PL2121691T3 - Spirocykliczne pochodne cykloheksanu - Google Patents

Spirocykliczne pochodne cykloheksanu

Info

Publication number: PL2121691T3
Authority: PL; Poland
Prior art keywords: spirocyclic cyclohexane; cyclohexane compounds; cyclohexane derivatives; spirocyclic; compounds
Prior art date: 2007-02-22

Application number

PL08715856T

Other languages

English (en)

Inventor

Stefan Schunk

Derek Saunders

Stephanie Harlfinger

Sonja Steufmehl

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-22

Filing date

2008-02-19

Publication date

2012-09-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39531427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2121691(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-02-19 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2012-09-28 Publication of PL2121691T3 publication Critical patent/PL2121691T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Child & Adolescent Psychology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

PL08715856T 2007-02-22 2008-02-19 Spirocykliczne pochodne cykloheksanu PL2121691T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102007009319A DE102007009319A1 (de)	2007-02-22	2007-02-22	Spirocyclische Cyclohexan-Derivate
EP08715856A EP2121691B1 (de)	2007-02-22	2008-02-19	Spirocyclische cyclohexan-derivate
PCT/EP2008/001271 WO2008101660A1 (de)	2007-02-22	2008-02-19	Spirocyclische cyclohexan-derivate

Publications (1)

Publication Number	Publication Date
PL2121691T3 true PL2121691T3 (pl)	2012-09-28

Family

ID=39531427

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL08715856T PL2121691T3 (pl)	2007-02-22	2008-02-19	Spirocykliczne pochodne cykloheksanu

Country Status (25)

Country	Link
US (1)	US7960404B2 (pl)
EP (1)	EP2121691B1 (pl)
JP (1)	JP5514556B2 (pl)
KR (1)	KR101517748B1 (pl)
CN (1)	CN101622256B (pl)
AT (1)	ATE554089T1 (pl)
AU (1)	AU2008217277B2 (pl)
BR (1)	BRPI0806794A2 (pl)
CA (1)	CA2679173C (pl)
CO (1)	CO6220948A2 (pl)
CY (1)	CY1112725T1 (pl)
DE (1)	DE102007009319A1 (pl)
DK (1)	DK2121691T3 (pl)
EC (1)	ECSP099621A (pl)
ES (1)	ES2386387T3 (pl)
HR (1)	HRP20120511T1 (pl)
IL (1)	IL200496A (pl)
MX (1)	MX2009007387A (pl)
NZ (1)	NZ578589A (pl)
PL (1)	PL2121691T3 (pl)
PT (1)	PT2121691E (pl)
RU (1)	RU2470933C2 (pl)
SI (1)	SI2121691T1 (pl)
WO (1)	WO2008101660A1 (pl)
ZA (1)	ZA200906584B (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006033114A1 (de) *	2006-07-18	2008-01-24	Grünenthal GmbH	Spirocyclische Azaindol-Derivate
CA2727055C (en)	2008-01-11	2016-12-20	Albany Molecular Research, Inc.	(1-azinone) -substituted pyridoindoles as mch antagonists
TWI466866B (zh)	2008-03-27	2015-01-01		被取代之環己基二胺
SI2260042T1 (sl)	2008-03-27	2011-11-30	Gruenenthal Gmbh	Substituirani spirociklični cikloheksanski derivati
RU2532545C2 (ru)	2008-03-27	2014-11-10	Грюненталь Гмбх	Замещенные производные 4-аминоциклогексана
CN102083790B (zh)	2008-03-27	2014-03-05	格吕伦塔尔有限公司	螺(5.5)十一烷衍生物
PE20091822A1 (es)	2008-03-27	2009-12-10	Gruenenthal Chemie	Hidroximetilciclohexilaminas
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
EP2448585B1 (en)	2009-07-01	2014-01-01	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
PT2649044T (pt)	2010-12-08	2017-12-07	Gruenenthal Gmbh	Método para síntese de derivados de aminociclo-hexanona substituídos
US8697700B2 (en)	2010-12-21	2014-04-15	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
CN104159902B (zh) *	2011-12-12	2016-05-04	格吕伦塔尔有限公司	制备(1r,4r)-6’-氟-(N,N-二甲基-和N-甲基)-4-苯基-4’,9’-二氢-3’H-螺[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺的方法
MX360290B (es)	2013-03-15	2018-10-29	Gruenenthal Gmbh	Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina.
US10214520B2 (en)	2014-07-15	2019-02-26	Gruenenthal Gmbh	Substituted azaspiro(4.5)decane derivatives
TW201607923A (zh)	2014-07-15	2016-03-01	歌林達有限公司	被取代之氮螺環（４．５）癸烷衍生物
EA201791662A1 (ru) *	2015-01-23	2017-12-29	Грюненталь Гмбх	Цебранопадол для лечения от боли субъектов с нарушенной печеночной и/или нарушенной почечной функцией
CN107383027A (zh) *	2017-07-24	2017-11-24	扬州大学	一种四氢螺类化合物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2265018C2 (ru) *	2001-04-18	2005-11-27	Эро-Селтик, С.А.	Производные бензимидазола и фармацевтические композиции на их основе
DE10252667A1 (de)	2002-11-11	2004-05-27	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) *	2003-12-23	2005-07-28	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de)	2005-04-11	2006-10-19	Grünenthal GmbH	Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006046745A1 (de)	2006-09-29	2008-04-03	Grünenthal GmbH	Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

