PL2073805T3 - Sposoby dawkowania 1,2,3-oksadiazolu aktywnego po podaniu doustnym w terapii supresyjnej mutacji nonsensownej - Google Patents

Sposoby dawkowania 1,2,3-oksadiazolu aktywnego po podaniu doustnym w terapii supresyjnej mutacji nonsensownej

Info

Publication number: PL2073805T3
Authority: PL; Poland
Prior art keywords: oxadiazole; dosing; methods; nonsense mutation; orally active
Prior art date: 2006-10-12

Application number

PL07852738T

Other languages

English (en)

Inventor

Samit Hirawat

Langdon Miller

Original Assignee

Ptc Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-12

Filing date

2007-10-11

Publication date

2015-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39102963&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2073805(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-10-11 Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc

2015-08-31 Publication of PL2073805T3 publication Critical patent/PL2073805T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Immunology (AREA)
Neurology (AREA)
Diabetes (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)

PL07852738T 2006-10-12 2007-10-11 Sposoby dawkowania 1,2,3-oksadiazolu aktywnego po podaniu doustnym w terapii supresyjnej mutacji nonsensownej PL2073805T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US85145006P	2006-10-12	2006-10-12
EP07852738.9A EP2073805B1 (en)	2006-10-12	2007-10-11	Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
PCT/US2007/021921 WO2008045566A1 (en)	2006-10-12	2007-10-11	Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

Publications (1)

Publication Number	Publication Date
PL2073805T3 true PL2073805T3 (pl)	2015-08-31

Family

ID=39102963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07852738T PL2073805T3 (pl)	2006-10-12	2007-10-11	Sposoby dawkowania 1,2,3-oksadiazolu aktywnego po podaniu doustnym w terapii supresyjnej mutacji nonsensownej

Country Status (23)

