PE73599A1 - Moduladores de receptores de aminoacidos excitadores - Google Patents
Moduladores de receptores de aminoacidos excitadoresInfo
- Publication number
- PE73599A1 PE73599A1 PE1998000370A PE00037098A PE73599A1 PE 73599 A1 PE73599 A1 PE 73599A1 PE 1998000370 A PE1998000370 A PE 1998000370A PE 00037098 A PE00037098 A PE 00037098A PE 73599 A1 PE73599 A1 PE 73599A1
- Authority
- PE
- Peru
- Prior art keywords
- excitors
- amino acid
- receptor modulators
- refers
- acid receptor
- Prior art date
Links
- 102000015404 Amino Acid Receptors Human genes 0.000 title 1
- 108010025177 Amino Acid Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 AMINO Chemical group 0.000 abstract 3
- 241000670727 Amida Species 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical group [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/383—Cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), SU ESTER O AMIDA O SAL, DONDE R1 ES FLUOR, XOR3, XNR4R5, SO3H, ENTRE OTROS; R2 ES H o R1 Y R2 SON FLUOR o =O, =NOR7 o =CR8R9 o UNO ES AMINO Y EL OTRO ES CARBOXILO, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, ALQUENILO C3-C6, ALQUINILO C3-C6, ENTRE OTROS; X ES UN ENLACE, CH2, CO; m ES 1-3; R4 ES COR10 o ES R3, R4, R5, R7, R8, R9, R10 SON IGUAL A R3, R6 ES H o ALQUILO C1-C6. UN COMPUESTO PREFERIDO ES ACIDO (1S*,2S*,5R*,6R*)-2-AMINO-4-OXOBICICLO[3.1.0]HEXANO-2,6-DICARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTOS DE FORMULA (II), DONDE R11 ES H, ACILO; R12 ES UN GRUPO CARBOXILO TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA SU PREPARACION. EL COMPUESTO (I) MODULA LA FUNCION DE RECEPTORES METABOTROPICOS DE GLUTAMATO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4701197P | 1997-05-14 | 1997-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE73599A1 true PE73599A1 (es) | 1999-08-14 |
Family
ID=21946570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000370A PE73599A1 (es) | 1997-05-14 | 1998-05-14 | Moduladores de receptores de aminoacidos excitadores |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US5958960A (es) |
| EP (1) | EP0878463B1 (es) |
| JP (1) | JP4191263B2 (es) |
| KR (1) | KR20010012489A (es) |
| CN (1) | CN1125807C (es) |
| AR (1) | AR015664A1 (es) |
| AT (1) | ATE198190T1 (es) |
| AU (1) | AU729632B2 (es) |
| BR (1) | BR9808787A (es) |
| CA (1) | CA2289472C (es) |
| CO (1) | CO4950558A1 (es) |
| DE (1) | DE69800430T2 (es) |
| DK (1) | DK0878463T3 (es) |
| EA (1) | EA199901029A1 (es) |
| ES (1) | ES2152738T3 (es) |
| GR (1) | GR3035156T3 (es) |
| HU (1) | HUP0001404A3 (es) |
| ID (1) | ID23183A (es) |
| IL (1) | IL132894A0 (es) |
| NO (1) | NO995480D0 (es) |
| NZ (1) | NZ500954A (es) |
| PE (1) | PE73599A1 (es) |
| PL (1) | PL336793A1 (es) |
| PT (1) | PT878463E (es) |
| SI (1) | SI0878463T1 (es) |
| SV (1) | SV1998000056A (es) |
| TR (1) | TR199902777T2 (es) |
| TW (1) | TW505623B (es) |
| WO (1) | WO1998051655A1 (es) |
| ZA (1) | ZA983930B (es) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| DK1052246T3 (da) * | 1998-01-28 | 2003-06-16 | Taisho Pharmaceutical Co Ltd | Fluorholdige aminosyrederivater |
| CN1247527C (zh) * | 1998-08-31 | 2006-03-29 | 大正制药株式会社 | 6－氟双环[3.1.0]己烷衍生物 |
| PE20001236A1 (es) * | 1998-11-13 | 2000-11-10 | Lilly Co Eli | Moduladores del receptor de aminoacidos excitadores |
| ES2226472T3 (es) | 1998-12-18 | 2005-03-16 | Taisho Pharmaceutical Co., Ltd | Intermedios y procedimiento para producir un compuesto de aminoacido que contiene fluor utilizando dichos intermedios. |
| WO2000058258A1 (en) * | 1999-03-25 | 2000-10-05 | Taisho Pharmaceutical Co., Ltd. | Novel carboxylic acid derivatives and process for producing the same |
| JP4505926B2 (ja) * | 1999-03-25 | 2010-07-21 | 大正製薬株式会社 | 新規カルボン酸誘導体及びその製造方法 |
| US6479470B1 (en) | 1999-04-28 | 2002-11-12 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase |
| US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
| US6417366B2 (en) * | 1999-06-24 | 2002-07-09 | Abbott Laboratories | Preparation of quinoline-substituted carbonate and carbamate derivatives |
| JP4783967B2 (ja) * | 1999-07-21 | 2011-09-28 | 大正製薬株式会社 | 含フッ素アミノ酸誘導体を有効成分とする医薬 |
| WO2001042203A1 (en) * | 1999-12-08 | 2001-06-14 | Eli Lilly And Company | Cyclopentyl sulfonamide derivatives |
| US6639107B1 (en) | 1999-12-08 | 2003-10-28 | Eli Lilly And Company | Cyclopentyl sulfonamide derivatives |
| HUP0400620A3 (en) * | 2001-01-11 | 2012-09-28 | Lilly Co Eli | Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds |
| EP1351925A1 (en) * | 2001-01-11 | 2003-10-15 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| EP1370519A1 (en) * | 2001-02-22 | 2003-12-17 | Eli Lilly And Company | Synthetic excitatory amino acids |
| RU2315622C2 (ru) * | 2001-12-27 | 2008-01-27 | Тайсо Фармасьютикал Ко.,Лтд. | Производные 6-фторбицикло[3.1.0]гексана |
| US20040116489A1 (en) * | 2002-02-12 | 2004-06-17 | Massey Steven Marc | Synthetic excitatory amino acids |
| US20050192273A1 (en) * | 2002-04-03 | 2005-09-01 | Johnson Bryan G. | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| HRP20090058A2 (hr) * | 2002-06-11 | 2009-04-30 | Eli Lilly And Company | Prekursorski oblici lijekova za aminokiseline s pobuđivačkom aktivnosti |
| CN100582087C (zh) | 2003-06-26 | 2010-01-20 | 大正制药株式会社 | 2-氨基-双环[3.1.0]己烷-2,6-二甲酸酯衍生物 |
| US7381746B2 (en) | 2003-06-26 | 2008-06-03 | Taisho Pharmaceutical Co., Ltd. | 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative |
| ATE487690T1 (de) * | 2003-06-26 | 2010-11-15 | Taisho Pharmaceutical Co Ltd | 2-aminobicyclo 3.1.0 hexan-2,6- dicarbonsäureesterderivat |
| RU2409557C2 (ru) * | 2003-06-26 | 2011-01-20 | Таишо Фармасьютикал Ко., Лтд. | Сложноэфирное производное 2-амино-бицикло[3.1.0]гексан-2,6-дикарбоновой кислоты |
| CN100475800C (zh) * | 2003-11-07 | 2009-04-08 | 大正制药株式会社 | 二环[3.1.0]己烷衍生物的制备方法及其中间体 |
| US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
| EP1915146A4 (en) | 2005-07-27 | 2010-06-02 | Dov Pharmaceutical Inc | NOVEL 1-ARYL-3-AZABICYCLO [3.1.0] HEXANEES. PREPARATION AND USE FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US20080045725A1 (en) * | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US8138377B2 (en) * | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| US20080269348A1 (en) * | 2006-11-07 | 2008-10-30 | Phil Skolnick | Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use |
| PT3699162T (pt) | 2006-11-08 | 2022-10-11 | Molecular Insight Pharm Inc | Heterodímeros de ácido glutâmico |
| US8586619B2 (en) * | 2007-03-12 | 2013-11-19 | Vm Therapeutics Llc | Agents of calcium ion channel modulators |
| US20090069374A1 (en) * | 2007-06-06 | 2009-03-12 | Phil Skolnick | Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| EP2679570A3 (en) * | 2008-05-21 | 2014-07-02 | Taisho Pharmaceutical Co., Ltd. | Method of producing bicyclo[3.1.0]hexane derivative |
| WO2010065899A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2010111080A2 (en) | 2009-03-27 | 2010-09-30 | Eli Lilly And Company | Optimized treatment of schizophrenia |
| US8465725B2 (en) | 2009-06-15 | 2013-06-18 | Molecular Insight Pharmaceuticlas, Inc. | Process for production of heterodimers of glutamic acid |
| AR079343A1 (es) | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
| JP5870111B2 (ja) * | 2010-11-18 | 2016-02-24 | イーライ リリー アンド カンパニー | ｍＧｌｕＲ２／３アンタゴニストとしての４−置換−３−ベンジルオキシ−ビシクロ［３．１．０］ヘキサン化合物 |
| AR083845A1 (es) * | 2010-11-18 | 2013-03-27 | Lilly Co Eli | COMPUESTOS 3-FENILSULFANILMETIL-BICICLO[3.1.0]HEXANO 4-SUSTITUIDOS COMO ANTAGONISTAS DE mGluR2/3 |
| HRP20160676T1 (hr) | 2011-06-17 | 2016-07-15 | Eli Lilly And Company | Derivati biciklo[3.1.0]heksan-2,6-dikarboksilne kiseline kao agonisti receptora mglu2 |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
| EP2800471A4 (en) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE |
| AR089718A1 (es) * | 2012-02-01 | 2014-09-10 | Lilly Co Eli | AGONISTAS DE mGlu2/3 |
| JP6468602B2 (ja) | 2013-01-14 | 2019-02-13 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | トリアジン系放射性医薬品及び放射線造影剤 |
| FR3050021B1 (fr) | 2016-04-06 | 2018-10-19 | Nitrates & Innovation | Ensemble de deux reservoirs prets a etre assembles par vissage pour former une cartouche d'explosif bi-composant |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL182285B1 (pl) * | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| AU3325095A (en) * | 1994-08-12 | 1996-03-07 | Eli Lilly And Company | Composition and method for protection against drug dependency |
| CA2195782A1 (en) * | 1994-08-12 | 1996-02-22 | David Reed Helton | Composition and method for treating anxiety |
| US5750566A (en) * | 1994-08-12 | 1998-05-12 | Eli Lilly And Company | Synthetic excitatory amino acids |
| IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
| GB9605429D0 (en) * | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
| US5912248A (en) | 1995-11-16 | 1999-06-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
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1998
- 1998-05-08 ZA ZA9803930A patent/ZA983930B/xx unknown
- 1998-05-12 CO CO98026351A patent/CO4950558A1/es unknown
- 1998-05-13 US US09/078,337 patent/US5958960A/en not_active Expired - Lifetime
- 1998-05-13 DK DK98303730T patent/DK0878463T3/da active
- 1998-05-13 PT PT98303730T patent/PT878463E/pt unknown
- 1998-05-13 AR ARP980102224A patent/AR015664A1/es active IP Right Grant
- 1998-05-13 SI SI9830021T patent/SI0878463T1/xx unknown
- 1998-05-13 DE DE69800430T patent/DE69800430T2/de not_active Expired - Lifetime
- 1998-05-13 AT AT98303730T patent/ATE198190T1/de not_active IP Right Cessation
- 1998-05-13 EP EP98303730A patent/EP0878463B1/en not_active Expired - Lifetime
- 1998-05-13 ES ES98303730T patent/ES2152738T3/es not_active Expired - Lifetime
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- 1998-05-14 CA CA002289472A patent/CA2289472C/en not_active Expired - Fee Related
- 1998-05-14 TW TW087107483A patent/TW505623B/zh active
- 1998-05-14 PL PL98336793A patent/PL336793A1/xx unknown
- 1998-05-14 JP JP54954398A patent/JP4191263B2/ja not_active Expired - Fee Related
- 1998-05-14 NZ NZ500954A patent/NZ500954A/en unknown
- 1998-05-14 CN CN98804992A patent/CN1125807C/zh not_active Expired - Fee Related
- 1998-05-14 BR BR9808787-8A patent/BR9808787A/pt active Search and Examination
- 1998-05-14 SV SV1998000056A patent/SV1998000056A/es unknown
- 1998-05-14 AU AU73869/98A patent/AU729632B2/en not_active Ceased
- 1998-05-14 KR KR1019997010444A patent/KR20010012489A/ko not_active Withdrawn
- 1998-05-14 EA EA199901029A patent/EA199901029A1/ru unknown
- 1998-05-14 WO PCT/US1998/009862 patent/WO1998051655A1/en not_active Ceased
- 1998-05-14 PE PE1998000370A patent/PE73599A1/es not_active Application Discontinuation
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1999
- 1999-05-28 US US09/322,651 patent/US6160009A/en not_active Expired - Lifetime
- 1999-11-09 NO NO995480A patent/NO995480D0/no not_active Application Discontinuation
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2000
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