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MA43490A1 - Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre divers cancers - Google Patents

Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre divers cancers

Info

Publication number
MA43490A1
MA43490A1 MA43490A MA43490A MA43490A1 MA 43490 A1 MA43490 A1 MA 43490A1 MA 43490 A MA43490 A MA 43490A MA 43490 A MA43490 A MA 43490A MA 43490 A1 MA43490 A1 MA 43490A1
Authority
MA
Morocco
Prior art keywords
peptides
combination
cells
present
relates
Prior art date
Application number
MA43490A
Other languages
English (en)
Inventor
Toni Weinschenk
Jens Fritsche
Colette Song
Harpreet Singh
Andrea Mahr
Oliver Schoor
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MA43490A1 publication Critical patent/MA43490A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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Abstract

La présente invention concerne des peptides, des protéines, des acides nucléiques et des cellules pour leur utilisation dans des procédés immunothérapeutiques. La présente invention concerne, en particulier, l'immunothérapie du cancer. La présente invention concerne, en outre, des épitopes peptidiques des lymphocytes t associés à une tumeur, seuls ou en combinaison avec d'autres peptides associés à une tumeur, qui peuvent, par exemple, servir de principes pharmaceutiques actifs pour des compositions vaccinales qui stimulent les réponses immunitaires antitumorales, ou pour stimuler des lymphocytes t ex vivo et les transférer aux patients. Des peptides liés aux molécules du complexe majeur d'histocompatibilité (cmh), ou des peptides en tant que tels, peuvent également être des cibles d'anticorps, de récepteurs des lymphocytes t solubles et d'autres molécules de liaison.
MA43490A 2015-12-11 2016-12-05 Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre divers cancers MA43490A1 (fr)

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GBGB1521894.4A GB201521894D0 (en) 2015-12-11 2015-12-11 Novel peptides and combination of peptides for use in immunotherapy against various cancers
PCT/EP2016/079737 WO2017097699A1 (fr) 2015-12-11 2016-12-05 Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre divers cancers

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MA042494A MA42494A (fr) 2015-12-11 2016-12-05 Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre divers cancers
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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3004830A1 (fr) 2015-11-11 2017-05-18 Opi Vi- Ip Holdco Llc Composition et methodes pour anticorps anti-tnfr2
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
GB201520595D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
IL298653A (en) 2015-12-11 2023-01-01 Immatics Biotechnologies Gmbh New peptides and a combination of peptides for use in immunotherapy against several types of cancer
AU2017240745B2 (en) * 2016-03-31 2021-08-19 Biontech Us Inc. Neoantigens and methods of their use
JP7075125B2 (ja) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
KR102639592B1 (ko) 2016-12-08 2024-02-21 이매틱스 바이오테크놀로지스 게엠베하 짝짓기가 향상된 t 세포 수용체
CN111533799A (zh) 2017-04-10 2020-08-14 伊玛提克斯生物技术有限公司 用于白血病和其他癌症免疫治疗的肽和肽组合物
EA201992416A1 (ru) 2017-04-10 2020-02-25 Имматикс Байотекнолоджиз Гмбх Пептиды и комбинации пептидов для применения в иммунотерапии лейкозов и других видов рака
GB201709866D0 (en) * 2017-06-20 2017-08-02 Immunocore Ltd T cell receptors
DE102017114737A1 (de) 2017-06-30 2019-01-03 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
ES2898210T3 (es) 2017-07-14 2022-03-04 Immatics Biotechnologies Gmbh Molécula de polipéptido con especificidad dual mejorada
WO2019086507A1 (fr) * 2017-10-31 2019-05-09 Pantarhei Bioscience B.V. Méthodes immunothérapeutiques pour traiter et/ou prévenir le cancer du poumon
DE102017127984B4 (de) 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
US10692605B2 (en) 2018-01-08 2020-06-23 International Business Machines Corporation Library screening for cancer probability
MX2020008327A (es) 2018-02-09 2020-10-28 Immatics Us Inc Metodos para preparar celulas t.
DE102018107224A1 (de) * 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
TW202016131A (zh) * 2018-05-16 2020-05-01 德商英麥提克生物技術股份有限公司 用於抗癌免疫治療的肽
TW202019955A (zh) * 2018-07-31 2020-06-01 德商英麥提克生物技術股份有限公司 B*07 限制肽和肽組合的抗癌免疫治療和相關方法
WO2020048924A1 (fr) * 2018-09-03 2020-03-12 Laboratoire Hra-Pharma Fragments de zp3 en immunothérapie du cancer de l'ovaire
JP7528058B2 (ja) * 2018-09-14 2024-08-05 イマティクス バイオテクノロジーズ ゲーエムベーハー Ｔｃｒリガンドの高スループットペプチド－ｍｈｃ親和性スクリーニングのための方法
TW202024121A (zh) * 2018-09-18 2020-07-01 德商英麥提克生物技術股份有限公司 A*01 限制肽和肽組合物在抗癌免疫治療中的用途和相關方法
EP3866827A1 (fr) 2018-10-19 2021-08-25 The Francis Crick Institute Limited Nouveaux antigènes de cancer et méthodes
JP7216995B2 (ja) * 2018-12-05 2023-02-02 学校法人関西医科大学 胸腺癌バイオマーカー及び胸腺腫瘍の予後予測マーカー
WO2020191172A1 (fr) 2019-03-19 2020-09-24 Immatics US, Inc. Cultures de cellules t cd28, leurs compositions et leurs méthodes d'utilisation
PE20220164A1 (es) 2019-05-27 2022-01-28 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas
AU2020286756A1 (en) 2019-06-06 2022-01-27 Immatics Biotechnologies Gmbh Sorting with counter selection using sequence similar peptides
CN114174323B (zh) * 2019-07-05 2025-01-07 弗朗西斯·克里克研究所有限公司 新的癌抗原和方法
US20210032370A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Recruiting agent further binding an mhc molecule
AU2021225817A1 (en) 2020-02-24 2022-10-20 Immatics US, Inc. Methods for expanding T cells for the treatment of cancer and related malignancies
DE102020106710A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
WO2022040631A1 (fr) 2020-08-21 2022-02-24 Immatics US, Inc. Procédés d'isolement de lymphocytes t sélectionnés cd8+
CN113416253B (zh) * 2021-05-24 2022-12-13 复旦大学 分离的抗原itpripl1结合蛋白及其用途
TW202241938A (zh) 2020-12-31 2022-11-01 美商英麥提克斯股份有限公司 Ｃｄ８多肽、組合物及其使用方法
JP2024516699A (ja) 2021-05-05 2024-04-16 イマティクス バイオテクノロジーズ ゲーエムベーハー Ｂｍａ０３１抗原結合ポリペプチド
US20250231185A1 (en) * 2021-05-13 2025-07-17 La Jolla Institute For Immunology Coronavirus T Cell Epitopes, Megapools and Uses Thereof
US20240358831A1 (en) 2021-08-24 2024-10-31 Immatics US, Inc. Selection of immune cells using peptide mhc complexes generated by conditional ligand exchange
TW202332765A (zh) 2021-09-20 2023-08-16 美商英麥提克斯股份有限公司 用於ｔ細胞療法之ｔ細胞群體的單核球耗盡
US20230192886A1 (en) 2021-11-08 2023-06-22 Immatics Biotechnologies Gmbh Adoptive cell therapy combination treatment and compositions thereof
EP4472659A1 (fr) 2022-02-03 2024-12-11 CeCaVa GmbH & Co. KG Co-vaccination avec des antigènes cd4 et cd8
CN114736298B (zh) * 2022-04-08 2023-12-12 陕西脉元生物科技有限公司 用于检测自身免疫系统疾病的抗Shroom2自身抗体及其产品和应用
JP2025516189A (ja) 2022-04-28 2025-05-27 イマティクス ユーエス，アイエヌシー． 膜結合型ｉｌ－１５、ｃｄ８ポリペプチド、細胞、組成物、およびそれらの使用方法
JP2025515603A (ja) 2022-04-28 2025-05-20 イマティクス ユーエス，アイエヌシー． Ｉｌ－１２ポリペプチド、ｉｌ－１５ポリペプチド、ｉｌ－１８ポリペプチド、ｃｄ８ポリペプチド、それらの組成物、およびそれらの使用方法
EP4514834A1 (fr) 2022-04-28 2025-03-05 Immatics US, Inc. Polypeptides récepteurs de tgfbêta négatifs dominants, polypeptides cd8, cellules, compositions et leurs méthodes d'utilisation
US20230355678A1 (en) 2022-05-05 2023-11-09 Immatics US, Inc. Methods for improving t cell efficacy
CN115785204B (zh) * 2022-06-10 2024-02-13 河北博海生物工程开发有限公司 肺癌特异性分子靶标08及其用途
CN116814642B (zh) * 2023-07-17 2024-09-17 南通大学 一种预测肝癌患者预后的生物标志物及其应用
WO2025040598A2 (fr) * 2023-08-18 2025-02-27 Immatics Biotechnologies Gmbh Peptides affichés par cmh destinés à être utilisés en immunothérapie contre différents types de cancer
WO2025096649A1 (fr) 2023-11-01 2025-05-08 Immatics US, Inc. Il-15 liée à une membrane, polypeptides de cd8, cellules, compositions et leurs procédés d'utilisation

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1118860A1 (fr) * 2000-01-21 2001-07-25 Rijksuniversiteit te Leiden Méthodes pour sélectionner et produire des épitopes peptidiques de cellules T ainsi que des vaccines comprenant lesdits épitopes sélectionnés
AUPQ776100A0 (en) * 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
US7919467B2 (en) 2000-12-04 2011-04-05 Immunotope, Inc. Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
US20030118585A1 (en) 2001-10-17 2003-06-26 Agy Therapeutics Use of protein biomolecular targets in the treatment and visualization of brain tumors
EP2153843B1 (fr) 2001-09-18 2012-08-15 Genentech, Inc. Compositions et procédés pour le traitement et le diagnostic d'une tumeur
US7205121B2 (en) 2002-11-26 2007-04-17 Cold Spring Harbor Laboratory DEP-1 receptor protein tyrosine phosphatase interacting proteins and related methods
CN1253469C (zh) * 2003-11-28 2006-04-26 北京大学 人的肿瘤－睾丸抗原hca587的抗原决定簇多肽及其用途
US7399469B2 (en) 2004-03-26 2008-07-15 Pdl Biopharma, Inc. Anti-LFL2 antibodies for the diagnosis, prognosis and treatment of cancer
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
CA2595699A1 (fr) 2005-02-17 2006-08-24 Dana-Farber Cancer Institute, Inc. Compositions, trousses et methodes servant a effectuer l'identification, l'evaluation, la prophylaxie et la therapie du cancer
US7608413B1 (en) 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof
US7842467B1 (en) 2005-05-12 2010-11-30 Celera Corporation Breast disease targets and uses thereof
WO2007086915A2 (fr) * 2005-05-12 2007-08-02 Applied Genomics, Inc. Reactifs et leurs procedes d’utilisation lors du diagnostic, de la classification et de la therapie de cancers
SI1760089T1 (sl) * 2005-09-05 2009-12-31 Immatics Biotechnologies Gmbh S tumorjem povezani peptidi, ki se veĹľejo na molekule humanega levkocitnega antigena (HLA) razreda I ali II in ustrezno cepivo proti raku
WO2007056523A2 (fr) 2005-11-08 2007-05-18 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Procedes de diagnostic et de surveillance de la progression d'un cancer
US7358231B1 (en) 2005-12-01 2008-04-15 Applera Corporation Pancreatic cancer secreted targets and uses thereof
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
US7910565B2 (en) * 2006-09-01 2011-03-22 Wisconsin Alumni Research Foundation Prostate cancer vaccine
CN101066991A (zh) * 2007-06-13 2007-11-07 北京大学 人肿瘤－睾丸抗原hca587的抗原决定簇多肽及其应用
PL2562182T3 (pl) * 2007-07-27 2016-03-31 Immatics Biotechnologies Gmbh Nowe immunogenne epitopy do immunoterapii
US7960134B1 (en) 2007-08-01 2011-06-14 Arqule, Inc. Kinase inhibition models and their uses
US7892770B2 (en) 2007-08-24 2011-02-22 Van Andel Research Institute Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
WO2009036246A2 (fr) * 2007-09-14 2009-03-19 Immunotope, Inc. Immunogènes qui induisent des lymphocytes t cytotoxiques et leur utilisation dans la prévention, le traitement et le diagnostic du cancer
GB0721686D0 (en) * 2007-11-05 2007-12-12 Medinnova As Polypeptides
US8455623B2 (en) 2008-05-21 2013-06-04 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
AU2012203810B2 (en) 2011-06-22 2013-12-05 Oncocyte Corporation Methods and compositions for the treatment and diagnosis of bladder cancer
NL2007536C2 (en) * 2011-10-05 2013-04-08 Academisch Ziekenhuis Leiden Lumc Adjuvant compound.
CA2898474A1 (fr) * 2013-02-14 2014-08-21 Immunocellular Therapeutics, Ltd. Vaccins contre le cancer et methodes de vaccination
TWI819228B (zh) 2013-08-05 2023-10-21 德商伊瑪提克斯生物科技有限公司 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（八）
GB201319446D0 (en) 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
GB201408255D0 (en) * 2014-05-09 2014-06-25 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML)
GB201520595D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
EP3383418B1 (fr) * 2015-12-04 2021-10-20 Board of Regents, The University of Texas System Peptides slc45a2 pour l'immunothérapie

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US20170189506A1 (en) 2017-07-06
CA3007382A1 (fr) 2017-06-15
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US20190015492A1 (en) 2019-01-17
US10004792B2 (en) 2018-06-26
JP7513562B2 (ja) 2024-07-09
CN108602854A (zh) 2018-09-28
US10098937B2 (en) 2018-10-16
JP7229516B2 (ja) 2023-02-28
US20170165338A1 (en) 2017-06-15
US20170189513A1 (en) 2017-07-06
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US10314896B2 (en) 2019-06-11
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