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PE20181316A1 - Nuevos peptidos y combinacion de peptidos para el uso en la inmunoterapia contra varios tipos de cancer - Google Patents

Nuevos peptidos y combinacion de peptidos para el uso en la inmunoterapia contra varios tipos de cancer

Info

Publication number
PE20181316A1
PE20181316A1 PE2018000553A PE2018000553A PE20181316A1 PE 20181316 A1 PE20181316 A1 PE 20181316A1 PE 2018000553 A PE2018000553 A PE 2018000553A PE 2018000553 A PE2018000553 A PE 2018000553A PE 20181316 A1 PE20181316 A1 PE 20181316A1
Authority
PE
Peru
Prior art keywords
peptide
cancer
various types
against various
seq
Prior art date
Application number
PE2018000553A
Other languages
English (en)
Inventor
Andrea Mahr
Toni Weinschenk
Colette Song
Oliver Schoor
Jens Fritsche
Harpreet Singh
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of PE20181316A1 publication Critical patent/PE20181316A1/es

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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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Abstract

Se refiere a un peptido que comprende una secuencia de aminoacidos seleccionada entre el grupo que consiste en la secuencia SEQ ID NO: 1-289, SEQ ID NO: 305 y SEQ ID NO: 306 y secuencias variantes de las mismas que son homologas en un 88% a las secuencias mencionadas; y en que dicha variante se une a una o varias moleculas del complejo mayor de histocompatibilidad (MHC) y/o induce la reaccion cruzada de linfocitos T con dicho peptido variante. Tambien se refiere a proteinas, acidos nucleicos y una sal farmaceuticamente aceptable del peptido. Dicho peptido es util para el tratamiento de enfermedades proliferativas tales como glioblastoma, cancer de mama, cancer colorrectal, entre otros
PE2018000553A 2015-12-11 2016-12-05 Nuevos peptidos y combinacion de peptidos para el uso en la inmunoterapia contra varios tipos de cancer PE20181316A1 (es)

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