CL2013002650A1 - Compuestos derivados triciclicos con actividad sobre los receptores hormonales nucleares; composicion farmaceutica que los comprende; proceso de reparacion de compuestos intermediarios; y uso en el tratamiento del sida, insuficiencia adrenal aguda, enfermedad de addison, rinitis alergica, enfermedad de alzheimer, entre otros. - Google Patents
Compuestos derivados triciclicos con actividad sobre los receptores hormonales nucleares; composicion farmaceutica que los comprende; proceso de reparacion de compuestos intermediarios; y uso en el tratamiento del sida, insuficiencia adrenal aguda, enfermedad de addison, rinitis alergica, enfermedad de alzheimer, entre otros.Info
- Publication number
- CL2013002650A1 CL2013002650A1 CL2013002650A CL2013002650A CL2013002650A1 CL 2013002650 A1 CL2013002650 A1 CL 2013002650A1 CL 2013002650 A CL2013002650 A CL 2013002650A CL 2013002650 A CL2013002650 A CL 2013002650A CL 2013002650 A1 CL2013002650 A1 CL 2013002650A1
- Authority
- CL
- Chile
- Prior art keywords
- disease
- addison
- alzheimer
- aids
- activity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 208000030507 AIDS Diseases 0.000 title 1
- 208000026872 Addison Disease Diseases 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 102000007399 Nuclear hormone receptor Human genes 0.000 title 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 title 1
- 206010039085 Rhinitis allergic Diseases 0.000 title 1
- 208000010981 acute adrenal insufficiency Diseases 0.000 title 1
- 201000010105 allergic rhinitis Diseases 0.000 title 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000008439 repair process Effects 0.000 title 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| CN104926815B (zh) | 2008-01-04 | 2017-11-03 | 英特利凯恩有限责任公司 | 某些化学实体、组合物和方法 |
| AR084824A1 (es) | 2011-01-10 | 2013-06-26 | Intellikine Inc | Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| HRP20181367T4 (hr) | 2012-11-01 | 2021-11-26 | Infinity Pharmaceuticals, Inc. | Liječenje raka korištenjem modulatora izoforme pi3 kinaze |
| EP2935284A4 (en) | 2012-12-21 | 2016-04-27 | Abbvie Inc | HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS |
| US9643947B2 (en) | 2013-08-28 | 2017-05-09 | Northwestern University | 7-membered fused heterocycles and methods of their synthesis |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| EP3423453A4 (en) * | 2016-03-01 | 2019-11-06 | Corcept Therapeutics, Inc. | USE OF GLUCOCORTICOID RECEPTOR MODULATORS TO POTENTIALIZE CHECKPOINT INHIBITORS |
| CA3028718A1 (en) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| KR101849301B1 (ko) * | 2018-01-29 | 2018-04-16 | 전북대학교 산학협력단 | 식나무 추출물을 포함하는 안구 건조증 예방 또는 치료용 조성물 |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN119775276A (zh) * | 2019-04-11 | 2025-04-08 | 百时美施贵宝公司 | 制备化合物的新颖合成选项 |
| PT4069691T (pt) | 2019-12-06 | 2024-12-18 | Vertex Pharma | Tetrahidrofuranos substituídos como moduladores dos canais de sódio |
| GEAP202416430A (en) | 2021-06-04 | 2024-03-25 | Vertex Pharma | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| AU2023367284A1 (en) | 2022-10-28 | 2025-05-29 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
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| CA2111138A1 (en) * | 1993-01-15 | 1994-07-16 | Thierry Godel | Octahydrophenanthrene derivatives |
| JP2002512639A (ja) * | 1998-04-06 | 2002-04-23 | 藤沢薬品工業株式会社 | プロパノールアミン誘導体 |
| EE05584B1 (et) * | 1999-04-30 | 2012-10-15 | Pfizer Products Inc. | Glkokortikoidretseptori modulaatorid |
| MXPA03001186A (es) * | 2000-08-07 | 2004-04-20 | Neurogen Corp | Compuestos heterociclicos como ligandos del receptor acido gamma aminobutirico (gabaa). |
| TW200400816A (en) * | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| US20060247266A1 (en) * | 2004-11-26 | 2006-11-02 | Asahi Kasei Pharma Corporation | Nitrogen-containing tricyclic compounds |
| WO2006081659A1 (en) * | 2005-02-01 | 2006-08-10 | The University Of British Columbia | Meroterpenoid inhibitors of phosphoinositide 3 kinase (pi3k) |
| JP4873614B2 (ja) * | 2006-01-16 | 2012-02-08 | 国立大学法人 東京大学 | カリウムチャネル開口薬 |
| PT2114970E (pt) * | 2007-02-02 | 2011-09-22 | Pfizer Prod Inc | Compostos tricíclicos e sua utilização como moduladores de receptor de glucocorticóide |
| BRPI0807121A2 (pt) * | 2007-02-02 | 2014-04-08 | Pfizer Prod Inc | Compostos tricíclicos e seu uso como moduladores de receptor glicocorticóide |
| JP2009209068A (ja) * | 2008-03-03 | 2009-09-17 | Univ Of Tokyo | カリウムチャネル開口薬 |
| KR101377860B1 (ko) * | 2008-07-28 | 2014-03-25 | 화이자 인코포레이티드 | 페난트렌온 화합물, 조성물 및 방법 |
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| AU2012229952A1 (en) | 2013-04-18 |
| JP2014509592A (ja) | 2014-04-21 |
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| CA2830234A1 (en) | 2012-09-20 |
| CN103732059A (zh) | 2014-04-16 |
| PH12013501898A1 (en) | 2020-10-19 |
| GT201300214A (es) | 2014-10-17 |
| DOP2013000208A (es) | 2013-11-15 |
| RU2013145912A (ru) | 2015-04-20 |
| KR20140015472A (ko) | 2014-02-06 |
| CR20130500A (es) | 2013-12-13 |
| AR085412A1 (es) | 2013-10-02 |
| ECSP13012920A (es) | 2013-11-29 |
| CO6771454A2 (es) | 2013-10-15 |
| IL228422A0 (en) | 2013-12-31 |
| EP2685821A1 (en) | 2014-01-22 |
| EP2685821A4 (en) | 2014-08-20 |
| TW201247610A (en) | 2012-12-01 |
| UY33957A (es) | 2012-10-31 |
| US20120238549A1 (en) | 2012-09-20 |
| PE20141211A1 (es) | 2014-10-15 |
| BR112013033777A2 (pt) | 2016-09-13 |
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