Country	Link
US (7)	US9226919B2 (pl)
EP (2)	EP2073805B1 (pl)
JP (4)	JP2010506840A (pl)
KR (4)	KR20160128468A (pl)
CN (2)	CN103211766B (pl)
AU (1)	AU2007308067B2 (pl)
BR (2)	BR122019020961B8 (pl)
CA (1)	CA2675518C (pl)
CL (1)	CL2007002923A1 (pl)
DK (1)	DK2073805T3 (pl)
ES (1)	ES2538359T3 (pl)
HR (1)	HRP20150590T1 (pl)
IL (2)	IL198147A (pl)
MX (1)	MX2009003909A (pl)
NO (1)	NO342061B1 (pl)
PE (4)	PE20120670A1 (pl)
PL (1)	PL2073805T3 (pl)
PT (1)	PT2073805E (pl)
RS (1)	RS54025B1 (pl)
RU (1)	RU2462247C2 (pl)
SI (1)	SI2073805T1 (pl)
TW (1)	TWI405570B (pl)
WO (1)	WO2008045566A1 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6992096B2 (en)	2003-04-11	2006-01-31	Ptc Therapeutics, Inc.	1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
SG170819A1 (en)	2006-03-30	2011-05-30	Ptc Therapeutics Inc	Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
EP2073805B1 (en)	2006-10-12	2015-03-04	PTC Therapeutics, Inc.	Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
US9945862B2 (en)	2011-06-03	2018-04-17	Eisai R&D Management Co., Ltd.	Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US9873677B2 (en) *	2014-03-06	2018-01-23	Ptc Therapeutics, Inc.	Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
CN106660964B (zh)	2014-08-28	2021-09-03	卫材R&D管理有限公司	高纯度喹啉衍生物及其生产方法
PL3263106T3 (pl) *	2015-02-25	2024-04-02	Eisai R&D Management Co., Ltd.	Sposób tłumienia goryczy pochodnej chinoliny
ES2886107T3 (es)	2015-06-16	2021-12-16	Prism Biolab Co Ltd	Antineoplásico
AU2016309356B2 (en)	2015-08-20	2021-06-24	Eisai R&D Management Co., Ltd.	Tumor therapeutic agent
MX2018005361A (es)	2015-10-30	2018-06-07	Ptc Therapeutics Inc	Metodos para tratar epilepsia.
MX380144B (es)	2017-02-08	2025-03-12	Eisai R&D Man Co Ltd	Composicion farmaceutica de tratamiento de tumores.
CA3061888A1 (en)	2017-05-16	2018-11-22	Eisai R&D Management Co., Ltd.	Treatment of hepatocellular carcinoma
CA3079508A1 (en)	2017-10-19	2019-04-25	Cipla USA, Inc	Synthesis of antibacterial aminoglycoside analogs
WO2019101709A1 (en)	2017-11-23	2019-05-31	Universita' Degli Studi Di Palermo	Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
CN114007608A (zh)	2019-04-10	2022-02-01	Ptc医疗公司	在儿科患者中治疗无义突变介导的杜氏肌营养不良症的方法
WO2022177267A1 (ko) *	2021-02-16	2022-08-25	라이보텍(주)	넌센스-매개 mrna 분해를 억제하기 위한 화합물
KR102378381B1 (ko) *	2021-08-23	2022-03-24	라이보텍(주)	넌센스-매개 mRNA 분해를 억제하기 위한 화합물
EP4337267A1 (en) *	2021-05-11	2024-03-20	RegenxBio Inc.	Treatment of duchenne muscular dystrophy and combinations thereof
KR102665711B1 (ko) *	2021-12-21	2024-05-14	재단법인 아산사회복지재단	Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물
CN119638642A (zh) *	2023-12-12	2025-03-18	暨南大学	双环类化合物及其药物组合物和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6660753B2 (en)	1999-08-19	2003-12-09	Nps Pharmaceuticals, Inc.	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1406632A4 (en)	2001-06-08	2009-11-04	Cytovia Inc	SUBSTITUTED 3-ARYL-5-ARYL-1,2,4-OXADIAZOLE AND ANALOGUE AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCTORS AND THEIR USE
MY151199A (en)	2001-11-02	2014-04-30	Rigel Pharmaceuticals Inc	Substituted diphenyl heterocycles useful for treating hcv infection
JP2006506340A (ja)	2002-08-09	2006-02-23	アストラゼネカアクチボラグ	代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール
GB0303503D0 (en)	2003-02-14	2003-03-19	Novartis Ag	Organic compounds
US6992096B2 (en) *	2003-04-11	2006-01-31	Ptc Therapeutics, Inc.	1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
WO2004110351A2 (en)	2003-05-14	2004-12-23	Anadys Pharmaceuticals, Inc.	Heterocyclic compounds for treating hepatitis c virus
JP2007516297A (ja) *	2003-12-23	2007-06-21	アルザ・コーポレーシヨン	制御送達用薬剤組成物の溶解度を高くする方法および投薬形態物
PT1874306E (pt) *	2005-04-08	2012-10-11	Ptc Therapeutics Inc	Composições de um 1,2,4-oxadiazole oralmente activo para terapia de supressão de mutações sem sentido (ou nonsense)
US20070010553A1 (en)	2005-07-01	2007-01-11	Astrazeneca Ab	New use
CN101535284B (zh)	2006-09-08	2014-12-10	Ptc医疗公司	制备1,2,4-噁二唑苯甲酸的方法
DK2076501T3 (da)	2006-09-25	2016-02-29	Ptc Therapeutics Inc	Krystallinske former af 3-[5-(2-fluorphenyl)-[1,2,4]oxadiazol-3-yl]-benzoesyre
EP2073805B1 (en)	2006-10-12	2015-03-04	PTC Therapeutics, Inc.	Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

2007
- 2007-10-11 EP EP07852738.9A patent/EP2073805B1/en active Active
- 2007-10-11 PT PT78527389T patent/PT2073805E/pt unknown
- 2007-10-11 EP EP12152282.5A patent/EP2460520B1/en active Active
- 2007-10-11 MX MX2009003909A patent/MX2009003909A/es active IP Right Grant
- 2007-10-11 KR KR1020167030361A patent/KR20160128468A/ko not_active Ceased
- 2007-10-11 JP JP2009532453A patent/JP2010506840A/ja active Pending
- 2007-10-11 CN CN201310098430.7A patent/CN103211766B/zh not_active Expired - Fee Related
- 2007-10-11 KR KR1020177023924A patent/KR20170100072A/ko not_active Ceased
- 2007-10-11 HR HRP20150590TT patent/HRP20150590T1/hr unknown
- 2007-10-11 AU AU2007308067A patent/AU2007308067B2/en not_active Ceased
- 2007-10-11 ES ES07852738.9T patent/ES2538359T3/es active Active
- 2007-10-11 SI SI200731657T patent/SI2073805T1/sl unknown
- 2007-10-11 US US11/974,068 patent/US9226919B2/en active Active
- 2007-10-11 BR BR122019020961A patent/BR122019020961B8/pt active IP Right Grant
- 2007-10-11 CA CA2675518A patent/CA2675518C/en active Active
- 2007-10-11 KR KR1020157013882A patent/KR101758341B1/ko not_active Expired - Fee Related
- 2007-10-11 WO PCT/US2007/021921 patent/WO2008045566A1/en not_active Ceased
- 2007-10-11 CL CL200702923A patent/CL2007002923A1/es unknown
- 2007-10-11 BR BRPI0719276-2A2A patent/BRPI0719276A2/pt not_active Application Discontinuation
- 2007-10-11 DK DK07852738.9T patent/DK2073805T3/da active
- 2007-10-11 KR KR1020097009602A patent/KR20090074231A/ko not_active Ceased
- 2007-10-11 RU RU2009117590/15A patent/RU2462247C2/ru active
- 2007-10-11 PL PL07852738T patent/PL2073805T3/pl unknown
- 2007-10-11 CN CN200780045655.9A patent/CN101553226B/zh not_active Expired - Fee Related
- 2007-10-11 RS RS20150384A patent/RS54025B1/sr unknown
- 2007-10-12 TW TW096138340A patent/TWI405570B/zh not_active IP Right Cessation
- 2007-10-12 PE PE2011001559A patent/PE20120670A1/es not_active Application Discontinuation
- 2007-10-12 PE PE2007001386A patent/PE20080982A1/es not_active Application Discontinuation
- 2007-10-12 PE PE2016000659A patent/PE20160947A1/es unknown
- 2007-10-12 PE PE2020002230A patent/PE20212245A1/es unknown
2009
- 2009-04-16 IL IL198147A patent/IL198147A/en active IP Right Grant
- 2009-05-08 NO NO20091826A patent/NO342061B1/no unknown
2013
- 2013-10-25 JP JP2013222531A patent/JP6129713B2/ja not_active Expired - Fee Related
2014
- 2014-12-30 IL IL236519A patent/IL236519A/en active IP Right Grant
2015
- 2015-10-08 JP JP2015200029A patent/JP6333227B2/ja not_active Expired - Fee Related
- 2015-12-17 US US14/972,269 patent/US9522137B2/en not_active Expired - Fee Related
2016
- 2016-11-08 US US15/345,748 patent/US9737513B2/en not_active Expired - Fee Related
- 2016-12-08 JP JP2016238230A patent/JP2017081946A/ja active Pending
2017
- 2017-07-07 US US15/643,724 patent/US9877952B2/en active Active
2018
- 2018-01-19 US US15/875,296 patent/US10172836B2/en active Active
- 2018-12-04 US US16/208,663 patent/US10849885B2/en not_active Expired - Fee Related
2020
- 2020-10-23 US US17/078,092 patent/US20210038572A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN103211766B (zh)	2015-03-11
US9522137B2 (en)	2016-12-20
TW200820968A (en)	2008-05-16
US9226919B2 (en)	2016-01-05
PE20212245A1 (es)	2021-11-24
RS54025B1 (sr)	2015-10-30
US20080114039A1 (en)	2008-05-15
CA2675518A1 (en)	2008-04-17
US20190099405A1 (en)	2019-04-04
US10849885B2 (en)	2020-12-01
CN103211766A (zh)	2013-07-24
AU2007308067B2 (en)	2013-05-30
US9737513B2 (en)	2017-08-22
EP2460520A1 (en)	2012-06-06
EP2073805A1 (en)	2009-07-01
TWI405570B (zh)	2013-08-21
JP2010506840A (ja)	2010-03-04
IL236519A0 (en)	2015-02-26
US20210038572A1 (en)	2021-02-11
US20170049752A1 (en)	2017-02-23
CN101553226A (zh)	2009-10-07
CA2675518C (en)	2017-11-14
AU2007308067A1 (en)	2008-04-17
KR20170100072A (ko)	2017-09-01
BR122019020961B1 (pt)	2021-03-09
PE20080982A1 (es)	2008-07-19
PT2073805E (pt)	2015-07-13
WO2008045566B1 (en)	2008-06-19
JP2014058533A (ja)	2014-04-03
NO20091826L (no)	2009-07-08
RU2462247C2 (ru)	2012-09-27
NO342061B1 (no)	2018-03-19
US20170304275A1 (en)	2017-10-26
US20160101087A1 (en)	2016-04-14
JP2017081946A (ja)	2017-05-18
EP2073805B1 (en)	2015-03-04
ES2538359T3 (es)	2015-06-19
HK1170690A1 (en)	2013-03-08
BR122019020961B8 (pt)	2021-07-27
PE20120670A1 (es)	2012-06-01
HK1136214A1 (en)	2010-06-25
MX2009003909A (es)	2009-05-25
JP2016029078A (ja)	2016-03-03
KR20150064244A (ko)	2015-06-10
US9877952B2 (en)	2018-01-30
EP2460520B1 (en)	2015-09-30
IL198147A0 (en)	2009-12-24
BRPI0719276A2 (pt)	2014-04-29
JP6333227B2 (ja)	2018-05-30
KR20090074231A (ko)	2009-07-06
CL2007002923A1 (es)	2008-06-06
JP6129713B2 (ja)	2017-05-17
KR20160128468A (ko)	2016-11-07
IL198147A (en)	2016-02-29
RU2009117590A (ru)	2010-11-20
US10172836B2 (en)	2019-01-08
IL236519A (en)	2017-03-30
US20180140583A1 (en)	2018-05-24
CN101553226B (zh)	2015-05-13
PE20160947A1 (es)	2016-09-26
KR101758341B1 (ko)	2017-07-14
WO2008045566A1 (en)	2008-04-17
SI2073805T1 (sl)	2015-10-30
HRP20150590T1 (hr)	2015-07-03
DK2073805T3 (da)	2015-06-15

