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WO2005018629A1 - Treatment for acne vulgaris and method of use - Google Patents

Treatment for acne vulgaris and method of use Download PDF

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Publication number
WO2005018629A1
WO2005018629A1 PCT/US2003/025207 US0325207W WO2005018629A1 WO 2005018629 A1 WO2005018629 A1 WO 2005018629A1 US 0325207 W US0325207 W US 0325207W WO 2005018629 A1 WO2005018629 A1 WO 2005018629A1
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WO
WIPO (PCT)
Prior art keywords
treatment
acne vulgaris
ethoxylate
composition
exchanged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/025207
Other languages
French (fr)
Inventor
William M. Yarbrough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/US2003/025207 priority Critical patent/WO2005018629A1/en
Priority to AU2003264053A priority patent/AU2003264053A1/en
Priority to JP2005508238A priority patent/JP2007521234A/en
Priority to CA002535550A priority patent/CA2535550A1/en
Priority to EP03818329A priority patent/EP1656128A4/en
Publication of WO2005018629A1 publication Critical patent/WO2005018629A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a composition including surfactants for the treatment of acne vulgaris. Methods of use are also included ⁇ . BACKGROUND OF THE INVENTION AND PRIOR ART Acne vulgaris (or "acne") is a disorder of the sebaceous glands. It is characterized by lesions that are either non-inflammatory or inflammatory papules and nodules. Non-inflammatory papules may be open, commonly referred to as “blackheads", or closed, commonly referred to as “whiteheads”. As a group, non- inflammatory papules are called comedones.
  • a topical treatment for acne 5 vulgaris a topical treatment for acne 5 vulgaris.
  • a method is provided for applying a composition of 6 substances to the infected area, working the composition into the infected area, and 7 removing the composition from the infected area.
  • the composition comprises at least 8 one ethoxylate in combination with Sodium Lauroyl Sarcosinate (or "SLS").
  • SLS Sodium Lauroyl Sarcosinate
  • An inert 9 scrubbing agent such as polyethylene beads, can also be included to the formula.
  • Acetylated lanolin alcohol, a second ethoxylate, EDTA, a foam stabilizer, and water can 11 also be added to the composition without effecting performance.
  • Other formulas that keep the polarity similar to that of the inventive formula will 13 also work. To keep the polarity similar, it is necessary for the compound to have similar 14 characteristics, such as Carbon chains, carbonyl groups, Nitrogen bound to Carbon, 15 Aromatic ring(s), Oxylate groups, and appropriate functional groups at the ends of the 16 individual molecules.
  • the ideal substitute chemicals would have all of the characteristics 17 mentioned above, but it is not necessary to have every one of those as listed.
  • the cutting agent must be added only in 2 sufficient amount that it promotes flow but does not effect the action of the composition. 3
  • an sufficient amount of the composition is used to cover the infected area, 4 the composition is applied to an infected area and worked over the area by a scrubbing 5 motion. After sufficient time has elapsed to ensure that the infected area has been 6 adequately exposed to the composition such that they area feels clean, approximately ten 7 to thirty seconds for the typical person, the area is rinsed cleaned.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

A treatment for Acne Vulgaris is provided for in a topical treatment. According to the invention, a method is provided for applying composition substances to the infected area, working the composition into the infected area, and removing the composition from the infected area. The composition comprises at least one ethoxylate in combination with Sodium Lauroyl Sarcosinate. Alternatively, the ethoxylate can be exchanged for a methoxylate or a propoxylate. An inert scrubbing agent, such as polyethylene beads, can also be included. Acetylated lanolin alcohol, sodium Lauroyl Sarcosinate, EDTA, a foam stabilizer, and water can also be added to the composition to assist performance.

Description

Invention: Treatment for Acne Vulgaris and Method of Use Inventor: William M. Yarbrough I. FIELD OF THE INVENTION The present invention relates to a composition including surfactants for the treatment of acne vulgaris. Methods of use are also included π. BACKGROUND OF THE INVENTION AND PRIOR ART Acne vulgaris (or "acne") is a disorder of the sebaceous glands. It is characterized by lesions that are either non-inflammatory or inflammatory papules and nodules. Non-inflammatory papules may be open, commonly referred to as "blackheads", or closed, commonly referred to as "whiteheads". As a group, non- inflammatory papules are called comedones. Closed comedones can lead to inflammatory nodules, papules, and pustules. Severe cases of acne vulgaris can lead to scars characterized by pitting. It is believed that acne results from partial rupture of a partially inflamed follicle. The follicle then spills its components, thereby resulting in the development of a perifollicular inflammatory process. Generally, fresh lesions are sterile, but later gram- positive diptheroids are present. Many times the skin will have a greasy look to it; this is probably due, at least in part, to the release of fatty acids during lipolysis induced by P. acnes. Acne can be a serious problem. It generally manifests itself during adolescence and spontaneously resolves in the late teens or early twenties; although for some, it can be a life long problem. Mild to moderate acne is most often treated with topical agents. INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 More severe cases are treated with incision and drainage of lesions, ultraviolet light 2 therapy, and systemic antibiotics. 3 The prior art is replete with compositions for use in the treatment of acne. 4 Topical agents, such as benzoyl peroxide, are thought to decrease bacteria and are often 5 used in the treatment of acne. These treatments are found in many forms, lotions, gels, 6 pads, etc. and are generally available over the counter. Retinol in various forms has been 7 more recently proposed by various Inventors. There are also many soaps used in the 8 treatment of acne. A major shortcoming of most of the prior art is that they often do not 9 penetrate sufficiently and they leave the skin dry. 10 H. OBJECTS OF THE INVENTION 11 It is an object of the present invention to provide a treatment that helps to alleviate 12 the local signs and symptoms caused by acne vulgaris. 13 It is a further object of the present invention to provide a method of use of the 14 present inventive treatment. 15 It is yet another object of the present invention to provide a treatment that 16 includes at least a first nonyl phenyl ethoxylate and sodium lauroyl sarcosinate to which a 17 second nonyl phenyl ethoxylate, acetylated lanolin alcohol, EDTA, a foam stabilizer, 18 water, and inert polyethylene granules can be added without altering the effectiveness of 19 the treatment. 20 It is a yet further object of the present invention to provide a treatment that is safe 21 to use. INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 It is yet another object of the present invention to provide such treatment that is 2 topical, can be purchased over the counter, and is economical. 3 TV. SUMMARY OF THE INVENTION 4 The above objects of the invention are provided for in a topical treatment for acne 5 vulgaris. According to the invention, a method is provided for applying a composition of 6 substances to the infected area, working the composition into the infected area, and 7 removing the composition from the infected area. The composition comprises at least 8 one ethoxylate in combination with Sodium Lauroyl Sarcosinate (or "SLS"). An inert 9 scrubbing agent, such as polyethylene beads, can also be included to the formula. 10 Acetylated lanolin alcohol, a second ethoxylate, EDTA, a foam stabilizer, and water can 11 also be added to the composition without effecting performance. 12 Other formulas that keep the polarity similar to that of the inventive formula will 13 also work. To keep the polarity similar, it is necessary for the compound to have similar 14 characteristics, such as Carbon chains, carbonyl groups, Nitrogen bound to Carbon, 15 Aromatic ring(s), Oxylate groups, and appropriate functional groups at the ends of the 16 individual molecules. The ideal substitute chemicals would have all of the characteristics 17 mentioned above, but it is not necessary to have every one of those as listed. For 18 example, if the functional groups at the ends of the individual molecules are exchanged 19 for other functional groups that retain the ability to undergo an emulsion polymerization, 20 then the effectiveness of the compound is also retained. Another example is to change the 21 ethoxylate to a methoxylate or propoxylate. These formations would still retain a similar INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 polarity but would be different compounds with different characteristics. Yet another 2 example would be to exchange triply bound Nitrogen with a doubly bound or perhaps 3 Nitrogen with 4 Carbons bound to it. 4 V. DETAILED DESCRIPTION OF THE INVENTION 5 Chemical analysis and research has revealed that two of the component parts of 6 the inventive composition are principally involved in its effectiveness as an acne 7 treatment: an ethoxylate and Sodium Lauroyl Sarcosinate ("SLS"). The ethoxylate is 8 preferably a nonyl phenol ethoxylate. 9 The Inventor has also found, however, that other formulas that keep the polarity 10 similar to that of the inventive formula will also work. To keep the polarity similar, it is 11 necessary for the compound to have similar characteristics, such as Carbon chains, 12 carbonyl groups, Nitrogen bound to Carbon, Aromatic ring(s), Oxylate groups, and 13 appropriate functional groups at the ends of the individual molecules. The ideal 14 substitute chemicals would have all of the characteristics mentioned above, but it is not 15 necessary to have every one of those as listed. For example, if the functional groups at the 16 ends of the individual molecules are exchanged for other functional groups that retain the 17 ability to undergo an emulsion polymerization, then the effectiveness of the compound is 18 also retained. Another example is to change the ethoxylate to a methoxylate or 19 propoxylate. These formations would still retain a similar polarity but would be different 20 compounds with different characteristics. Yet another example would be to exchange INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 triply bound Nitrogen with a doubly bound or perhaps Nitrogen with 4 Carbons bound to 2 it. 3 The inventor has also discovered that the addition of an inert scrubbing agent 4 improves the action of the inventive composition. The beads should be large enough to 5 be effective but not so large as to cause abrasions. The inventor suggests beads in the 6 range of 5 to 50 microns with an average size being approximately 25 microns or 50 7 mesh. 8 To make the inventive composition, an exact ratio of ethoxylate to SLS is not 9 critical. The only requirement is that the ethoxylate is completely reacted with the SLS, 10 creating a polymer. This will vary with the ethoxylate used, but the Inventor has 11 determined that a ratio of ethoxylate-to- SLS of 1.5:2 is preferred. The amount by weight 12 of polyethylene beads can vary according to the grittiness desired. The Inventor has 13 found that a formula of ethoxylate: SLS .polyethylene of 40:20:40 is preferred but that 14 formulas of other concentrations are useful. Thus, for production purposes, formulas 15 having SLS ranging from 10 to 20 % by weight, ethoxylate ranging from 20 to 40 % by 16 weight, and polyethylene beads from 20 to 50% by weight are reasonable. But again, the 17 formula is not restricted to these ranges, which ranges are presented for example purposes 18 only. 19 Also, a cutting agent that does not chemically react with the composition may be 20 added. The cutting agent makes the overall composition flow more easily, thereby INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 enabling more packaging options, such as tubes. The cutting agent must be added only in 2 sufficient amount that it promotes flow but does not effect the action of the composition. 3 In use, an sufficient amount of the composition is used to cover the infected area, 4 the composition is applied to an infected area and worked over the area by a scrubbing 5 motion. After sufficient time has elapsed to ensure that the infected area has been 6 adequately exposed to the composition such that they area feels clean, approximately ten 7 to thirty seconds for the typical person, the area is rinsed cleaned.

Claims

INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 CLAIMS 2 I CLAIM: 3 1. A Treatment for Acne Vulgaris comprising sodium lauroyl sarcosinate and a 4 nonyl phenyl ethoxylate in combination. 5 6 2. The treatment for Acne Vulgaris of Claim 1 further including a second nonyl 7 phenyl ethoxylate. 8 9 3. The treatment for Acne Vulgaris of Claim 1 further including acetylated lanolin 10 alcohol. 11 12 4. The treatment for Acne Vulgaris of Claim 1 further including polyethylene 13 granules. 14 15 5. The treatment for Acne Vulgaris of Claim 1 further including water. 16 17 6. The treatment for Acne Vulgaris of Claim 1 further including 18 ethylenediaminetetraacetic acid. 19 20 7. The treatment for Acne Vulgaris of Claim 1 further including a foam stabilizing 21 agent. INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 2 8. The treatment for Acne Vulgaris of Claim 1 further including a cutting agent. 3 4 9. The cutting agent of Claim 8 being selected from the group of aqueous based 5 solutions and oil based solutions. 6 7 10. The treatment for Acne Vulgaris of Claim 1 wherein the ethoxylate is exchanged 8 for a methoxylate. 9 10 11. The treatment for Acne Vulgaris of Claim 1 wherein the ethoxylate is exchanged 11 for a propoxylate. 12 13 12. A treatment for Acne Vulgaris comprising an ethoxylate, sodium lauroyl 14 sarcosinate, and scrubbing means. 15 16 13. The treatment for Acne Vulgaris of Claim 12 wherein the scrubbing mean is 17 polyethylene beads. 18 19 14. The treatment for Acne Vulgaris of Claim 12 further including a cutting agent. 20 INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 15. The treatment for Acne Vulgaris of Claim 12 wherein the ethoxylate is exchanged 2 for a methoxylate. 3 4 16. The treatment for Acne Vulgaris of Claim 12 wherein the ethoxylate is exchanged 5 for a propoxylate. 6 7 17. A treatment for Acne Vulgaris comprising: a first ethoxylate, a second ethoxylate, 8 acetylated lanolin alcohol, sodium lauroyl sarcosinate, EDTA, a foam stabilizer, water, 9 and inert polyethylene granules. 10 11 18. The treatment for Acne Vulgaris of Claim 17 wherein the first ethoxylate is 12 exchanged for a methoxylate. 13 14 19. The treatment for Acne Vulgaris of Claim 17 wherein the first ethoxylate is 15 exchanged for a propoxylate. 16 17 20. A treatment for Acne Vulgaris comprising an ethoxylate, sodium lauroyl 18 sarcosinate, and EDTA. 19 20 21. The treatment for Acne Vulgaris of Claim 20 wherein the ethoxylate is exchanged 21 for a methoxylate. INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 2 22. The treatment for Acne Vulgaris of Claim 20 wherein the ethoxylate is exchanged 3 for a propoxylate. 4 5 23. A method for treating Acne Vulgaris comprising the steps of: 6 preparing a composition comprising an ethoxylate and sodium lauroyl 7 sarcosinate; 8 applying the composition to an infected area; 9 permitting the composition to remain on the infected area a sufficient 10 amount of time to enable the composition of matter to cause an effect; and, 11 removing the composition from the infected area. 12 13 24. The method of Claim 23 wherein preparing the composition further includes 14 adding second ethoxylate. 15 16 25. The method of Claim 23 wherein preparing the composition further includes 17 adding acetylated lanolin alcohol. 18 19 26. The method of Claim 23 wherein preparing the composition further includes 20 adding acetylated polyethylene granules. 21 INVENTION: Treatment for Acne Vulgaris Treatment and Method of Use
INVENTOR: William Yarbrough
1 27. The method of Claim 23 wherein preparing the composition further includes 2 adding water. 3 4 28. The method of Claim 23 wherein preparing the composition further includes 5 EDTA. 6 7 29. The method of Claim 23 wherein preparing the composition further includes a 8 foam stabilizer. 9 10 30. The method of Claim 23 further including the step of adding a thinning agent to 11 the composition. 12 13 31. The method of Claim 23 wherein the ethoxylate is exchanged for a methoxylate. 14 15 32. The method of Claim 23 wherein the ethoxylate is exchanged for a propoxylate.
PCT/US2003/025207 2003-08-12 2003-08-12 Treatment for acne vulgaris and method of use Ceased WO2005018629A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PCT/US2003/025207 WO2005018629A1 (en) 2003-08-12 2003-08-12 Treatment for acne vulgaris and method of use
AU2003264053A AU2003264053A1 (en) 2003-08-12 2003-08-12 Treatment for acne vulgaris and method of use
JP2005508238A JP2007521234A (en) 2003-08-12 2003-08-12 Therapeutic agent and method of use for acne vulgaris
CA002535550A CA2535550A1 (en) 2003-08-12 2003-08-12 Treatment for acne vulgaris and method of use
EP03818329A EP1656128A4 (en) 2003-08-12 2003-08-12 Treatment for acne vulgaris and method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/025207 WO2005018629A1 (en) 2003-08-12 2003-08-12 Treatment for acne vulgaris and method of use

Publications (1)

Publication Number Publication Date
WO2005018629A1 true WO2005018629A1 (en) 2005-03-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025207 Ceased WO2005018629A1 (en) 2003-08-12 2003-08-12 Treatment for acne vulgaris and method of use

Country Status (5)

Country Link
EP (1) EP1656128A4 (en)
JP (1) JP2007521234A (en)
AU (1) AU2003264053A1 (en)
CA (1) CA2535550A1 (en)
WO (1) WO2005018629A1 (en)

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US9512236B2 (en) 2006-12-19 2016-12-06 Ablynx N.V. Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
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