PL2125779T3 - Polimorfy antagonisty receptora mglur5 - Google Patents

Polimorfy antagonisty receptora mglur5

Info

Publication number: PL2125779T3
Authority: PL; Poland
Prior art keywords: polymorphs; receptor antagonist; mglur5 receptor; mglur5; antagonist
Prior art date: 2006-12-21

Application number

PL07857408.4T

Other languages

English (en)

Inventor

Thomas P. Cleary

Alexander Glomme

Olaf Grassmann

Shan-Ming Kuang

Roland Meier

Doreen Miller

Regina Moog

Franziska E. Rohrer

Jason Yang

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-21

Filing date

2007-12-11

Publication date

2016-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39186951&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2125779(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-12-11 Application filed filed Critical

2016-11-30 Publication of PL2125779T3 publication Critical patent/PL2125779T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL07857408.4T 2006-12-21 2007-12-11 Polimorfy antagonisty receptora mglur5 PL2125779T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US87639806P	2006-12-21	2006-12-21

Publications (1)

Publication Number	Publication Date
PL2125779T3 true PL2125779T3 (pl)	2016-11-30

Family

ID=39186951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07857408.4T PL2125779T3 (pl)	2006-12-21	2007-12-11	Polimorfy antagonisty receptora mglur5

Country Status (32)

Country	Link
US (2)	US8063076B2 (pl)
EP (1)	EP2125779B1 (pl)
JP (1)	JP5405311B2 (pl)
KR (1)	KR101148580B1 (pl)
CN (1)	CN101568531B (pl)
AR (1)	AR064654A1 (pl)
AU (1)	AU2007336369B2 (pl)
CA (1)	CA2673444C (pl)
CL (1)	CL2007003695A1 (pl)
CO (1)	CO6210731A2 (pl)
CY (1)	CY1117810T1 (pl)
DK (1)	DK2125779T3 (pl)
EC (1)	ECSP099431A (pl)
ES (1)	ES2577391T3 (pl)
HR (1)	HRP20160950T1 (pl)
HU (1)	HUE029324T2 (pl)
IL (1)	IL199181A (pl)
MA (1)	MA31008B1 (pl)
MX (1)	MX2009006694A (pl)
MY (1)	MY148217A (pl)
NO (1)	NO342451B1 (pl)
NZ (1)	NZ577440A (pl)
PE (1)	PE20081484A1 (pl)
PL (1)	PL2125779T3 (pl)
PT (1)	PT2125779T (pl)
RS (1)	RS54853B1 (pl)
RU (1)	RU2460728C2 (pl)
SI (1)	SI2125779T1 (pl)
TW (1)	TWI347320B (pl)
UA (1)	UA96970C2 (pl)
WO (1)	WO2008074697A1 (pl)
ZA (1)	ZA200904289B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT2125779T (pt)	2006-12-21	2016-07-19	Hoffmann La Roche	Polimorfos de um antagonista de um recetor de mglur5
US20120039999A1 (en) *	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
MX2013010698A (es)	2011-03-18	2014-02-17	Novartis Ag	Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
EP2837631A1 (en) *	2013-08-14	2015-02-18	Merck & Cie	New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
GB201317022D0 (en) *	2013-09-25	2013-11-06	Addex Pharmaceuticals Sa	Polymorphs
CA2936377A1 (en)	2014-01-10	2015-07-16	Shanghai Birdie Biotech, Inc.	Compounds and compositions for treating egfr expressing tumors
CN115252792A (zh)	2016-01-07	2022-11-01	博笛生物科技有限公司	用于治疗肿瘤的抗-egfr组合
CN118515666A (zh)	2017-04-27	2024-08-20	博笛生物科技有限公司	2-氨基-喹啉衍生物
KR20230027145A (ko)	2020-06-05	2023-02-27	노에마 파르마 아게	결절성 경화증 복합증의 치료 방법
TW202220649A (zh) *	2020-07-30	2022-06-01	瑞士商諾埃瑪製藥公司	三叉神經痛之治療方法
CN120459099A (zh) *	2025-06-17	2025-08-12	北京大学成都前沿交叉生物技术研究院	mGlu5抑制剂在治疗或预防非酒精性脂肪肝病和/或肥胖、改善瘦素敏感性方面的应用

Family Cites Families (20)

