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PE48895A1 - Separacion de enantiomeros de amlodipina - Google Patents

Separacion de enantiomeros de amlodipina

Info

Publication number
PE48895A1
PE48895A1 PE1995264250A PE26425095A PE48895A1 PE 48895 A1 PE48895 A1 PE 48895A1 PE 1995264250 A PE1995264250 A PE 1995264250A PE 26425095 A PE26425095 A PE 26425095A PE 48895 A1 PE48895 A1 PE 48895A1
Authority
PE
Peru
Prior art keywords
amlodipine
separation
enantiomers
isomer
isomers
Prior art date
Application number
PE1995264250A
Other languages
English (en)
Inventor
Lionel Spargo Peter
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of PE48895A1 publication Critical patent/PE48895A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA SEPARACION DE LOS ISOMEROS R-(+) Y S-(-) DE LA AMLODIPINA A PARTIR DE SUS MEZCLAS; QUE COMPRENDE LA REACCION DE LA MEZCLA DE ISOMEROS CON ACIDO L o D TARTARICO EN UN DISOLVENTE ORGANICO QUE CONTIENE DIMETIL SULFOXIDO (DMSO) SUFICIENTE PARA LA PRECIPITACION DE: A) UN SOLVATO DE DIMETILSULFOXIDO DE UNA SAL DE L-TARTRATO DE LA R-(+)-AMLODIPINA, o B) UN SOLVATO DE DIMETILSULFOXIDO DE UNA SAL DE D-TARTRATO DE LA S-(-)-AMLODIPINA; DICHOS ENANTIOMEROS SON BLOQUEANTES DEL CANAL DE CALCIO, POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE TRANSTORNOS CARDIOVASCULARES, SIENDO MAS POTENTE EL ISOMERO S-(-), MIENTRAS QUE EL ISOMERO R-(+) TAMBIEN MUESTRA ACTIVIDAD EN EL TRATAMIENTO DE LA ATEROESCLEROSIS
PE1995264250A 1994-03-24 1995-03-16 Separacion de enantiomeros de amlodipina PE48895A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9405833A GB9405833D0 (en) 1994-03-24 1994-03-24 Separation of the enantiomers of amlodipine

Publications (1)

Publication Number Publication Date
PE48895A1 true PE48895A1 (es) 1996-01-06

Family

ID=10752425

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995264250A PE48895A1 (es) 1994-03-24 1995-03-16 Separacion de enantiomeros de amlodipina

Country Status (27)

Country Link
US (2) US5750707A (es)
EP (1) EP0751938B1 (es)
JP (1) JP2843681B2 (es)
KR (1) KR100188980B1 (es)
CN (1) CN1067055C (es)
AT (1) ATE166050T1 (es)
AU (1) AU677765B2 (es)
BR (1) BR9507137A (es)
CA (1) CA2186263C (es)
CO (1) CO4230248A1 (es)
CZ (1) CZ287324B6 (es)
DE (1) DE69502486T2 (es)
DK (1) DK0751938T3 (es)
ES (1) ES2116737T3 (es)
FI (1) FI113646B (es)
GB (1) GB9405833D0 (es)
HU (1) HU214720B (es)
IL (1) IL113008A (es)
MY (1) MY111979A (es)
NO (1) NO306110B1 (es)
NZ (1) NZ282404A (es)
PE (1) PE48895A1 (es)
PL (1) PL180085B1 (es)
RU (1) RU2132845C1 (es)
TW (1) TW448156B (es)
WO (1) WO1995025722A1 (es)
ZA (1) ZA952362B (es)

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US20050158408A1 (en) * 1998-07-24 2005-07-21 Yoo Seo H. Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof
US7772220B2 (en) * 2004-10-15 2010-08-10 Seo Hong Yoo Methods and compositions for reducing toxicity of a pharmaceutical compound
US20070072828A1 (en) * 1998-07-24 2007-03-29 Yoo Seo H Bile preparations for colorectal disorders
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CN1100038C (zh) * 2000-02-21 2003-01-29 张喜田 氨氯地平对映体的拆分
GB0020842D0 (en) * 2000-08-23 2000-10-11 Pfizer Ltd Therapeutic compositions
US6737430B2 (en) 2000-11-09 2004-05-18 Pfizer, Inc. Mutual prodrug of amlodipine and atorvastatin
HUP0401887A3 (en) * 2001-10-24 2005-05-30 Sepracor Inc Marlborough Method of resolving amlodipine racemate
CN1152013C (zh) * 2001-11-22 2004-06-02 张喜田 一类左旋氨氯地平盐的水合物及其制剂
US20030176706A1 (en) * 2002-03-18 2003-09-18 Joshi Rohini Ramesh Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate]
EP1348697A1 (en) * 2002-03-28 2003-10-01 Council Of Scientific & Industrial Research Process for the preparation of S(-)-amlodipine-L(+)-hemitartrate
KR100476636B1 (ko) * 2002-09-11 2005-03-17 한림제약(주) 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
AU2004208615C1 (en) * 2003-01-31 2010-05-13 Daiichi Sankyo Company, Limited Medicine for prevention of and treatment for arteriosclerosis and hypertension
US7145125B2 (en) 2003-06-23 2006-12-05 Advanced Optical Technologies, Llc Integrating chamber cone light using LED sources
KR20060086432A (ko) * 2003-11-20 2006-07-31 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 키랄 암로디핀 염의 제조방법
US6846932B1 (en) * 2003-11-20 2005-01-25 Council Of Scientific And Industrial Research Process for preparation of chiral amlodipine salts
CN1231469C (zh) * 2003-12-05 2005-12-14 石家庄制药集团欧意药业有限公司 一种光学活性氨氯地平的拆分方法
US20060035940A1 (en) * 2004-03-16 2006-02-16 Sepracor Inc. (S)-Amlodipine malate
CN101035541B (zh) * 2004-08-30 2012-05-30 柳署弘 溶解的udca在局灶缺血模型中的神经保护作用
CN101039699B (zh) * 2004-10-15 2011-07-27 柳署弘 用于减小药物化合物毒性的方法和组合物
DE602005007763D1 (de) * 2004-10-20 2008-08-07 Emcure Pharmaceuticals Ltd Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit
DE602005025391D1 (de) * 2004-11-01 2011-01-27 Seo Hong Yoo Verfahren und zusammensetzungen zur verringerung der neurodegeneration bei amyotrophischer lateralsklerose
KR101152608B1 (ko) * 2004-12-02 2012-06-07 에스케이케미칼주식회사 (ｒ,ｓ)-암로디핀으로부터 암로디핀 이성질체의 분리방법
BRPI0519093A2 (pt) * 2004-12-02 2008-12-23 Sk Chemicals Co Ltd mÉtodo para preparaÇço de amlodipina opticamente ativa e composto
HUP0500570A3 (en) * 2005-06-08 2008-03-28 Richter Gedeon Nyrt Process for the preparation of (s)-(-)-amlodipine
US20080279942A1 (en) * 2005-06-27 2008-11-13 Takeshi Hamaura Pharmaceutical Preparation Containing an Angiotensin II Receptor Antagonist and a Calcium Channel Blocker
KR101235116B1 (ko) * 2005-10-17 2013-02-20 에스케이케미칼주식회사 광학활성 암로디핀 겐티세이트 염의 제조방법
CN100436417C (zh) * 2006-04-11 2008-11-26 石药集团中奇制药技术（石家庄）有限公司 一种光学活性氨氯地平的拆分方法
KR100913791B1 (ko) * 2006-07-21 2009-08-26 한미약품 주식회사 (ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물
TWI399223B (zh) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
KR100828883B1 (ko) * 2006-10-27 2008-05-09 씨제이제일제당 (주) 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법
KR100830003B1 (ko) * 2006-10-31 2008-05-15 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법
KR100868160B1 (ko) 2007-02-14 2008-11-12 한미약품 주식회사 Ｓ-(-)-암로디핀 또는 이의 염의 제조방법 및 이에사용되는 중간체
RU2357781C1 (ru) * 2008-02-06 2009-06-10 Емельяна Зиповна Гильдеева Способ разделения оптических изомеров амлодипина
KR100979772B1 (ko) 2008-06-12 2010-09-02 에이치 엘 지노믹스(주) 광학적으로 순수한 에스-(-)-암로디핀 벤젠술폰산염의제조방법
KR100989970B1 (ko) 2008-07-01 2010-10-26 미래파인켐 주식회사 (ｓ)-(-)-암로디핀의 분리방법
KR101085169B1 (ko) 2009-03-25 2011-11-18 (주)켐트로스 암로디핀 광학 이성질체의 분리방법
KR101705535B1 (ko) * 2009-04-01 2017-02-28 주식회사 씨트리 광학활성을 갖는 1-(3-히드록시페닐)에틸아민의 제조방법
RU2537361C1 (ru) * 2013-07-18 2015-01-10 Общество С Ограниченной Ответственностью "Синтегал" Оптические изомеры (+) и (-)-бензгидрилмочевин и (+) и (-)-1-[(3-хлорфенил)-фенил-метил]мочевины, фармацевтическая композиция на их основе и способ их получения
CN110882249B (zh) 2019-11-08 2021-04-30 北京吾为尔创科技有限公司 含苯磺酸左氨氯地平水合物的组合物及其制备方法
CN111100064B (zh) * 2020-01-08 2024-01-02 湖南理工学院 一种从废液中富集、回收和拆分碱性手性药物氨氯地平的方法
CN111777547B (zh) * 2020-07-17 2021-10-08 江西施美药业股份有限公司 一种诱导析晶拆分左旋氨氯地平的方法
US11452690B1 (en) 2021-01-27 2022-09-27 ECI Pharmaceuticals, LLC Oral liquid compositions comprising amlodipine besylate and methods of using the same
CN115850159B (zh) * 2022-11-11 2025-03-14 常州瑞明药业有限公司 一种马来酸左旋氨氯地平的制备方法

