PL2066647T3 - Benzoksazole i oksazolopirydyny użyteczne jako inhibitory kinaz Janusa - Google Patents

Benzoksazole i oksazolopirydyny użyteczne jako inhibitory kinaz Janusa

Info

Publication number: PL2066647T3
Authority: PL; Poland
Prior art keywords: oxazolopyridines; benzoxazoles; useful; janus kinases; kinases inhibitors
Prior art date: 2006-09-15

Application number

PL07802300T

Other languages

English (en)

Inventor

Marc Gerspacher

Pascal Furet

Eric Vangrevelinghe

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-15

Filing date

2007-09-13

Publication date

2012-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37717673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2066647(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-09-13 Application filed by Novartis Ag filed Critical Novartis Ag

2012-04-30 Publication of PL2066647T3 publication Critical patent/PL2066647T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

PL07802300T 2006-09-15 2007-09-13 Benzoksazole i oksazolopirydyny użyteczne jako inhibitory kinaz Janusa PL2066647T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP06120733A EP1900729A1 (en)	2006-09-15	2006-09-15	Benzoxazoles and oxazolopyridines being useful as Janus kinases inhibitors
PCT/EP2007/007983 WO2008031594A1 (en)	2006-09-15	2007-09-13	Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors
EP07802300A EP2066647B1 (en)	2006-09-15	2007-09-13	Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors

Publications (1)

Publication Number	Publication Date
PL2066647T3 true PL2066647T3 (pl)	2012-04-30

Family

ID=37717673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07802300T PL2066647T3 (pl)	2006-09-15	2007-09-13	Benzoksazole i oksazolopirydyny użyteczne jako inhibitory kinaz Janusa

Country Status (30)

Country	Link
US (1)	US8629168B2 (pl)
EP (2)	EP1900729A1 (pl)
JP (1)	JP5325105B2 (pl)
KR (1)	KR20090064389A (pl)
CN (1)	CN101516860B (pl)
AR (1)	AR062786A1 (pl)
AT (1)	ATE532774T1 (pl)
AU (1)	AU2007296916B2 (pl)
BR (1)	BRPI0716841A2 (pl)
CA (1)	CA2660987A1 (pl)
CL (1)	CL2007002669A1 (pl)
CO (1)	CO6150142A2 (pl)
CR (1)	CR10639A (pl)
EA (1)	EA200900388A1 (pl)
ES (1)	ES2377148T3 (pl)
GT (1)	GT200900056A (pl)
IL (1)	IL196860A0 (pl)
MA (1)	MA30723B1 (pl)
MX (1)	MX2009002812A (pl)
NO (1)	NO20091469L (pl)
PA (1)	PA8748101A1 (pl)
PE (1)	PE20080842A1 (pl)
PL (1)	PL2066647T3 (pl)
PT (1)	PT2066647E (pl)
SM (1)	SMP200900023B (pl)
TN (1)	TN2009000070A1 (pl)
TW (1)	TW200819444A (pl)
UY (1)	UY30587A1 (pl)
WO (1)	WO2008031594A1 (pl)
ZA (1)	ZA200900477B (pl)

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GB2467670B (en)	2007-10-04	2012-08-01	Intellikine Inc	Chemical entities and therapeutic uses thereof
WO2009114874A2 (en)	2008-03-14	2009-09-17	Intellikine, Inc.	Benzothiazole kinase inhibitors and methods of use
WO2010006086A2 (en)	2008-07-08	2010-01-14	Intellikine, Inc.	Kinase inhibitors and methods of use
CN102159582B (zh) *	2008-07-15	2014-05-07	赛诺菲-安万特	作为Edg-1受体激动剂的噁唑并嘧啶
JP2011530483A (ja) *	2008-08-12	2011-12-22	武田薬品工業株式会社	アミド化合物
US8476431B2 (en)	2008-11-03	2013-07-02	Itellikine LLC	Benzoxazole kinase inhibitors and methods of use
EA021367B1 (ru)	2008-11-28	2015-06-30	Кова Компани, Лтд.	Производное пиридин-3-карбоксамида
WO2011078360A1 (ja)	2009-12-24	2011-06-30	武田薬品工業株式会社	アミド化合物
UY33176A (es) *	2010-01-13	2011-08-31	Sanofi Aventis	Derivados de oxazolopirimidina sustituida en 2, 5, 7.
CN103491962B (zh)	2011-02-23	2016-10-12	因特利凯有限责任公司	激酶抑制剂的组合及其用途
US8580816B2 (en) *	2011-07-07	2013-11-12	Sanofi	Carboxylic acid derivatives having an oxazolo[5,4-b]pyridine ring
US8907093B2 (en) *	2011-07-07	2014-12-09	Sanofi	Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring
CN103102359B (zh) *	2011-11-15	2016-11-09	江苏先声药业有限公司	嘧啶类化合物及其应用
EP2785184B1 (en)	2011-11-30	2020-06-10	Emory University	Compositions comprising jak inhibitors and haart drugs for use in the prevention or treatment of hiv
WO2014075318A1 (zh) *	2012-11-19	2014-05-22	江苏先声药业有限公司	嘧啶类化合物及其应用
WO2014153509A1 (en)	2013-03-22	2014-09-25	Millennium Pharmaceuticals, Inc.	Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
CN103664759A (zh) *	2013-12-06	2014-03-26	常熟市联创化学有限公司	一种3-羟基-2-硝基吡啶的制备方法
CN106163509B (zh)	2014-02-03	2019-05-03	夸德里加生物科学公司	作为化疗剂的β-取代的β-氨基酸及类似物
BR112016017993A2 (pt)	2014-02-03	2017-08-08	Quadriga Biosciences Inc	Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos
WO2016047678A1 (ja) *	2014-09-25	2016-03-31	武田薬品工業株式会社	複素環化合物
WO2017024009A1 (en)	2015-08-03	2017-02-09	Quadriga Biosciences, Inc.	Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
CN114761013A (zh)	2019-09-27	2022-07-15	迪斯克医药公司	治疗骨髓纤维化和相关病症的方法
JP2023528223A (ja)	2020-05-13	2023-07-04	ディスク・メディシン・インコーポレイテッド	骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
WO2022251597A1 (en)	2021-05-28	2022-12-01	Verge Analytics, Inc.	Methods of treating neurological disorders with modulators of ribosomal protein s6 kinase alpha-1 (rsk1) and ribosomal protein s6 kinase alpha-3 (rsk2)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020509B1 (en) *	1999-12-10	2005-06-30	Pfizer Products Inc.	PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
SE0301373D0 (sv) *	2003-05-09	2003-05-09	Astrazeneca Ab	Novel compounds
DE10344223A1 (de) *	2003-09-24	2005-04-21	Merck Patent Gmbh	1,3-Benzoxazolylderivate als Kinase-Inhibitoren
GB0402140D0 (en) *	2004-01-30	2004-03-03	Smithkline Beecham Corp	Novel compounds
EP1674467A1 (en) *	2004-12-22	2006-06-28	4Sc Ag	2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
BRPI0615449A2 (pt) *	2005-09-02	2011-05-17	Hoffmann La Roche	compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método de tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de sst do subtipo 5 e uso desses compostos
MX2009000769A (es) *	2006-07-21	2009-01-28	Novartis Ag	Compuestos de 2,4-di(arilaminio)-pirimidin-5-carboxamida como inhibidores de cinasas jak.

2006
- 2006-09-15 EP EP06120733A patent/EP1900729A1/en not_active Ceased
2007
- 2007-09-12 UY UY30587A patent/UY30587A1/es not_active Application Discontinuation
- 2007-09-13 EA EA200900388A patent/EA200900388A1/ru unknown
- 2007-09-13 AU AU2007296916A patent/AU2007296916B2/en not_active Ceased
- 2007-09-13 US US12/440,298 patent/US8629168B2/en not_active Expired - Fee Related
- 2007-09-13 MX MX2009002812A patent/MX2009002812A/es active IP Right Grant
- 2007-09-13 CN CN2007800339907A patent/CN101516860B/zh not_active Expired - Fee Related
- 2007-09-13 AT AT07802300T patent/ATE532774T1/de active
- 2007-09-13 BR BRPI0716841-1A2A patent/BRPI0716841A2/pt not_active IP Right Cessation
- 2007-09-13 WO PCT/EP2007/007983 patent/WO2008031594A1/en not_active Ceased
- 2007-09-13 CA CA002660987A patent/CA2660987A1/en not_active Abandoned
- 2007-09-13 EP EP07802300A patent/EP2066647B1/en active Active
- 2007-09-13 PE PE2007001237A patent/PE20080842A1/es not_active Application Discontinuation
- 2007-09-13 KR KR1020097005248A patent/KR20090064389A/ko not_active Withdrawn
- 2007-09-13 AR ARP070104060A patent/AR062786A1/es unknown
- 2007-09-13 PT PT07802300T patent/PT2066647E/pt unknown
- 2007-09-13 ES ES07802300T patent/ES2377148T3/es active Active
- 2007-09-13 PL PL07802300T patent/PL2066647T3/pl unknown
- 2007-09-13 JP JP2009527741A patent/JP5325105B2/ja not_active Expired - Fee Related
- 2007-09-14 PA PA20078748101A patent/PA8748101A1/es unknown
- 2007-09-14 CL CL200702669A patent/CL2007002669A1/es unknown
- 2007-09-14 TW TW096134606A patent/TW200819444A/zh unknown
2009
- 2009-01-21 ZA ZA200900477A patent/ZA200900477B/xx unknown
- 2009-02-02 IL IL196860A patent/IL196860A0/en unknown
- 2009-02-26 CR CR10639A patent/CR10639A/es not_active Application Discontinuation
- 2009-02-27 TN TN2009000070A patent/TN2009000070A1/fr unknown
- 2009-03-10 CO CO09024347A patent/CO6150142A2/es unknown
- 2009-03-11 GT GT200900056A patent/GT200900056A/es unknown
- 2009-03-30 MA MA31738A patent/MA30723B1/fr unknown
- 2009-04-09 SM SM200900023T patent/SMP200900023B/it unknown
- 2009-04-15 NO NO20091469A patent/NO20091469L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2010503629A (ja)	2010-02-04
AU2007296916B2 (en)	2011-10-06
UY30587A1 (es)	2008-05-02
TN2009000070A1 (en)	2010-08-19
ZA200900477B (en)	2010-01-27
NO20091469L (no)	2009-04-15
KR20090064389A (ko)	2009-06-18
US20100009978A1 (en)	2010-01-14
CL2007002669A1 (es)	2008-05-09
JP5325105B2 (ja)	2013-10-23
WO2008031594A1 (en)	2008-03-20
GT200900056A (es)	2011-11-08
CA2660987A1 (en)	2008-03-20
ES2377148T3 (es)	2012-03-22
CO6150142A2 (es)	2010-04-20
SMP200900023B (it)	2009-07-14
TW200819444A (en)	2008-05-01
MX2009002812A (es)	2009-03-31
MA30723B1 (fr)	2009-09-01
AU2007296916A1 (en)	2008-03-20
AR062786A1 (es)	2008-12-03
BRPI0716841A2 (pt)	2013-10-01
PT2066647E (pt)	2012-01-17
US8629168B2 (en)	2014-01-14
EP2066647A1 (en)	2009-06-10
CN101516860B (zh)	2012-06-27
CN101516860A (zh)	2009-08-26
CR10639A (es)	2009-07-03
PA8748101A1 (es)	2009-08-26
SMAP200900023A (it)	2009-05-11
PE20080842A1 (es)	2008-08-11
IL196860A0 (en)	2009-11-18
ATE532774T1 (de)	2011-11-15
EP2066647B1 (en)	2011-11-09
EA200900388A1 (ru)	2009-08-28
EP1900729A1 (en)	2008-03-19

Publication	Publication Date	Title
IL196860A0 (en)	2009-11-18	Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors
IL284889A (en)	2021-08-31	Imidazotriazines and imidazopyrimidines as kinase inhibitors
ZA200808536B (en)	2012-07-25	Deazapurines useful as inhibitors of janus kinases
ZA201004055B (en)	2012-09-26	4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
ZA200805053B (en)	2010-11-24	Azaindoles useful as inhibitors of janus kinases
ZA200802685B (en)	2009-10-28	Deazapurines useful as inhibitors of janus kinases
IL192634A0 (en)	2009-08-03	Thiazoles as 11 beta-hsd1 inhibitors
GB0619753D0 (en)	2006-11-15	Enzyme inhibitors
PL1910348T3 (pl)	2016-09-30	Związki benzotiazolowe i azabenzotiazolowe użyteczne jako inhibitory kinazy
EP2166846A4 (en)	2011-03-23	JANUS KINASE INHIBITORS
EP2231143A4 (en)	2010-12-22	JANUS KINASE INHIBITORS
IL194699A0 (en)	2009-08-03	Tetrahydropteridines useful as inhibitors of protein kinases
IL194339A0 (en)	2009-08-03	Enzyme inhibitors
EP2032141A4 (en)	2009-12-30	JANUS KINASE INHIBITORS
EP2200612A4 (en)	2011-06-22	JANUS KINASE INHIBITORS
ZA200806871B (en)	2009-10-28	Dihydrodiazepines useful as inhibitors of protein kinases
ZA200902091B (en)	2010-07-28	Serine hydrolase inhibitors
GB0608844D0 (en)	2006-06-14	Enzyme inhibitors
IL197981A0 (en)	2009-12-24	Kinase inhibitors
GB0617161D0 (en)	2006-10-11	Enzyme inhibitors
HK1131393A (en)	2010-01-22	Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors
GB0612544D0 (en)	2006-08-02	Enzyme inhibitors
GB0624958D0 (en)	2007-01-24	Enzyme inhibitors
GB0620884D0 (en)	2006-11-29	Enzyme inhibitors
ZA200808237B (en)	2010-01-27	Enzyme inhibitors