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PE28196A1 - Forma fisica de un derivado de dihidro-2,3-benzodiazepina - Google Patents

Forma fisica de un derivado de dihidro-2,3-benzodiazepina

Info

Publication number
PE28196A1
PE28196A1 PE1995273616A PE27361695A PE28196A1 PE 28196 A1 PE28196 A1 PE 28196A1 PE 1995273616 A PE1995273616 A PE 1995273616A PE 27361695 A PE27361695 A PE 27361695A PE 28196 A1 PE28196 A1 PE 28196A1
Authority
PE
Peru
Prior art keywords
compound
acetyl
ethanol
methyl
formula
Prior art date
Application number
PE1995273616A
Other languages
English (en)
Inventor
Jeffrey Thomas Vicenzi
David Lee Varie
Benjamin Alan Anderson
Jr Milton Joseph Zmijewski
Marvin Martin Hansen
Allen Robert Harkness
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE28196A1 publication Critical patent/PE28196A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

SE REFIERE AL ENANTIOMERO (R)-7-ACETIL-5-(4-AMINOFENIL)-8,9-DIHIDRO-8-METIL-7H-1,3-DIOXOLO[4,5-h][2,3] BENZODIACEPINA QUE TIENE UN PATRON DE DIFRACCION EN POLVO DE RAYOS X CON SEPARACION d A 10,61 A�, 8,83 A�, 6,78 A�, 5,83 A�, 4,13 A� Y 3,74 A�, TAMBIEN SE REFIERE A SU PROCEDIMIENTO DE PREPARACION, QUE COMPRENDE: a)LA REACCION DE UN COMPUESTO DE FORMULA VII DONDE Ms ES METANOSULFONILO, R ES METILO, X ES ACETILO, ARILO ES p-NITROFENILO CON SOSA CAUSTICA PARA PROPORCIONAR UN COMPUESTO DE FORMULA I DONDE R ES METILO, X ES ACETILO Y ARILO ES p-NITROFENILO; A UNA TEMPERATURA EN EL INTERVALO DE 0�C A 100�C, USANDO DISOLVENTES COMO METANOL Y ETANOL; b)REDUCCION DEL GRUPO p-NITROFENILO EN EL COMPUESTO I EN UN GRUPO ANILINO USANDO FORMIATO DE POTASIO EN PRESENCIA DE PALADIO SOBRE CARBON PARA OBTENER UN COMPUESTO DE FORMULA I DONDE ARILO ES p-AMINOFENILO; c)CRISTALIZACION DEL COMPUESTO DE FORMULA I DONDE ARILO ES p-AMINOFENILO EN UNA MEZCLA DE AGUA Y ETANOL EN LA QUE EL NUMERO DE VOLUMENES DE AGUA POR VOLUMEN DE ETANOL ES MENOR DE 1,1 A 1,0. ESTE ENANTIOMERO JUNTO A UN VEHICULO FARMACEUTICAMENTE ACEPTABLE CONSTITUYE UNA FORMA FARMACEUTICA UTIL COMO ANTAGONISTA DEL RECEPTOR DE AMINOACIDOS EXITATIVOS (AMPA)
PE1995273616A 1994-08-31 1995-07-12 Forma fisica de un derivado de dihidro-2,3-benzodiazepina PE28196A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29864594A 1994-08-31 1994-08-31
US08/413,024 US6288057B1 (en) 1994-08-31 1995-03-28 Physical form of dihydro-2,3-benzodiazepine derivative

Publications (1)

Publication Number Publication Date
PE28196A1 true PE28196A1 (es) 1996-07-04

Family

ID=23151416

Family Applications (3)

Application Number Title Priority Date Filing Date
PE1995273614A PE32996A1 (es) 1994-08-31 1995-07-12 Forma cristalina de un derivado de dihidro-2,3-benzodiazepina
PE1995273615A PE32896A1 (es) 1994-08-31 1995-07-12 Procedimiento estereoselectivo para producir derivados de dihidro-2,3-benzodiacepina
PE1995273616A PE28196A1 (es) 1994-08-31 1995-07-12 Forma fisica de un derivado de dihidro-2,3-benzodiazepina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PE1995273614A PE32996A1 (es) 1994-08-31 1995-07-12 Forma cristalina de un derivado de dihidro-2,3-benzodiazepina
PE1995273615A PE32896A1 (es) 1994-08-31 1995-07-12 Procedimiento estereoselectivo para producir derivados de dihidro-2,3-benzodiacepina

Country Status (13)

Country Link
US (3) US6329364B1 (es)
KR (2) KR100386933B1 (es)
CO (3) CO4410198A1 (es)
HU (1) HU223846B1 (es)
MY (2) MY117754A (es)
NZ (1) NZ272896A (es)
PE (3) PE32996A1 (es)
RU (1) RU2142465C1 (es)
SI (2) SI0699677T1 (es)
TW (3) TW372965B (es)
UA (3) UA44698C2 (es)
YU (3) YU49288B (es)
ZA (3) ZA957279B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100303523B1 (ko) * 1992-07-24 2001-11-22 린다 에스. 스티븐슨 Ampa수용체에의해중재되는시냅스반응을증진하는약제
KR100478129B1 (ko) * 1996-12-20 2005-12-26 주식회사 효성 투습방수직물의제조방법
EP1406880A1 (en) * 2001-07-10 2004-04-14 PHARMACIA & UPJOHN COMPANY Crystalline thiazine oxazolidinones
ES2623094T3 (es) 2001-08-15 2017-07-10 Pharmacia & Upjohn Company Llc Procedimientos de preparación de cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida
KR20040032188A (ko) * 2002-10-01 2004-04-17 기아자동차주식회사 개량형 아웃사이드 미러
US20090233913A1 (en) * 2005-12-30 2009-09-17 Istvan Ling Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
US20160137573A1 (en) * 2014-11-14 2016-05-19 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Methods and catalyst systems for carbon dioxide conversion
CN119998433A (zh) * 2022-07-08 2025-05-13 思维医学股份有限公司 R-mdma的制造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748342A (en) * 1971-05-06 1973-07-24 Sandoz Ag Intermediates for preparing quinazolinones
US3794642A (en) * 1973-01-15 1974-02-26 Lilly Co Eli Oxidation of substituted methanes to the corresponding substituted methanols
US4560510A (en) * 1984-04-06 1985-12-24 A. H. Robins Company, Incorporated Process and intermediates for the preparation of aryl substituted pyrido[1,4]benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
EP0357787B1 (en) * 1988-02-12 1996-05-08 Daicel Chemical Industries, Ltd. Process for preparing optically active 2-hydroxy acid derivatives
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219777B (hu) 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására

Also Published As

Publication number Publication date
HU0003319D0 (es) 1995-08-30
TW372965B (en) 1999-11-01
HU223846B1 (hu) 2005-02-28
US6288057B1 (en) 2001-09-11
KR960007597A (ko) 1996-03-22
CO4410199A1 (es) 1997-01-09
CO4410198A1 (es) 1997-01-09
NZ272896A (en) 1997-03-24
US6329364B1 (en) 2001-12-11
YU49288B (sh) 2005-03-15
KR100386934B1 (ko) 2003-10-04
TW390881B (en) 2000-05-21
TW393485B (en) 2000-06-11
ZA957280B (en) 1997-02-28
KR960007596A (ko) 1996-03-22
YU49289B (sh) 2005-03-15
UA44698C2 (uk) 2002-03-15
US5665878A (en) 1997-09-09
KR100386933B1 (ko) 2003-09-19
SI0699678T1 (en) 2004-06-30
ZA957278B (en) 1997-02-28
RU2142465C1 (ru) 1999-12-10
YU57795A (sh) 1998-07-10
PE32996A1 (es) 1996-08-10
PE32896A1 (es) 1996-08-07
SI0699677T1 (en) 2003-06-30
UA41354C2 (uk) 2001-09-17
YU57695A (sh) 1998-07-10
MY118394A (en) 2004-10-30
MY117754A (en) 2004-08-30
ZA957279B (en) 1997-02-28
CO4410197A1 (es) 1997-01-09
UA45309C2 (uk) 2002-04-15
YU57895A (sh) 1998-07-10
YU49349B (sh) 2005-07-19

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed