-10	Toyama Chemical Co Ltd	Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
GB8607683D0 (en)	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents
GB8827305D0 (en)	1988-11-23	1988-12-29	British Bio Technology	Compounds
FR2687676B1 (fr)	1992-02-24	1994-07-08	Union Pharma Scient Appl	Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5455258A (en)	1993-01-06	1995-10-03	Ciba-Geigy Corporation	Arylsulfonamido-substituted hydroxamic acids
WO1995003286A1 (en)	1993-07-23	1995-02-02	The Green Cross Corporation	Triazole derivative and pharmaceutical use thereof
AU691834B2 (en) *	1993-10-01	1998-05-28	Novartis Ag	Pharmacologically active pyridine derivatives and processes for the preparation thereof
US5525625A (en)	1995-01-24	1996-06-11	Warner-Lambert Company	2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders
US5863949A (en)	1995-03-08	1999-01-26	Pfizer Inc	Arylsulfonylamino hydroxamic acid derivatives
PT821671E (pt)	1995-04-20	2001-04-30	Pfizer	Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf
GB9624482D0 (en)	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
DK0780386T3 (da)	1995-12-20	2003-02-03	Hoffmann La Roche	Matrixmetalloproteaseinhibitorer
PT880508E (pt)	1996-02-13	2003-07-31	Astrazeneca Ab	Derivados de quinazolina como inibidores de vegf
IL125954A (en)	1996-03-05	2003-06-24	Zeneca Ltd	Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect
EP0818442A3 (en)	1996-07-12	1998-12-30	Pfizer Inc.	Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
SI0923585T1 (en)	1996-07-18	2002-08-31	Pfizer Inc.	Phosphinate based inhibitors of matrix metalloproteases
PL331895A1 (en)	1996-08-23	1999-08-16	Pfizer	Arylosulphonylamino derivatives of hydroxamic acid
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
PT950059E (pt)	1997-01-06	2004-10-29	Pfizer	Derivados de sulfona ciclicos
HUP0000852A2 (hu)	1997-02-03	2001-05-28	Pfizer Products Inc.	Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
EP0966438A1 (en)	1997-02-07	1999-12-29	Pfizer Inc.	N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
JP3710489B2 (ja)	1997-02-11	2005-10-26	ファイザー・インク	アリールスルホニルヒドロキサム酸誘導体
DE69837529T2 (de)	1997-02-12	2007-07-26	Electrophoretics Ltd., Cobham	Proteinmarker für lungenkrebs und deren verwendung
UA73073C2 (uk)	1997-04-03	2005-06-15	Уайт Холдінгз Корпорейшн	Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
CA2290509A1 (en)	1997-07-01	1999-01-14	Warner-Lambert Company	2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as mek inhibitors
US6506798B1 (en)	1997-07-01	2003-01-14	Warner-Lambert Company	4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
ES2229515T3 (es)	1997-07-01	2005-04-16	Warner-Lambert Company Llc	Derivados 4-bromo o 4-yodo del acido fenilamino benzhidroxamico y su uso como inhibidores de la mek.
US6310060B1 (en)	1998-06-24	2001-10-30	Warner-Lambert Company	2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
US6821963B2 (en)	1997-07-01	2004-11-23	Warner-Lambert Company	4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
GB9714249D0 (en)	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
US6214872B1 (en)	1997-08-08	2001-04-10	Pfizer Inc.	Aryloxyarylsulfonylamino hydroxamic acid derivatives
GB9725782D0 (en)	1997-12-05	1998-02-04	Pfizer Ltd	Therapeutic agents
GB9801690D0 (en)	1998-01-27	1998-03-25	Pfizer Ltd	Therapeutic agents
JP4462654B2 (ja)	1998-03-26	2010-05-12	ソニー株式会社	映像素材選択装置及び映像素材選択方法
PA8469401A1 (es)	1998-04-10	2000-05-24	Pfizer Prod Inc	Derivados biciclicos del acido hidroxamico
PA8469501A1 (es)	1998-04-10	2000-09-29	Pfizer Prod Inc	Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
AUPP466598A0 (en)	1998-07-14	1998-08-06	University Of Newcastle Research Associates Limited, The	Product and process
EP1004578B1 (en)	1998-11-05	2004-02-25	Pfizer Products Inc.	5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
HUP0104933A3 (en)	1999-01-07	2003-12-29	Warner Lambert Co	Antiviral method using mek inhibitors
WO2000040235A2 (en)	1999-01-07	2000-07-13	Warner-Lambert Company	Treatment of asthma with mek inhibitors
BR9916904A (pt)	1999-01-13	2001-10-30	Warner Lambert Co	Benzo heterociclos e seu uso como inibidores demek
IL144215A0 (en)	1999-01-13	2002-05-23	Warner Lambert Co	1-heterocycle substituted diarylamines
AU2483400A (en)	1999-01-13	2000-08-01	Warner-Lambert Company	4'heteroaryl diarylamines
DE69928697T2 (de)	1999-01-13	2006-06-22	Warner-Lambert Co. Llc	Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren
CA2348236A1 (en)	1999-01-13	2000-07-20	Stephen Douglas Barrett	4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
DE69928286T2 (de)	1999-01-13	2006-07-13	Warner-Lambert Co. Llc	Benzenesulfonamid-derivative und ihre verwendung als mek-inhibitoren
GB9900752D0 (en)	1999-01-15	1999-03-03	Angiogene Pharm Ltd	Benzimidazole vascular damaging agents
CZ305827B6 (cs)	1999-02-10	2016-03-30	Astrazeneca Ab	Indolové deriváty
GB9910577D0 (en)	1999-05-08	1999-07-07	Zeneca Ltd	Chemical compounds
PL352835A1 (pl)	1999-07-16	2003-09-08	Warner-Lambert Company	Sposób leczenia przewlekłego bólu z użyciem inhibitorów MEK
TR200200082T2 (tr)	1999-07-16	2002-04-22	Warner-Lambert Company	MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.