2007
- 2007-02-22 DE DE102007009319A patent/DE102007009319A1/de not_active Withdrawn
2008
- 2008-02-19 NZ NZ578589A patent/NZ578589A/en not_active IP Right Cessation
- 2008-02-19 AU AU2008217277A patent/AU2008217277B2/en not_active Ceased
- 2008-02-19 SI SI200830635T patent/SI2121691T1/sl unknown
- 2008-02-19 CA CA2679173A patent/CA2679173C/en not_active Expired - Fee Related
- 2008-02-19 JP JP2009550672A patent/JP5514556B2/ja not_active Expired - Fee Related
- 2008-02-19 AT AT08715856T patent/ATE554089T1/de active
- 2008-02-19 WO PCT/EP2008/001271 patent/WO2008101660A1/de not_active Ceased
- 2008-02-19 HR HRP20120511AT patent/HRP20120511T1/hr unknown
- 2008-02-19 MX MX2009007387A patent/MX2009007387A/es active IP Right Grant
- 2008-02-19 EP EP08715856A patent/EP2121691B1/de not_active Not-in-force
- 2008-02-19 BR BRPI0806794-5A patent/BRPI0806794A2/pt not_active IP Right Cessation
- 2008-02-19 RU RU2009135070/04A patent/RU2470933C2/ru not_active IP Right Cessation
- 2008-02-19 DK DK08715856.4T patent/DK2121691T3/da active
- 2008-02-19 CN CN200880006055.6A patent/CN101622256B/zh not_active Expired - Fee Related
- 2008-02-19 KR KR1020097019738A patent/KR101517748B1/ko not_active Expired - Fee Related
- 2008-02-19 PT PT08715856T patent/PT2121691E/pt unknown
- 2008-02-19 ES ES08715856T patent/ES2386387T3/es active Active
- 2008-02-19 PL PL08715856T patent/PL2121691T3/pl unknown
2009
- 2009-08-19 CO CO09086728A patent/CO6220948A2/es active IP Right Grant
- 2009-08-20 IL IL200496A patent/IL200496A/en active IP Right Grant
- 2009-08-21 US US12/545,261 patent/US7960404B2/en not_active Expired - Fee Related
- 2009-09-09 EC EC2009009621A patent/ECSP099621A/es unknown
- 2009-09-21 ZA ZA200906584A patent/ZA200906584B/xx unknown
2012
- 2012-05-11 CY CY20121100445T patent/CY1112725T1/el unknown

Also Published As

Publication number	Publication date
ATE554089T1 (de)	2012-05-15
DE102007009319A1 (de)	2008-08-28
KR20090114470A (ko)	2009-11-03
CN101622256B (zh)	2015-07-22
CO6220948A2 (es)	2010-11-19
IL200496A0 (en)	2010-04-29
US7960404B2 (en)	2011-06-14
PT2121691E (pt)	2012-05-25
NZ578589A (en)	2012-02-24
JP5514556B2 (ja)	2014-06-04
DK2121691T3 (da)	2012-07-02
MX2009007387A (es)	2009-07-17
US20100048553A1 (en)	2010-02-25
EP2121691B1 (de)	2012-04-18
BRPI0806794A2 (pt)	2011-09-13
HK1136827A1 (en)	2010-07-09
WO2008101660A1 (de)	2008-08-28
JP2010519265A (ja)	2010-06-03
ECSP099621A (es)	2009-10-30
EP2121691A1 (de)	2009-11-25
RU2470933C2 (ru)	2012-12-27
ZA200906584B (en)	2010-06-30
AU2008217277B2 (en)	2012-09-06
HRP20120511T1 (hr)	2012-07-31
CA2679173A1 (en)	2008-08-28
AU2008217277A1 (en)	2008-08-28
IL200496A (en)	2014-02-27
CA2679173C (en)	2015-11-24
CN101622256A (zh)	2010-01-06
ES2386387T3 (es)	2012-08-20
KR101517748B1 (ko)	2015-05-06
SI2121691T1 (sl)	2012-06-29
RU2009135070A (ru)	2011-03-27
CY1112725T1 (el)	2016-02-10

Publication	Publication Date	Title
IL200496A0 (en)	2010-04-29	Spirocyclic cyclohexane derivatives
MY149731A (en)	2013-10-14	Compounds
MX2010009922A (es)	2010-09-28	Activadores de piridazinona glucocinasa.
PL2150530T3 (pl)	2012-03-30	Podstawione pochodne sulfonamidu
TW200806300A (en)	2008-02-01	New therapeutic combinations for the treatment of depression
NZ602754A (en)	2014-05-30	Substituted 1,3-benzothiazepines useful in treating metabolic disorders
CY1108794T1 (el)	2014-04-09	Σπειροκυκλικα παραγωγα κυκλοεξανιου
PH12013500007A1 (en)	2017-05-19	Piperidine derivatives and their use for the treatment of metabolic disorders
TNSN07360A1 (en)	2008-12-31	Substituted pyrrolo-pyridines, composition containing them, method for their producing and use thereof
MX2010009022A (es)	2010-09-07	Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
IN2012DN03182A (pl)	2015-09-25
IL189298A0 (en)	2008-06-05	3.5-disubstituted phenyl-piperidines as modulators of dopamine meurotransmission
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