PL2010563T3 - Sekwencja syntetycznego MECP2 do białkowej terapii substytucyjnej - Google Patents
Sekwencja syntetycznego MECP2 do białkowej terapii substytucyjnejInfo
- Publication number
- PL2010563T3 PL2010563T3 PL06724141T PL06724141T PL2010563T3 PL 2010563 T3 PL2010563 T3 PL 2010563T3 PL 06724141 T PL06724141 T PL 06724141T PL 06724141 T PL06724141 T PL 06724141T PL 2010563 T3 PL2010563 T3 PL 2010563T3
- Authority
- PL
- Poland
- Prior art keywords
- protein
- proteins
- nucleic acid
- relates
- substitution therapy
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 238000002560 therapeutic procedure Methods 0.000 title abstract 3
- 238000006467 substitution reaction Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 4
- 102000006890 Methyl-CpG-Binding Protein 2 Human genes 0.000 abstract 2
- 108010072388 Methyl-CpG-Binding Protein 2 Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 208000006289 Rett Syndrome Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2006/003203 WO2007115578A1 (en) | 2006-04-07 | 2006-04-07 | Synthetic mecp2 sequence for protein substitution therapy |
| EP06724141A EP2010563B1 (en) | 2006-04-07 | 2006-04-07 | Synthetic mecp2 sequence for protein substitution therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2010563T3 true PL2010563T3 (pl) | 2011-11-30 |
Family
ID=36589309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06724141T PL2010563T3 (pl) | 2006-04-07 | 2006-04-07 | Sekwencja syntetycznego MECP2 do białkowej terapii substytucyjnej |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8226930B2 (pl) |
| EP (1) | EP2010563B1 (pl) |
| JP (1) | JP5102283B2 (pl) |
| CN (1) | CN101415726B (pl) |
| AT (1) | ATE500265T1 (pl) |
| AU (1) | AU2006341726B2 (pl) |
| CA (1) | CA2647125C (pl) |
| DE (1) | DE602006020501D1 (pl) |
| DK (1) | DK2010563T3 (pl) |
| ES (1) | ES2362195T3 (pl) |
| HR (1) | HRP20110386T1 (pl) |
| IL (1) | IL194274A (pl) |
| PL (1) | PL2010563T3 (pl) |
| SI (1) | SI2010563T1 (pl) |
| WO (1) | WO2007115578A1 (pl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1398191B1 (it) * | 2010-02-17 | 2013-02-14 | Ist Superiore Sanita | Uso di tossine che attivano le rho gtpasi per il trattamento e/o la prevenzione della sintomatologia associata alla sindrome di rett (rtt). |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| ES2633565T3 (es) | 2010-11-12 | 2017-09-22 | The General Hospital Corporation | ARN no codificantes asociados a polycomb |
| CA2873766A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating atp2a2 expression |
| EP2850185A4 (en) | 2012-05-16 | 2015-12-30 | Rana Therapeutics Inc | COMPOSITIONS AND METHOD FOR MODULATING UTRN GENE EXPRESSION |
| EP2850190B1 (en) | 2012-05-16 | 2020-07-08 | Translate Bio MA, Inc. | Compositions and methods for modulating mecp2 expression |
| AU2013262649A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating smn gene family expression |
| US10174315B2 (en) | 2012-05-16 | 2019-01-08 | The General Hospital Corporation | Compositions and methods for modulating hemoglobin gene family expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| WO2014130408A1 (en) * | 2013-02-20 | 2014-08-28 | The Research Foundation For The State University Of New York | Regulators of rab5 activity |
| CA2966044A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| US10900036B2 (en) | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
| TWI601821B (zh) * | 2016-04-15 | 2017-10-11 | 中央研究院 | 治療神經發展性疾病 |
| US20210268072A1 (en) * | 2016-06-28 | 2021-09-02 | Alma Mater Studiorum - Universitá Di Bologna | TATk-CDKL5 Fusion Proteins, Compositions, Formulations, and Use Thereof |
| US20210101938A1 (en) * | 2017-03-24 | 2021-04-08 | The University Court Of The University Of Edinburgh | Mecp2 based therapy |
| WO2019079462A1 (en) * | 2017-10-17 | 2019-04-25 | President And Fellows Of Harvard College | TRANSCRIPTION MODULATION SYSTEMS BASED ON CAS9 |
| KR102052097B1 (ko) * | 2017-11-30 | 2019-12-05 | 한국과학기술연구원 | Mecp2 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물 |
| CN114026236A (zh) * | 2019-04-24 | 2022-02-08 | 宾夕法尼亚州大学信托人 | 可用于治疗雷特综合征的组合物 |
| WO2023235648A1 (en) * | 2022-06-03 | 2023-12-07 | The Regents Of The University Of California | Nuclear Delivery and Transcriptional Repression with a Cell-penetrant MeCP2 |
| CN119971036A (zh) * | 2023-11-13 | 2025-05-13 | 中国科学院分子细胞科学卓越创新中心 | 核糖核酸酶RNase H修复神经元树突生长缺陷的应用和方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000062067A1 (en) | 1999-02-28 | 2000-10-19 | Washington University | Novel transduction molecules and methods for using same |
| US6709817B1 (en) * | 1999-09-07 | 2004-03-23 | Baylor College Of Medicine | Method of screening Rett syndrome by detecting a mutation in MECP2 |
| WO2002085948A1 (en) | 2001-04-20 | 2002-10-31 | Man-Wook Hur | Repressors for hiv transcription and methods thereof |
| JP5830213B2 (ja) * | 2004-02-17 | 2015-12-09 | ザ ホスピタル フォー シック チルドレン | Ｍｅｃｐ２ｅ１遺伝子 |
-
2006
- 2006-04-07 AT AT06724141T patent/ATE500265T1/de active
- 2006-04-07 CA CA2647125A patent/CA2647125C/en not_active Expired - Fee Related
- 2006-04-07 PL PL06724141T patent/PL2010563T3/pl unknown
- 2006-04-07 SI SI200631023T patent/SI2010563T1/sl unknown
- 2006-04-07 JP JP2009503417A patent/JP5102283B2/ja not_active Expired - Fee Related
- 2006-04-07 CN CN2006800541487A patent/CN101415726B/zh not_active Expired - Fee Related
- 2006-04-07 US US12/295,856 patent/US8226930B2/en not_active Expired - Fee Related
- 2006-04-07 HR HR20110386T patent/HRP20110386T1/hr unknown
- 2006-04-07 DE DE602006020501T patent/DE602006020501D1/de active Active
- 2006-04-07 ES ES06724141T patent/ES2362195T3/es active Active
- 2006-04-07 AU AU2006341726A patent/AU2006341726B2/en not_active Ceased
- 2006-04-07 EP EP06724141A patent/EP2010563B1/en active Active
- 2006-04-07 DK DK06724141.4T patent/DK2010563T3/da active
- 2006-04-07 WO PCT/EP2006/003203 patent/WO2007115578A1/en not_active Ceased
-
2008
- 2008-09-22 IL IL194274A patent/IL194274A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006020501D1 (de) | 2011-04-14 |
| WO2007115578A1 (en) | 2007-10-18 |
| WO2007115578A8 (en) | 2008-10-30 |
| HK1121468A1 (en) | 2009-04-24 |
| EP2010563A1 (en) | 2009-01-07 |
| AU2006341726B2 (en) | 2012-09-20 |
| CN101415726B (zh) | 2013-07-31 |
| ATE500265T1 (de) | 2011-03-15 |
| JP2009532045A (ja) | 2009-09-10 |
| IL194274A (en) | 2011-07-31 |
| HRP20110386T1 (hr) | 2011-08-31 |
| SI2010563T1 (sl) | 2011-07-29 |
| US20090233856A1 (en) | 2009-09-17 |
| DK2010563T3 (da) | 2011-05-23 |
| EP2010563B1 (en) | 2011-03-02 |
| CA2647125A1 (en) | 2007-10-18 |
| CN101415726A (zh) | 2009-04-22 |
| CA2647125C (en) | 2015-02-03 |
| AU2006341726A1 (en) | 2007-10-18 |
| ES2362195T3 (es) | 2011-06-29 |
| JP5102283B2 (ja) | 2012-12-19 |
| US8226930B2 (en) | 2012-07-24 |
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