PE27799A1 - Formulaciones y formas polimorficas de desferrioxamina y su preparacion - Google Patents
Formulaciones y formas polimorficas de desferrioxamina y su preparacionInfo
- Publication number
- PE27799A1 PE27799A1 PE1997001097A PE00109797A PE27799A1 PE 27799 A1 PE27799 A1 PE 27799A1 PE 1997001097 A PE1997001097 A PE 1997001097A PE 00109797 A PE00109797 A PE 00109797A PE 27799 A1 PE27799 A1 PE 27799A1
- Authority
- PE
- Peru
- Prior art keywords
- despherrioxamine
- refers
- salt
- acid
- crystal
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- KVGOXGQSTGQXDD-UHFFFAOYSA-N 1-decane-sulfonic-acid Chemical compound CCCCCCCCCCS(O)(=O)=O KVGOXGQSTGQXDD-UHFFFAOYSA-N 0.000 abstract 4
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 229960000958 deferoxamine Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA FORMULACION PARENTERAL DE LIBERACION SOSTENIDA, QUE COMPRENDE: PARTICULAS DE 5� A 10� DE UNA SAL DE DESFERRIOXAMINA-B DE UN ACIDO SULFONICO ALIFATICO DE AL MENOS 8 CARBONOS, SUSPENDIDA EN ACEITE. TAMBIEN SE REFIERE A UNA FORMA CRISTALINA DE 1-DECANSULFONATO DE DESFERRIOXAMINA DE FORMULA (I), CARACTERIZADO POR UN PUNTO DE FUSION DE 154�C A 158�C, Y POR UN PATRON DE DIFRACCION DE RAYOS X EN 2U�: 3,1 4,2 7,3 8,4 9,4 10,5 13,7 16,8 17,4 18,0 18,4 19,6 20,1 20,9 22,3 23,7 25,1 25,6. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE DICHO CRISTAL, QUE COMPRENDE: CALENTAR UNA SOLUCION DE METANOSULFONATO DE DESFERRIOXAMINA; AGREGAR UNA CANTIDAD EQUIMOLAR DE UNA SAL DE ACIDO 1-DECANSULFONICO; INDUCIR LA CRISTALIZACION CON UN CRISTAL DE SIEMBRA Y CONTINUAR AGREGANDO EL RESTO DE LA CANTIDAD EQUIMOLAR DE LA SAL DE ACIDO 1-DECANSULFONICO, OBTENIENDOSE UNA SOLUCION SATURADA EN CALIENTE DE 1-DECANSULFONATO DE DESFERRIOXAMINA EN UN SOLVENTE POLAR, A UNA TEMPERATURA ELEVADA; LA CRISTALIZACION OCURRE A UNA VELOCIDAD DE ENFRIAMIENTO DE 1�C/MINUTO. ESTE CRISTAL MAS ESTABLE, NO MOSTRARA UNA TRANSFORMACION DE ESTADO SOLIDO, INDEPENDIENTE DE LA FASE DE DISPERSION, EN LA PRODUCCION, ALMACENAMIENTO Y USO PARA EL TRATAMIENTO UNA ENFERMEDAD DE SOBRECARGA DE Fe o Al, MALARIA, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH302496 | 1996-12-10 | ||
| GBGB9625878.5A GB9625878D0 (en) | 1996-12-12 | 1996-12-12 | Compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE27799A1 true PE27799A1 (es) | 1999-03-18 |
Family
ID=25691970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001097A PE27799A1 (es) | 1996-12-10 | 1997-12-05 | Formulaciones y formas polimorficas de desferrioxamina y su preparacion |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0944586A2 (es) |
| KR (1) | KR20000069376A (es) |
| CN (1) | CN1239946A (es) |
| AR (1) | AR009655A1 (es) |
| AU (1) | AU5983998A (es) |
| BR (1) | BR9713570A (es) |
| CA (1) | CA2274761A1 (es) |
| CO (1) | CO4910160A1 (es) |
| CZ (1) | CZ204499A3 (es) |
| ID (1) | ID22388A (es) |
| IL (1) | IL130203A0 (es) |
| PE (1) | PE27799A1 (es) |
| PL (1) | PL334316A1 (es) |
| TR (1) | TR199901260T2 (es) |
| WO (1) | WO1998025887A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670399B2 (en) * | 1999-12-23 | 2003-12-30 | Neurochem (International) Limited | Compounds and methods for modulating cerebral amyloid angiopathy |
| GB0117645D0 (en) * | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| DE10223913A1 (de) * | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Verfahren zur Herstellung spezifischer Kristallmodifikationen polymorpher Substanzen |
| JP6810988B2 (ja) | 2015-10-23 | 2021-01-13 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ | 新規なフェロポーチン阻害剤 |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛（國際）股份有限公司 | 新穎的鐵螯合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH438351A (de) * | 1959-09-25 | 1967-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Wuchsstoffe |
| FR1898M (fr) * | 1961-04-07 | 1963-07-08 | Ciba Geigy | Nouvelle substance utilisable en thérapeutique. |
| GB9211779D0 (en) * | 1992-06-03 | 1992-07-15 | Ciba Geigy Ag | Amine salts |
-
1997
- 1997-12-05 AR ARP970105722A patent/AR009655A1/es unknown
- 1997-12-05 PE PE1997001097A patent/PE27799A1/es not_active Application Discontinuation
- 1997-12-08 CZ CZ992044A patent/CZ204499A3/cs unknown
- 1997-12-08 EP EP97954727A patent/EP0944586A2/en not_active Withdrawn
- 1997-12-08 ID IDW990473A patent/ID22388A/id unknown
- 1997-12-08 AU AU59839/98A patent/AU5983998A/en not_active Abandoned
- 1997-12-08 CA CA002274761A patent/CA2274761A1/en not_active Abandoned
- 1997-12-08 CN CN97180523A patent/CN1239946A/zh active Pending
- 1997-12-08 IL IL13020397A patent/IL130203A0/xx unknown
- 1997-12-08 WO PCT/EP1997/006849 patent/WO1998025887A2/en not_active Ceased
- 1997-12-08 PL PL97334316A patent/PL334316A1/xx unknown
- 1997-12-08 BR BR9713570-4A patent/BR9713570A/pt not_active Application Discontinuation
- 1997-12-08 KR KR1019997005104A patent/KR20000069376A/ko not_active Withdrawn
- 1997-12-08 TR TR1999/01260T patent/TR199901260T2/xx unknown
- 1997-12-10 CO CO97072069A patent/CO4910160A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ204499A3 (cs) | 1999-09-15 |
| AR009655A1 (es) | 2000-04-26 |
| EP0944586A2 (en) | 1999-09-29 |
| BR9713570A (pt) | 2000-03-14 |
| CN1239946A (zh) | 1999-12-29 |
| KR20000069376A (ko) | 2000-11-25 |
| CA2274761A1 (en) | 1998-06-18 |
| CO4910160A1 (es) | 2000-04-24 |
| IL130203A0 (en) | 2000-06-01 |
| AU5983998A (en) | 1998-07-03 |
| PL334316A1 (en) | 2000-02-14 |
| WO1998025887A3 (en) | 1998-08-13 |
| ID22388A (id) | 1999-10-07 |
| WO1998025887A2 (en) | 1998-06-18 |
| TR199901260T2 (xx) | 1999-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |