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MX2022013520A - Polipeptidos que se enlazan a cxcr2. - Google Patents

Polipeptidos que se enlazan a cxcr2.

Info

Publication number
MX2022013520A
MX2022013520A MX2022013520A MX2022013520A MX2022013520A MX 2022013520 A MX2022013520 A MX 2022013520A MX 2022013520 A MX2022013520 A MX 2022013520A MX 2022013520 A MX2022013520 A MX 2022013520A MX 2022013520 A MX2022013520 A MX 2022013520A
Authority
MX
Mexico
Prior art keywords
polypeptides
cxcr2
binding polypeptides
relates
cxcr2 binding
Prior art date
Application number
MX2022013520A
Other languages
English (en)
Inventor
Bruno Dombrecht
Zarin Brown
Michelle Bradley
Steven John Charlton
Karen Cromie
Soren Steffensen
Heeke Gino Van
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of MX2022013520A publication Critical patent/MX2022013520A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a polipéptidos dirigidos contra, o que se enlazan específicamente a, el receptor de quimiocina CXCR2, y en particular a polipéptidos capaces de modular la transducción de señales a partir del CXCR2. La invención también se refiere a ácidos nucleicos, vectores, y células huésped capaces de expresar los polipéptidos de la invención, a composiciones farmacéuticas que comprenden los polipéptidos, y a los usos de estos polipéptidos y composiciones para el tratamiento de las enfermedades que involucran un funcionamiento aberrante del CXCR2.
MX2022013520A 2010-11-08 2013-05-08 Polipeptidos que se enlazan a cxcr2. MX2022013520A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41108310P 2010-11-08 2010-11-08

Publications (1)

Publication Number Publication Date
MX2022013520A true MX2022013520A (es) 2022-11-16

Family

ID=45001722

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013005186A MX343085B (es) 2010-11-08 2011-11-07 Polipeptidos que se enlazan a cxcr2.
MX2022013520A MX2022013520A (es) 2010-11-08 2013-05-08 Polipeptidos que se enlazan a cxcr2.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2013005186A MX343085B (es) 2010-11-08 2011-11-07 Polipeptidos que se enlazan a cxcr2.

Country Status (27)

Country Link
US (3) US8591896B2 (es)
EP (3) EP3575321B1 (es)
JP (2) JP5933573B2 (es)
KR (2) KR101650995B1 (es)
CN (1) CN103328512B (es)
AR (1) AR083784A1 (es)
AU (4) AU2011328246B2 (es)
BR (1) BR112013011003B1 (es)
CA (2) CA2817132C (es)
CL (1) CL2013001168A1 (es)
CO (1) CO6761351A2 (es)
CR (1) CR20130202A (es)
CU (1) CU24111B1 (es)
EA (2) EA202092589A3 (es)
ES (2) ES2723775T3 (es)
GT (1) GT201300113A (es)
IL (1) IL225897B (es)
MA (1) MA34711B1 (es)
MX (2) MX343085B (es)
NZ (1) NZ610075A (es)
PE (1) PE20140772A1 (es)
PH (1) PH12013500910A1 (es)
SG (1) SG189981A1 (es)
TW (2) TWI619730B (es)
UA (1) UA115027C2 (es)
UY (1) UY33714A (es)
WO (1) WO2012062713A1 (es)

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WO2014170317A1 (en) * 2013-04-17 2014-10-23 Morphosys Ag Antibodies targeting specifically human cxcr2
CN103396482B (zh) * 2013-05-17 2016-08-10 东南大学 一种前白蛋白纳米抗体、其编码序列及应用
US10017559B2 (en) 2013-11-04 2018-07-10 INSERM (Institut National de la Santé et de la Recherche Médicale Synthetic single domain antibody
WO2015189162A1 (en) * 2014-06-09 2015-12-17 Theranyx Single-domain antibodies directed against a cys-loop receptor and methods for obtaining them
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MX2019008827A (es) * 2017-01-30 2019-09-26 Alexion Pharma Inc Anticuerpos anti-properdina monovalentes y fragmentos de anticuerpo.
US11053319B2 (en) 2017-02-27 2021-07-06 Monash University CXCR2 antibodies and uses thereof
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US20220332835A1 (en) * 2019-09-04 2022-10-20 Shanghaitech University Anti-cxcr2 antibodies and uses thereof
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US20230271940A1 (en) 2020-08-03 2023-08-31 Novartis Ag Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
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EP4573120A1 (en) * 2022-08-15 2025-06-25 MBrace Therapeutics, Inc. Cell-free methods of producing antibodies to intracellular targets
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TW202517677A (zh) * 2023-07-07 2025-05-01 大陸商深圳市生葆生物科技有限公司 降低腫瘤內嗜中性球水平的抗腫瘤細菌
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