PL2234974T3 - Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidydu - Google Patents
Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidyduInfo
- Publication number
- PL2234974T3 PL2234974T3 PL08707040T PL08707040T PL2234974T3 PL 2234974 T3 PL2234974 T3 PL 2234974T3 PL 08707040 T PL08707040 T PL 08707040T PL 08707040 T PL08707040 T PL 08707040T PL 2234974 T3 PL2234974 T3 PL 2234974T3
- Authority
- PL
- Poland
- Prior art keywords
- pipecoloxylidide
- alkyl
- compound
- preparation
- levobupivacaine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 229960004288 levobupivacaine Drugs 0.000 abstract 1
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 abstract 1
- 229960001549 ropivacaine Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2008/000236 WO2009089841A1 (en) | 2008-01-15 | 2008-01-15 | Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound |
| EP08707040A EP2234974B1 (en) | 2008-01-15 | 2008-01-15 | Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2234974T3 true PL2234974T3 (pl) | 2012-09-28 |
Family
ID=39485172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08707040T PL2234974T3 (pl) | 2008-01-15 | 2008-01-15 | Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidydu |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2234974B1 (pl) |
| AT (1) | ATE555093T1 (pl) |
| CY (1) | CY1112979T1 (pl) |
| DK (1) | DK2234974T3 (pl) |
| ES (1) | ES2383714T3 (pl) |
| PL (1) | PL2234974T3 (pl) |
| PT (1) | PT2234974E (pl) |
| WO (1) | WO2009089841A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103073484B (zh) * | 2013-01-28 | 2014-10-22 | 山东诚创医药技术开发有限公司 | 一种甲哌卡因及其光学对映体的制备方法 |
| CN107848973A (zh) * | 2015-09-01 | 2018-03-27 | 四川海思科制药有限公司 | S‑(‑)‑1‑丙基‑2’,6’‑二甲苯胺甲酰基哌啶晶体及其缓释制剂 |
| CN105585520A (zh) * | 2015-12-24 | 2016-05-18 | 山东齐都药业有限公司 | 盐酸左布比卡因a晶型及其制备方法 |
| CN113717094B (zh) * | 2021-08-11 | 2023-05-05 | 山东辰龙药业有限公司 | 一种制备甲哌卡因的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0151110B1 (en) * | 1983-08-01 | 1989-03-01 | Astra Läkemedel Aktiebolag | L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same |
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
| WO1996012699A1 (en) * | 1994-10-25 | 1996-05-02 | Chiroscience Limited | Crystallisation of levobupivacaine and analogues thereof |
| JP2009535327A (ja) * | 2006-04-25 | 2009-10-01 | ディシュマン・ファーマシューティカルズ・アンド・ケミカルズ・リミテッド | ロピバカイン塩酸塩無水物およびその調製 |
-
2008
- 2008-01-15 ES ES08707040T patent/ES2383714T3/es active Active
- 2008-01-15 PL PL08707040T patent/PL2234974T3/pl unknown
- 2008-01-15 PT PT08707040T patent/PT2234974E/pt unknown
- 2008-01-15 EP EP08707040A patent/EP2234974B1/en active Active
- 2008-01-15 WO PCT/EP2008/000236 patent/WO2009089841A1/en not_active Ceased
- 2008-01-15 DK DK08707040.5T patent/DK2234974T3/da active
- 2008-01-15 AT AT08707040T patent/ATE555093T1/de active
-
2012
- 2012-07-24 CY CY20121100654T patent/CY1112979T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE555093T1 (de) | 2012-05-15 |
| EP2234974A1 (en) | 2010-10-06 |
| WO2009089841A1 (en) | 2009-07-23 |
| DK2234974T3 (da) | 2012-06-25 |
| EP2234974B1 (en) | 2012-04-25 |
| ES2383714T3 (es) | 2012-06-25 |
| PT2234974E (pt) | 2012-05-29 |
| CY1112979T1 (el) | 2016-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ591818A (en) | Processes for the preparation of sglt2 inhibitors | |
| JO3142B1 (ar) | طريقة تحضير 5-ثنائي فينيل -4-أمينو-2-ميثيل بينتانويك أسيد | |
| UA109774C2 (uk) | Кристалічні форми саксагліптину та процес його одержання (варіанти) | |
| PH12015501226A1 (en) | Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing the same | |
| MX2009005616A (es) | Derivados de pirido-pirazina utiles como compuestos herbicidas. | |
| SI2091948T1 (sl) | Novi inhibitorji glutaminil ciklaze | |
| SG170729A1 (en) | Processes and intermediates for preparing steric compounds | |
| MY160542A (en) | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase | |
| MX2009003739A (es) | Derivados de hidrobenzamida como inhibidores de hsp90. | |
| MX2010012698A (es) | Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico. | |
| TW200714586A (en) | Crystalline forms of a biphenyl compound | |
| MX2012013332A (es) | Preparacion de intermediarios de posaconazol. | |
| WO2009141091A8 (de) | Neue [f-18] -markierte l-glutaminsäure- und l-glutaminderivate (i), ihre verwendung sowie verfahren zu ihrer herstellung | |
| MX2013003558A (es) | Sales de oxalato cristalinas de un compuesto diamida. | |
| WO2009126861A3 (en) | Triazolopyridine compounds useful as dgat1 inhibitors | |
| CY1112979T1 (el) | Διαδικασια για την παρασκευη της ενωσης (s)-1-αλκυλ-2',6'-πιπεκολοξυλιδιδιου | |
| WO2008087654A3 (en) | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | |
| MX2010013758A (es) | Procedimiento para elaborar 2-amino-tiazolonas sustituidas. | |
| WO2011102640A3 (en) | Method for preparing sitagliptin and amine salt intermediates used therein | |
| WO2010038948A3 (en) | Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders | |
| WO2006066044A3 (en) | Processes for producing 4-aminoquinazolines | |
| WO2007083243A3 (en) | An improved process for the preparation of risedronate sodium hemi-pentahydrate | |
| WO2008059518A3 (en) | Process for preparing crystalline aripiprazole | |
| WO2013117869A3 (fr) | Procédé de synthèse enzymatique de l'acide (7s)-3,4-dimethoxybicyclo [4.2.0]|octa-1,3,5-triene-7-carboxylique ou de ses esters, et application a la synthèse|de l'ivabradine et de ses sels | |
| WO2009034582A3 (en) | Process for the preparation of amorphous fexofenadine hydrochloride |