PE20160211A1 - DELAYED RELEASE DRUG FORMULATION - Google Patents
DELAYED RELEASE DRUG FORMULATIONInfo
- Publication number
- PE20160211A1 PE20160211A1 PE2016000264A PE2016000264A PE20160211A1 PE 20160211 A1 PE20160211 A1 PE 20160211A1 PE 2016000264 A PE2016000264 A PE 2016000264A PE 2016000264 A PE2016000264 A PE 2016000264A PE 20160211 A1 PE20160211 A1 PE 20160211A1
- Authority
- PE
- Peru
- Prior art keywords
- polymeric material
- delayed release
- soluble polymeric
- delayed
- inner layer
- Prior art date
Links
- 230000003111 delayed effect Effects 0.000 title abstract 5
- 239000013583 drug formulation Substances 0.000 title 1
- 239000000463 material Substances 0.000 abstract 4
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 230000000968 intestinal effect Effects 0.000 abstract 2
- 229920000831 ionic polymer Polymers 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
En una formulacion de liberacion retardada que comprende un nucleo que contiene un farmaco y un recubrimiento de liberacion retardada para proporciona la liberacion intestinal, la liberacion del farmaco en el colon se acelera mediante la inclusion de una capa aislante entre el nucleo y el recubrimiento de liberacion retardada. El recubrimiento de liberacion retardada comprende una capa interior y una capa exterior. La capa exterior comprende material polimerico soluble con dependencia del pH que tiene umbral de pH a aproximadamente pH 5 o mas alto. La capa interior comprende un material polimerico soluble que es soluble en el fluido intestinal o fluido gastrointestinal, tal material polimerico soluble se selecciona del grupo que consiste de a un polimero de acido policarboxilico que esta al menos parcialmente neutralizado, y un polimero no ionico, siempre que, cuando tal material polimerico soluble sea un polimero no ionico, la capa interior comprende al menos un aditivo seleccionado de un agente regulador de pH y una base.In a delayed release formulation comprising a core containing a drug and a delayed release coating to provide intestinal release, release of the drug into the colon is accelerated by the inclusion of an insulating layer between the core and the release coating. delayed. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises pH dependent soluble polymeric material having a pH threshold at about pH 5 or higher. The inner layer comprises a soluble polymeric material that is soluble in intestinal fluid or gastrointestinal fluid, such soluble polymeric material is selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralized, and a non-ionic polymer, provided that, when such soluble polymeric material is a non-ionic polymer, the inner layer comprises at least one additive selected from a pH regulating agent and a base.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2016000264A PE20160211A1 (en) | 2013-10-29 | 2013-10-29 | DELAYED RELEASE DRUG FORMULATION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2016000264A PE20160211A1 (en) | 2013-10-29 | 2013-10-29 | DELAYED RELEASE DRUG FORMULATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160211A1 true PE20160211A1 (en) | 2016-04-20 |
Family
ID=58508004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016000264A PE20160211A1 (en) | 2013-10-29 | 2013-10-29 | DELAYED RELEASE DRUG FORMULATION |
Country Status (1)
| Country | Link |
|---|---|
| PE (1) | PE20160211A1 (en) |
-
2013
- 2013-10-29 PE PE2016000264A patent/PE20160211A1/en unknown
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