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US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
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Also Published As

Publication number Publication date
HU9602597D0 (en) 1996-11-28
KR100188980B1 (ko) 1999-06-01
CN1067055C (zh) 2001-06-13
BR9507137A (pt) 1997-09-30
MY111979A (en) 2001-03-31
WO1995025722A1 (en) 1995-09-28
EP0751938B1 (en) 1998-05-13
RU2132845C1 (ru) 1999-07-10
CO4230248A1 (es) 1995-10-19
CA2186263A1 (en) 1995-09-28
HUT76290A (en) 1997-07-28
CZ287324B6 (en) 2000-10-11
HU214720B (hu) 1998-05-28
JP2843681B2 (ja) 1999-01-06
EP0751938A1 (en) 1997-01-08
US6046338A (en) 2000-04-04
DE69502486T2 (de) 1998-09-10
FI963775L (fi) 1996-09-23
CA2186263C (en) 1999-05-11
IL113008A (en) 1999-07-14
ATE166050T1 (de) 1998-05-15
CN1144523A (zh) 1997-03-05
DE69502486D1 (de) 1998-06-18
FI963775A0 (fi) 1996-09-23
TW448156B (en) 2001-08-01
JPH09510707A (ja) 1997-10-28
PL316535A1 (en) 1997-01-20
IL113008A0 (en) 1995-06-29
NO963991D0 (no) 1996-09-23
ZA952362B (en) 1996-09-23
CZ278496A3 (en) 1997-03-12
KR970701697A (ko) 1997-04-12
AU677765B2 (en) 1997-05-01
FI113646B (fi) 2004-05-31
MX9604299A (es) 1998-05-31
NO963991L (no) 1996-11-19
NO306110B1 (no) 1999-09-20
GB9405833D0 (en) 1994-05-11
AU1949395A (en) 1995-10-09
DK0751938T3 (da) 1998-10-07
US5750707A (en) 1998-05-12
PL180085B1 (pl) 2000-12-29
ES2116737T3 (es) 1998-07-16
NZ282404A (en) 1997-11-24

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