PE48995A1 - Composicion para la administracion pulmonar de insulina - Google Patents
Composicion para la administracion pulmonar de insulinaInfo
- Publication number
- PE48995A1 PE48995A1 PE26227895A PE26227895A PE48995A1 PE 48995 A1 PE48995 A1 PE 48995A1 PE 26227895 A PE26227895 A PE 26227895A PE 26227895 A PE26227895 A PE 26227895A PE 48995 A1 PE48995 A1 PE 48995A1
- Authority
- PE
- Peru
- Prior art keywords
- composition
- insulin administration
- sodium
- pulmonary insulin
- carrier
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 230000002685 pulmonary effect Effects 0.000 title 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229920002774 Maltodextrin Polymers 0.000 abstract 1
- 239000005913 Maltodextrin Substances 0.000 abstract 1
- -1 RAFINOSA Chemical compound 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 239000012876 carrier material Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 229940035034 maltodextrin Drugs 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000010378 sodium ascorbate Nutrition 0.000 abstract 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 abstract 1
- 229960005055 sodium ascorbate Drugs 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 229960001790 sodium citrate Drugs 0.000 abstract 1
- 235000011083 sodium citrates Nutrition 0.000 abstract 1
- 235000012207 sodium gluconate Nutrition 0.000 abstract 1
- 239000000176 sodium gluconate Substances 0.000 abstract 1
- 229940005574 sodium gluconate Drugs 0.000 abstract 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION EN BASE A PARTICULAS INDIVIDUALES, CON UN TAMANO PROMEDIO MENOR DE 10�m, QUE CONTIENE INSULINA EN UN MATERIAL PORTADOR QUE PRODUCE POLVO POR SECADO POR PULVERIZACION; DONDE EL PORTADOR SE SELECCIONA DEL GRUPO DE: 1) CARBOHIDRATOS, COMO: MANITOL, RAFINOSA, LACTOSA, MALTODEXTRINA, TREHALOSA; 2) SALES ORGANICAS, COMO: CITRATO DE SODIO, GLUCONATO DE SODIO, ASCORBATO DE SODIO; 3) UN AMINOACIDO, UN PEPTIDO O UNA PROTEINA; DICHA COMPOSICION PODRIA ADMINISTRARSE USANDO UN INHALADOR Y PRODUCIR ABSORCION DE INSULINA A TRAVES DE LAS CELULAS EPITELIALES DE LOS ALVEOLOS PULMONARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20747294A | 1994-03-07 | 1994-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE48995A1 true PE48995A1 (es) | 1996-01-13 |
Family
ID=22770701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE26227895A PE48995A1 (es) | 1994-03-07 | 1995-02-20 | Composicion para la administracion pulmonar de insulina |
Country Status (3)
| Country | Link |
|---|---|
| PE (1) | PE48995A1 (es) |
| RU (1) | RU2175556C2 (es) |
| ZA (1) | ZA951883B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1438019A1 (en) * | 2001-10-24 | 2004-07-21 | PARI GmbH Spezialisten für effektive Inhalation | Kit for the preparation of a pharmaceutical composition |
| US6962006B2 (en) * | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| UA90013C2 (ru) | 2008-03-19 | 2010-03-25 | Давид Анатолійович Нога | Фармацевтическая композиция, содержащая инсулин, и способ его получения |
| HUE027239T2 (en) * | 2009-06-26 | 2016-10-28 | Novo Nordisk As | Preparation containing insulin, nicotinamide and arginine |
| US9180261B2 (en) * | 2010-01-12 | 2015-11-10 | Dance Biopharm Inc. | Preservative free insulin formulations and systems and methods for aerosolizing |
| RU2509375C2 (ru) * | 2012-05-29 | 2014-03-10 | Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А.И. Бурназяна" | Импактор-фантом респираторного тракта человека |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| GB9001635D0 (en) * | 1990-01-24 | 1990-03-21 | Ganderton David | Aerosol carriers |
| US5230884A (en) * | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
-
1995
- 1995-02-07 RU RU96118508A patent/RU2175556C2/ru not_active IP Right Cessation
- 1995-02-20 PE PE26227895A patent/PE48995A1/es not_active Application Discontinuation
- 1995-03-07 ZA ZA951883A patent/ZA951883B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA951883B (en) | 1995-12-14 |
| RU2175556C2 (ru) | 2001-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |