PE20160839A1 - Derivados de 4-azaindol - Google Patents
Derivados de 4-azaindolInfo
- Publication number
- PE20160839A1 PE20160839A1 PE2016000374A PE2016000374A PE20160839A1 PE 20160839 A1 PE20160839 A1 PE 20160839A1 PE 2016000374 A PE2016000374 A PE 2016000374A PE 2016000374 A PE2016000374 A PE 2016000374A PE 20160839 A1 PE20160839 A1 PE 20160839A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- alkyl
- azaindol
- compounds
- hydroxyclohexyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 4-AZAINDOL DE FORMULAS (IA) Y (IB) DONDE R1 ES H, HALOGENO, CN, ENTRE OTROS; R2 ES H; p ES 1 O 2; R4 ES HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS, EN LA FORMULA (IA); Y PARA LA FORMULA (IB) R1 ES ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R2 ES H; R4a ES H O HALOGENO; R4b ES H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; R4c ES H, HALOGENO, HALOALQUILO C1-C4, ENTRE OTROS; R4d ES H O HALOGENO. SON COMPUESTOS PREFERIDOS: 1-(4-FLUOROBENCIL)-N-((1S-2S)-2-HIDROXICICLOHEXIL)-7-METIL-1H-PIRROL[3,2-b]PIRIDINA-3-CARBOXAMIDA; 1-(3-FLUOROBENCIL)-N-((1S-2S)-2-HIDROXICICLOHEXIL)-1H-PIRROL[3,2-b]PIRIDINA-3-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE ACETILCOLINA MUSCARINICO M1 (mAChR) SIENDO UTILES EN EL TRATAMIENTO DE DEMENCIA TIPO ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1317363.8A GB201317363D0 (en) | 2013-10-01 | 2013-10-01 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160839A1 true PE20160839A1 (es) | 2016-08-20 |
Family
ID=49585123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016000374A PE20160839A1 (es) | 2013-10-01 | 2014-09-30 | Derivados de 4-azaindol |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9926312B2 (es) |
| EP (2) | EP3052496B1 (es) |
| JP (3) | JP6517790B2 (es) |
| KR (1) | KR102248559B1 (es) |
| CN (1) | CN105873927B (es) |
| AR (1) | AR097866A1 (es) |
| AU (1) | AU2014330880B2 (es) |
| BR (1) | BR112016007016A8 (es) |
| CA (1) | CA2924619C (es) |
| CL (1) | CL2016000726A1 (es) |
| ES (2) | ES2710190T3 (es) |
| GB (1) | GB201317363D0 (es) |
| HK (1) | HK1223090A1 (es) |
| IL (1) | IL244609B (es) |
| MX (1) | MX368956B (es) |
| PE (1) | PE20160839A1 (es) |
| PH (1) | PH12016500529A1 (es) |
| RU (1) | RU2688938C2 (es) |
| SG (1) | SG11201602052YA (es) |
| TW (1) | TW201546070A (es) |
| WO (1) | WO2015049574A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| WO2015163485A1 (en) | 2014-04-23 | 2015-10-29 | Takeda Pharmaceutical Company Limited | Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease |
| JP6531093B2 (ja) | 2014-05-16 | 2019-06-12 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| MA43913B1 (fr) * | 2015-06-08 | 2019-05-31 | Suven Life Sciences Ltd | Modulateurs allostériques positifs du récepteur m1 muscarinique |
| PT3347349T (pt) * | 2015-09-10 | 2019-10-30 | Suven Life Sciences Ltd | Derivados de fluoroindole como moduladores alostéricos positivos para recetor m1 muscarínico |
| MX385975B (es) | 2016-02-16 | 2025-03-18 | Univ Vanderbilt | Moduladores alostéricos positivos del receptor de acetilcolina muscarínico m1. |
| US10899759B2 (en) | 2016-09-30 | 2021-01-26 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
| MX2020003832A (es) * | 2017-10-18 | 2020-08-06 | Suven Life Sciences Ltd | Compuestos heteroarilos como moduladores alostericos positivos del receptor muscarinico m1. |
| KR102406885B1 (ko) * | 2017-10-27 | 2022-06-08 | 수벤 라이프 사이언시스 리미티드 | 무스카린 m1 수용체 양성 알로스테릭 조절제로서 다환형 아미드 |
| US12065433B2 (en) | 2018-10-24 | 2024-08-20 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
| KR102347368B1 (ko) * | 2020-11-03 | 2022-01-07 | (주)케이메디켐 | 신규한 아자인돌 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물 |
| CN118440041B (zh) * | 2024-07-02 | 2024-09-27 | 苏州凯瑞医药科技有限公司 | 一种手性4-氨基-3-羟基四氢吡喃的制备方法 |
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| AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
| DE602004027171D1 (de) | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
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| WO2012112933A1 (en) | 2011-02-18 | 2012-08-23 | The Scripps Research Institute | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate |
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| CA2918925A1 (en) * | 2013-09-27 | 2015-04-02 | F. Hoffmann-La Roche Ag | Indol and indazol derivatives |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
-
2013
- 2013-10-01 GB GBGB1317363.8A patent/GB201317363D0/en not_active Ceased
-
2014
- 2014-09-30 US US15/025,996 patent/US9926312B2/en active Active
- 2014-09-30 CA CA2924619A patent/CA2924619C/en not_active Expired - Fee Related
- 2014-09-30 KR KR1020167011471A patent/KR102248559B1/ko not_active Expired - Fee Related
- 2014-09-30 PE PE2016000374A patent/PE20160839A1/es not_active Application Discontinuation
- 2014-09-30 ES ES14799529T patent/ES2710190T3/es active Active
- 2014-09-30 BR BR112016007016A patent/BR112016007016A8/pt active Search and Examination
- 2014-09-30 US US14/501,355 patent/US20150094328A1/en not_active Abandoned
- 2014-09-30 RU RU2016116775A patent/RU2688938C2/ru active
- 2014-09-30 SG SG11201602052YA patent/SG11201602052YA/en unknown
- 2014-09-30 MX MX2016004014A patent/MX368956B/es active IP Right Grant
- 2014-09-30 EP EP14799529.4A patent/EP3052496B1/en active Active
- 2014-09-30 CN CN201480062539.8A patent/CN105873927B/zh not_active Expired - Fee Related
- 2014-09-30 HK HK16111182.7A patent/HK1223090A1/zh unknown
- 2014-09-30 JP JP2016519874A patent/JP6517790B2/ja not_active Expired - Fee Related
- 2014-09-30 ES ES18204685T patent/ES2807221T3/es active Active
- 2014-09-30 WO PCT/IB2014/001978 patent/WO2015049574A1/en not_active Ceased
- 2014-09-30 EP EP18204685.4A patent/EP3489237B1/en active Active
- 2014-09-30 AU AU2014330880A patent/AU2014330880B2/en not_active Ceased
- 2014-10-01 TW TW103134194A patent/TW201546070A/zh unknown
- 2014-10-01 AR ARP140103638A patent/AR097866A1/es unknown
-
2016
- 2016-03-15 IL IL244609A patent/IL244609B/en active IP Right Grant
- 2016-03-17 PH PH12016500529A patent/PH12016500529A1/en unknown
- 2016-03-29 CL CL2016000726A patent/CL2016000726A1/es unknown
-
2018
- 2018-01-19 US US15/875,069 patent/US10072005B2/en active Active
-
2019
- 2019-03-01 JP JP2019037299A patent/JP2019112433A/ja active Pending
-
2020
- 2020-05-08 JP JP2020082404A patent/JP6899944B2/ja not_active Expired - Fee Related
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