CN1365277A (zh)	1999-07-16	2002-08-21	沃尼尔·朗伯公司	使用mek抑制剂治疗慢性疼痛的方法
US7030119B1 (en)	1999-07-16	2006-04-18	Warner-Lambert Company	Method for treating chronic pain using MEK inhibitors
WO2001005391A2 (en)	1999-07-16	2001-01-25	Warner-Lambert Company	Method for treating chronic pain using mek inhibitors
HK1049664B (en)	1999-11-05	2006-11-10	Genzyme Corporation	Quinazoline derivatives as vegf inhibitors
BRPI0108394B8 (pt)	2000-02-15	2021-05-25	Upjohn Co	inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos
EP1339702A1 (en)	2000-03-15	2003-09-03	Warner-Lambert Company	5-amide substituted diarylamines as mek inhibitors
CA2403017A1 (en)	2000-03-15	2001-09-20	Warner-Lambert Company	5-amide substituted diarylamines as mex inhibitors
WO2001092224A1 (en)	2000-05-31	2001-12-06	Astrazeneca Ab	Indole derivatives with vascular damaging activity
AU6623301A (en)	2000-07-07	2002-01-21	Angiogene Pharm Ltd	Colchinol derivatives as vascular damaging agents
HUP0301742A3 (en)	2000-07-07	2005-08-29	Angiogene Pharm Ltd	Colchinol derivatives as angiogenesis inhibitors, process for producing them, pharmaceutical compositions containing them and their use
CN1219753C (zh)	2000-07-19	2005-09-21	沃尼尔·朗伯公司	4－碘苯氨基苯氧肟酸的氧合酯
RU2167659C1 (ru)	2000-08-02	2001-05-27	Закрытое акционерное общество "Центр современной медицины "Медикор"	Способ коррекции иммунной системы живого организма
CZ2003477A3 (cs)	2000-08-25	2003-10-15	Warner - Lambert Company Llc	Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů
US7067532B2 (en)	2000-11-02	2006-06-27	Astrazeneca	Substituted quinolines as antitumor agents
US6642215B2 (en)	2001-05-24	2003-11-04	Leo Pharma A/S	Method of modulating NF-kB activity
US20040039208A1 (en)	2001-07-20	2004-02-26	Chen Michael Huai Gu	Process for making n-aryl-anthranilic acids and their derivatives
US20030187026A1 (en)	2001-12-13	2003-10-02	Qun Li	Kinase inhibitors
WO2003077855A2 (en)	2002-03-13	2003-09-25	Array Biopharma, Inc	N3 alkylated benzimidazole derivatives as mek inhibitors
US7235537B2 (en) *	2002-03-13	2007-06-26	Array Biopharma, Inc.	N3 alkylated benzimidazole derivatives as MEK inhibitors
IL163995A0 (en)	2002-03-13	2005-12-18	Array Biopharma Inc	N3 alkylated benzimidazole derivatives as mek inhibitors
BR0308429A (pt)	2002-03-14	2005-01-11	Bayer Healthcare Ag	Aroilpiridinonas monocìclicas como agentes antiinflamatórios
AU2003250844A1 (en)	2002-06-24	2004-01-06	Fagerdala Deutschland Gmbh	Method for producing parts from high-grade lignocellulose fiber-filled thermoplastics
WO2005000818A1 (en)	2003-06-27	2005-01-06	Warner-Lambert Company Llc	5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
TW200510425A (en)	2003-08-13	2005-03-16	Japan Tobacco Inc	Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US7144907B2 (en) *	2003-09-03	2006-12-05	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
WO2005051300A2 (en) *	2003-11-19	2005-06-09	Array Biopharma Inc.	Bicyclic inhibitors of mek and methods of use thereof
US7517994B2 (en)	2003-11-19	2009-04-14	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en)	2003-11-19	2010-06-08	Array Biopharma Inc.	Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
ES2251866B1 (es)	2004-06-18	2007-06-16	Laboratorios Almirall S.A.	Nuevos derivados de piridazin-3(2h)-ona.
