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PE20171336A1 - Anticuerpos contra tau y sus usos - Google Patents

Anticuerpos contra tau y sus usos

Info

Publication number
PE20171336A1
PE20171336A1 PE2017001280A PE2017001280A PE20171336A1 PE 20171336 A1 PE20171336 A1 PE 20171336A1 PE 2017001280 A PE2017001280 A PE 2017001280A PE 2017001280 A PE2017001280 A PE 2017001280A PE 20171336 A1 PE20171336 A1 PE 20171336A1
Authority
PE
Peru
Prior art keywords
amino acid
acid sequence
chain variable
sequence seq
variable region
Prior art date
Application number
PE2017001280A
Other languages
English (en)
Inventor
Alberto Alvarado
David Driver
Mansuo Lu Hayashi
Jirong Lu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20171336A1 publication Critical patent/PE20171336A1/es

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Abstract

Se refiere a un anticuerpo monoclonal que comprende: a) una region variable de cadena ligera (con una secuencia de aminoacidos SEQ ID NO: 9 y una region variable de cadena pesada con una secuencia de aminoacidos SEQ ID NO: 10; o b) una region variable de cadena ligera con una secuencia de aminoacidos SEQ ID NO: 1 y una region variable de cadena pesada con una secuencia de aminoacidos SEQ ID NO: 2. Tambien se refiere a una molecula de ADN, a una celula de expresion, a un procedimiento de obtencion, a una composicion farmaceutica y a un metodo de tratamiento. Dicho anticuerpo monoclonal se une especificamente a la proteina de union a microtubulos Tau, siendo util en el tratamiento de enfermedades neurodegenerativas tales como la enfermedad de Alzheimer, enfermedad de Pick, entre otros
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