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PE20180672A1 - Anticuerpos anti-ctla-4 y metodos de uso de los mismos - Google Patents

Anticuerpos anti-ctla-4 y metodos de uso de los mismos

Info

Publication number
PE20180672A1
PE20180672A1 PE2017002485A PE2017002485A PE20180672A1 PE 20180672 A1 PE20180672 A1 PE 20180672A1 PE 2017002485 A PE2017002485 A PE 2017002485A PE 2017002485 A PE2017002485 A PE 2017002485A PE 20180672 A1 PE20180672 A1 PE 20180672A1
Authority
PE
Peru
Prior art keywords
antibodies
ctla
methods
same
antagonize
Prior art date
Application number
PE2017002485A
Other languages
English (en)
Inventor
Marc Van Dijk
Cornelia Anne Mundt
Gerd Ritter
David Schaer
Jedd David Wolchok
Taha Merghoub
David Adam Savitsky
Mark Arthur Findeis
Nicholas Stuart Wilson
Original Assignee
Agenus Inc
Ludwig Inst For Cancer Res Ltd
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenus Inc, Ludwig Inst For Cancer Res Ltd, Memorial Sloan Kettering Cancer Center filed Critical Agenus Inc
Publication of PE20180672A1 publication Critical patent/PE20180672A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Abstract

Anticuerpos que se unen especificamente al CTLA-4 humano y antagonizan la funcion del CTLA-4. Tambien se proveen composiciones farmaceuticas que comprenden estos anticuerpos, acidos nucleicos que codifican estos anticuerpos, vectores de expresion y celulas huesped para elaborar estos anticuerpos, y metodos de tratamiento de un sujeto usando estos anticuerpos
PE2017002485A 2015-05-29 2016-05-27 Anticuerpos anti-ctla-4 y metodos de uso de los mismos PE20180672A1 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562168391P 2015-05-29 2015-05-29
US201562182363P 2015-06-19 2015-06-19
US201562190653P 2015-07-09 2015-07-09
US201562257202P 2015-11-18 2015-11-18
US201662280263P 2016-01-19 2016-01-19
US201662292500P 2016-02-08 2016-02-08
US201662294558P 2016-02-12 2016-02-12
US201662323226P 2016-04-15 2016-04-15

Publications (1)

Publication Number Publication Date
PE20180672A1 true PE20180672A1 (es) 2018-04-19

Family

ID=56118035

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017002485A PE20180672A1 (es) 2015-05-29 2016-05-27 Anticuerpos anti-ctla-4 y metodos de uso de los mismos

Country Status (25)

Country Link
US (4) US10144779B2 (es)
EP (2) EP3303394B1 (es)
JP (2) JP6900323B2 (es)
KR (2) KR20230028478A (es)
CN (2) CN107849144B (es)
AU (3) AU2016271591A1 (es)
BR (1) BR112017025564B8 (es)
CA (1) CA2986765A1 (es)
CL (1) CL2017003023A1 (es)
CO (1) CO2017013398A2 (es)
DK (1) DK3303394T3 (es)
ES (1) ES2803655T3 (es)
HR (1) HRP20201031T1 (es)
HU (1) HUE050750T2 (es)
IL (2) IL255468B (es)
LT (1) LT3303394T (es)
MA (2) MA44594B1 (es)
MX (2) MX2017015046A (es)
PE (1) PE20180672A1 (es)
PL (1) PL3303394T3 (es)
PT (1) PT3303394T (es)
RS (1) RS60792B1 (es)
SG (1) SG10201913500TA (es)
SI (1) SI3303394T1 (es)
WO (1) WO2016196237A1 (es)

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PE20180672A1 (es) 2015-05-29 2018-04-19 Agenus Inc Anticuerpos anti-ctla-4 y metodos de uso de los mismos
CN107949573B (zh) 2015-09-01 2022-05-03 艾吉纳斯公司 抗-pd-1抗体及其使用方法
MA43259A (fr) 2015-11-18 2018-09-26 Merck Sharp & Dohme Liants ctla4
RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
KR102531889B1 (ko) 2016-06-20 2023-05-17 키맵 리미티드 항-pd-l1 및 il-2 사이토카인
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
CN107815468B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN107815467B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
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CN118634323A (zh) * 2016-12-07 2024-09-13 艾吉纳斯公司 抗体和其使用方法
AU2017373944B2 (en) 2016-12-07 2022-02-03 Agenus Inc. Anti-CTLA-4 antibodies and methods of use thereof
EP3579848B1 (en) 2017-02-08 2024-10-30 Dragonfly Therapeutics, Inc. Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
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