EP1967516B1 (en)	2005-05-18	2009-11-04	Array Biopharma, Inc.	4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases

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Also Published As

Publication number	Publication date
MY149960A (en)	2013-11-15
IL212396A0 (en)	2011-06-30
PL1922307T3 (pl)	2012-07-31
RS52243B (sr)	2012-10-31
WO2007044084A3 (en)	2009-04-16
EP2364973B1 (en)	2014-07-09
ES2405785T3 (es)	2013-06-03
JP2009215312A (ja)	2009-09-24
JP5089649B2 (ja)	2012-12-05
NZ587189A (en)	2011-11-25
IL187353A (en)	2013-02-28
US20080280957A1 (en)	2008-11-13
JP5270336B2 (ja)	2013-08-21
EP1967516A1 (en)	2008-09-10
HK1121140A1 (en)	2009-04-17
CL2009001993A1 (es)	2010-06-11
TWI441637B (zh)	2014-06-21
TW200714590A (en)	2007-04-16
CN101626767A (zh)	2010-01-13
EP2361905B1 (en)	2013-03-06
DE602006010243D1 (de)	2009-12-17
HRP20120154T1 (hr)	2012-03-31
KR20110074908A (ko)	2011-07-04
TW201238952A (en)	2012-10-01
EP1922307B1 (en)	2011-12-28
ZA201203844B (en)	2014-02-26
EP2361905A1 (en)	2011-08-31
HK1124048A1 (en)	2009-07-03
ES2378760T3 (es)	2012-04-17
JP2013028637A (ja)	2013-02-07
CN102304086B (zh)	2013-12-04
CN102321030A (zh)	2012-01-18
RU2010144823A (ru)	2012-05-10
JP2008545654A (ja)	2008-12-18
CL2008003486A1 (es)	2009-03-20
AR055057A1 (es)	2007-08-01
HK1162028A1 (en)	2012-08-17
ES2500068T3 (es)	2014-09-30
JP5576919B2 (ja)	2014-08-20
UA100007C2 (ru)	2012-11-12
AR082826A2 (es)	2013-01-09
EP1967516B1 (en)	2009-11-04
US8299076B2 (en)	2012-10-30
DK1922307T3 (da)	2012-04-02
IL187353A0 (en)	2008-04-13
IL212396A (en)	2015-09-24
ATE539064T1 (de)	2012-01-15
CA2608201C (en)	2013-12-31
SI1922307T1 (pl)	2012-04-30
AU2006299902B2 (en)	2012-11-01
ES2333182T3 (es)	2010-02-17
PL2361905T3 (pl)	2013-07-31
PT1922307E (pt)	2012-01-25
NO20076412L (no)	2008-01-14
KR20110074772A (ko)	2011-07-01
RU2010128512A (ru)	2012-01-20
AR082825A2 (es)	2013-01-09
PT2361905E (pt)	2013-03-18
ATE447559T1 (de)	2009-11-15
HK1161250A1 (en)	2012-08-24
EP1922307A4 (en)	2009-12-30
ZA200710318B (en)	2012-09-26
CN102304086A (zh)	2012-01-04
TWI506020B (zh)	2015-11-01
TW201302708A (zh)	2013-01-16
IL212398A0 (en)	2011-06-30
EP1922307A2 (en)	2008-05-21
CA2608201A1 (en)	2007-04-19
NZ563707A (en)	2011-01-28
SA06270141B1 (ar)	2009-11-15
CN102898364A (zh)	2013-01-30
CY1112297T1 (el)	2015-12-09
RU2500673C2 (ru)	2013-12-10
EP2364973A1 (en)	2011-09-14
WO2007044084A2 (en)	2007-04-19
ECSP078013A (es)	2008-04-28
RU2007146115A (ru)	2009-06-27
UA93678C2 (ru)	2011-03-10
KR20080019236A (ko)	2008-03-03
NZ587190A (en)	2011-11-25
IL212398A (en)	2014-09-30
RU2009118281A (ru)	2010-11-20
RU2414455C2 (ru)	2011-03-20
AU2006299902A1 (en)	2007-04-19
BRPI0610139A2 (pt)	2010-06-01
SG177981A1 (en)	2012-02-28
CN102942522A (zh)	2013-02-27
MY149957A (en)	2013-11-15
SG161318A1 (en)	2010-05-27

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