[go: up one dir, main page]

MX2010012698A - Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico. - Google Patents

Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico.

Info

Publication number
MX2010012698A
MX2010012698A MX2010012698A MX2010012698A MX2010012698A MX 2010012698 A MX2010012698 A MX 2010012698A MX 2010012698 A MX2010012698 A MX 2010012698A MX 2010012698 A MX2010012698 A MX 2010012698A MX 2010012698 A MX2010012698 A MX 2010012698A
Authority
MX
Mexico
Prior art keywords
nitromethyl
methyl
hexanoic acid
acid ester
enzymatic hydrolysis
Prior art date
Application number
MX2010012698A
Other languages
English (en)
Inventor
Albert Martin
Berger Andreas
Zepeck Ferdinand
Riethorst Waander
Schwab Helmut
Luschnig Daniel
Remler Peter
Salchenegger Joerg
Osl Doris
Desouza Dominic
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of MX2010012698A publication Critical patent/MX2010012698A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a procesos para la preparación del éster del ácido 5-metil-3-nitro-metil-hexanoico y sus sales. También se dan a conocer procesos para la preparación de la sal del ácido 5-metil-3-nitro-metil-hexanoico, y un proceso para la preparación del ácido 3-(amino-metil)-5-metil-hexanoico. También se dan a conocer el ácido (S)-5-metil-3-nitro-metil-hexanoico o el ácido (R)-5-metil-3-nitro-metil-hexanoico en una forma enantioenriquecida o en una forma enantiopura, y un compuesto, es decir, de la fórmula (XIII): (ver fórmula (XIII)) en una forma racémica, en una forma enantioenriquecida, o en una forma enantiopura.
MX2010012698A 2008-05-21 2009-05-19 Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico. MX2010012698A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12837108P 2008-05-21 2008-05-21
PCT/EP2009/056099 WO2009141362A2 (en) 2008-05-21 2009-05-19 Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester

Publications (1)

Publication Number Publication Date
MX2010012698A true MX2010012698A (es) 2011-03-15

Family

ID=41319680

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010012698A MX2010012698A (es) 2008-05-21 2009-05-19 Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico.

Country Status (13)

Country Link
US (1) US8546112B2 (es)
EP (1) EP2294207B1 (es)
KR (1) KR20110025917A (es)
CN (1) CN102099482B (es)
AU (1) AU2009248750B2 (es)
BR (1) BRPI0913094A2 (es)
CA (1) CA2724828C (es)
EA (1) EA019285B1 (es)
IL (1) IL209271A (es)
MX (1) MX2010012698A (es)
SI (1) SI2294207T1 (es)
UA (1) UA103997C2 (es)
WO (1) WO2009141362A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090312560A1 (en) * 2008-06-10 2009-12-17 Lambertus Thijs Processes for making pregabalin and intermediates therefor
CN103833562B (zh) * 2013-12-04 2015-08-12 惠州市莱佛士制药技术有限公司 一种不对称合成普瑞巴林的制备方法
US9745249B2 (en) 2014-06-12 2017-08-29 Siegfried Ltd. Method for the preparation of beta-substituted gamma-amino carboxylic acids
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
EP3088383A1 (de) * 2015-04-29 2016-11-02 K.H.S. Pharma Holding GmbH Optimierte synthese von pregabalin sowie 4-aminobutansäuren unter einsatz eines verbesserten herstellverfahrens von konjugierten nitroalkenen
CN108358799B (zh) * 2018-04-24 2020-11-10 贵州师范大学 一种普瑞巴林的制备方法
EP3819290A4 (en) * 2018-06-06 2022-01-26 Zhejiang Huahai Pharmaceutical Co., Ltd METHOD FOR THE PREPARATION OF PREGABALIN
CN108997128B (zh) * 2018-08-03 2021-02-02 浙江工业大学 一种普瑞巴林中间体3-硝甲基-5-甲基己酸乙酯的制备方法
CN109503403B (zh) * 2018-12-21 2021-11-16 卓和药业集团股份有限公司 一种普瑞巴林的拆分方法
CN110256229A (zh) * 2019-07-29 2019-09-20 常州工程职业技术学院 一种制备3-异丁基戊二酸的方法
CN110803994B (zh) * 2019-11-19 2023-06-30 陕西科技大学 一种普瑞巴林中间体3-硝基亚甲基-5-甲基-己酸乙酯的合成方法
CN110803993B (zh) * 2019-11-19 2023-06-30 陕西科技大学 一种普瑞巴林中间体2-羧乙基-3-硝基亚甲基-5-甲基己酸乙酯的合成方法
CN110862322B (zh) * 2019-11-19 2023-06-30 陕西科技大学 一种普瑞巴林中间体2-乙酰基-3-硝基亚甲基-5-甲基-己酸乙酯的合成方法
EP4103168A4 (en) * 2020-02-14 2024-04-24 Council Of Scientific & Industrial Research PROCESS FOR PREPARING GAMMA-AMINO-BUTYRIC ACIDS AND THEIR ANALOGS

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447783A1 (de) * 1984-12-29 1986-07-10 Henkel Kgaa Verfahren zur herstellung von salzen der 1.3-dioxolan-4-carbonsaeuren und deren verwendung
US5616793A (en) 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
RS50257B (sr) 2000-01-27 2009-07-15 Warner-Lambert Company Llc., Asimetrična sinteza pregabalina
US6562603B2 (en) * 2000-08-04 2003-05-13 E. I. Du Pont De Nemours And Company 3-hydroxycarboxylic acid production and use in branched polymers
DE10203122A1 (de) 2002-01-25 2003-07-31 Gruenenthal Gmbh Verfahren zur Herstellung von substituierten Acrylsäureestern bzw. deren Einsatz zur Herstellung von substituierten gamma-Aminosäuren
PL1727620T3 (pl) 2004-03-12 2007-12-31 Warner Lambert Co C1-symetryczne ligandy bifosfin i ich zastosowanie w asymetrycznej syntezie pregabaliny
UA82292C2 (uk) 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
HRP20100054T1 (hr) 2004-06-21 2010-05-31 Warner-Lambert Company Llc Dobivanje pregabalina i njemu sličnih spojeva
MX2007012606A (es) 2005-04-11 2008-01-11 Teva Pharma Proceso para elaborar (s)-pregabalina.
US7763749B2 (en) 2005-05-10 2010-07-27 Teva Pharmaceutical Industries Ltd. Method for the preparation of Pregabalin and salts thereof
EP1879854B1 (en) 2005-05-10 2011-09-07 Teva Pharmaceutical Industries Ltd Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
BRPI0605833A (pt) 2005-05-10 2007-12-18 Teva Pharma pregabalina livre de ácido isobutilglutárico e um processo para sua preparação
WO2006121557A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
CN100410242C (zh) 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
US9015059B2 (en) 2005-09-19 2015-04-21 Omnitracs, Llc Wireless system for automatic ordering of maintenance parts for equipment
ES2398579T3 (es) 2005-09-19 2013-03-20 Teva Pharmaceutical Industries Ltd Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico
US20070141684A1 (en) * 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
WO2007139933A2 (en) 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
EP1912931A2 (en) 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
EP2071032A3 (en) 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd The use of enzymatic resolution for the preparation of intermediates of pregabalin
WO2008007145A2 (en) 2006-07-12 2008-01-17 Generics [Uk] Limited Process of preparing a gamma-amino acid
JP5234901B2 (ja) * 2007-10-04 2013-07-10 学校法人東京理科大学 不斉触媒マイケル反応生成物の製造方法
EP2222630A1 (en) * 2007-12-26 2010-09-01 Generics (UK) Limited Processes to pregabalin

Also Published As

Publication number Publication date
CN102099482A (zh) 2011-06-15
AU2009248750B2 (en) 2015-05-21
CA2724828A1 (en) 2009-11-26
EA019285B1 (ru) 2014-02-28
US8546112B2 (en) 2013-10-01
WO2009141362A3 (en) 2010-04-15
US20110165636A1 (en) 2011-07-07
SI2294207T1 (sl) 2013-01-31
IL209271A (en) 2015-05-31
EA201001671A1 (ru) 2011-10-31
CN102099482B (zh) 2014-04-16
AU2009248750A1 (en) 2009-11-26
IL209271A0 (en) 2011-01-31
KR20110025917A (ko) 2011-03-14
CA2724828C (en) 2016-01-12
UA103997C2 (ru) 2013-12-25
WO2009141362A2 (en) 2009-11-26
EP2294207B1 (en) 2012-09-26
EP2294207A2 (en) 2011-03-16
BRPI0913094A2 (pt) 2015-08-11

Similar Documents

Publication Publication Date Title
MX2010012698A (es) Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico.
SG170729A1 (en) Processes and intermediates for preparing steric compounds
WO2014072785A3 (en) A process for the preparation of pregabalin
NZ586203A (en) Process and compounds for the production of (+) opiates
DE602007004111D1 (de) Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren
NZ593102A (en) Dihydroetorphines and their preparation
MY157569A (en) Method for producing a solid with sufficiently low hygroscopicity which comprises glutamic acid-n,n-diacetic acid (glda) or a derivative thereof
MX2010013758A (es) Procedimiento para elaborar 2-amino-tiazolonas sustituidas.
MX2011011025A (es) Preparacion de c-piracin-metilaminas.
WO2010063446A3 (en) Improved turfgrass quality
MX2010001229A (es) Procedimiento para la resolucion de zopiclona y compuestos intermedios.
WO2009001203A3 (en) An improved process for the preparation of aprepitant
UA93212C2 (ru) Способ получения оксазолидинзащищенных аминодиолов полезных kak промежуточные соединения для получения флорфеникола
WO2009122429A3 (en) Crystalline oxybutynin and process for preparing the same
MX2010009931A (es) Proceso para la preparacion de 2-amino-2-[2-(4-c3-c21-alquil-fenil )-etil]-propano-1,3-dioles.
CY1112979T1 (el) Διαδικασια για την παρασκευη της ενωσης (s)-1-αλκυλ-2',6'-πιπεκολοξυλιδιδιου
EP2151499A3 (en) Processes for the preparation of phosphatides
ZA201006422B (en) Novel method for the production of sulphonylpyrroles as hdac inhibitors
NZ589496A (en) Processes and compounds for the preparation of normorphinans
WO2012070896A3 (en) Synthetic method of enantiomerically pure 2,2'-dihydroxy-1,1'-binaphthyl-3-carboxylic acid
EA200900430A1 (ru) Способ получения некоторых соединений фенилаланина
DE602005013007D1 (de) Verfahren zur herstellung von lactonen
WO2009087674A3 (en) Improved process for the preparation of (s)-pregabalin
UA92752C2 (ru) Способ получения кристаллического периндоприла
DE602006008335D1 (de) Neuartiges verfahren zur herstellung von quaternärer säure und ammoniumsalzen

Legal Events

Date Code Title Description
FG Grant or registration