Publication	Publication Date	Title
IL236519A0 (en)	2015-02-26	Dosing methods of active 4,2,1-oxadiazole in oral administration to suppress non-sense mutation
IL236518A0 (en)	2015-02-26	Compounds of active 4,2,1-oxadiazole for oral administration for the treatment of suppression of nonsense mutation
IL182459A0 (en)	2007-07-24	Compounds for nonsense suppression, and methods for their use
IL251539A0 (en)	2017-05-29	Single pharmaceutical dosage form
PL2058020T3 (pl)	2013-03-29	Urządzenie do podawania leków
SI2464337T1 (sl)	2019-05-31	Formulacija tablete N-(2,4-bis(1,1-dimetiletil)-5-hidroksifenil)-1,4-dihidro-4-oksokinolin -3-karboksamida za uporabo v zdravljenju cistične fibroze
IL222557A (en)	2016-09-29	A compound for use in treating mutant disorders has ruled
PL2059243T3 (pl)	2013-09-30	Buprenorfina w opłatku do farmakologicznego leczenia substytucyjnego
AU315345S (en)	2007-07-25	Gaming machine
ZA201003963B (en)	2011-11-30	Oxadiazole derivatives active on sphingosine-1-phosphate (sip)
SI2043944T1 (sl)	2012-11-30	Obdelovalni stroj
IL185889A0 (en)	2008-01-06	Dispenser for delivering medicament
IL193094A0 (en)	2011-08-01	Improved antitumoral treatments
AU310941S (en)	2006-10-25	Gaming machine
SG138565A1 (en)	2008-01-28	Punctal plugs for the delivery of active agents
SG138567A1 (en)	2008-01-28	Punctal plugs for the delivery of active agents
IL199239A0 (en)	2010-03-28	Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-
GB0616794D0 (en)	2006-10-04	Solid dosage form
EP2023894A4 (en)	2010-10-20	FIXED COMBINATION DOSAGE FOR TREATING MIGRAINE
SG138564A1 (en)	2008-01-28	Punctal plugs for the delivery of active agents
ZA200809554B (en)	2010-01-27	3-(pyridin-2-yl)-[1,2,4]-triazines for use as fungicides
AU2006904946A0 (en)	2006-09-21	Improved floor treatment machine
GB0612429D0 (en)	2006-08-02	Vibrating gaming chair
HK1105599A (zh)	2008-02-22	用於输送药物的给药器
AU2006905385A0 (en)	2006-10-12	Personal Care Vending Machine