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PL1695991T3 - Koordynacyjny kompleks diaminocykloheksanu platyny (II) z blokowym kopolimerem zawierającym fragment poli(kwasu karboksylowego), oraz środek przeciw-nowotworowy zawierający ten kompleks - Google Patents

Koordynacyjny kompleks diaminocykloheksanu platyny (II) z blokowym kopolimerem zawierającym fragment poli(kwasu karboksylowego), oraz środek przeciw-nowotworowy zawierający ten kompleks

Info

Publication number
PL1695991T3
PL1695991T3 PL04807038T PL04807038T PL1695991T3 PL 1695991 T3 PL1695991 T3 PL 1695991T3 PL 04807038 T PL04807038 T PL 04807038T PL 04807038 T PL04807038 T PL 04807038T PL 1695991 T3 PL1695991 T3 PL 1695991T3
Authority
PL
Poland
Prior art keywords
segment
carboxylic acid
block copolymer
diaminocyclohexaneplatinum
same
Prior art date
Application number
PL04807038T
Other languages
English (en)
Inventor
Kazunori Kataoka
Nobuhiro Nishiyama
Horacio Cabral
Soichiro Okazaki
Original Assignee
Toudai Tlo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toudai Tlo Ltd filed Critical Toudai Tlo Ltd
Publication of PL1695991T3 publication Critical patent/PL1695991T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G85/00—General processes for preparing compounds provided for in this subclass
    • C08G85/002—Post-polymerisation treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/10—Metal compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
PL04807038T 2003-12-10 2004-12-08 Koordynacyjny kompleks diaminocykloheksanu platyny (II) z blokowym kopolimerem zawierającym fragment poli(kwasu karboksylowego), oraz środek przeciw-nowotworowy zawierający ten kompleks PL1695991T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003412315 2003-12-10
PCT/JP2004/018679 WO2005056641A1 (ja) 2003-12-10 2004-12-08 ジアミノシクロヘキサン白金(ii)とポリ(カルボン酸)セグメント含有ブロック共重合体との配位錯体、その抗腫瘍剤
EP04807038A EP1695991B1 (en) 2003-12-10 2004-12-08 Coordination complex of diaminocyclohexaneplatinum(ii) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same

Publications (1)

Publication Number Publication Date
PL1695991T3 true PL1695991T3 (pl) 2010-05-31

Family

ID=34675022

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04807038T PL1695991T3 (pl) 2003-12-10 2004-12-08 Koordynacyjny kompleks diaminocykloheksanu platyny (II) z blokowym kopolimerem zawierającym fragment poli(kwasu karboksylowego), oraz środek przeciw-nowotworowy zawierający ten kompleks

Country Status (17)

Country Link
US (1) US8012463B2 (pl)
EP (1) EP1695991B1 (pl)
JP (1) JP3955992B2 (pl)
KR (1) KR100982933B1 (pl)
CN (1) CN100457185C (pl)
AT (1) ATE458022T1 (pl)
AU (1) AU2004297126B2 (pl)
CA (1) CA2548457C (pl)
CY (1) CY1110233T1 (pl)
DE (1) DE602004025612D1 (pl)
DK (1) DK1695991T3 (pl)
ES (1) ES2337904T3 (pl)
PL (1) PL1695991T3 (pl)
PT (1) PT1695991E (pl)
RU (1) RU2335512C2 (pl)
SI (1) SI1695991T1 (pl)
WO (1) WO2005056641A1 (pl)

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US20090082438A1 (en) * 2005-03-18 2009-03-26 Kazunori Kataoka Coordination Compound Composed of Diaminocyclohexane Platinum (II) and Block Copolymer and Anti-Cancer Agent Comprising the Same
US8304497B2 (en) * 2005-05-02 2012-11-06 The University Of Tokyo Electrostatically bonded polymer vesicle
RU2404980C2 (ru) * 2005-05-11 2010-11-27 Ниппон Каяку Кабусики Кайся Полимерное производное антиметаболита цитидина
DK2656840T3 (en) * 2005-06-09 2015-11-02 Nanocarrier Co Ltd Process for preparing polymerized platinum complex coordination compounds
ATE432955T1 (de) 2005-12-05 2009-06-15 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
WO2008120690A1 (ja) * 2007-03-29 2008-10-09 Osaka University 光学活性有機酸架橋二核白金（ｉｉ）錯体
US20080253969A1 (en) * 2007-04-10 2008-10-16 Nitto Denko Corporation Multi-functional polyglutamate drug carriers
US20080279782A1 (en) * 2007-05-09 2008-11-13 Nitto Denko Corporation Polymers conjugated with platinum drugs
US8197828B2 (en) 2007-05-09 2012-06-12 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
EP2236145B1 (en) 2008-01-28 2014-05-14 NanoCarrier Co., Ltd. Pharmaceutical composition and combined agent
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
US20090232762A1 (en) * 2008-03-11 2009-09-17 May Pang Xiong Compositions for delivery of therapeutic agents
CA2728960C (en) * 2008-06-26 2016-04-12 Japan Science And Technology Agency Polymer-metal complex composite having mri contrast ability and mri contrasting and/or antitumor composition using the same
JP2011105792A (ja) * 2009-11-12 2011-06-02 Japan Science & Technology Agency ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア
CN102091025B (zh) * 2009-12-14 2012-07-11 中国科学院化学研究所 抗肿瘤可注射水凝胶及其制备方法和用途
JP5594730B2 (ja) * 2010-11-02 2014-09-24 学校法人東京理科大学 金属高分子錯体からなるミセルの分散液
AU2012233171B2 (en) * 2011-03-31 2015-08-20 Nanocarrier Co., Ltd. Pharmaceutical composition containing block copolymer comprising boronic acid compound
US8785569B2 (en) 2011-11-22 2014-07-22 Original Biomedicals Co., Ltd. Drug carrier with chelating complex micelles and the application thereof
TWI568453B (zh) * 2011-11-22 2017-02-01 原創生醫股份有限公司 具有螯合型複合微胞之藥物載體及其應用
CN105997878B (zh) * 2012-11-22 2019-03-22 原创生医股份有限公司 降低自由基伤害的复合微胞载体医药组成物
EP2740737B1 (de) * 2012-12-05 2015-09-16 Heraeus Deutschland GmbH & Co. KG 1,2-Cyclohexandiaminplatin(II) bis-(4-methylbenzolsulfonat) und dessen Hydrate
CN103394095B (zh) * 2013-08-19 2016-03-23 中国科学院长春应用化学研究所 二氯-1,2-环己二胺合铂配合物及其制备方法
EP3315487B1 (en) 2015-06-24 2020-10-28 Nippon Kayaku Kabushiki Kaisha Novel platinum (iv) complex
EP3351580B1 (en) * 2015-09-14 2021-02-24 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of hexa-coordinated platinum complex
AU2016374759B2 (en) * 2015-12-22 2021-04-01 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex
JP7281140B2 (ja) * 2019-04-15 2023-05-25 日油株式会社 生体関連物質とブロックポリマーとの結合体、および前記結合体を得るためのブロックポリマー誘導体
US20240043615A1 (en) * 2020-12-04 2024-02-08 The Methodist Hospital System Amino acid polymer-platinum anticancer drug conjugates
CN113929898B (zh) * 2021-10-09 2023-03-24 苏州大学 一种金属基纳米聚合物及其制备方法与应用

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Also Published As

Publication number Publication date
CA2548457C (en) 2010-08-24
KR20060123299A (ko) 2006-12-01
US20070148125A1 (en) 2007-06-28
SI1695991T1 (sl) 2010-04-30
AU2004297126B2 (en) 2010-11-25
DK1695991T3 (da) 2010-04-19
DE602004025612D1 (de) 2010-04-01
EP1695991A1 (en) 2006-08-30
EP1695991A4 (en) 2009-06-24
RU2335512C2 (ru) 2008-10-10
CN1890295A (zh) 2007-01-03
KR100982933B1 (ko) 2010-09-17
US8012463B2 (en) 2011-09-06
EP1695991B1 (en) 2010-02-17
RU2006124552A (ru) 2008-01-20
AU2004297126A1 (en) 2005-06-23
JPWO2005056641A1 (ja) 2007-07-05
CA2548457A1 (en) 2005-06-23
WO2005056641A1 (ja) 2005-06-23
PT1695991E (pt) 2010-03-02
ES2337904T3 (es) 2010-04-30
JP3955992B2 (ja) 2007-08-08
CY1110233T1 (el) 2015-01-14
ATE458022T1 (de) 2010-03-15
CN100457185C (zh) 2009-02-04

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