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US3303199A (en)	1963-07-15	1967-02-07	Geigy Chem Corp	Certain imidazolone derivatives and process for making same
US3341548A (en)	1964-04-29	1967-09-12	Hoffmann La Roche	Nitroimidazoles and their preparation
DE2035905A1 (de)	1970-07-20	1972-02-03	Chemische Fabrik Stockhausen & Cie.,4150Krefeld	Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (en)	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
US4508560A (en)	1981-11-11	1985-04-02	Ciba Geigy Corporation	Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use
US4711962A (en)	1984-10-18	1987-12-08	Stauffer Chemical Company	Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
AU644802B2 (en)	1989-06-30	1993-12-23	E.I. Du Pont De Nemours And Company	Substituted imidazoles
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
CN1154489C (zh)	1997-08-14	2004-06-23	弗·哈夫曼-拉罗切有限公司	抗神经学疾病的杂环乙烯基醚
AU780009B2 (en)	1999-08-31	2005-02-24	Merck Sharp & Dohme Corp.	Heterocyclic compounds and methods of use thereof
JP5154728B2 (ja)	2000-07-24	2013-02-27	クレニツキー・ファーマシューティカルズ，インコーポレイテッド	神経栄養活性を有する置換５−アルキニルピリミジン
MXPA03004862A (es)	2000-12-04	2005-02-14	Hoffmann La Roche	Derivados de feniletenilo o feniletinilo como antagonistas del receptor de glutamato.
US6627646B2 (en) *	2001-07-17	2003-09-30	Sepracor Inc.	Norastemizole polymorphs
AU2002360621B2 (en)	2001-12-19	2007-01-25	Merck & Co., Inc.	heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
TWI292318B (en)	2003-03-10	2008-01-11	Hoffmann La Roche	Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) *	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
US7091222B2 (en)	2003-07-03	2006-08-15	Hoffmann-La Roche Inc.	Imidazole derivatives
US7452909B2 (en)	2003-09-04	2008-11-18	Hoffman-La Roche Inc.	Imidazole derivatives
ATE397601T1 (de) *	2004-06-01	2008-06-15	Hoffmann La Roche	Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors
PT2125779T (pt)	2006-12-21	2016-07-19	Hoffmann La Roche	Polimorfos de um antagonista de um recetor de mglur5

2007
- 2007-12-11 PT PT78574084T patent/PT2125779T/pt unknown
- 2007-12-11 MY MYPI20092393A patent/MY148217A/en unknown
- 2007-12-11 MX MX2009006694A patent/MX2009006694A/es active IP Right Grant
- 2007-12-11 NZ NZ577440A patent/NZ577440A/en unknown
- 2007-12-11 HU HUE07857408A patent/HUE029324T2/en unknown
- 2007-12-11 DK DK07857408.4T patent/DK2125779T3/en active
- 2007-12-11 RU RU2009123135/04A patent/RU2460728C2/ru active
- 2007-12-11 CN CN2007800475969A patent/CN101568531B/zh active Active
- 2007-12-11 SI SI200731792A patent/SI2125779T1/sl unknown
- 2007-12-11 RS RS20160461A patent/RS54853B1/sr unknown
- 2007-12-11 UA UAA200907474A patent/UA96970C2/ru unknown
- 2007-12-11 AU AU2007336369A patent/AU2007336369B2/en active Active
- 2007-12-11 PL PL07857408.4T patent/PL2125779T3/pl unknown
- 2007-12-11 HR HRP20160950TT patent/HRP20160950T1/hr unknown
- 2007-12-11 KR KR1020097012810A patent/KR101148580B1/ko active Active
- 2007-12-11 WO PCT/EP2007/063721 patent/WO2008074697A1/en not_active Ceased
- 2007-12-11 CA CA2673444A patent/CA2673444C/en active Active
- 2007-12-11 ES ES07857408.4T patent/ES2577391T3/es active Active
- 2007-12-11 JP JP2009541986A patent/JP5405311B2/ja active Active
- 2007-12-11 EP EP07857408.4A patent/EP2125779B1/en active Active
- 2007-12-14 PE PE2007001802A patent/PE20081484A1/es not_active Application Discontinuation
- 2007-12-17 US US11/957,515 patent/US8063076B2/en active Active
- 2007-12-19 CL CL200703695A patent/CL2007003695A1/es unknown
- 2007-12-19 TW TW096148786A patent/TWI347320B/zh active
- 2007-12-21 AR ARP070105822A patent/AR064654A1/es not_active Application Discontinuation
2009
- 2009-06-04 IL IL199181A patent/IL199181A/en active IP Right Grant
- 2009-06-05 CO CO09058653A patent/CO6210731A2/es not_active Application Discontinuation
- 2009-06-15 EC EC2009009431A patent/ECSP099431A/es unknown
- 2009-06-17 MA MA32012A patent/MA31008B1/fr unknown
- 2009-06-18 ZA ZA200904289A patent/ZA200904289B/xx unknown
- 2009-06-19 NO NO20092357A patent/NO342451B1/no unknown
2011
- 2011-10-14 US US13/273,266 patent/US8329912B2/en active Active
2016
- 2016-07-19 CY CY20161100705T patent/CY1117810T1/el unknown

Also Published As

Publication number	Publication date
CY1117810T1 (el)	2017-05-17
CL2007003695A1 (es)	2008-07-04
HRP20160950T1 (hr)	2016-10-07
HUE029324T2 (en)	2017-02-28
TW200833679A (en)	2008-08-16
KR101148580B1 (ko)	2012-05-24
AU2007336369A1 (en)	2008-06-26
EP2125779B1 (en)	2016-04-27
KR20090081026A (ko)	2009-07-27
SI2125779T1 (sl)	2016-07-29
MY148217A (en)	2013-03-29
CN101568531B (zh)	2013-11-13
RS54853B1 (sr)	2016-10-31
TWI347320B (en)	2011-08-21
DK2125779T3 (en)	2016-07-04
CA2673444C (en)	2015-01-20
US20080312288A1 (en)	2008-12-18
ECSP099431A (es)	2009-07-31
RU2460728C2 (ru)	2012-09-10
PE20081484A1 (es)	2008-10-18
BRPI0720954A2 (pt)	2014-03-18
US8063076B2 (en)	2011-11-22
NZ577440A (en)	2011-12-22
EP2125779A1 (en)	2009-12-02
CN101568531A (zh)	2009-10-28
WO2008074697A1 (en)	2008-06-26
RU2009123135A (ru)	2011-01-27
ES2577391T3 (es)	2016-07-14
NO342451B1 (no)	2018-05-22
US20120035222A1 (en)	2012-02-09
MA31008B1 (fr)	2009-12-01
NO20092357L (no)	2009-07-15
US8329912B2 (en)	2012-12-11
AU2007336369B2 (en)	2013-01-17
ZA200904289B (en)	2010-04-28
JP5405311B2 (ja)	2014-02-05
PT2125779T (pt)	2016-07-19
MX2009006694A (es)	2009-06-30
JP2010513378A (ja)	2010-04-30
AR064654A1 (es)	2009-04-15
IL199181A (en)	2016-02-29
CA2673444A1 (en)	2008-06-26
UA96970C2 (en)	2011-12-26
CO6210731A2 (es)	2010-10-20

Publication	Publication Date	Title
ZA200904289B (en)	2010-04-28	Polymorphs of a Mglur5 receptor antagonist
EP2034832A4 (en)	2010-12-08	IL-8 RECEPTOR ANTAGONIST
IL195029A0 (en)	2009-08-03	Polymorphs
PT1981902E (pt)	2015-11-02	Antagonistas dos recetores nogo
IL196587A0 (en)	2009-11-18	2-phenyl-indoles as prostaglandin d2 receptor antagonists
IL194811A0 (en)	2009-08-03	Il-8 receptor antagonists
ZA201006830B (en)	2011-05-25	Heterocyclic compounds as adenosine receptor antagonist
IL198241A0 (en)	2009-12-24	Pyrazoline compounds as mineralocorticoid receptor antagonists
IL194700A0 (en)	2009-08-03	Il-8 receptor antagonists
EP2099300A4 (en)	2011-12-07	IL-8 RECEPTOR ANTAGONISTS
ZA200903271B (en)	2010-04-28	Solid dispersion of a neurokinin antagonist
EP2191830A4 (en)	2011-11-23	SOLID PREPARATION COMPRISING A NPYY5 RECEPTOR ANTAGONIST
IL195807A0 (en)	2009-09-01	Cgrp receptor antagonists
EP2153736A4 (en)	2011-08-24	NEW LEUKOTRIEN RECEPTOR ANTAGONIST
ZA200808766B (en)	2010-01-27	Nitrated heterocyclic compounds as endothelin receptor antagonist
IL205949A0 (en)	2010-11-30	3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
EP2229400A4 (en)	2012-01-04	ADVANTAGEOUS SALTS OF MU-OPIOD RECEPTOR PEPTIDES
ZA200903523B (en)	2010-05-26	Poly-TLR antagonist
EP2057144A4 (en)	2010-06-02	NEW POLYMORPHIC FROM RIMONABANT
ZA200810564B (en)	2009-11-25	2-phenyl-indoles as prostaglandin D2 receptor antagonists
ZA200903609B (en)	2010-07-28	Motilide polymorphs
GB0525029D0 (en)	2006-01-18	Receptor Antagonist
HK1126354A (en)	2009-09-04	Il-8 receptor antagonist
GB0701632D0 (en)	2007-03-07	MET receptor antagonists
GB0623853D0 (en)	2007-01-10	Receptor