PH12015500400A1 - 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders - Google Patents
2-oxo-2,3-dihydro-indoles for the treatment of cns disordersInfo
- Publication number
- PH12015500400A1 PH12015500400A1 PH12015500400A PH12015500400A PH12015500400A1 PH 12015500400 A1 PH12015500400 A1 PH 12015500400A1 PH 12015500400 A PH12015500400 A PH 12015500400A PH 12015500400 A PH12015500400 A PH 12015500400A PH 12015500400 A1 PH12015500400 A1 PH 12015500400A1
- Authority
- PH
- Philippines
- Prior art keywords
- lower alkyl
- cycloalkyl
- halogen
- indoles
- dihydro
- Prior art date
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- -1 CH2-C3-6-cycloalkyl Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12184249 | 2012-09-13 | ||
| PCT/EP2013/068668 WO2014040969A1 (fr) | 2012-09-13 | 2013-09-10 | 2-oxo-2,3-dihydro-indoles destinés au traitement de troubles du snc |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12015500400A1 true PH12015500400A1 (en) | 2015-04-27 |
Family
ID=47044777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12015500400A PH12015500400A1 (en) | 2012-09-13 | 2015-02-24 | 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9221816B2 (fr) |
| EP (1) | EP2895476B1 (fr) |
| JP (1) | JP6116693B2 (fr) |
| KR (1) | KR101706877B1 (fr) |
| CN (1) | CN104619701B (fr) |
| AR (1) | AR092555A1 (fr) |
| AU (1) | AU2013314417B2 (fr) |
| BR (1) | BR112015005186A2 (fr) |
| CA (1) | CA2883817C (fr) |
| CL (1) | CL2015000559A1 (fr) |
| CR (1) | CR20150084A (fr) |
| EA (1) | EA027176B1 (fr) |
| ES (1) | ES2590531T3 (fr) |
| IL (1) | IL237266A0 (fr) |
| MA (1) | MA37943B1 (fr) |
| MX (1) | MX2015003330A (fr) |
| PE (1) | PE20150943A1 (fr) |
| PH (1) | PH12015500400A1 (fr) |
| SG (1) | SG11201501923WA (fr) |
| TW (1) | TWI490213B (fr) |
| WO (1) | WO2014040969A1 (fr) |
| ZA (1) | ZA201501262B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2666532C2 (ru) * | 2013-06-19 | 2018-09-11 | Ф. Хоффманн-Ля Рош Аг | Производные индолин-2-она или пирролопиридин/пиримидин-2-она |
| KR101898364B1 (ko) | 2014-05-22 | 2018-09-12 | 에프. 호프만-라 로슈 아게 | 인돌린-2-온 및 1,3-다이하이드로-피롤로[3,2-c]피리딘-2-온 유도체 |
| KR101819433B1 (ko) | 2014-06-26 | 2018-01-16 | 에프. 호프만-라 로슈 아게 | 인돌린-2-온 또는 피롤로-피리딘-2-온 유도체 |
| EP3371170B1 (fr) | 2015-11-06 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Dérivés d'indoline-2-one utiles dans le traitement de maladies du système nerveux central |
| JP6857653B2 (ja) | 2015-11-06 | 2021-04-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体 |
| MX380215B (es) | 2015-11-06 | 2025-03-12 | Hoffmann La Roche | Derivados de indolin-2-ona. |
| EP3371174B1 (fr) | 2015-11-06 | 2021-03-17 | H. Hoffnabb-La Roche Ag | Dérivés d'indolin-2-one |
| CN106065008B (zh) * | 2016-06-16 | 2018-06-05 | 黑龙江中医药大学 | 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用 |
| GB201709456D0 (en) * | 2017-06-14 | 2017-07-26 | Ucb Biopharma Sprl | Therapeutic agents |
| WO2020087031A1 (fr) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combinaison d'un inhibiteur de réabsorption spécifique de la sérotonine et d'un agoniste partiel du récepteur de la sérotonine 1a pour réduire la dyskinésie induite par l-dopa |
| JP2025523507A (ja) * | 2022-06-23 | 2025-07-23 | バイオジェン・エムエイ・インコーポレイテッド | チロシンキナーゼ２阻害剤及びその使用 |
| CN116640083A (zh) * | 2023-05-30 | 2023-08-25 | 江苏海洋大学 | 一种gpr52调节剂化合物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3417643A1 (de) | 1984-05-12 | 1985-11-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| PL147842B1 (en) | 1984-05-12 | 1989-08-31 | Method of obtaining novel pyroisobenzimidazoles | |
| DE3445669A1 (de) | 1984-12-14 | 1986-06-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3501497A1 (de) | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| US4835280A (en) | 1985-01-18 | 1989-05-30 | Boehringer Mannheim Gmbh | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles |
| DE3803775A1 (de) | 1988-02-09 | 1989-08-17 | Boehringer Mannheim Gmbh | Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| DE3818830A1 (de) | 1988-06-03 | 1989-12-14 | Boehringer Mannheim Gmbh | Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel |
| DE3925584A1 (de) | 1989-08-02 | 1991-02-07 | Boehringer Mannheim Gmbh | Neue n-(dimethyloxophosphinylmethyl-)-lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JP2002522452A (ja) | 1998-08-04 | 2002-07-23 | スージェン・インコーポレーテッド | 蛋白質キナーゼの調節剤３−メチリデニル−２−インドリノン |
| WO2000056709A1 (fr) | 1999-03-24 | 2000-09-28 | Sugen, Inc. | Composes d'indolinone tels que des inhibiteurs de kinase |
| CN100562513C (zh) * | 2003-06-12 | 2009-11-25 | 安斯泰来制药有限公司 | 苯甲酰胺衍生物或其盐 |
| BRPI0411083A (pt) * | 2003-06-12 | 2006-07-25 | Astellas Pharma Inc | derivado de benzamida ou sais do mesmo |
| KR101318012B1 (ko) | 2004-10-20 | 2013-10-14 | 메르크 세로노 에스.에이. | 3-아릴아미노 피리딘 유도체 |
| US20060142247A1 (en) | 2004-12-17 | 2006-06-29 | Guy Georges | Tricyclic heterocycles |
| EP1955697B1 (fr) * | 2005-11-30 | 2012-05-02 | Astellas Pharma Inc. | Dérivés de 2-aminobenzamide comme inhibiteurs du récepteur vanilloïde 1 (vr1) utiles pour le traitement de la douleur ou du disfonctionnement de la vessie |
| EP2182935A1 (fr) * | 2007-08-02 | 2010-05-12 | F. Hoffmann-Roche AG | Utilisation de dérivés de benzamide pour le traitement de troubles du snc |
| EP2108641A1 (fr) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | Nouveaux dérivés substitués de spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one et leur utilisation comme ihibiteurs de p38 mitogen-activated kinase |
| WO2010123139A1 (fr) * | 2009-04-24 | 2010-10-28 | 持田製薬株式会社 | Dérivé arylcarboxamide ayant un groupe sulfamoyle |
| US9512111B2 (en) * | 2010-11-08 | 2016-12-06 | Lycera Corporation | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease |
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2013
- 2013-09-10 SG SG11201501923WA patent/SG11201501923WA/en unknown
- 2013-09-10 BR BR112015005186A patent/BR112015005186A2/pt not_active IP Right Cessation
- 2013-09-10 CN CN201380047631.2A patent/CN104619701B/zh active Active
- 2013-09-10 AU AU2013314417A patent/AU2013314417B2/en not_active Ceased
- 2013-09-10 WO PCT/EP2013/068668 patent/WO2014040969A1/fr not_active Ceased
- 2013-09-10 JP JP2015531533A patent/JP6116693B2/ja active Active
- 2013-09-10 EP EP13759241.6A patent/EP2895476B1/fr active Active
- 2013-09-10 KR KR1020157009290A patent/KR101706877B1/ko not_active Expired - Fee Related
- 2013-09-10 MX MX2015003330A patent/MX2015003330A/es unknown
- 2013-09-10 PE PE2015000365A patent/PE20150943A1/es not_active Application Discontinuation
- 2013-09-10 CA CA2883817A patent/CA2883817C/fr not_active Expired - Fee Related
- 2013-09-10 EA EA201590438A patent/EA027176B1/ru not_active IP Right Cessation
- 2013-09-10 ES ES13759241.6T patent/ES2590531T3/es active Active
- 2013-09-12 TW TW102133020A patent/TWI490213B/zh not_active IP Right Cessation
- 2013-09-13 AR ARP130103279A patent/AR092555A1/es unknown
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2015
- 2015-02-16 IL IL237266A patent/IL237266A0/en unknown
- 2015-02-19 CR CR20150084A patent/CR20150084A/es unknown
- 2015-02-24 PH PH12015500400A patent/PH12015500400A1/en unknown
- 2015-02-24 ZA ZA2015/01262A patent/ZA201501262B/en unknown
- 2015-03-06 CL CL2015000559A patent/CL2015000559A1/es unknown
- 2015-03-11 US US14/645,033 patent/US9221816B2/en active Active
- 2015-03-20 MA MA37943A patent/MA37943B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6116693B2 (ja) | 2017-04-19 |
| AR092555A1 (es) | 2015-04-22 |
| CN104619701A (zh) | 2015-05-13 |
| MX2015003330A (es) | 2015-06-05 |
| EA201590438A1 (ru) | 2015-06-30 |
| HK1206721A1 (en) | 2016-01-15 |
| ZA201501262B (en) | 2016-03-30 |
| KR20150054991A (ko) | 2015-05-20 |
| AU2013314417A1 (en) | 2015-03-05 |
| JP2015529673A (ja) | 2015-10-08 |
| BR112015005186A2 (pt) | 2017-07-04 |
| EA027176B1 (ru) | 2017-06-30 |
| CN104619701B (zh) | 2016-10-19 |
| US20150284386A1 (en) | 2015-10-08 |
| TW201416358A (zh) | 2014-05-01 |
| EP2895476B1 (fr) | 2016-06-22 |
| WO2014040969A1 (fr) | 2014-03-20 |
| US9221816B2 (en) | 2015-12-29 |
| CA2883817A1 (fr) | 2014-03-20 |
| CR20150084A (es) | 2015-04-06 |
| CL2015000559A1 (es) | 2015-07-10 |
| ES2590531T3 (es) | 2016-11-22 |
| AU2013314417B2 (en) | 2016-01-21 |
| PE20150943A1 (es) | 2015-06-20 |
| KR101706877B1 (ko) | 2017-02-15 |
| EP2895476A1 (fr) | 2015-07-22 |
| IL237266A0 (en) | 2015-04-30 |
| MA37943A1 (fr) | 2016-04-29 |
| TWI490213B (zh) | 2015-07-01 |
| CA2883817C (fr) | 2017-09-05 |
| MA37943B1 (fr) | 2016-11-30 |
| SG11201501923WA (en) | 2015-04-29 |
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