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NO20091826L - Fremgangsmater for dosering av oralt aktive 1,2,4-oksadiazol for nonsense mutasjonsuppresjonsterapi - Google Patents

Fremgangsmater for dosering av oralt aktive 1,2,4-oksadiazol for nonsense mutasjonsuppresjonsterapi

Info

Publication number
NO20091826L
NO20091826L NO20091826A NO20091826A NO20091826L NO 20091826 L NO20091826 L NO 20091826L NO 20091826 A NO20091826 A NO 20091826A NO 20091826 A NO20091826 A NO 20091826A NO 20091826 L NO20091826 L NO 20091826L
Authority
NO
Norway
Prior art keywords
oxadiazole
nonsense
mutational
repression
therapy
Prior art date
Application number
NO20091826A
Other languages
English (en)
Other versions
NO342061B1 (no
Inventor
Samit Hirawat
Langdon Miller
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39102963&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20091826(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of NO20091826L publication Critical patent/NO20091826L/no
Publication of NO342061B1 publication Critical patent/NO342061B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

Den foreliggende oppfinnelsen er relatert til spesifikke doser av og doseringsregimer for å benytte en 1,2,4-oksadiazolbenzosyreforbindelse i behandling eller forebygging av sykdommer assosiert med nonsense-mutasjoner. Spesielt er oppfinnelsen relatert til spesifikke doser og doseringsregimer for anvendelsen av 3-[5-(2-fluorfenyl)-[1,2,4]oksadiazol-3-yl]-benzosyre i pattedyr som har sykdommer assosiert med nonsense-mutasjoner.
NO20091826A 2006-10-12 2009-05-08 Forbindelse for behandling, forebygging eller håndtering av Duchenne muskulær dystrofi NO342061B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85145006P 2006-10-12 2006-10-12
PCT/US2007/021921 WO2008045566A1 (en) 2006-10-12 2007-10-11 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

Publications (2)

Publication Number Publication Date
NO20091826L true NO20091826L (no) 2009-07-08
NO342061B1 NO342061B1 (no) 2018-03-19

Family

ID=39102963

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091826A NO342061B1 (no) 2006-10-12 2009-05-08 Forbindelse for behandling, forebygging eller håndtering av Duchenne muskulær dystrofi

Country Status (23)

Country Link
US (7) US9226919B2 (no)
EP (2) EP2073805B1 (no)
JP (4) JP2010506840A (no)
KR (4) KR20090074231A (no)
CN (2) CN103211766B (no)
AU (1) AU2007308067B2 (no)
BR (2) BR122019020961B8 (no)
CA (1) CA2675518C (no)
CL (1) CL2007002923A1 (no)
DK (1) DK2073805T3 (no)
ES (1) ES2538359T3 (no)
HR (1) HRP20150590T1 (no)
IL (2) IL198147A (no)
MX (1) MX2009003909A (no)
NO (1) NO342061B1 (no)
PE (4) PE20160947A1 (no)
PL (1) PL2073805T3 (no)
PT (1) PT2073805E (no)
RS (1) RS54025B1 (no)
RU (1) RU2462247C2 (no)
SI (1) SI2073805T1 (no)
TW (1) TWI405570B (no)
WO (1) WO2008045566A1 (no)

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EP3178816A1 (en) 2003-04-11 2017-06-14 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease
CN101505739A (zh) * 2006-03-30 2009-08-12 Ptc医疗公司 由具有无义突变的dna生产功能蛋白的方法以及相关疾病的治疗
EP2073805B1 (en) * 2006-10-12 2015-03-04 PTC Therapeutics, Inc. Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
EP2714937B1 (en) 2011-06-03 2018-11-14 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
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CN113683564A (zh) 2014-08-28 2021-11-23 卫材R&D管理有限公司 高纯度喹啉衍生物及其生产方法
LT3263106T (lt) * 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
RU2718048C2 (ru) 2015-08-20 2020-03-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое терапевтическое средство
KR20180081516A (ko) 2015-10-30 2018-07-16 피티씨 테라퓨틱스, 인크. 간질 치료 방법
WO2018147275A1 (ja) 2017-02-08 2018-08-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療用医薬組成物
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
TWI801438B (zh) 2017-10-19 2023-05-11 中國大陸商軒竹（北京）醫藥科技有限公司 抗菌胺基糖苷類似物之合成
US11203578B2 (en) 2017-11-23 2021-12-21 Universita'degli Studi Dipalermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
KR20210151131A (ko) * 2019-04-10 2021-12-13 피티씨 테라퓨틱스, 인크. 소아 환자에서 넌센스 돌연변이 매개된 뒤센 근이영양증의 치료 방법
WO2022177267A1 (ko) * 2021-02-16 2022-08-25 라이보텍(주) 넌센스-매개 mrna 분해를 억제하기 위한 화합물
KR102378381B1 (ko) * 2021-08-23 2022-03-24 라이보텍(주) 넌센스-매개 mRNA 분해를 억제하기 위한 화합물
WO2022241030A1 (en) * 2021-05-11 2022-11-17 Regenxbio Inc. Treatment of duchenne muscular dystrophy and combinations thereof
KR102665711B1 (ko) * 2021-12-21 2024-05-14 재단법인 아산사회복지재단 Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물
CN119638642A (zh) * 2023-12-12 2025-03-18 暨南大学 双环类化合物及其药物组合物和应用

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US20210038572A1 (en) 2021-02-11
CA2675518C (en) 2017-11-14
KR20150064244A (ko) 2015-06-10
US10849885B2 (en) 2020-12-01
RS54025B1 (sr) 2015-10-30
TWI405570B (zh) 2013-08-21
DK2073805T3 (da) 2015-06-15
EP2073805B1 (en) 2015-03-04
EP2073805A1 (en) 2009-07-01
AU2007308067B2 (en) 2013-05-30
PE20120670A1 (es) 2012-06-01
US9877952B2 (en) 2018-01-30
HK1136214A1 (en) 2010-06-25
JP2014058533A (ja) 2014-04-03
IL198147A (en) 2016-02-29
IL236519A (en) 2017-03-30
KR101758341B1 (ko) 2017-07-14
EP2460520A1 (en) 2012-06-06
US9737513B2 (en) 2017-08-22
US9522137B2 (en) 2016-12-20
KR20090074231A (ko) 2009-07-06
HRP20150590T1 (hr) 2015-07-03
EP2460520B1 (en) 2015-09-30
US20190099405A1 (en) 2019-04-04
WO2008045566A1 (en) 2008-04-17
JP2017081946A (ja) 2017-05-18
JP6333227B2 (ja) 2018-05-30
US20180140583A1 (en) 2018-05-24
IL236519A0 (en) 2015-02-26
US20160101087A1 (en) 2016-04-14
CN103211766A (zh) 2013-07-24
US20170304275A1 (en) 2017-10-26
KR20160128468A (ko) 2016-11-07
RU2462247C2 (ru) 2012-09-27
SI2073805T1 (sl) 2015-10-30
JP2016029078A (ja) 2016-03-03
US20170049752A1 (en) 2017-02-23
PL2073805T3 (pl) 2015-08-31
CN101553226B (zh) 2015-05-13
PT2073805E (pt) 2015-07-13
CL2007002923A1 (es) 2008-06-06
CN101553226A (zh) 2009-10-07
BRPI0719276A2 (pt) 2014-04-29
WO2008045566B1 (en) 2008-06-19
RU2009117590A (ru) 2010-11-20
CN103211766B (zh) 2015-03-11
KR20170100072A (ko) 2017-09-01
BR122019020961B1 (pt) 2021-03-09
IL198147A0 (en) 2009-12-24
JP6129713B2 (ja) 2017-05-17
JP2010506840A (ja) 2010-03-04
US10172836B2 (en) 2019-01-08
US9226919B2 (en) 2016-01-05
US20080114039A1 (en) 2008-05-15
PE20212245A1 (es) 2021-11-24
ES2538359T3 (es) 2015-06-19
CA2675518A1 (en) 2008-04-17
PE20160947A1 (es) 2016-09-26
MX2009003909A (es) 2009-05-25
NO342061B1 (no) 2018-03-19
TW200820968A (en) 2008-05-16
AU2007308067A1 (en) 2008-04-17

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