PE20220948A1 - Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- PE20220948A1 PE20220948A1 PE2018003132A PE2018003132A PE20220948A1 PE 20220948 A1 PE20220948 A1 PE 20220948A1 PE 2018003132 A PE2018003132 A PE 2018003132A PE 2018003132 A PE2018003132 A PE 2018003132A PE 20220948 A1 PE20220948 A1 PE 20220948A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- group
- piperidinil
- hetero
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a un compuesto derivado de piperidinilo de formula I o sus enantiomeros, diastereoisomeros o una sal de adicion del mismo, donde: R1 es un grupo arilo o heteroarilo; R2 es un atomo de hidrogeno o halogeno; n es 0 a 2; J es un grupo -CO-, SO2-, entre otros; K es un enlace, entre otros; L es un grupo -CY2, entre otros; W representa el grupo (i), donde: A es un anillo heteroarilo, X es un atomo de carbono o nitrogeno, R4 es hidrogeno, halogeno, entre otros, R5 es hidrogeno, halogeno, entre otros; CY1 es un grupo cicloalquilo, arilo, entre otros. Tambien se refiere a una composicion farmaceutica y a un proceso de preparacion. Dicho compuesto es un inhibidor de la proteasa especifica de ubiquitina 7 (USP7), tambien conocida como Proteasa especifica de ubiquitina asociada con el virus del herpes (HAUSP), siendo util en el tratamiento del cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1655387A FR3052451B1 (fr) | 2016-06-10 | 2016-06-10 | Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR1663463A FR3061177B1 (fr) | 2016-12-28 | 2016-12-28 | Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| PCT/EP2017/064062 WO2017212010A1 (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20220948A1 true PE20220948A1 (es) | 2022-05-31 |
Family
ID=59021522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018003132A PE20220948A1 (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (42)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018067964B1 (pt) | 2016-03-07 | 2024-01-16 | Enanta Pharmaceuticals, Inc | Composto, composição farmacêutica que o compreende e uso do referido composto |
| FR3052452B1 (fr) * | 2016-06-10 | 2018-06-22 | Les Laboratoires Servier | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2018195450A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
| TWI811236B (zh) | 2017-08-28 | 2023-08-11 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| GB201801562D0 (en) * | 2018-01-31 | 2018-03-14 | Almac Diagnostics Ltd | Pharmaceutical compounds |
| UY38291A (es) * | 2018-07-05 | 2020-06-30 | Servier Lab | Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas |
| CA3113235A1 (en) | 2018-09-21 | 2020-03-26 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| UY38423A (es) * | 2018-10-19 | 2021-02-26 | Servier Lab | Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| US11198693B2 (en) | 2018-11-21 | 2021-12-14 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2020115501A1 (en) * | 2018-12-06 | 2020-06-11 | Almac Discovery Limited | Pharmaceutical compounds and their use as inhibitors of ubiquitin specific protease 19 (usp19) |
| CN114401715A (zh) * | 2019-05-06 | 2022-04-26 | 瓦洛健康股份有限公司 | 抑制usp19 |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| ES2989675T3 (es) | 2019-07-03 | 2024-11-27 | Bayer Ag | Carboxamidas de tiofeno sustituidas y derivados de estas como microbicidas |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| PE20221327A1 (es) | 2019-12-20 | 2022-09-09 | Bayer Ag | Carboxamidas de tiofeno, acidos carboxilicos de tiofeno sustituidos y derivados de estos |
| CN113087718B (zh) * | 2020-01-09 | 2024-02-09 | 四川科伦博泰生物医药股份有限公司 | 噻吩并嘧啶酮类化合物及其医药应用 |
| GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| CN116574084A (zh) * | 2023-04-17 | 2023-08-11 | 华南理工大学 | 一种噻吩衍生物及其合成方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR065494A1 (es) * | 2007-03-02 | 2009-06-10 | Schering Corp | Derivados de piperidina y metodos de uso de los mismos |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| MA41291A (fr) * | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| TWI770525B (zh) | 2014-12-30 | 2022-07-11 | 美商瓦洛健康公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| HK1248220A1 (zh) | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 喹唑啉酮和偶氮喹唑啉作为泛特丁胺蛋白酶7抑制剂 |
| HK1248221A1 (zh) | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 异噻唑啉酮类，吡唑并嘧啶酮类和吡咯并嘧啶酮作为泛蛋白特异性蛋白酶7抑制剂 |
| WO2016126929A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
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2017
- 2017-06-09 UY UY0001037289A patent/UY37289A/es unknown
- 2017-06-09 CN CN201780047088.4A patent/CN109563094B/zh active Active
- 2017-06-09 TN TNP/2018/000395A patent/TN2018000395A1/en unknown
- 2017-06-09 HR HRP20200556TT patent/HRP20200556T1/hr unknown
- 2017-06-09 US US16/306,941 patent/US10654849B2/en active Active
- 2017-06-09 PE PE2018003132A patent/PE20220948A1/es unknown
- 2017-06-09 EP EP17728567.3A patent/EP3468971B1/en active Active
- 2017-06-09 JP JP2018564752A patent/JP6985299B2/ja not_active Expired - Fee Related
- 2017-06-09 CA CA3027008A patent/CA3027008C/en active Active
- 2017-06-09 BR BR112018075284-3A patent/BR112018075284A2/pt not_active Application Discontinuation
- 2017-06-09 MX MX2018015212A patent/MX374443B/es active IP Right Grant
- 2017-06-09 KR KR1020197000798A patent/KR102003532B1/ko active Active
- 2017-06-09 WO PCT/EP2017/064062 patent/WO2017212010A1/en not_active Ceased
- 2017-06-09 PT PT177285673T patent/PT3468971T/pt unknown
- 2017-06-09 CU CU2018000146A patent/CU20180146A7/es unknown
- 2017-06-09 RU RU2018147424A patent/RU2742271C2/ru active
- 2017-06-09 HU HUE17728567A patent/HUE048590T2/hu unknown
- 2017-06-09 PL PL17728567T patent/PL3468971T3/pl unknown
- 2017-06-09 SG SG11201810576QA patent/SG11201810576QA/en unknown
- 2017-06-09 MA MA45223A patent/MA45223B1/fr unknown
- 2017-06-09 MY MYPI2018002417A patent/MY196328A/en unknown
- 2017-06-09 RS RS20200510A patent/RS60279B1/sr unknown
- 2017-06-09 MD MDE20190461T patent/MD3468971T2/ro unknown
- 2017-06-09 TW TW106119243A patent/TWI647228B/zh not_active IP Right Cessation
- 2017-06-09 GE GEAP201714982A patent/GEP20207161B/en unknown
- 2017-06-09 ES ES17728567T patent/ES2778700T3/es active Active
- 2017-06-09 AU AU2017277732A patent/AU2017277732B2/en not_active Ceased
- 2017-06-09 SI SI201730267T patent/SI3468971T1/sl unknown
- 2017-06-09 CR CR20180563A patent/CR20180563A/es unknown
- 2017-06-09 DK DK17728567.3T patent/DK3468971T3/da active
- 2017-06-09 UA UAA201900070A patent/UA123793C2/uk unknown
- 2017-06-09 LT LTEP17728567.3T patent/LT3468971T/lt unknown
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2018
- 2018-11-28 PH PH12018502516A patent/PH12018502516B1/en unknown
- 2018-11-29 SV SV2018005792A patent/SV2018005792A/es unknown
- 2018-12-03 IL IL263455A patent/IL263455B/en active IP Right Grant
- 2018-12-03 DO DO2018000264A patent/DOP2018000264A/es unknown
- 2018-12-04 CL CL2018003473A patent/CL2018003473A1/es unknown
- 2018-12-04 EC ECSENADI201890046A patent/ECSP18090046A/es unknown
- 2018-12-04 CO CONC2018/0013141A patent/CO2018013141A2/es unknown
- 2018-12-07 NI NI201800133A patent/NI201800133A/es unknown
- 2018-12-07 ZA ZA2018/08286A patent/ZA201808286B/en unknown
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2020
- 2020-05-18 CY CY20201100451T patent/CY1123069T1/el unknown
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