PE20181539A1 - Proceso de hidrogenacion catalitico para preparar pirazoles - Google Patents
Proceso de hidrogenacion catalitico para preparar pirazolesInfo
- Publication number
- PE20181539A1 PE20181539A1 PE2018001381A PE2018001381A PE20181539A1 PE 20181539 A1 PE20181539 A1 PE 20181539A1 PE 2018001381 A PE2018001381 A PE 2018001381A PE 2018001381 A PE2018001381 A PE 2018001381A PE 20181539 A1 PE20181539 A1 PE 20181539A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- acids
- compound
- catalytic hydrogenation
- prepare
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000009903 catalytic hydrogenation reaction Methods 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000003586 protic polar solvent Substances 0.000 abstract 1
- -1 pyrazole compound Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
- B01J21/18—Carbon
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/42—Platinum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Se refiere a un proceso catalitico para preparar un compuesto de pirazol de la formula V o una de sus sales, estereoisomeros, tautomeros o N-oxidos que comprende la etapa de ciclar un compuesto de carbonilo ?,?-insaturado sustituido por hidrazona de la formula IV mediante su reaccion con hidrogeno en donde el compuesto de la formula IV se proporciona de una mezcla de reaccion que comprende como componentes: (a) un catalizador de hidrogenacion, (b) un acido seleccionado de acidos de Brønsted, sales de amonio de acidos de Brønsted y acidos de Lewis, (c) un solvente protico y opcionalmente (d) un solvente aprotico y en donde R1 es C(O)ORC, en donde RC es alquilo C1-C4 o bencilo; R2 es CH3 o fluorometilo; R3 es H; R4 es C1-C4 cuyo grupo no esta sustituido o esta parcialmente halogenado y R5 es C1-C4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16153833 | 2016-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181539A1 true PE20181539A1 (es) | 2018-09-26 |
Family
ID=55304873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018001381A PE20181539A1 (es) | 2016-02-02 | 2017-01-25 | Proceso de hidrogenacion catalitico para preparar pirazoles |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10975036B2 (es) |
| EP (1) | EP3411360B1 (es) |
| JP (1) | JP6900400B2 (es) |
| KR (1) | KR102651666B1 (es) |
| CN (1) | CN108699003B (es) |
| AU (1) | AU2017216082B2 (es) |
| BR (1) | BR112018014357B8 (es) |
| CA (1) | CA3010561C (es) |
| CL (1) | CL2018002075A1 (es) |
| CO (1) | CO2018008428A2 (es) |
| DK (1) | DK3411360T3 (es) |
| ES (1) | ES2795874T3 (es) |
| IL (1) | IL260375B (es) |
| MX (1) | MX384709B (es) |
| PE (1) | PE20181539A1 (es) |
| PL (1) | PL3411360T3 (es) |
| PT (1) | PT3411360T (es) |
| RU (1) | RU2733958C2 (es) |
| UA (1) | UA124928C2 (es) |
| WO (1) | WO2017133942A1 (es) |
| ZA (1) | ZA201805742B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2712192C2 (ru) | 2014-07-31 | 2020-01-24 | Басф Се | Способ получения пиразолов |
| ES2856454T3 (es) | 2015-05-08 | 2021-09-27 | Basf Agro Bv | Procedimiento para la preparación de epóxido de terpinoleno. |
| US10538470B2 (en) | 2015-05-08 | 2020-01-21 | BASF Agro B.V. | Process for the preparation of limonene-4-ol |
| BR112017023935B1 (pt) | 2015-05-11 | 2020-07-07 | Basf Se | processo para a preparação de um composto |
| DK3472138T3 (da) | 2016-06-15 | 2020-11-23 | Basf Agro Bv | Fremgangsmåde til epoxidering af en tetrasubstitueret alken |
| EP3472139B1 (en) | 2016-06-15 | 2021-04-07 | BASF Agro B.V. | Process for the epoxidation of a tetrasubstituted alkene |
| CN109415280A (zh) | 2016-07-07 | 2019-03-01 | 巴斯夫欧洲公司 | 用于制备杀虫环戊烯类化合物的Oxy-Cope重排 |
| ES2858699T3 (es) | 2016-11-04 | 2021-09-30 | Basf Se | Procedimiento para la purificación de pirazolpiridazinas |
| WO2018091338A1 (en) | 2016-11-17 | 2018-05-24 | Basf Se | Process for the purification of 1-(4-chlorophenyl)pyrazol-3-ol |
| EP3573978A1 (en) | 2017-01-25 | 2019-12-04 | Basf Se | Process for preparation of benzylic amides |
| CN110431126B (zh) | 2017-03-20 | 2022-12-02 | 巴斯夫欧洲公司 | 制备一溴三氯甲烷的方法 |
| WO2019086545A1 (en) | 2017-11-02 | 2019-05-09 | Basf Se | Process for preparing 4-chlorobenzyl propargyl ether |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007326784A (ja) * | 2006-06-06 | 2007-12-20 | Sagami Chem Res Center | １−置換−５−フルオロアルキルピラゾール−４−カルボン酸エステルの製造方法 |
| US20110189167A1 (en) | 2007-04-20 | 2011-08-04 | Flynn Daniel L | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases |
| AU2008242697A1 (en) * | 2007-04-20 | 2008-10-30 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| MX2010001462A (es) | 2007-08-27 | 2010-03-01 | Basf Se | Compuestos de pirazol para controlar plagas de invertebrados. |
| WO2009068652A1 (en) | 2007-11-30 | 2009-06-04 | Smithkline Beecham Corporation | 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines as soluble guanylate cyclase activators |
| EA019312B1 (ru) * | 2008-05-05 | 2014-02-28 | Басф Се | Способ получения 1,3,4-замещённых пиразольных соединений |
| KR101364869B1 (ko) * | 2008-09-24 | 2014-02-21 | 바스프 에스이 | 무척추 해충을 방제하기 위한 피라졸 화합물 |
| US8853125B2 (en) | 2008-09-24 | 2014-10-07 | Basf Se | Pyrazole compounds for controlling invertebrate pests |
| EP2236505A1 (de) | 2009-04-03 | 2010-10-06 | Bayer CropScience AG | Acylierte Aminopyridine und - pyridazine als Insektizide |
| AR076984A1 (es) | 2009-06-08 | 2011-07-20 | Merck Serono Sa | Derivados de pirazol oxadiazol |
| US9445861B2 (en) | 2011-04-12 | 2016-09-20 | Thermedical, Inc. | Methods and devices for controlling ablation therapy |
| EP2699563B3 (en) * | 2011-04-21 | 2024-06-12 | Basf Se | Novel pesticidal pyrazole compounds |
| JO3407B1 (ar) * | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| EP2671873A1 (en) | 2012-06-06 | 2013-12-11 | Solvay Sa | Method for the cyclization of hydrazinoacrylic acid derivatives |
| BR122019015121B1 (pt) * | 2012-06-20 | 2020-04-07 | Basf Se | mistura pesticida, composição, composição agrícola, métodos para o combate ou controle das pragas de invertebrados, para a proteção dos vegetais em crescimento ou dos materias de propagação vegetal, para a proteção de material de propagação vegetal, uso de uma mistura pesticida e métodos para o combate dos fungos fitopatogênicos nocivos e para proteger vegetais de fungos fitopatogênicos nocivos |
| EP3763367A1 (en) | 2012-12-06 | 2021-01-13 | Celgene Quanticel Research, Inc. | Pyridine-pyrazole derivatives as histone demethylase inhibitors |
| RU2712192C2 (ru) * | 2014-07-31 | 2020-01-24 | Басф Се | Способ получения пиразолов |
| BR112017023935B1 (pt) | 2015-05-11 | 2020-07-07 | Basf Se | processo para a preparação de um composto |
-
2017
- 2017-01-25 RU RU2018130339A patent/RU2733958C2/ru active
- 2017-01-25 ES ES17701485T patent/ES2795874T3/es active Active
- 2017-01-25 AU AU2017216082A patent/AU2017216082B2/en active Active
- 2017-01-25 EP EP17701485.9A patent/EP3411360B1/en active Active
- 2017-01-25 US US16/074,537 patent/US10975036B2/en active Active
- 2017-01-25 CN CN201780009304.6A patent/CN108699003B/zh active Active
- 2017-01-25 UA UAA201808830A patent/UA124928C2/uk unknown
- 2017-01-25 JP JP2018558485A patent/JP6900400B2/ja active Active
- 2017-01-25 PE PE2018001381A patent/PE20181539A1/es unknown
- 2017-01-25 WO PCT/EP2017/051524 patent/WO2017133942A1/en not_active Ceased
- 2017-01-25 BR BR112018014357A patent/BR112018014357B8/pt active IP Right Grant
- 2017-01-25 MX MX2018009453A patent/MX384709B/es unknown
- 2017-01-25 PL PL17701485T patent/PL3411360T3/pl unknown
- 2017-01-25 CA CA3010561A patent/CA3010561C/en active Active
- 2017-01-25 DK DK17701485.9T patent/DK3411360T3/da active
- 2017-01-25 KR KR1020187025347A patent/KR102651666B1/ko active Active
- 2017-01-25 PT PT177014859T patent/PT3411360T/pt unknown
-
2018
- 2018-07-02 IL IL260375A patent/IL260375B/en active IP Right Grant
- 2018-08-02 CL CL2018002075A patent/CL2018002075A1/es unknown
- 2018-08-10 CO CONC2018/0008428A patent/CO2018008428A2/es unknown
- 2018-08-28 ZA ZA201805742A patent/ZA201805742B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN108699003B (zh) | 2023-02-03 |
| AU2017216082B2 (en) | 2020-12-03 |
| IL260375B (en) | 2021-03-25 |
| WO2017133942A1 (en) | 2017-08-10 |
| DK3411360T3 (da) | 2020-06-08 |
| BR112018014357B1 (pt) | 2022-08-16 |
| RU2018130339A (ru) | 2020-03-04 |
| JP2019504883A (ja) | 2019-02-21 |
| EP3411360B1 (en) | 2020-03-11 |
| CA3010561A1 (en) | 2017-08-10 |
| CA3010561C (en) | 2024-04-16 |
| US10975036B2 (en) | 2021-04-13 |
| PT3411360T (pt) | 2020-06-01 |
| KR20180104743A (ko) | 2018-09-21 |
| RU2018130339A3 (es) | 2020-03-19 |
| ES2795874T3 (es) | 2020-11-25 |
| BR112018014357B8 (pt) | 2022-09-06 |
| MX384709B (es) | 2025-03-14 |
| CN108699003A (zh) | 2018-10-23 |
| KR102651666B1 (ko) | 2024-03-26 |
| JP6900400B2 (ja) | 2021-07-07 |
| PL3411360T3 (pl) | 2020-08-24 |
| US20190055200A1 (en) | 2019-02-21 |
| MX2018009453A (es) | 2018-09-21 |
| UA124928C2 (uk) | 2021-12-15 |
| ZA201805742B (en) | 2019-11-27 |
| BR112018014357A2 (pt) | 2018-12-18 |
| CL2018002075A1 (es) | 2018-09-14 |
| EP3411360A1 (en) | 2018-12-12 |
| AU2017216082A1 (en) | 2018-07-26 |
| CO2018008428A2 (es) | 2018-08-21 |
| RU2733958C2 (ru) | 2020-10-08 |
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