PE20399A1 - Muteina ob - Google Patents
Muteina obInfo
- Publication number
- PE20399A1 PE20399A1 PE00108697A PE00108697A PE20399A1 PE 20399 A1 PE20399 A1 PE 20399A1 PE 00108697 A PE00108697 A PE 00108697A PE 00108697 A PE00108697 A PE 00108697A PE 20399 A1 PE20399 A1 PE 20399A1
- Authority
- PE
- Peru
- Prior art keywords
- muteina
- muteins
- making
- methods
- relates
- Prior art date
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Child & Adolescent Psychology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
CARACTERIZADA PORQUE COMPRENDE UNA SEQ. ID. 1, CON 146 AMINOACIDOS, EN DONDE EN LA POSICION 127 Ser ES Asp Y EN LA POSICION 128 Arg ES Gln. TAMBIEN SE REFIERE AL METODO DE PRODUCCION DE UNA MUTEINA OB, AL VECTOR DE EXPRESION QUE CODIFICA LA MUTEINA OB Y A LA CELULA HOSPEDADORA SELECCIONADA DE UNA CELULA PROCARIOTA, DE INSECTO o DE MAMIFERO; EN DONDE DICHO METODO DE PRODUCCION COMPRENDE: CULTIVAR UNA CELULA HOSPEDADORA TRANSFORMADA CON LA INSERCION DE UN VECTOR DE EXPRESION, EN UN MEDIO DE CULTIVO ADECUADO PARA LA EXPRESION DE LA MUTEINA, Y, PURIFICAR LA MUTEINA OBTENIDA. ADEMAS SE REFIERE A LOS ANTICUERPOS POLI- Y/O MONOCLONALES CONTRA UNA MUTEINA OB. LA MUTEINA OB ACTUA COMO ANTAGONISTA DE LA PROTEINA DE OBESIDAD HUMANA (LEPTINA), CAUSANDO UN AUMENTO EN EL PESO CORPORAL, SIENDO USADA SOLA O EN COMBINACION CON UN ANTICUERPO MONOCLONAL CONTRA UNA PROTEINA DE LA OBESIDAD, PARA LA PREVENCION, TRATAMIENTO Y CONTROL DE LA OBESIDAD Y DE ENFERMEDADES ASOCIADAS TALES COMO ANOREXIA, CAQUEXIA, TRASTORNOS POR DEMACRACION, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96119606 | 1996-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20399A1 true PE20399A1 (es) | 1999-03-05 |
Family
ID=8223476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE00108697A PE20399A1 (es) | 1996-12-06 | 1997-12-02 | Muteina ob |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR010333A1 (es) |
| AU (1) | AU5654998A (es) |
| CO (1) | CO4930295A1 (es) |
| HR (1) | HRP970654A2 (es) |
| MA (1) | MA24411A1 (es) |
| PE (1) | PE20399A1 (es) |
| WO (1) | WO1998024896A2 (es) |
| ZA (1) | ZA9710832B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777388B1 (en) | 1998-08-21 | 2004-08-17 | Clf Medical Technology Acceleration Program, Inc. | Leptin-related peptides |
| US7208572B2 (en) | 1998-08-21 | 2007-04-24 | Albany Medical College | Leptin-related peptides |
| US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| US8227408B2 (en) | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
| CA2725143A1 (en) | 2008-05-21 | 2009-11-26 | Neurotez, Inc. | Methods for treating progressive cognitive disorders related to neurofibrillary tangles |
| CN102300581B (zh) | 2008-11-04 | 2016-12-21 | 尼古拉斯·泰萨普塞蒂斯 | 用于治疗因神经原纤维缠结和β淀粉状蛋白的积聚引起的进行性认知功能障碍的瘦蛋白组合物和方法 |
| EP2621515B1 (en) | 2010-09-28 | 2017-03-29 | Aegerion Pharmaceuticals, Inc. | A chimeric seal-human leptin polypeptide with increased solubility |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1259923A (en) * | 1983-08-17 | 1989-09-26 | Roger Aston | Physiologically active compositions |
| US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| YU5396A (sh) * | 1995-01-31 | 1998-08-14 | Eli Lilly And Company, Lilly Corporate Center | Novi biološki aktivni proteini, njihove farmaceutske formulacije i postupak za njihovo dobijanje |
| GB9509164D0 (en) * | 1995-05-05 | 1995-06-28 | Smithkline Beecham Plc | Novel compounds |
-
1997
- 1997-11-22 AU AU56549/98A patent/AU5654998A/en not_active Abandoned
- 1997-11-22 WO PCT/EP1997/006541 patent/WO1998024896A2/en not_active Ceased
- 1997-12-01 MA MA24881A patent/MA24411A1/fr unknown
- 1997-12-02 ZA ZA9710832A patent/ZA9710832B/xx unknown
- 1997-12-02 PE PE00108697A patent/PE20399A1/es not_active Application Discontinuation
- 1997-12-03 HR HRP970654 patent/HRP970654A2/hr not_active Application Discontinuation
- 1997-12-04 CO CO97071061A patent/CO4930295A1/es unknown
- 1997-12-04 AR ARP970105715 patent/AR010333A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO4930295A1 (es) | 2000-06-27 |
| HRP970654A2 (en) | 1998-10-31 |
| MA24411A1 (fr) | 1998-07-01 |
| WO1998024896A2 (en) | 1998-06-11 |
| ZA9710832B (en) | 1998-06-08 |
| AU5654998A (en) | 1998-06-29 |
| AR010333A1 (es) | 2000-06-07 |
| WO1998024896A3 (en) | 1998-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |