PL1711470T3 - Pochodne malonoamidu blokujące czynność gamma-sekretazy - Google Patents

Pochodne malonoamidu blokujące czynność gamma-sekretazy

Info

Publication number: PL1711470T3
Authority: PL; Poland
Prior art keywords: activtiy; secretase; gamma; malonamide derivatives; blocking
Prior art date: 2003-09-09

Application number

PL04764665T

Other languages

English (en)

Inventor

Alexander Flohr

Guido Galley

Roland Jakob-Roetne

Eric Argirios Kitas

Jens-Uwe Peters

Wolfgang Wostl

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-09

Filing date

2004-08-31

Publication date

2009-09-30

2004-08-31 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-09-30 Publication of PL1711470T3 publication Critical patent/PL1711470T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Hydrogenated Pyridines (AREA)

PL04764665T 2003-09-09 2004-08-31 Pochodne malonoamidu blokujące czynność gamma-sekretazy PL1711470T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03019683		2003-09-09
PCT/EP2004/009700 WO2005023772A1 (en)	2003-09-09	2004-08-31	Malonamide derivatives blocking the activity of gama-secretase
EP04764665A EP1711470B1 (en)	2003-09-09	2004-08-31	Malonamide derivatives blocking the activtiy of gamma-secretase

Publications (1)

Publication Number	Publication Date
PL1711470T3 true PL1711470T3 (pl)	2009-09-30

Family

ID=34224068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04764665T PL1711470T3 (pl)	2003-09-09	2004-08-31	Pochodne malonoamidu blokujące czynność gamma-sekretazy

Country Status (34)

Country	Link
US (1)	US7160875B2 (pl)
EP (1)	EP1711470B1 (pl)
JP (2)	JP4571639B2 (pl)
KR (3)	KR100838852B1 (pl)
CN (1)	CN100593539C (pl)
AR (1)	AR045609A1 (pl)
AT (1)	ATE428698T1 (pl)
AU (1)	AU2004270361B2 (pl)
BR (1)	BRPI0413533A (pl)
CA (1)	CA2537440C (pl)
CO (1)	CO5660268A2 (pl)
CR (1)	CR8264A (pl)
CY (1)	CY1109225T1 (pl)
DE (1)	DE602004020680D1 (pl)
DK (1)	DK1711470T3 (pl)
EA (1)	EA009940B1 (pl)
EC (1)	ECSP066414A (pl)
ES (1)	ES2322652T3 (pl)
HR (1)	HRP20090266T1 (pl)
IL (1)	IL173905A (pl)
MA (1)	MA28034A1 (pl)
MX (1)	MXPA06002562A (pl)
MY (1)	MY141308A (pl)
NO (1)	NO20061047L (pl)
NZ (1)	NZ545538A (pl)
PL (1)	PL1711470T3 (pl)
PT (1)	PT1711470E (pl)
RS (1)	RS20060146A (pl)
SI (1)	SI1711470T1 (pl)
TN (1)	TNSN06077A1 (pl)
TW (1)	TW200519092A (pl)
UA (1)	UA83501C2 (pl)
WO (1)	WO2005023772A1 (pl)
ZA (1)	ZA200601989B (pl)

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JP4662914B2 (ja) *	2003-02-04	2011-03-30	エフ．ホフマン−ラロシュアーゲー	ガンマ−セクレターゼ阻害剤としてのマロンアミド誘導体
SI1711470T1 (sl) *	2003-09-09	2009-08-31	Hoffmann La Roche	Derivati malonamida, ki blokirajo aktivnost gama-sekretaze
PL1673347T3 (pl) *	2003-10-06	2016-01-29	Hoffmann La Roche	Podstawione pochodne dibenzo-azepiny i benzo-diazepiny użyteczne jako inhibitory gamma-sekretazy
US7211573B2 (en)	2004-12-08	2007-05-01	Hoffmann-La Roche Inc.	Malonamide derivatives
CA2645756C (en) *	2006-03-27	2013-12-31	F. Hoffmann-La Roche Ag	Malonamide derivatives as gamma secretase inhibitors
EP2069317A2 (en)	2006-09-20	2009-06-17	F. Hoffmann-Roche AG	4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives
WO2008092786A1 (en) *	2007-02-02	2008-08-07	F. Hoffmann-La Roche Ag	6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives
CN101636378A (zh) *	2007-03-15	2010-01-27	弗·哈夫曼-拉罗切有限公司	作为食欲肽拮抗剂的丙二酰胺类
US7579464B2 (en) *	2007-05-25	2009-08-25	Hoffmann-La Roche Inc.	Process for preparation of enantiomerically pure compounds
US8741889B2 (en)	2008-01-11	2014-06-03	Hoffmann-La Roche Inc	Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor
CN101909633B (zh) *	2008-01-11	2012-05-30	霍夫曼-拉罗奇有限公司	γ-分泌酶抑制剂用于治疗癌症的应用
US8309299B2 (en)	2010-05-19	2012-11-13	Hoffmann-La Roche Inc.	Combination therapy and method for assessing resistance to treatment
WO2012040444A2 (en) *	2010-09-24	2012-03-29	Bristol-Myers Squibb Company	Treatment of patients with incipient alzheimer's disease
KR101330184B1 (ko)	2010-10-15	2013-11-15	성균관대학교산학협력단	감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물
WO2012050370A2 (ko) *	2010-10-15	2012-04-19	성균관대학교산학협력단	감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물
US20120114638A1 (en)	2010-11-08	2012-05-10	John Boylan	Combination therapy
US20120184529A1 (en)	2011-01-14	2012-07-19	Demario Mark D	Combination therapy
US20120225860A1 (en)	2011-03-02	2012-09-06	John Frederick Boylan	Method for administration of a gamma secretase inhibitor
TWI530489B (zh)	2011-03-22	2016-04-21	必治妥美雅史谷比公司	雙（氟烷基）－１，４－苯二氮呯酮化合物
AR087107A1 (es)	2011-07-27	2014-02-12	Lilly Co Eli	Compuesto inhibidor de la señalizacion de la trayectoria notch
WO2014047397A1 (en)	2012-09-21	2014-03-27	Bristol-Myers Squibb Company	Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch\|inhibitors
TWI614238B (zh)	2012-09-21	2018-02-11	必治妥美雅史谷比公司	雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
WO2014047374A1 (en)	2012-09-21	2014-03-27	Bristol-Myers Squibb Company	Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds
US9242940B2 (en)	2012-09-21	2016-01-26	Bristol-Myers Squibb Company	N-substituted bis(fluoroalkyl)-1,4-benzodiazepinone compounds
EP2897941B1 (en)	2012-09-21	2016-09-07	Bristol-Myers Squibb Company	Prodrugs of 1,4-benzodiazepinone compounds
CN104797584A (zh)	2012-09-21	2015-07-22	百时美施贵宝公司	作为notch抑制剂的三环杂环化合物
EP2897954B1 (en)	2012-09-21	2016-10-26	Bristol-Myers Squibb Company	Fluoroalkyl-1,4-benzodiazepinone compounds
EP2897938B1 (en)	2012-09-21	2017-03-15	Bristol-Myers Squibb Company	Fluoroalkyl dibenzodiazepinone compounds
JP2015534553A (ja)	2012-09-21	2015-12-03	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	置換１，５−ベンゾジアゼピノン化合物
CN105101968A (zh)	2013-04-04	2015-11-25	百时美施贵宝公司	治疗增殖性疾病的组合疗法
EP2932966A1 (en)	2014-04-16	2015-10-21	Novartis AG	Gamma secretase inhibitors for treating respiratory diseases
CN109071450B (zh) *	2015-10-30	2021-06-22	帕珀莱恩医疗公司	二苯并氮杂卓化合物及其治疗耳部疾病和病症的用途
JP6904612B2 (ja) *	2016-12-16	2021-07-21	パイプラインセラピューティクス，インコーポレイテッド	蝸牛シナプス障害を処置する方法
EP3615055A1 (en)	2017-04-28	2020-03-04	Novartis AG	Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
WO2018201051A1 (en)	2017-04-28	2018-11-01	Novartis Ag	Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
US11161825B2 (en) *	2017-08-15	2021-11-02	Bayer Aktiengesellschaft	4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamides
TWI848951B (zh)	2018-06-01	2024-07-21	瑞士商諾華公司	針對ｂｃｍａ之結合分子及其用途
CA3144324A1 (en)	2019-06-24	2020-12-30	Novartis Ag	Dosing regimen and combination therapies for multispecific antibodies targeting b-cell maturation antigen
EP4185306A4 (en) *	2020-07-23	2024-11-06	Purdue Research Foundation	NOTCH SIGNAL INHIBITORS FOR THE TREATMENT OF OBESITY AND METABOLIC DISEASES
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JP2025515017A (ja)	2022-11-04	2025-05-13	エルジー・ケム・リミテッド	ホログラム記録媒体およびこれを含む光学素子
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JP2004500419A (ja) *	2000-04-11	2004-01-08	デュポン　ファーマシューティカルズ　カンパニー	Ａβタンパク質産生阻害剤としての置換ラクタム
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JP4662914B2 (ja) *	2003-02-04	2011-03-30	エフ．ホフマン−ラロシュアーゲー	ガンマ−セクレターゼ阻害剤としてのマロンアミド誘導体
SI1711470T1 (sl) *	2003-09-09	2009-08-31	Hoffmann La Roche	Derivati malonamida, ki blokirajo aktivnost gama-sekretaze

2004
- 2004-08-31 SI SI200431116T patent/SI1711470T1/sl unknown
- 2004-08-31 CA CA2537440A patent/CA2537440C/en not_active Expired - Fee Related
- 2004-08-31 KR KR1020077017457A patent/KR100838852B1/ko not_active Expired - Fee Related
- 2004-08-31 JP JP2006525701A patent/JP4571639B2/ja not_active Expired - Lifetime
- 2004-08-31 DK DK04764665T patent/DK1711470T3/da active
- 2004-08-31 MX MXPA06002562A patent/MXPA06002562A/es active IP Right Grant
- 2004-08-31 KR KR1020077017458A patent/KR20070087233A/ko not_active Ceased
- 2004-08-31 EA EA200600503A patent/EA009940B1/ru not_active IP Right Cessation
- 2004-08-31 PL PL04764665T patent/PL1711470T3/pl unknown
- 2004-08-31 BR BRPI0413533-4A patent/BRPI0413533A/pt not_active Application Discontinuation
- 2004-08-31 UA UAA200602854A patent/UA83501C2/uk unknown
- 2004-08-31 ES ES04764665T patent/ES2322652T3/es not_active Expired - Lifetime
- 2004-08-31 WO PCT/EP2004/009700 patent/WO2005023772A1/en not_active Ceased
- 2004-08-31 DE DE602004020680T patent/DE602004020680D1/de not_active Expired - Lifetime
- 2004-08-31 AU AU2004270361A patent/AU2004270361B2/en not_active Ceased
- 2004-08-31 CN CN200480032641A patent/CN100593539C/zh not_active Expired - Lifetime
- 2004-08-31 AT AT04764665T patent/ATE428698T1/de active
- 2004-08-31 NZ NZ545538A patent/NZ545538A/en not_active IP Right Cessation
- 2004-08-31 KR KR1020067004763A patent/KR100834177B1/ko not_active Expired - Fee Related
- 2004-08-31 PT PT04764665T patent/PT1711470E/pt unknown
- 2004-08-31 RS YUP-2006/0146A patent/RS20060146A/sr unknown
- 2004-08-31 HR HR20090266T patent/HRP20090266T1/xx unknown
- 2004-08-31 EP EP04764665A patent/EP1711470B1/en not_active Expired - Lifetime
- 2004-09-02 US US10/933,177 patent/US7160875B2/en not_active Expired - Lifetime
- 2004-09-06 MY MYPI20043603A patent/MY141308A/en unknown
- 2004-09-06 TW TW093126876A patent/TW200519092A/zh unknown
- 2004-09-08 AR ARP040103214A patent/AR045609A1/es not_active Application Discontinuation
2006
- 2006-02-23 IL IL173905A patent/IL173905A/en active IP Right Grant
- 2006-02-23 CO CO06018272A patent/CO5660268A2/es not_active Application Discontinuation
- 2006-03-01 CR CR8264A patent/CR8264A/es not_active Application Discontinuation
- 2006-03-03 NO NO20061047A patent/NO20061047L/no not_active Application Discontinuation
- 2006-03-07 EC EC2006006414A patent/ECSP066414A/es unknown
- 2006-03-07 TN TNP2006000077A patent/TNSN06077A1/fr unknown
- 2006-03-08 ZA ZA200601989A patent/ZA200601989B/en unknown
- 2006-03-10 MA MA28867A patent/MA28034A1/fr unknown
2009
- 2009-07-10 CY CY20091100729T patent/CY1109225T1/el unknown
2010
- 2010-06-18 JP JP2010138970A patent/JP2010229153A/ja active Pending

Also Published As

Publication number	Publication date
TW200519092A (en)	2005-06-16
EP1711470A1 (en)	2006-10-18
WO2005023772A1 (en)	2005-03-17
US20050054633A1 (en)	2005-03-10
HK1099014A1 (zh)	2007-08-03
CN1875005A (zh)	2006-12-06
UA83501C2 (uk)	2008-07-25
KR20070087690A (ko)	2007-08-28
JP4571639B2 (ja)	2010-10-27
MY141308A (en)	2010-04-16
ES2322652T3 (es)	2009-06-24
BRPI0413533A (pt)	2006-10-10
HRP20090266T1 (en)	2009-06-30
NO20061047L (no)	2006-04-04
RS20060146A (sr)	2008-06-05
CY1109225T1 (el)	2014-07-02
IL173905A0 (en)	2006-07-05
EA009940B1 (ru)	2008-04-28
ZA200601989B (en)	2007-05-30
EP1711470B1 (en)	2009-04-15
IL173905A (en)	2011-05-31
AR045609A1 (es)	2005-11-02
MA28034A1 (fr)	2006-07-03
CN100593539C (zh)	2010-03-10
JP2007505063A (ja)	2007-03-08
CO5660268A2 (es)	2006-07-31
KR20060054455A (ko)	2006-05-22
AU2004270361B2 (en)	2009-06-25
EA200600503A1 (ru)	2006-08-25
SI1711470T1 (sl)	2009-08-31
KR100838852B1 (ko)	2008-06-16
TNSN06077A1 (fr)	2007-10-03
AU2004270361A1 (en)	2005-03-17
CR8264A (es)	2008-09-22
MXPA06002562A (es)	2006-06-20
KR100834177B1 (ko)	2008-05-30
JP2010229153A (ja)	2010-10-14
ATE428698T1 (de)	2009-05-15
ECSP066414A (es)	2006-09-18
US7160875B2 (en)	2007-01-09
CA2537440C (en)	2012-07-10
DE602004020680D1 (de)	2009-05-28
NZ545538A (en)	2008-12-24
PT1711470E (pt)	2009-05-21
DK1711470T3 (da)	2009-06-08
KR20070087233A (ko)	2007-08-27
CA2537440A1 (en)	2005-03-17

Publication	Publication Date	Title
PL1711470T3 (pl)	2009-09-30	Pochodne malonoamidu blokujące czynność gamma-sekretazy
IL169691A0 (en)	2007-07-04	Malonamide derivatives as gamma-secretase inhibitors
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